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Generalized Morrey spaces and trace operator

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Science China Mathematics 2016年第2期59卷 281-336页

作者： nakamura Shohei NOI Takahiro SAWANO Yoshihiro Department of Mathematics and Information Science Tokyo Metropolitan University

The theory of generalized Besov-Morrey spaces and generalized Triebel-Lizorkin-Morrey spaces is developed. Generalized Morrey spaces, which Mizuhara and Nakai proposed, are equipped with a parameter and a function. The trace property is one of the main focuses of the present paper, which will clarify the role of the parameter of generalized Morrey spaces. The quarkonial decomposition is obtained as an application of the atomic decomposition. In the end, the relation between the function spaces dealt in the present paper and the foregoing researches is discussed.

关键词：广义Morrey空间迹算子原子分解空间理论跟踪性能空间参数功能空间

The first Japanese case of intraductal cancer of the prostate with checkpoint kinase 2 mutation

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Asian Journal of Urology 2022年第4期9卷 480-482页

作者： Hiroshi Hongo Takeo Kosaka Kohei nakamura Shuji Mikami Hiroshi Nishihara Mototsugu Oya Department of Urology Keio University School of MedicineJapan Genomics Unit Keio Cancer CenterKeio University School of MedicineJapan Department of Diagnostic Pathology Keio University HospitalJapan

Dear editor:Intraductalcarcinomaoftheprostate(IDC-P)ischaracterized by expansive growth of cancer cells in normal prostatic ducts with basal cell layer and associated with high grade invasive prostate cancer(PCa).However,the molecular profile or clinical character of IDC-P in progressive castration-resistant PCa(CRPC)was not fully characterized yet.

关键词： cancer clinical prostatic

Cobalt-based magnetic Weyl semimetals with high-thermodynamic stabilities

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npj Computational Materials 2021年第1期7卷 41-48页

作者： Wei Luo Yuma nakamura Jinseon Park Mina Yoon Center for Nanophase Materials Sciences Oak Ridge National LaboratoryOak RidgeTN 37831USA Department of Physics and Astronomy University of TennesseeKnoxvilleTN 37916USA

Recent experiments identified Co_(3)Sn_(2)S_(2) as the first magnetic Weyl semimetal(MWSM).Using first-principles calculation with a global optimization approach,we explore the structural stabilities and topological electronic properties of cobalt(Co)-based shandite and alloys,Co_(3)MM’X_(2)(M/M’=Ge,Sn,Pb,X=S,Se,Te),and identify stable structures with different Weyl *** a tight-binding model,for the first time,we reveal that the physical origin of the nodal lines of a Co-based shandite structure is the interlayer coupling between Co atoms in different Kagome layers,while the number of Weyl points and their types are mainly governed by the interaction between Co and the metal atoms,Sn,Ge,and *** Co_(3)SnPbS_(2) alloy exhibits two distinguished topological phases,depending on the relative positions of the Sn and Pb atoms:a three-dimensional quantum anomalous Hall metal,and a MWSM phase with anomalous Hall conductivity(~1290Ω^(−1) cm^(−1))that is larger than that of Co_(2)Sn_(2)S_(2).Our work reveals the physical mechanism of the origination of Weyl fermions in Co-based shandite structures and proposes topological quantum states with high thermal stability.

关键词： stability alloy magnetic

Neuromelanin-sensitive magnetic resonance imaging:a promising technique for depicting tissue characteristics containing neuromelanin

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Neural Regeneration Research 2014年第7期9卷 759-760页

作者： Ken nakamura Keizo Sugaya Department of Neurology Tokyo Metropolitan Neurological Hospital

Idiopathic Parkinson＇s disease （IPD） is a progressive, neurodegenerative movement disorder characterized by bradykinesia, muscular rigidity, pos- tural instability and tremor. IPD is usually diagnosed based on clinical findings, but diagnoses are only 75-90% accurate when compared with autopsy results. Improving diagnostic accuracy is critical for the early dif- ferentiation of IPD from other Parkinsonism-related disorders because of differences in their prognoses and treatment. Furthermore, IPD is clinically heterogeneous, with variable prognosis. Although the biological function of neuromelanin has not yet been determined, the selective vulnerability of neuromelanin-containing neurons in patients with IPD suggests a role for this pigment in neurodegeneration. Recently developed ultra-high-field magnetic resonance imaging （MRI） systems produce Tl-weighted neuro- melanin-sensitive images with very high spatial resolution, enabling the de- piction of tissue containing neuromelanin. Here we review recent advances in neuromelanin-sensitive MRI in IPD and related conditions suggesting that neuromelanin may be a potential diagnostic biomarker for IPD.

关键词： IPD Neuromelanin-sensitive magnetic resonance imaging MRI BTP

Mechanotransduction,nanotechnology,and nanomedicine

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The Journal of Biomedical Research 2021年第4期35卷 284-293页

作者： Xiaowei Liu Fumihiko nakamura School of Pharmaceutical Science and Technology Tianjin UniversityTianjin 300072China.

Mechanotransduction,a conversion of mechanical forces into biochemical signals,is essential for human development and *** is observable at all levels ranging from the whole body,organs,tissues,organelles down to *** results in various diseases such as muscular dystrophies,hypertension-induced vascular and cardiac hypertrophy,altered bone repair and cell *** mechanotransduction occurs at nanoscale,nanosciences and applied nanotechnology are powerful for studying molecular mechanisms and pathways of *** force microscopy,magnetic and optical tweezers are commonly used for force measurement and manipulation at the single molecular *** is also used to control cells,topographically and mechanically by specific types of nano materials for tissue *** research will become increasingly important as a sub-discipline under *** we review nanotechnology approaches using force measurements and manipulations at the molecular and cellular levels during mechanotransduction,which has been increasingly play important role in the advancement of nanomedicine.

关键词： nanomedicine mechanotransduction mechanical force differentiation tissue engineering

The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models

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Neural Regeneration Research 2017年第1期12卷 43-46页

作者： Syoichi Tashiro Masaya nakamura Hideyuki Okano Department of Rehabilitation Medicine Keio University School of MedicineTokyoJapan Department of Orthopaedic Surgery Keio University School of MedicineTokyoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury（SCI）.By contrast,there are still only a few studies have focused on the treatment of the chronically injured spinal cord,in which cell-based regenerative medicine seems less *** the majority of SCI patients are in the chronic phase,representing a major challenge for the clinical application of cellbased regenerative *** combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized,there had been very few studies involving rehabilitative treatments to *** a recent study,we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI,not only in additive but also in synergistic *** though we have succeeded to outline the profiles of recovery secondary to the combination therapy,the mechanism underlying the effects remain *** this review article,we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models.

关键词： transplantation spinal cord injury regenerative medicine chronic phase rehabilitation treadmill training

Blood glucose control in patients with severe sepsis and septic shock

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World Journal of Gastroenterology 2009年第33期15卷 4132-4136页

作者： Hiroyuki Hirasawa Shigeto Oda Masataka nakamura Department of Emergency and Critical Care Medicine Chiba University Graduate School of Medicine

The main pathophysiological feature of sepsis is the uncontrollable activation of both pro-and anti-inflammatory responses arising from the overwhelming pro-duction of mediators such as pro-and anti-inflammatory cytokines. Such an uncontrollable inflammatory response would cause many kinds of metabolic derangements. One such metabolic derangement is hyperglycemia. Accordingly, control of hyperglycemia in sepsis is considered to be a very effective therapeutic approach. However, despite the initial enthusiasm, recent studies reported that tight glycemic control with intensive insulin therapy failed to show a beneficial effect on mortality of patients with severe sepsis and septic shock. One of the main reasons for this disappointing result is the incidence of harmful hypoglycemia during intensive insulin therapy. Therefore, avoidance of hypoglycemia during intensive insulin therapy may be a key issue in effective tight glycemic control. It is generally accepted that glycemic control aimed at a blood glucose level of 80-100 mg/dL, as initially proposed by van den Berghe, seems to be too tight and that such a level of tight glycemic control puts septic patients at increased risk of hypoglycemia. Therefore, now many researchers suggest less strict glycemic control with a target blood glucose level of 140-180 mg/dL. Also specific targeting of glycemic control in diabetic patients should be considered. Since there is a significantcorrelation between success rate of glycemic control and the degree of hypercytokinemia in septic patients, some countermeasures to hypercytokinemia may be an important aspect of successful glycemic control. Thus, in future, use of an artificial pancreas to avoid hypoglycemia during insulin therapy, special consideration of septic diabetic patients, and control of hypercytokinemia should be considered for more effective glycemic control in patients with severe sepsis and septic shock.

关键词：感染性休克脓毒症控制血糖患者

TREM2 marks tumor-associated macrophages

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Signal Transduction and Targeted Therapy 2020年第1期5卷 493-494页

作者： Kyohei nakamura Mark J.Smyth QIMR Berghofer Medical Research Institute Herston 4006 QLDAustralia

Immunosuppressive myeloid cells are recognized as a key barrier for cancer *** an integrated technology for single-cell RNA-sequencing and intracellular protein measurements,A recent paper published in Cell provides e... 详细信息

关键词： tumor immunotherapy myeloid

A preliminary study on the effects of line and selective thinning on bird communities in Hokkaido, northern Japan

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Journal of Forestry Research 2013年第3期24卷 553-559页

作者： Yuya Toyoshima Yuichi Yamaura Yuki Yabuhara Futoshi nakamura Division of Environmental Resources Graduate School of Agriculture Hokkaido UniversityNishi 9 Kita 9 Kitaku Sapporo Hokkaido 0608589 Japan

In Japan, selective thinning is a common thinning method, though line thinning receives much attention because of its economic merits. In this study, we examined effects of the two thinning methods on bird communities in Todo fir （Abies sachalinensis） plantations in Hok- kaido, Japan. We surveyed bird species in forests under four different management types - unthinned, selectively thinned, line-thinned planta- tion, and naturally regenerated forest （here after referred to as natural forest） stands - using a line-transect method. We also investigated vege- tation structure （canopy tree and understory） of these stands. Bird species richness did not differ between natural forests and plantations, while bird total abundance was greater in plantations than in natural forests. Bird species richness and total abundance were comparable among the three management types for plantations. Abundances of 10 bird species were different among the four management types, and five species were more abundant in line-thinned plantations. However, two species were more abundant in selectively thinned stands than in line-thinned stands, and they frequently appeared in natural forests. There were no distinct differ- ences in vegetation structure among the management types for planta- tions. Our results suggest that line thinning could be beneficial for some bird species in plantations.

关键词： line thinning selective thinning Todo fir (Abies sachalinen-sis) plantation improved indicator species analysis bird community