Extrusion process of Acanthopanax senticosus leaves enhances the gastroprotective effect of compound 48/80 on acute gastric mucosal lesion in rats

作     者：Hye Kyung Kim Myung-Gyou Kim Kang-Hyun Leem 

作者机构：Department of Food & BiotechnologyHanseo University College of Korean Medicine Semyung University 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2016年第36卷第2期

页      面：187-196页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by Cooperative Research Program for Agriculture Science and Technology Development and Rural Development Administration Republic of Korea(Investigation of Functional Nutrients from Agricultural Food and Development of Integrated Information No.PJ011644) 

主　　题：挤压工艺 胃黏膜 保护作用 膜损伤 化合物 刺五加 大鼠 急性 

摘      要：OBJECTIVE:To investigate the gastroprotective effects of Acanthopanax senticosus leaves(ASLs)extrusion on acute gastric mucosal lesion in rats induced by compound 48/80(C48/80).METHODS:Rats were divided into six groups:normal;C48/80-induced gastric lesion control;gastric lesion positive control(famotidine 4 mg/kg);gastric lesion administered with two levels of extruded ASLs(ASLE,40 and 200 mg/kg);and gastric lesion treated with ASLs(ASL 200 mg/kg).Mucus secretion/damage was determined by immunohistological *** and western blotting were performed to determine gastric mucosal Bax and Bcl-2 *** mucosal oxidative-stress-related enzymes and malondialdehyde were ***:C48/80-induced mucus depletion and inflammation in the gastric mucosa were significantly attenuated by *** increased serum serotonin and histamine concentrations in C48/80-treated rats were also attenuated by *** mucosal Bax protein expression was increased and Bcl-2 expression was decreased after C48/80 treatment,and ASLs ameliorated Bax and Bcl-2 *** extrusion process significantly augmented the effects of ASLs in a dosedependent *** at 200 mg/kg normalized mucus damage/secretion,C48/80-induced increases of mucosal myeloperoxidase activity(index of inflammation),xanthine oxidase,and malondialdehyde content(index of lipid peroxidation).The effects of ASLs on Bax and Bcl-2expression were also enhanced by ***,these effects of ASLEs at 200 mg/kg were similar to those of famotidine,a histamine H2-receptor antagonist commonly used to treat gastric ***:ASLEs prevented acute gastric mucosal lesion progression induced by C48/80,possibly by inducing mucus production,and reduced inflammation and oxidative stress in gastric mucosa through an anti-apoptotic mechanism.