Limited therapeutic potential of astrocyte elevated gene-1 transduction in an animal model of Parkinson’s disease

作     者：Eunju Leem Sang Ryong Kim 

作者机构：School of Life SciencesBK21 plus KNU Creative BioResearch GroupKyungpook National UniversityDaeguKorea Brain Science and Engineering InstituteKyungpook National UniversityDaeguKorea 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第10期

页      面：1850-1851页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：supported by a grant from the National Research Foundation of Korea(NRF-2020R1A2C2007954) 

主　　题：elevated al. invasion 

摘      要：Biological roles of astrocyte elevated gene-1(AEG-1):AEG-1,also known as metadherin,was originally identified as a human immunodeficiency virus-1-and tumor necrosis factor-alpha-inducible gene in human fetal *** increase in AEG-1 expression is a well-established and important oncogenic event in various types of human cancer,and its upregulation triggers evasion of cellular apoptosis,metastasis,and invasion in cancer(Emdad at al.,2016;Dhiman et al.,2019).AEG-1 can promote tumor progression via multiple phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)pathways,contributing to an invasive phenotype and angiogenesis(Emdad at al.,2016;Dhiman et al.,2019).In addition,there is evidence for a functional link between AEG-1 and pro-survival mechanisms in various cancers(Dhiman et al.,2019),suggesting that AEG-1 is a key molecule for oncogenic events in cancer.