SRC-3/AIB1:transcriptional coactivator in oncogenesis

作     者：Sophia Y TSAI Ming-jer TSAI 

作者机构：Department of Molecular and Cellular Biology Department of Molecular and Cellular BiologyProstate SPOREBaylor College of MedicineOne Baylor PlazaHouston.Texas 77030USA 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2006年第27卷第4期

页      面：387-394页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Project supported by grants from the National Institutes of Health(U01DK62424) Prostate SPORE(CA58204)to Ming-jer TSAT 

主　　题：SRC-3/AIB1 oncogene mouse model cancer signal transduction 

摘      要：Steroid receptor coactivator-3(SRC-3,also known as NCoA3,AIB1,p/CIP,RAC3,ACTR,and TRAM 1),localized on a frequently amplified region,20q 12,has beenassociated with multiple cancers,including breast,gastric and prostate *** SRC-3 has been implicated as an oncogene,compelling evidence hasonly recently emerged implicating it as a causal factor in the genesis of ***,we summarize recent evidence that indicates aberrant SRC-3 ex-pression is important in hormone-sensitive and -insensitive human cancers.