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Acta Biochimica et Biophysica Sinica 2006年第11期38卷 773-779页

作者： Hideki MURAKAMI kai-jow tsai William C.HUTTON Atlanta Veteran's Administration Medical Center Decatur 30033USA Department of Orthopaedics and Spine CenterEmory University School of MedicineAtlanta 30329USA

In order to compare the difference between young and old intervertebral disc cells and theirresponsiveness to recombinant human bone morphogenetic protein-2 (rhBMP-2),disc cells were isolatedfrom the anulus fibrosus (AF) and transition zones of lumbar discs from eight old and eight young NewZealand white *** with the ceils from the young rabbits,cells from old rabbits respond less torhBMP-2 treatment with respect to sulfated-glycosaminoglycan (sGAG) synthesis and aggrecan *** in collagen Ⅰ and collagen Ⅱ gene expressions,there are no significant differences betweenthe old and the *** comparing sGAG content,aggrecan,and collagen Ⅱ gene expression of the oldAF cells after rhBMP-2 treatment with that of the young AF cells without rhBMP-2 treatment,the old AFcells with rhBMP-2 treatment have a greater capacity to synthesize sGAG bound in the cells and to releasesGAG in the media,as well as to express aggrecan and collagen Ⅱ *** can be concluded that old AF cellsafter rhBMP-2 treatment have a greater capacity to synthesize sGAG and express aggrecan and collagen Ⅱ ascompared to young AF cells without rhBMP-2 *** rhBMP-2 can reverse the decline in theanabolic capacity of the disc cells with *** it seems that rhBMP-2 has potential for use as an agent toretard a key component of disc degeneration and loss of disc matrix.

关键词： ageing anulus fibrosus cells bone morphogenetic protein-2

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming tsai Ti-Hui Wu Hsu-kai Huang tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

Extensive spectral tuning of the proton transfer emission from green to red via a rational derivatization of salicylideneaniline

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Chinese Chemical Letters 2012年第11期23卷 1279-1282页

作者： Hsing Yang tsai Sin kai Fang Kew Yu Chen Department of Chemical Engineering Feng Chia University

A series of salicylideneaniline derivatives 1a-lf were synthesized under mild condition in high yields, and characterized by ^1H NMR, HRMS, UV-vis and emission spectra. In solid and aprotic solvents 1a-1f exist mainly as E conformers that possess a sixmembered-ring hydrogen bond and undergo excited-state intramolecular proton transfer （ESIPT） reactions, resulting in a protontransfer tautomer emission. Depending on the electronic donor or acceptor strength of the substituent in either the HOMO or LUMO site, a broad tuning range of the emission from green （1c） to red （1a） has been achieved.

关键词： ESIPT Schiff bases Salicylideneaniline derivatives Db'T calculations

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The role of tazarotene-induced gene 1 in carcinogenesis:is it a tumor suppressor gene or an oncogene?

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BIOCELL 2024年第9期48卷 1285-1297页

作者： CHUN-HUA WANG LU-kai WANG RONG-YAUN SHYU FU-MING tsai Department of Dermatology Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina School of Medicine Tzu Chi UniversityHualien970TaiwanChina Department of Life Sciences Ministry of Science and TechnologyTaipei106TaiwanChina Department of Internal Medicine Taipei Tzu Chi HospitalThe Buddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina Department of Research Taipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina

Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of ***1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its ***,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor ***,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer *** review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.

关键词： Tazarotene-induced gene 1 Retinoic acid receptor responder protein 1 Tumor suppressor gene Oncogene

Achalasia combined with esophageal intramural hematoma:Case report and literature review

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World Journal of Gastroenterology 2010年第42期16卷 5391-5394页

作者： Yin-Yi Chu kai-Feng Sung Soh-Ching Ng Hao-tsai Cheng Cheng-Tang Chiu Division of Gastroenterology Department of Internal MedicineShin Kong Wu Ho-Su Memorial HospitalTaipei 111TaiwanChina Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalChang Gung University College of MedicineKweishanTaoyuan 333TaiwanChina Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalChang Gung University College of Medicine KweishanTaoyuan 333TaiwanChina Department of Internal Medicine Chang Gung Memorial HospitalChang Gung University College of MedicineKeelung 204TaiwanChina

A 62-year-old male patient was admitted to our hospital due to severe chest pain,odynophagia,and *** computed tomography showed an esophageal submucosal ***(EGD) revealed a longitudinal purplish bulging tumor of the *** ultrasound(EUS) showed a mixed echoic tumor with partial liquefaction from the submucosal *** patient was diagnosed with esophageal intramural hematoma as well as achalasia by upper gastrointestinal endoscopy,esophagography and esophageal *** patient was managed conservatively with intravenous nutrition,and oral feeding was ***-up EGD and EUS showed complete recovery of the esophageal wall,and finally,the patient underwent endoscopic dilatation for *** patient was symptom free at the time when we wrote this manuscript.

关键词： Esophageal intramural hematoma Achalasia Endoscopic ultrasound

A HYBRID MODEL OF KNOWLEDGE MANAGEMENT FOR NEW SERVICE DEVELOPMENT

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Journal of Systems Science and Systems Engineering 2016年第4期25卷 424-447页

作者： August tsai Department of Industrial Management College of Management Chien Hsin University of Science and Technology Taoyuan32097 Taiwan China

Although many theories regarding the implementation of knowledge management （KM） in organizations have been proposed and studied, most applications tend to stand alone without incorporating the business processes. Different categories of knowledge provide different benefits and how to integrate various categories of KM into a hybrid approach as an effective KM manner remains strategically important, and yet is still understudied. Therefore, in this paper a hybrid model that integrates principal KM applications for new service development （NSD） and the measurement of the resulting f＇mancial benefits have been developed. The proposed KM model incorporates newsgroups, knowledge forums, knowledge asset management and knowledge application processes as a hybrid means for sharing organizational knowledge along two axes, explicit vs. implicit and individual vs. collective. One of the largest management consulting companies in Taiwan, China, whose process model of NSD was standing alone with KM applications, was selected for the case study. A set of hybrid KM processes was developed to implement the proposed KM model, and it illustrates an application with greater financial benefits for integrating hybrid KM practices into the business process. Based on knowledge value added （KVA） validation, the proposed KM model provides a new operating system for sharing NSD knowledge within an organization. Through the case study by measuring the achieved financial results, the proposed KM model is found to provide an exclusive hybrid platform with an empirical process model to address innovative approaches and practical values of KM within an organization.

关键词： Knowledge management new service development (NSD) newsgroup knowledge forum knowledge asset knowledge application process knowledge value added (KVA)

Low Phase Noise and Wide Tuning Range VCO Using the MOS Differential Amplifier with Active Load

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Circuits and Systems 2012年第4期3卷 307-310页

作者： Cher-Shiung tsai Kwang-jow Gan Ming-Shin Lin Department of Electrical Engineering National Chiayi University Chinese Taipei Department of Electronic Engineering Kun Shan University Chinese Taipei

We demonstrate the design of a novel voltage-controlled oscillator (VCO), which is based on a metal-oxide-semiconductor field-effect transistor (MOS) differential amplifier with active load. This VCO achieves low phase noise and wide tuning range. The phase noise is –120 dBc/Hz at 600 KHz offset from a 1.216 GHz carrier frequency. This value is comparable to that of a LC-based integrated oscillator. The operating frequency can be tuned from 117 MHz to 1.216 GHz with the supply voltage varying from 1.3 V to 3.3 V. Therefore, the tuning range is about 90.38% which is larger than most of the LC and ring oscillator. The VCO circuit, which is constructed using a standard 0.35 μm CMOS technology, occupies only 26.25 × 7.52 μm2 die area and dissipated 10.56 mW under a 3.3 V supply voltage.

关键词： Voltage-Controlled Oscillator (VCO) Differential Amplifier Phase Noise Tuning Range

PESOI: Process Embedded Service-Oriented Architecture

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软件学报 2006年第6期17卷 1470-1484页

作者： Wei-Tek tsai Department of Computer Science and Engineering Arizona State University Tempe AZ 85281 USA

Service-Oriented Architecture (SOA) has drawn significant attention recently, and numerous architecture approaches have been proposed to represent SOA-based applications. The architecture of SOA-based applications is different from traditional software architecture, which is mainly static. The architecture of an SOA-based application is dynamic, i.e., the application can be composed at runtime using existing services, and thus the architecture is really determined at runtime, instead of design time. SOA applications have provided a new direction for software architecture study, where the architecture can be dynamically changed at runtime to meet the new application requirements. This paper proposes a Process-Embedded Service-Oriented Infrastructure to build SOA-based applications. This infrastructure embeds the entire software lifecycle management and service-oriented system engineering into the application developed on this infrastructure. Thus, the users can easily re-develop the applications during operation to meet the changing environments and requirements, through the supports provided by the embedded infrastructure.

关键词：服务导向处理服务导向体系软件体系结构分类

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SRC-3/AIB1:transcriptional coactivator in oncogenesis

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Acta Pharmacologica Sinica 2006年第4期27卷 387-394页

作者： Sophia Y tsai Ming-jer tsai Department of Molecular and Cellular Biology Department of Molecular and Cellular Biology Prostate SPOREBaylor College of MedicineOne Baylor PlazaHouston.Texas 77030USA

Steroid receptor coactivator-3(SRC-3,also known as NCoA3,AIB1,p/CIP,RAC3,ACTR,and TRAM 1),localized on a frequently amplified region,20q 12,has beenassociated with multiple cancers,including breast,gastric and prostate *** SRC-3 has been implicated as an oncogene,compelling evidence hasonly recently emerged implicating it as a causal factor in the genesis of ***,we summarize recent evidence that indicates aberrant SRC-3 ex-pression is important in hormone-sensitive and -insensitive human cancers.

关键词： SRC-3/AIB1 oncogene mouse model cancer signal transduction

Recovery and stabilization of heavy metal sludge (Cu and Ni) from etching and electroplating plants by electrolysis and sintering

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Science China Chemistry 2009年第5期52卷 644-651页

作者： tsai LungChang tsai FangChang Graduate School of Environment and Safety Engineering National Yunlin University of Science and Technology Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei University Faculty of Material Science and Engineering Hubei University

This work dealt with the recovery and stabilization of the sludge with heavy metals (Cu and Ni) produced from etching and electroplating plants. The heavy metals in the sludge were deprived of by acid leaching, followed by precipitation with 28% NH4OH, and finally by electrolysis. In the electrolysis, the recovery percentage and purity were investigated at different electronic currency and temperature. The metal-deprived sludge was stabilized by mixing with glass powder and clay, followed by sintering at high temperature. How the ratio of glass powder to metal-deprived sludge affected final products (sludge bricks) was explored, in terms of specific gravity, absorption capacity, unconfined compressive strength, morphology, the volume shrinkage ratio and burn-up ratio. The volume shrinkage ratio and burn-up ratio of sludge bricks increased with metal-deprived sludge contents. The heavy metal remaining in sludge bricks was assessed through TCLP (toxicity characteristic leaching procedure) and by the analysis of SEM and EDX. The results from TCLP showed that the contents of leached metals were all below the regulatory criteria. This fact approved the feasibility of our method.

关键词： heavy metal sludge treatment stability electrolysis brick material toxicity characteristic leaching procedure (TCLP)

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