Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

作     者：Yukitoshi Izumi Kazuko A.O'Dell Charles F.Zorumski Yukitoshi Izumi;Kazuko A.O'Dell;Charles F.Zorumski

作者机构：Department of PsychiatryWashington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric ResearchWashington University School of MedicineSt.LouisMOUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2024年第19卷第10期

页      面：2212-2218页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by MH101874 (to CFZ) MH122379 (to CFZ) the Taylor Family Institute for Innovative Psychiatric Research and the Bantly Foundation (to CFZ) 

主　　题：cognitive impairment glyphosate microglia neuroinflammation roundup toll-like receptor 4 zinc chelation 

摘      要：Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently found that a single injection of glyphosate inhibits long-term potentiation, a cellular model of learning and memory, in rat hippocampal slices dissected 1 day after injection, indicating that glyphosate-based herbicides can alter cognitive function. Glyphosate-based herbicides could adversely affect cognitive function either indirectly and/or directly. Indirectly, glyphosate could affect gut microbiota, and if dysbiosis results in endotoxemia(leaky gut), infiltrated bacterial by-products such as lipopolysaccharides could activate pro-inflammatory cascades. Glyphosate can also directly trigger pro-inflammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of long-term potentiation by glyphosate appears to be similar to that of lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinflammation caused by glyphosate. Dietary intake of polyphenols, such as quercetin, which overcome the inhibitory effect of glyphosate on long-term potentiation, could be one effective strategy. The aim of this narrative review is to discuss possible mechanisms underlying neurotoxicity following glyphosate exposure as a means to identify potential treatments.