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Heterosexual risk of HIV infection in China： systematic review and meta-analysis

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Chinese Medical Journal 2011年第12期124卷 1890-1896页

作者： ZANG Chun-peng JIA Zhong-wei Katherine Brown kathleen heather reilly WANG Jun-jie WANG Ning National Center for AIDS/STD Control and Prevention ChineseCenter for Disease Control and Prevention 155 Changbai RoadChangping District Beijing 102206 China National Institute of Drug Dependence 38 Xueyuan Road HaidianDistrict Beijing 100083 China Tulane University Health Sciences Center School of Public Healthand Tropical Medicine New Orleans LA USA

Background Heterosexual sex has become the dominant transmission route in China. Recently studies reported high heterogeneity in heterosexual transmission risk in resource-limited countries. The aim of this study was to summarize the risk of HIV transmission among Chinese serodiscordant couples. Methods A systematic review and meta-analysis of observational studies of heterosexual HIV transmission among serodiscordant couples in China was conducted. Two reviewers conducted a literature search using the China National Knowledge Infrastructure （CNKI）, Chinese Medical Current Contents （CMCC）, and Medline databases. Pooled transmission estimates per 100 person-years （PY） were calculated using a random-effects model. Meta-regression analysis and subgroup analysis stratified by study design, transmission direction and period of antiretroviral therapy （ART） availability were conducted to assess the factors associated with transmission. Results Eleven eligible studies were identified reporting on 11 984 couples and 405 HIV transmission events. HIV transmission risk from HIV-positive individuals to heterosexual partners was 1.68 （95% Cl 0.74-2.62） per 100 PY. Study design did not reach statistical significance in meta-regression analysis. The pooled female-to-male transmission estimate was 1.11 （95% CI 0.09-2.14） per 100 PY and male-to-female transmission estimate was 1.43 （95% Cl 0.19-2.68） per 100 PY. The pooled estimate for those before the availability of the Chinese National Free Antiretroviral Therapy Program （2.13 （95% Cl 0.00-4.63） per 100 PY） was higher than that for those after the implementation of this program （1.44 （95% CI 0.62-2.26） per 100 PY）. Conclusions Transmission estimates in China were lower than other developing countries, but higher than developed countries. Research that better defines HIV secondary transmission rates and the associated behavioral, treatment adherence, and health-related risk factors among heterosexual serodiscordant couples in China

关键词： human immunodeficiency virus heterosexual transmission

Estimation and Projection of the HIV Epidemic Trend among the Migrant Population in China

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Biomedical and Environmental Sciences 2011年第4期24卷 343-348页

作者： MENGXiaoJun WANG Lu Susan CHAN kathleen heather reilly PENG ZhiHang GUO Wei DING GuoWei DING ZhengWei QIN QianQian National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206 China Department of Public Health Nanjing Medical University Nanjing 210029 Jiangsu China

Objective The migrant population is a vulnerable group for HIV infection in *** potential epidemic trends among migrants is critical for developing HIV preventative measures in this *** The Estimation and Projection Package （EPP） model was used to process prefecture and county-level surveillance data to generate HIV prevalence and epidemic trends for migrant populations in *** The prevalence of HIV among migrants in 2009 was estimated at 0.075% （95% CI：0.042%,0.108%） in *** HIV epidemic among migrants is likely to increase over the next 5 years,with the prevalence expected to reach 0.110% （95% CI：0.070%,0.150%） by *** Although the 2009 estimates for the HIV/AIDS epidemic in China indicate a slower rate of increase compared with the national HIV/AIDS epidemic,it is estimated to persistently increase among migrants over the next 5 *** will have a strong impact on the overall future of the HIV epidemic trend in China and evidence-based prevention and monitoring efforts should be expanded for this vulnerable population.

关键词： China Transients and migrants Estimation and projection package HIV/AIDS

Dynamic Characteristic Analysis of HIV Mother to Child Transmission in China

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Biomedical and Environmental Sciences 2010年第5期23卷 402-408页

作者： JUN-JIE WANG kathleen heather reilly HUA HAN ZHI-HANG PENG NING WANG National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100050China Tulane University Health Sciences Center School of Public Health and Tropical MedicineNew OrleansLAUSA National ASIC Design Engineering Center Institute of AutomationChinese Academy of SciencesBeijing 100190China Department of Epidemiology and Biostatistics Nanjing Medical UniversityNanjing 210029China

Objective to explore dynamic characteristics of the HIV mother to child transmission （MTCT） epidemic in *** A deterministic dynamic transmission model was used to determine the effect of key parameters on the likely long-term trends of the HIV MTCT epidemic in *** 7.0 was used to develop the *** The number of the susceptibles （S）,the transmission rate （β）,and the screening proportion （α） of HIV positive pregnant women have the greatest impact on the HIV MTCT epidemic in *** growth of the MTCT epidemic in China could not be controlled only by decreasing the MTCT transmission *** prevalence of HIV positive women should be reduced and more pregnant women should be tested for *** Prevention of MTCT （PMTCT） should focus not only on the reduction of HIV transmission rates and incidences of HIV among women but also on the increase of HIV testing for pregnant *** most cost-effective PMTCT means for China should be investigated in future studies.

关键词： mother to child transmission dynamic model HIV China

冠状动脉旁路移植术后前蛋白转化酶枯草溶菌素9与晚期隐静脉移植血管疾病的相关性分析:一项横断面研究

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英国医学杂志中文版 2019年第2期22卷 87-93页

作者：高静汪海波肖健勇任珉 kathleen heather reilly 李玉明刘寅中国人民武装警察部队后勤学院附属医院天津天津市胸科医院心血管病研究所天津北京大学临床研究所北京天津市胸科医院心内科天津美国纽约

目的探讨冠状动脉旁路移植术(CABG)后血清前蛋白转化酶枯草溶菌素9(PCSK9)与隐静脉移植血管疾病(SVGD)的关系。研究设计一项横断面研究。研究地点中国天津市1所二级医院。研究对象总计231名患者参与该研究。入选标准如下:年龄≥18岁;CAB... 详细信息

目的探讨冠状动脉旁路移植术(CABG)后血清前蛋白转化酶枯草溶菌素9(PCSK9)与隐静脉移植血管疾病(SVGD)的关系。研究设计一项横断面研究。研究地点中国天津市1所二级医院。研究对象总计231名患者参与该研究。入选标准如下:年龄≥18岁;CABG术后12个月以上;至少含有1支SVG,非侵入性检查结果异常或复发稳定型心绞痛有冠脉造影指征;愿意参与研究并签署知情同意书。存在以下任何一种情况的患者予以排除:先天性心脏瓣膜病、失代偿性心力衰竭、贫血(定义为女性血红蛋白水平<12g/dl或男性血红蛋白水平<13g/dl)、恶性肿瘤、肾功能衰竭、严重肝脏疾病、甲状腺疾病、急性或慢性炎症性疾病和慢性阻塞性肺部疾病。主要结果测量SVGD被定义为至少1支SVG狭窄≥50%。应用ELISA试剂盒并根据制造商提供的说明书测定循环PCSK9浓度。结果SVGD组平均PCSK9水平显著高于非SVGD组(275.2±38.6比249.3±37.7,P<0.01)。多因素回归模型显示血清PCSK9每增加1个标准差,SVGD发生风险显著增加(比值比2.08,95%可信区间1.46~2.95)。结论本研究在调整了确定的心血管危险因素后,首次确定PCSK9与晚期SVGD之间独立相关。未来需多中心大样本的前瞻性队列研究来进一步探究它们之间的关系。

关键词：冠状动脉旁路移植术后血清前蛋白血管疾病静脉移植横断面转化酶晚期菌素

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Chinese Medical Journal 2012年第16期125卷 2819-2825页

作者： WANG Xiao-fang Jessie L. Norris LIUYingjie kathleen H. reilly WANG Ning National Center for AIDS/STD Control and Prev'ention Chinese Center for Disease Control and Prevention Beijing 102206 China Institute for AIDS/STD Control and Prevention Beijing Chaoyang District Center for Disease Control and Prevention Beijing 100021 China

Background Previous studies have shown evidence of health-related risk behaviors among women who have sex with women （WSW）, such as sex with men, multiple bisexual partners, and drug use. Women who have sex with women have also been known to avoid routine physical examinations and conceal their same-sex history from physicians, which can affect their ability to receive an accurate diagnosis and treatment. No previous research has targeted women who have sex with women in China. We sought to describe women who have sex with women in China and explore risk factors for their reproductive tract infections （RTI）/sexually transmitted infections （STI）. Methods Participants were recruited through outreach in venues and online for a cross-sectional study. Data were collected using interviews and laboratory tests. Results We recruited 224 women who have sex with women. In the year preceding their participation in the study, 92% （206/224） of women reported sexual relations with women. The RTI rates were： gonorrhea （15.8%）, chlamydia （3.5%）, syphilis （0.5%）, bacterial vaginosis （14.4%）, hepatitis B virus （HBV）（0.9%）, hepatitis C virus （HCV）（0.5%）, and candidiasis （6.9%）. No HIV or herpes simplex virus （HSV） positive cases were detected. Factors associated with gonorrhea infection were non-Beijing local residency （odds ratio （OR）=2.1, 95% confidence interval （C/）： 1.2-3.8） and genital-genital contact （OR=3.1, 95% CI： 1.3-7.2）; factors associated with curable STI （excluding bacterial vaginosis, candidiasis, HBV and HCV） were non-Beijing local residency （OR=1.9; 95% CI： 1.2-3.0） and bleeding during or after sex （OR=18.1; 95% CI： 5.2-62.6）; and the factor associated with RTI （including all the infections tested） was bleeding during or after sex （OR=37.8, 95% CI： 11.2-127.4）. Conclusions Behaviors that may cause RTI/STI exist among Chinese women who have sex with women. Researchers should consider these behaviors when planninq correspondin.q prevention and interventions.

关键词： women who have sex with women, lesbian, gay, bisexual, transgender HIV/AIDS sexual transmission,sexually transmitted infection

Estimation of Population-Size Changes and HIV Prevalence among Female Sex Workers from 2006 to 2009 in Kaiyuan,Yunnan,China

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Biomedical and Environmental Sciences 2012年第4期25卷 489-494页

作者： WANG Jun Jie YANG Qian FAN Pan Ying reilly kathleen H. DING Guo Wei WANG Ning National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China Department of Public Health Peking Union Medical College Tsinghua University Beij'ing 100730 China Tulane University Health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA

Objective This study is to estimate the population size and prevalence of HIV and herpes simplex virus type 2 （HSV-2） infections among female sex workers （FSWs） in Kaiyuan, Yunnan Province, China. Methods Eight cross-sectional studies were conducted among FSWs in Kaiyuan from 2006 to 2009. Based on the data from two study time points each year, the total numbers of FSWs and HIV positive FSWs were estimated by using the capture-recapture technique （CR）. Results Estimated sizes of FSWs in Kaiyuan were 1 629, 1 672, 1 186, and 1 014 in the respective years from 2006 to 2009. Although the crude prevalence rates of HIV and HSV-2 varied over time, the adjusted prevalence among this population was relatively stable at 10%-12% and the adjusted HSV-2 prevalence ranged from 67% to72%. Conclusion The reason for the slight decrease of the size of the FSW population is unknown. The adjusted prevalence rates of HIV and HSV-2 among them were stable over the course of this study.

关键词： Population HIV FSWs Capture-recapture

Estimation of Probability of Unprotected Heterosexual Vaginal Transmission of HIV-1 from Clients to Female Sex Workers in Kaiyuan,Yunnan Province, China

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Biomedical and Environmental Sciences 2010年第4期23卷 287-292页

作者： WEN-JUAN MA JUN-JIE WANG kathleen-H. reilly AI-MEI BI GUO-WEI DING KUMI SMITH NING WANG School of Public Health Peking Union Medical College Tsinghua University Beijing 100730 China National Center for AIDS/STD Control and Prevention Beijing 102206 China Tulane University Health Sciences Center School of Public Health and Tropical Medicine New Orleans LA USA Kaiyuan Center for Disease Control and Prevention Kaiyuan 661600 Yunnan China University of North Carolina at Chapel Hill Chapel Hill NC USA

Objective To estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to Female Sex Workers （FSWs） in Kaiyuan County, Yunnan province, China, and analyze factors which impact the transmission probability. Methods An open cohort research of FSWs in Kaiyuan was created from surveys conducted in April 2008, October 2008, and April 2009. Two cross-sectional surveys of local clients were also carried out in May 2008 and November 2008. A model was developed to estimate the probability of unprotected heterosexual vaginal transmission of HIV-1 from clients to FSWs. Results The transmission probability from clients to FSWs was estimated as 0.0023 [95% CI 0.0014-0.0032] per unprotected heterosexual act. Conclusion The transmission probability among this group engaging in commercial sex in Yunnan province differs from that found in studies from other countries, and future studies should estimate the influence factors of HIV-1 transmission probability, such as stage of HIV infection, co-morbid sexually transmitted infections （STIs）.

关键词： Transmission Probability HIV/AIDS Model FSW Clients

Prevention of Deep Vein Thrombosis by Panax Notoginseng Saponins Combined with Low-Molecular-Weight Heparin in Surgical Patients

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Chinese Journal of Integrative Medicine 2022年第9期28卷 771-778页

作者： WANG Chun-mei GUO Xiang-feng LIU Li-min HUANG Ying MENG Liang SONG Li-po WU Ying-feng NING Ya-chan kathleen H.reilly WANG Hai-bo Department of Vascular Surgery Xuanwu HospitalCapital Medical UniversityBeijing100053China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of Orthopaedics Xuanwu HospitalCapital Medical UniversityBeijing100053China Centers for Disease Control and Prevention New York CityNY12237USA Peking University Clinical Research Institute Peking University First HospitalBeijing100191China

Objective:To evaluate the efficacy of deep vein thrombosis(DVT)prevention among realworld surgical inpatients who received panax notoginseng saponins(PNS)combined with low-molecularweight heparin(LMWH).Methods:A prospective cohort study was conducted among surgical patients between January 2016 and November 2018 in Xuanwu Hospital,Capital Medical University,Beijing,*** received LMWH alone or PNS combined with LMWH for preventing *** primary outcome was incidence of lower extremity DVT,which was screened once a *** in the LMWH group were given LMWH(enoxaparin)via hypodermic injection,4000-8000 AxalU once *** in the exposure group received PNS(Xuesaitong oral tablets,100 mg,3 times daily)combined with LMWH given the same as LMWH ***:Of the 325 patients screened for the study,281 participants were included in the final *** cohort was divided into PNS+LMWH group and LMWH group with 134 and 147 participants,*** was a significant difference of DVT incidence between two groups(P=0.01),with 21(15.7%)incident DVT in the PNS+LMWH group,and 41(27.9%)incident DVT in the LMWH *** with participants without DVT,the participants diagnosed with DVT were older and had higher D-dimer *** multivariate logistic regression moclel showed a significant lower risk of incident DVT among participants in the PNS+LMWH group compared with the LMWH group(odds ratio 0.46,95%confidence interval,0.25-0.86).There were no significant differences in thromboelaslography values(including R,K,Angle,and MA)and differences in severe bleeding between two *** symptomatic pulmonary embolism occurred during the ***:Combined application of PNS and LMWH can effectively reduce the incidence of DVT among surgical inpatients compared with LMWH monotherapy,without increased risk of bleeding.

关键词： panax notoginseng saponins deep vein thrombosis low-molecular-weight heparin thromboelastography risk factor

Determinants of nurse faculty intention to remain employed

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Open Journal of Nursing 2012年第3期2卷 254-261页

作者： Ann E. Tourangeau heather Thomson Margaret Saari Kimberley Widger Era Mae Ferron kathleen MacMillan Lawrence S. Bloomberg Faculty of Nursing University of Toronto Toronto Canada School of Health Sciences Humber College Toronto Canada

Shortage of nurses is a major concern across healthcare systems. One contributing factor that has received little attention is the shortage of adequately prepared nurse faculty. The nurse shortage will be exacerbated if the supply of adequately prepared nurse faculty is insufficient. Little is known about the factors that influence nurse faculty to remain employed. Focus groups were conducted in 2011 with nurse faculty from both colleges and universities in Ontario, Canada. Six focus groups including 37 participants were held with different groups of nurse faculty in geographically diverse areas of the province. Focus group transcripts were reviewed by five members of the research team using thematic analysis strategies to identify factors related to nurse faculty intention to remain employed. Nurse faculty members’ intention to remain employed was influenced by factors that fell into four thematic categories: personal characteristics, work environment and organizational support, job content, and external characteristics. Each thematic category includes several factors reported to influence nurse faculty intention to remain employed. The “Determinants of Nurse Faculty Intention to Remain Employed” Model is hypothesized. Strategies to address modifiable factors and support non-modifiable factors are suggested to promote retention of nurse faculty. Additional research is needed to test the hypothesized model of nurse faculty intention to remain employed.

关键词： Nurse Faculty Retention Work Environment Organizational Support Theory Development Focus Groups Nursing Workforce