SRC-3/AIB1:transcriptional coactivator in oncogenesis
SRC-3/AIB1:transcriptional coactivator in oncogenesis作者机构:Department of Molecular and Cellular Biology Department of Molecular and Cellular BiologyProstate SPOREBaylor College of MedicineOne Baylor PlazaHouston.Texas 77030USA
出 版 物:《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期:2006年第27卷第4期
页 面:387-394页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金:Project supported by grants from the National Institutes of Health(U01DK62424) Prostate SPORE(CA58204)to Ming-jer TSAT
主 题:SRC-3/AIB1 oncogene mouse model cancer signal transduction
摘 要:Steroid receptor coactivator-3(SRC-3,also known as NCoA3,AIB1,p/CIP,RAC3,ACTR,and TRAM 1),localized on a frequently amplified region,20q 12,has beenassociated with multiple cancers,including breast,gastric and prostate *** SRC-3 has been implicated as an oncogene,compelling evidence hasonly recently emerged implicating it as a causal factor in the genesis of ***,we summarize recent evidence that indicates aberrant SRC-3 ex-pression is important in hormone-sensitive and -insensitive human cancers.