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Extrusion process of Acanthopanax senticosus leaves enhances the gastroprotective effect of compound 48/80 on acute gastric mucosal lesion in rats

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Journal of Traditional Chinese Medicine 2016年第2期36卷 187-196页

作者： Hye Kyung Kim Myung-Gyou Kim kang-hyun leem Department of Food & Biotechnology Hanseo University College of Korean Medicine Semyung University

OBJECTIVE:To investigate the gastroprotective effects of Acanthopanax senticosus leaves(ASLs)extrusion on acute gastric mucosal lesion in rats induced by compound 48/80(C48/80).METHODS:Rats were divided into six groups:normal;C48/80-induced gastric lesion control;gastric lesion positive control(famotidine 4 mg/kg);gastric lesion administered with two levels of extruded ASLs(ASLE,40 and 200 mg/kg);and gastric lesion treated with ASLs(ASL 200 mg/kg).Mucus secretion/damage was determined by immunohistological *** and western blotting were performed to determine gastric mucosal Bax and Bcl-2 *** mucosal oxidative-stress-related enzymes and malondialdehyde were ***:C48/80-induced mucus depletion and inflammation in the gastric mucosa were significantly attenuated by *** increased serum serotonin and histamine concentrations in C48/80-treated rats were also attenuated by *** mucosal Bax protein expression was increased and Bcl-2 expression was decreased after C48/80 treatment,and ASLs ameliorated Bax and Bcl-2 *** extrusion process significantly augmented the effects of ASLs in a dosedependent *** at 200 mg/kg normalized mucus damage/secretion,C48/80-induced increases of mucosal myeloperoxidase activity(index of inflammation),xanthine oxidase,and malondialdehyde content(index of lipid peroxidation).The effects of ASLs on Bax and Bcl-2expression were also enhanced by ***,these effects of ASLEs at 200 mg/kg were similar to those of famotidine,a histamine H2-receptor antagonist commonly used to treat gastric ***:ASLEs prevented acute gastric mucosal lesion progression induced by C48/80,possibly by inducing mucus production,and reduced inflammation and oxidative stress in gastric mucosa through an anti-apoptotic mechanism.

关键词：挤压工艺胃黏膜保护作用膜损伤化合物刺五加大鼠急性

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Anticancer effects of oligomeric proanthocyanidins on human colorectal cancer cell line, SNU-C4

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World Journal of Gastroenterology 2005年第30期11卷 4674-4678页

作者： Youn-Jung Kim Hae-Jeong Park Seo-hyun Yoon Mi-Ja Kim kang-hyun leem Joo-Ho Chung Hye-Kyung Kim Department of Dental Hygiene Department of Pharmacology Department of Obesity Management College of Oriental Medicine Department of Food and Biotechnology

AIM: Oligomeric proanthocyanidins (OPC), natural polyphenolic compounds found in plants, are known to have antioxidant and anti-cancer effects. We investigated whether the anti-cancer effects of the OPC are induced by apoptosis on human colorectal cancer cell line, ***: Colorectal cancer cell line, SNU-C4 was cultured in RPMI 1640 medium supplemented with 10% fetal bovine serum. The cytotoxic effect of OPC was assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenylt-etrazolium bromide (MTT) assay. To find out the apoptotic cell death, 4, 6-diamidino-2-phenylindole (DAPI) staining,terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), and caspase-3 enzyme assay were ***: In this study, cytotoxic effect of OPC on SNUC4 cells appeared in a dose-dependent manner. OPC treatment (100 μg/mL) revealed typical morphological apoptotic features. Additionally OPC treatment (100 μg/mL)increased level of BAX and CASPASE-3, and decreased level of BCL-2 mRNA expression. Caspase-3 enzyme activity was also significantly increased by treatment of OPC (100 μg/mL) compared with ***: These data indicate that OPC caused cell death by apoptosis through caspase pathways on human colorectal cancer cell line, SNU-C4.

关键词：抗癌作用结直肠癌肿瘤细胞 SNU-C4 低聚体肿瘤药物

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Prevention and management of adverse events following COVID-19 vaccination using traditional Korean medicine:An online survey of public health doctors

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World Journal of Clinical Cases 2022年第28期10卷 10053-10065页

作者： Byungsoo kang Hongmin Chu Bo-Young Youn Jungtae leem College of Korean Medicine Dongshin UniversityNaju-si 58245South Korea Daecheong Public Health Subcenter Ongjin Public HealthcenterIncheon 23105IncheonSouth Korea Department of Preventive Medicine College of Korean MedicineKyung Hee UniversitySeoul 02447South Korea College of Korean Medicine Wonkwang UniversityIksan 54538Jeollabuk-doSouth Korea

BACKGROUND Since February 2021,vaccination against coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2 has started in *** To perform a questionnaire survey about the prevention and management of adverse events of COVID-19 vaccination among public health doctors of Korean Medicine(PHKMDs).METHODS An online questionnaire was developed,comprising categories about adverse events of vaccination(AEVs)and perception of using Korean medicine(KM)in managing vaccine adverse events(AEs)among ***’experience of AEVs,usage of Korean medicine for AEVs,and perception and attitude in using KM for AEVs were *** survey web-link was emailed to the association of *** links were sent through Survey Monkey to all PHKMDs in *** A total of 143 participants were recruited for this study;65%of participants were vaccinated at the same of the survey(n=93).Although most participants did not take any medication for prevention of the adverse events,62%(n=58)of participants had taken herbal medicine to treat the adverse events(n=52).Approximately 35%of participants(n=33)said that they would recommend taking herbal medicine to prevent any *** various KM interventions,the participants strongly recommended taking an herbal medicine(n=69,74.19%)to treat AEs,and the second-highest was acupuncture treatment(n=19,20.43%).CONCLUSION Overall,this research demonstrated a high prevalence of KM usage by the ***,this study’s results may serve as fundamental evidence for health professionals to consider using KM treatments when treating or preventing AEVs in the near future.

关键词： COVID-19 Vaccination Adverse events Herbal medicine Korean medicine

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Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease

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Neural Regeneration Research 2020年第10期15卷 1850-1851页

作者： Eunju leem Sang Ryong Kim School of Life Sciences BK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguKorea Brain Science and Engineering Institute Kyungpook National UniversityDaeguKorea

Biological roles of astrocyte elevated gene-1(AEG-1):AEG-1,also known as metadherin,was originally identified as a human immunodeficiency virus-1-and tumor necrosis factor-alpha-inducible gene in human fetal *** increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer,and its upregulation triggers evasion of cellular apoptosis,metastasis,and invasion in cancer(Emdad at al.,2016;Dhiman et al.,2019).AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)pathways,contributing to an invasive phenotype and angiogenesis(Emdad at al.,2016;Dhiman et al.,2019).In addition,there is evidence for a functional link between AEG-1 and pro-survival mechanisms in various cancers(Dhiman et al.,2019),suggesting that AEG-1 is a key molecule for oncogenic events in cancer.

关键词： elevated al. invasion

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Safety of acupotomy in a real-world setting:A prospective pilot and feasibility study

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Journal of Integrative Medicine 2022年第6期20卷 514-523页

作者： Sang-Hoon Yoon Chan-Young Kwon Hee-Geun Jo Jae-Uk Sul Hyangsook Lee Jiyoon Won Su Jin Jeong Jun-Hwan Lee Jungtae leem Chung-Yeon Korean Medicine Clinic Gangnam-guSeoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusanjin-guBusan 47340Republic of Korea Department of Herbal Pharmacology College of Korean MedicineGachon University1342 Seongnamdae-roSujeong-guSeongnam 13120Republic of Korea Department of Korean Rehabilitation Medicine Dongshin University Korean Medicine HospitalGwangju 61619Republic of Korea Acupuncture and Meridian Science Research Center Kyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea Department of Science in Korean Medicine Graduate SchoolKyung Hee UniversityDongdaemun-guSeoul 02447Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Statistics Support Medical Science Research InstituteKyung Hee University Medical CenterDongdaemun-guSeoul 02447Republic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea Korean Medicine Life Science University of Science&Technology(UST)Campus of Korea Institute of Oriental MedicineYuseong-guDaejeon 34054Republic of Korea College of Korean Medicine Wonkwang UniversityIksanJeollabuk-do54538Republic of Korea

Objective:Acupotomy is a modern acupuncture method that includes modern surgical *** acupotomy is relatively more invasive than filiform acupuncture treatment,it is important to establish the safety profile of this *** justify further large-scale prospective observational studies,this preliminary study was performed to assess the feasibility of the approach and investigate the safety profile and factors potentially associated with adverse events(AEs).Methods:This was a prospective pilot study that assessed the feasibility of a large-scale forthcoming safety study on acupotomy treatment in a real-world *** feasibility(call response rate,dropout rate,response rate for each variable and recruitment per month)and safety profile(incidence,type,severity and causality of AEs,and factors potentially associated with AEs)were ***:A total of 28 participants joined the study from January to May 2018.A follow-up assessment was achieved in 258(1185 treatment points)out of 261 sessions(1214 treatment points).The response rate via telephone on the day after treatment was 87.3%.There were 8 systemic AEs in all the sessions(8/258;3.11%)and 27 local AEs on the total points treated(27/1185;2.28%).Severe AEs did not *** AE and local AE occurrence were associated with blade width and the number of needle stimulations per treatment ***:The findings suggest that it could be feasible to analyze the safety of acupotomy in a realworld ***,the primary data on some relevant AEs could be *** are planning large-scale prospective studies based on these *** registration:Clinical Research Information Service(CRIS)KCT0002849(https://***/cris/search/***/11487).

关键词： Acupotomy Acupuncture Safety Adverse effects Observational study Traditional Chinese medicine

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Enhanced singlet oxygen generation by hybrid Mn-doped nanocomposites for selective photo-oxidation of benzylic alcohols

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Nano Research 2020年第6期13卷 1668-1676页

作者： Zhi-Jun Li Shuya Li Andrew Hunter Davis Elan Hofman Gyu leem Weiwei Zheng Department of Chemistry Syracuse UniversitySyracuseNY13244USA Department of Chemistry State University of New York College of Environmental Science and ForestrySyracuseNY13210USA The Michael M.Szwarc Polymer Research Institute SyracuseNY13210USA

Transition-metal ions doped nanocrystals(NCs),specifically Mn-doped NCs,hold great potential in the field of photocatalysis,especially,to improve photocatalytic performance for singlet oxygen(1O2)***,we report the design of a novel Mn-doped NC-based nanocomposites,specifically,silica-coated Mn-doped CdS/ZnS NCs decorated with Pt NCs(denoted as Mn-NCs@SiO2-Pt),which enhance photocatalytic 1O2 *** to the long-lived Mn excited state(on the order of ms),the energy-transfer between Mn-NCs and molecular oxygen is facilitated with the assistance of the Pt NCs adhered to the Mn-NC@SiO2 ***,the Mn-NCs@SiO2-Pt composites,integrate the advantages of Mn-doped NCs,a protective silica layer,and Pt NCs to exhibit excellent catalytic activity and selectivity for the selective oxidation of primary benzylic alcohols to aldehydes through an 1O2 engaged oxidation process under visible-light *** work paves the way for enhancing catalytic performance via facilitated energy transfer relaxation by utilizing the long-lived excited-state of Mn2+dopant ions in nanocomposites.

关键词： doped nanocrystals energy transfer photocatalysis singlet oxygen selective oxidation

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Uniaxially crumpled graphene as a platform for guided myotube formation

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Microsystems & Nanoengineering 2019年第1期5卷 144-153页

作者： Junghoon Kim Juyoung leem Hong Nam Kim Pilgyu kang Jonghyun Choi Md Farhadul Haque Daeshik kang SungWoo Nam Department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA Center for BioMicrosystems Brain Science InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Department of Mechanical Engineering George Mason UniversityFairfaxVA 22030USA Department of Mechanical Engineering Ajou UniversitySuwon 16499Republic of Korea Department of Materials Science and Engineering University of Illinois at Urbana-ChampaignUrbanaIL 61801USA

Graphene,owing to its inherent chemical inertness,biocompatibility,and mechanical flexibility,has great potential in guiding cell behaviors such as adhesion and ***,due to the two-dimensional(2D)nature of graphene,the microfabrication of graphene into micro/nanoscale patterns has been widely adopted for guiding cellular *** this study,we report crumpled graphene,i.e.,monolithically defined graphene with a nanoscale wavy surface texture,as a tissue engineering platform that can efficiently promote aligned C2C12 mouse myoblast cell *** imparted out-of-plane,nanoscale crumpled morphologies to flat graphene via compressive straininduced *** C2C12 mouse myoblast cells were seeded on the uniaxially crumpled graphene,not only were the alignment and elongation promoted at a single-cell level but also the differentiation and maturation of myotubes were enhanced compared to that on flat *** results demonstrate the utility of the crumpled graphene platform for tissue engineering and regenerative medicine for skeletal muscle tissues.

关键词： Uniaxial graphene alignment

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运动计时系统中的多阅读器算法及其在低频带宽中的应用（英文）

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China Communications 2013年第12期10卷 16-24页

作者： Min-Ho Paek Choon-Seong leem Dae-Jung Bae Department of Information and Industrial Engineering Yonsei University

In sports timing systems,P2P communication is used at low frequency bandwidths(under 135 KHz) between tags and readers in the RFID ***,in such cases,collisions tend to occur when a reader deals with multiple RFID tags *** overcome this issue,a sports timing system including a Multi Reader Controller(MRC)loaded with an advanced multiple reader algorithm and application was created and applied at large-scale citizens' marathon *** these cases,a large number of people pass over the installed urethane type's antenna mat continually during a short period of *** study verified the superiority of the improved algorithm and application through the on-thespot application of the multi reader algorithm and application program,which allows us to smoothly measure runners' times through multiaccess reading for rapid collision avoidance.

关键词：应用程序改进算法计时系统运动员频率带宽读取 RFID标签多重

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Material Culture of Dinosaurs—This is not about dinosaurs

Material Culture of Dinosaurs—This is not about dinosaurs

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第6届东亚科技与社会（STS）国际学术会议

作者： So Yeon leem

＜正＞ IntroductionThere have been a number of attempts to study science and technology through social or c ultural approaches. This work is also one of those ventures to bring things that are ’not human s’ so are usually materials for ’scientists’ to human world and study them.1. What is Material Culture?Material culture is just what it says it is- namely, the manifestations of culture through mat erial productions. And the study of material culture is the study of material to understand cultur

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Noise and detectivity limits in organic shortwave infrared photodiodes with low disorder

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npj Flexible Electronics 2020年第1期4卷 58-65页

作者： Zhenghui Wu Ning Li Naresh Eedugurala Jason DAzoulay Dong-Seok leem Tse Nga Ng Department of Electrical and Computer Engineering University of California San Diego9500 Gilman DriveLa JollaCA 92093-0407USA Department of Electrical and Electronic Engineering Southern University of Science and Technology1088 Xueyuan AvenueShenzhenGuangdong 518023China Center for Optoelectronic Materials and Devices School of Polymer Science and EngineeringUniversity of Southern Mississippi118 College Drive#5050HattiesburgMS 39406USA Samsung Advanced Institute of Technology(SAIT) Samsung ElectronicsCo.Ltd.130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803South Korea

To achieve high detectivity in infrared detectors,it is critical to reduce the device ***,for non-crystalline semiconductors,an essential framework is missing to understand and predict the effects of disorder on the dark *** report presents experimental and modeling studies on the noise current in exemplar organic bulk heterojunction photodiodes,with 10 donor-acceptor combinations spanning wavelength between 800 and 1600 nm.A significant reduction of the noise and higher detectivity were found in devices using non-fullerene acceptors(NFAs)in comparison to those using fullerene *** low noise in NFA blends was attributed to a sharp drop off in the distribution of bandtail states,as revealed by variable-temperature density-of-states *** disorder into account,we developed a general physical model to explain the dependence of thermal noise on the effective bandgap and bandtail *** model provides theoretical targets for the maximum detectivity that can be obtained at different detection wavelengths in inherently disordered infrared photodiodes.

关键词： heterojunction noise donor

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