The role of tazarotene-induced gene 1 in carcinogenesis:is it a tumor suppressor gene or an oncogene?
作者机构：Department of DermatologyTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina School of MedicineTzu Chi UniversityHualien970TaiwanChina Department of Life SciencesMinistry of Science and TechnologyTaipei106TaiwanChina Department of Internal MedicineTaipei Tzu Chi HospitalThe Buddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina Department of ResearchTaipei Tzu Chi HospitalBuddhist Tzu Chi Medical FoundationNew Taipei City231TaiwanChina
出 版 物：《BIOCELL》 (生物细胞（英文）)
年 卷 期：2024年第48卷第9期
页 面：1285-1297页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by the Taipei Tzu Chi Hospital through grants from the Buddhist Tzu Chi Medical Foundation under the Numbers TCRD-TPE-111-23(2/3)and TCRD-TPE-113-20 Taipei Taiwan
主 题：Tazarotene-induced gene 1 Retinoic acid receptor responder protein 1 Tumor suppressor gene Oncogene
摘 要：Tazarotene-induced gene 1(TIG1)is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of ***1 is widely expressed in various tissues;yet in many cancer tissues,it is not expressed because of the methylation of its ***,the expression of TIG1 in cancer cells inhibits their growth and invasion,suggesting that TIG1 acts as a tumor suppressor ***,in some cancers,poor prognosis is associated with TIG1 expression,indicating its protumor growth characteristics,especially in promoting the invasion of inflammatory breast cancer *** review comprehensively summarizes the roles of the TIG1 gene in cancer development and details the mechanisms through which TIG1 regulates cancer development,with the aim of understanding its various roles in cancer development.
维普期刊数据库