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Growth Hormone Replacement Therapy in Patients without Adult Growth Hormone Deficiency: What Answers Do We Have So Far?

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Health 2017年第5期9卷 799-810页

作者： karine rucker Larissa Bianca Paiva Cunha de Sá Alberto Krayyem Arbex Endocrinology Division IPEMED Medical School S&#227 o Paulo Brazil Diabetology Department Malteser Krankenhaus St. Franziskus-Hospital Flensburg Germany

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) have been suggested as “anti-aging” therapies, or for improving quality of life with aging. In this study, we focus on the actions of GH in the main organs and organ systems of the human body, like skeletal muscle, bones and brain, particularly in regard to data and research on the use of GH replacement therapy in adults without growth hormone deficiency, especially elderly patients. Several different studies have been carried out to show what the effects and side effects of GH replacement in healthy people and what would be the impact in quality of life and life span. In this review, we demonstrate what answers we have so far about the effects of GH replacement in many organs and systems in healthy people.

关键词： Growth Hormone Insulin-Like Growth Factor 1 Sarcopenia Growth Hormone Replacement Adult Growth Hormone Deficiency

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Health, Physical Activity and the Rio de Janeiro 2016 Olympic Games: Legacy or Fallacy?

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Health 2016年第1期8卷 9-17页

作者： Vagner Rosa Bizarro Tatiane Andreazza Lucchese Amanda Maia Breis karine rucker Minelli Salles Alves Fernandes Mikele Torino Paletti Ana Luísa Conceição de Jesus Raphael Calafange Marques Pereira Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School Rio de Janeiro Brazil Division of Rehabilitation Sciences UNISUAM Rio de Janeiro Brazil Harvard School of Public Health Harvard University Boston USA

It is generally expected that the Rio de Janeiro 2016 Olympic and Paralympic Games will bring health and social benefits to their host city and to Brazil. This assumption comes from “common sense”, as a logical conclusion arising from the fact that host cities “inspire” and stimulate lifestyle changes. Benefits are also expected on tourism, self-image, architecture and the economy of the country as a whole. But are these expectations real and evidence-based? What parts of these “facts” are concrete and which ones are not? This paper suggests available ways of quantifying positive effects of hosting an Olympic Game, and puts the focus of this approach on the Rio de Janeiro 2016 Olympic Games and their true legacy, seeking scientific certainties.

关键词： Physical Activity Olympic Games Paralympic Games Olympic Legacy Rio de Janeiro Rio 2016

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Diabetes, Obesity and the Nutrition Transition in the Mercosur

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Open Journal of Endocrine and Metabolic Diseases 2016年第1期6卷 28-37页

作者： Tatiane Andreazza Lucchese Amanda Maia Breis karine rucker Vagner Rosa Bizarro Lis Marina Mesquita Araújo Alessandre Gomes Mikele Torino Paletti Ana Luísa Conceição de Jesus Marcella Garcez Duarte Denise Rosso Tenório Wanderley Rocha Alberto Krayyem Arbex Division of Endocrinology IPEMED Medical School (IPEMED) Sao Paulo Brazil Brazilian Association of Nutrology (ABRAN) Catanduva Sao Paulo Brazil Visiting Scholar Harvard T. H. Chan School of Public Health Harvard University Boston USA

Diabetes and obesity are major health hazards in Latin America nowadays. Their prevalence has steadily increased since the eighties. Today, more than 50% of the population are overweight, 15% has obesity and 6% to 15% has diabetes. The nutrition transition is a long-term process that brings chronic metabolic diseases as an undesired consequence, whilst ultra processed foods become increasingly part of daily food choices. These changes bring impacts in all fields of daily life, especially in the economic and legal fields—the “Right to Health”—and regarding autonomy of the individual and their choices, when confronted with an ideal of health and well-being. Governments and citizens struggle to propose new pathways and find effective solutions to control both epidemics and solve these issues. This article poses the evolution of diabetes and obesity in the Mercosur, seeking a better understanding of these chronic, non-communicable diseases, and looking for concrete, effective solutions towards health in South America.

关键词： Obesity Diabetes Mercosur Nutrition Transition Right to Health South America

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