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Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

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Neural Regeneration Research 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi kazuko A.O'Dell Charles F.Zorumski Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently found that a single injection of glyphosate inhibits long-term potentiation, a cellular model of learning and memory, in rat hippocampal slices dissected 1 day after injection, indicating that glyphosate-based herbicides can alter cognitive function. Glyphosate-based herbicides could adversely affect cognitive function either indirectly and/or directly. Indirectly, glyphosate could affect gut microbiota, and if dysbiosis results in endotoxemia(leaky gut), infiltrated bacterial by-products such as lipopolysaccharides could activate pro-inflammatory cascades. Glyphosate can also directly trigger pro-inflammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of long-term potentiation by glyphosate appears to be similar to that of lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinflammation caused by glyphosate. Dietary intake of polyphenols, such as quercetin, which overcome the inhibitory effect of glyphosate on long-term potentiation, could be one effective strategy. The aim of this narrative review is to discuss possible mechanisms underlying neurotoxicity following glyphosate exposure as a means to identify potential treatments.

关键词： cognitive impairment glyphosate microglia neuroinflammation roundup toll-like receptor 4 zinc chelation

Dynamic robust optimal reorder point with uncertain lead time and changeable demand distribution

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第12期11卷 938-945页

作者： Masaki TAMURA kazuko MORIZAWA Hiroyuki NAGASAWA Department of Electrical and Information Systems Engineering Graduate School of EngineeringOsaka Prefecture University Osaka Prefectural College of Technology

In fixed order quantity systems,uncertainty in lead time is expressed as a set of scenarios with occurrence probabilities,and the mean and variance in demand distribution are supposed to be changeable according to a known pattern.A new concept of "dynamic robust optimal reorder point" is proposed in this paper and its value is calculated as a "robust optimal reorder point function with respect to reorder time".Two approaches were employed in determining the dynamic optimal reorder *** first is a shortage rate satisfaction approach and the second is a backorder cost minimization *** former aims at finding the minimum value of reorder point at each reorder time which satisfies the condition that the cumulative distribution function (CDF) of shortage rate under a given set of scenarios in lead time is greater than or equal to a basic CDF of shortage rate predetermined by a *** the latter approach,the CDF of closeness of reorder point is defined at each reorder time to express how close to the optimal reorder points under the set of scenarios,and the dynamic optimal reorder point is defined according to stochastic *** numerical examples demonstrate the features of these dynamic robust optimal reorder points.

关键词： Reorder point Lead time Robust optimum Uncertainty Scenario

Image of Ne Trap by a Microwave Cavity

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Chinese Physics Letters 1997年第2期14卷 93-95页

作者： XU Lei Satoshi Oishi kazuko Shimizu Hiroshi Takuma Fujio Shimizu Department of Physics Fudan UniversityShanghai 200433 Institute for Laser Science The University of Electro-communicationsChofugaokaChofushiTokyo 182Japan Department of Applied Physics University of TokyoBunkyo-kuTokyo 113Japan

The focusing of Ne metastable atoms trapped in magnetic-optical trap by a microwave cavity was *** cavity was operated at TM010 *** a microwave power of 14W,the Ne trap was imaged to a spot of about 0.25mm(full width ... 详细信息

关键词： microwave Microwave cavity

LANDUSE AND SOILS IN KARST AREAS OF JAVA ISLAND

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中国岩溶 1992年第S1期11卷 102-111页

作者： kazuko Urushibara-Yoshino Dept. Natural Sciences The Komazawa University Komazawa Setagayaku Tokyo 154 Japan

In Gunung Sewu, which locates southeast of Yogyakarta, cone karst composed of the Tertiary pure limestone is utilized intensively for agriculture. High population has been supported by efficient agricultural landuse in this area. The population in the high density areas is increasing until 1990. Especially, the higher steep slope and the top of cones have been utilized as fields by deforestation since few years, because of continuous rapid increase of population.

关键词： limestone southeast Tertiary karst steep utilized agricultural cones agriculture season

Efficacy of incremental loads of cow's milk as a treatment for lactose malabsorption in Japan

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World Journal of Clinical Cases 2023年第4期11卷 797-808页

作者： Matsuri Hasegawa kazuko Okada Satoru Nagata Shigetaka Sugihara Department of Pediatrics Tokyo Women's Medical University Medical Center EastDepartment of PediatricsTokyo Women’s Medical University Medical Center EastArakawa-ku 116-8561TokyoJapan Department of Pediatrics Okada Pediatric ClinicShinjuku-ku 169-0072TokyoJapan Department of Pediatrics Tokyo Women’s Medical UniversityShinjuku-ku 162-8666TokyoJapan

BACKGROUND Lactose intolerance(LI)is commonly seen in East Asian *** studies showed that lactose or milk loading has been used as a treatment for lactose malabsorption(LM)in Western countries,but there have been no reports regarding this type of treatment in *** lactose or milk loading requires ingestion of large amounts of lactose within a short period,this is considered to be too harsh for Japanese people because of their less habitual milk consumption(175 mL per day in average)than Western *** this study,we demonstrated lactose tolerance acquisition in a suitable way for *** To examine the efficacy of lactose(cow’s milk)loading treatment in patients with *** Individuals with abdominal symptoms induced by milk or dairy products(LI symptoms)were identified with a questionnaire.A 20 g lactose hydrogen breath test(LHBT)was carried out to confirm LM diagnosis and to evaluate co-existence of small intestinal bacterial overgrowth(SIBO).Respondents diagnosed with LM were selected as study subjects and were treated with incremental loads of cow’s milk,starting from 30 mL and increasing up to 200 mL at 4-7 d *** the treatment,changes in symptoms and LM diagnostic value of 20 g LHBT were *** samples pre-and post-treatment were examined for changes in intestinal microbiota using 16S rRNA *** consent was obtained prior to each stage of the *** In 46 subjects with LI symptoms(10-68 years old,mean age 34 years old)identified with the questionnaire,35(76.1%)were diagnosed with LM by 20 g LHBT,and 6 had co-existing *** treatment with incremental cow’s milk was carried out in 32 subjects diagnosed with LM(14-68 years old,median age 38.5 years old).The mean period of the treatment was 41±8.6 *** of symptoms was observed in 29(90.6%;95%confidence interval:75.0%-98.0%)*** 20 g LHBT indicated that 10(34.5%)subjects had improved diagnostic value of LM,no change was

关键词： Lactose Intolerance Lactose Malabsorption lactose loading treatment Intestinal bacterial flora Fecal microbiota

How utilizing the genes involved in drought tolerance could tackle the climate change-related food crisis?

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Molecular Plant 2021年第10期14卷 1601-1603页

作者： Angela Fernando Michael Selvaraj Manabu Ishitani Kazuo Nakashima Kazuo Shinozaki kazuko Yamaguchi-Shinozaki Crops for Nutrition and Health Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT)Km 17 Recta Cali-PalmiraApartado Aereo 6713763537 CaliColombia Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaJapan Stable Agricultural Production Program Japan International Research Center for Agricultural Science(JIRCAS)TsukubaIbarakiJapan Graduate School of Agricultural and Life Sciences University of TokyoTokyoJapan Gene Discovery Research Group RIKEN Center for Sustainable Resource ScienceTsukubaIbarakiJapan

The global population is expected to increase by 10 billion by 2050,the demand for food and water is also likely to *** factors intensify the growing water scarcity,such as inefficient water use in the food value chain and inadequate infrastructure to save *** changing climate also exacerbates the rising temperature by making the drier areas drier and negatively impacting agriculture production in most parts of the world.A decrease in precipitation has been observed in the tropics and sub-tropics,such as the Sahel region of Southern Africa,the Mediterranean,South Asia,and the Southwest of US since 1970(https://***).

关键词： utilizing drought likely

Differential effects of physical activity and sleep duration on cognitive function in young adults

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Journal of Sport and Health Science 2018年第2期7卷 227-236页

作者： kazuko Kato Kunihiro Iwamoto Naoko Kawano Yukihiro Noda Norio Ozaki Akiko Noda Department of Biomedical Sciences Chubu University Graduate School of Life and Health Sciences Department of Psychiatry Nagoya University Graduate School of Medicine Institutes of Innovation for Future Society Nagoya University Division of Clinical Sciences and Neuropsychopharmacology Graduate School of PharmacyMeijo University

Purpose: Although exercise and sleep duration habits are associated with cognitive function, their beneficial effects on cognitive function remain unclear. We aimed to examine the effect of sleep duration and daily physical activity on cognitive function, elucidating the neural mechanisms using near-infrared spectroscopy(NIRS).Methods: A total of 23 healthy young adults(age 22.0 ± 2.2 years) participated in this study. Exercise amount was assessed using a uniaxial accelerometer. We evaluated total sleep time(TST) and sleep efficiency by actigraphy. Cognitive function was tested using the N-back task, the Wisconsin Card Sorting Test(WCST), and the Continuous Performance Test—Identical Pairs(CPT-IP), and the cortical oxygenated hemoglobin levels during a word fluency task were measured with ***: Exercise amount was significantly correlated with reaction time on 0- and 1-back tasks(r = —0.602, p = 0.002; r = —0.446, p = 0.033,respectively), whereas TST was significantly correlated with % corrects on the 2-back task(r = 0.486, p = 0.019). Multiple regression analysis,including exercise amount, TST, and sleep efficiency, revealed that exercise amount was the most significant factor for reaction time on 0- and 1-back tasks(b = —0.634, p = 0.002; b = —0.454, p = 0.031, respectively), and TST was the most significant factor for % corrects on the 2-back task(b = 0.542, p = 0.014). The parameter measured by WCST and CPT-IP was not significantly correlated with TST or exercise amount. Exercise amount, but not TST, was significantly correlated with the mean area under the NIRS curve in the prefrontal area(r = 0.492, p = 0.017).Conclusion: Exercise amount and TST had differential effects on working memory and cortical activation in the prefrontal area. Daily physical activity and appropriate sleep duration may play an important role in working memory.

关键词： Cortical oxygenation Executive function Exercise Sustained attention Total sleep time Working memory

Screening of agonistic activities against four nuclear receptors in wastewater treatment plants in Japan using a yeast two-hybrid assay

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Journal of Environmental Sciences 2011年第1期23卷 125-132页

作者： Daisuke Inoue Koki Nakama kazuko Sawada Taro Watanabe Hisae Matsui Kazunari Sei Tsuyoshi Nakanishi Michihiko Ike Division of Sustainable Energy and Environmental Engineering Osaka University2-1 YamadaokaSuitaOsaka 565-0871Japan Laboratory of Hygienic Chemistry and Molecular Toxicology Gifu Pharmaceutical University5-6-1 Mitahora-higashiGifu 502-8585Japan

To assess the potential endocrine disruptive effects through multiple nuclear receptors （NRs）, especially non-steroidal NRs, in municipal wastewater, we examined the agonistic activities on four NRs （estrogen receptor α, thyroid hormone receptor α, retinoic acid receptor ct and retinoid X receptor α） of untreated and treated wastewater from municipal wastewater treatment plants （WWTPs） in Japan using a yeast two-hybrid assay. Investigation of the influent and effluent of seven WWTPs revealed that agonistic activities against steroidal and non-steroidal NRs were always detected in the influents and partially remained in the effluents. Further investigation of four WWTPs employing conventional activated sludge, pseudo-anoxic-oxic, anoxic-oxic and anaerobic-anoxic-oxic processes revealed that the ability to reduce the agonistic activity against each of the four NRs varies depending on the treatment process. These results indicated that municipal wastewater in Japan commonly contains endocrine disrupting chemicals that exert agonistic activities on steroidal and non-steroidal NRs, and that some of these chemicals are released into the natural aquatic environment. Although the results obtained in yeast assays suggested that measured levels of non-steroidal NR agonists in the effluent of WWTPs were not likely to cause any biological effect, further study is required to assess their possible risks in detail.

关键词： agonistic activity endocrine disrupting chemicals non-steroidal nuclear receptor wastewater treatment plants

Impairment of IFN-a production capacity in patients with hepatitis C virus and the risk of the development of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第46期11卷 7330-7334页

作者： kazuko Uno Yoshiki Suginoshita Kazuhiro Kakimi Fuminori Moriyasu Mayumi Hirosaki Taro Shirakawa Tsunataro Kishida Louis Pasteur Center for Medical ResearchKyoto Japan Department of Gastroenterology and HepatologyFaculty of Medicine Kyoto UniversityKyotoJapan Department of Health Promotion and Human BehaviorKyoto University Graduate School of Public Health KyotoJapan

AIM: To determine the utility of interferon (IFN) -αproduction capacity in patients with hepatitis C virus (HCV) infection for the measurement of immunosurveillance potential and for the early detection of hepatocellular carcinoma (HCC) by investigating the Sendai virus (HVJ) stimulated IFN-α production capacity of patients with HCV ***: HVJ stimulated IFN-α production was determined in a large number of patients with HCV infection and the development of HCC was monitored for 3 years in patients with liver cirrhosis (LC).RESULTS: IFN-α production capacity decreases gradually with the progression of liver disease from chronic hepatitis (CH) to HCC. A significant correlation between the duration of HCV infection and impaired IFN-α production capacity was observed. IFN-α production in patients who developed HCC within 3 years was significantly lower than that of patients who remained in LC without developing ***: Measurement of IFN-α production in LC patients may be useful for the early detection of HCC.

关键词： IFN-α production capacity Hepatitis C virus Hepatocellular carcinoma