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巨噬细胞负载Fe_(3)O_(4)@PLGA纳米颗粒触发智能催化功能杀死多重耐药大肠杆菌

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Engineering 2024年第3期34卷 174-186页

作者： Jieni Fu Xiangmei Liu Zhaoyang Li Yufeng Zheng Yu Zhang hui Jiang Yanqin Liang Shengli Zhu Zhenduo cui Shuilin Wu Key Laboratory of Advanced Ceramics and Machining Technology of the Ministry of Education School of Materials Science and EngineeringTianjin UniversityTianjin 300401China School of Materials Science and Engineering Peking UniversityBeijing 100871China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin 300401China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Infections with multidrug-resistant(MDR)Gram-negative bacteria,such as MDR Escherichia coli(***),remain a challenge due to the lack of safe antibiotics and high fatality rates under anti-infection *** work presents a form of biomimetic intelligent catalysis inspired by the selective biocatalytic property of macrophages(MΦs),consisting of an intelligent controlling center(a living MΦ)and a Fenton reaction catalyst(Fe_(3)O_(4)@poly(lactic-co-glycolic acid)(PLGA)nanoparticles)for killing MDR *** without harming normal *** MΦ-Fe_(3)O_(4)@PLGA particles(i.e.,the intelligent catalysis particles)exhibit selective biocatalysis activity toward MDR *** by producing H_(2)O_(2) and lipid droplets(LDs).This process activates the lipid metabolism and glycan biosynthesis and metabolism pathways based on the result of RNA sequencing data *** H_(2)O_(2) further reacts with Fe_(3)O_(4)@PLGA to form highly toxic hydroxyl radicals(·OH),while the LDs contain antimicrobial peptides and can target MDR *** highly toxicOH and antimicrobial peptides are shown to combat with MDR ***,such that the antibacterial efficiency of the MΦ-Fe_(3)O_(4)@PLGA particles against MDR *** is 99.29%±0.31%in *** importantly,after several passages,the intelligent catalysis function of the MΦ-Fe_(3)O_(4)@PLGA particles is well ***,the concept of biomimetic intelligent catalysts displays potential for treating diseases other than infections.

关键词： Multidrug-resistant Escherichia coli Macrophage-Fe_(3)O_(4)@PLGA particles Biomimetic intelligent catalysis

Identification and distribution of 13003 landslides in the northwest margin of Qinghai-Tibet Plateau based on human-computer interaction remote sensing interpretation

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China Geology 2024年第2期7卷 171-187页

作者： Wei Wang Yuan-dong Huang Chong Xu Xiao-yi Shao Lei Li Li-ye Feng hui-ran Gao Yu-long cui Shuai Wu Zhi-qiang Yang kai Ma National Institute of Natural Hazards Ministry of Emergency Management of ChinaBeijing 100085China Key Laboratory of Compound and Chained Natural Hazards Dynamics Ministry of Emergency Management of Chin12eijing 100085China School of Emergency Management Science and Engineering University of Chinese Academy of SciencesBeijing 100049China School of Soil and Water Conservation Beijing Forestry UniversityBeijing 100083China School of Civil Engineering and Architecture Anhui University of Science and TechnologyHuainan 232001China No.3 Bureau of China Metallurgical Geology Bureau Taiyuan 030031China

The periphery of the Qinghai-Tibet Plateau is renowned for its susceptibility to ***,the northwestern margin of this region,characterised by limited human activities and challenging transportation,remains insufficiently explored concerning landslide occurrence and *** the planning and construction of the Xinjiang-Tibet Railway,a comprehensive investigation into disastrous landslides in this area is essential for effective disaster preparedness and mitigation *** using the human-computer interaction interpretation approach,the authors established a landslide database encompassing 13003 landslides,collectively spanning an area of 3351.24 km^(2)(36°N-40°N,73°E-78°E).The database incorporates diverse topographical and environmental parameters,including regional elevation,slope angle,slope aspect,distance to faults,distance to roads,distance to rivers,annual precipitation,and *** statistical characteristics of number and area of landslides,landslide number density(LND),and landslide area percentage(LAP)are *** authors found that a predominant concentration of landslide origins within high slope angle regions,with the highest incidence observed in intervals characterised by average slopes of 20°to 30°,maximum slope angle above 80°,along with orientations towards the north(N),northeast(NE),and southwest(SW).Additionally,elevations above 4.5 km,distance to rivers below 1 km,rainfall between 20-30 mm and 30-40 mm emerge as particularly susceptible to landslide *** study area’s geological composition primarily comprises Mesozoic and Upper Paleozoic *** fault and human engineering activities have different degrees of influence on landslide ***,the significance of the landslide database,the relationship between landslide distribution and environmental factors,and the geometric and morphological characteristics of landslides are *** landslide H/L ratios in the study area are

关键词： Landslides Human-computer interaction interpretation Landslide database Spatial distribution Earthquake Rainfall Human engineering activity Qinghai-Tibet Plateau Geological hazards survey engineering

Circulating metabolites difference in type 2 diabetes patients from regions:a cross-sectional study

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Medical Data Mining 2024年第4期7卷 1-9页

作者： Jiang-Lan Long Zeng-hui Miao Ling-Wei Kong hui-Jing cui Na-Na Zhang Dan Yan Beijing Institute of Clinical Pharmacy Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Clinical laboratory Beijing Jiaotong University Community Health CenterBeijing 100044China Department of Pharmacy Kaifeng Hospital of Traditional Chinese MedicineKaifeng 475000China

Background:Type 2 diabetes(T2D)has already become a global *** its simple,rapid,economical,and relatively non-invasive,metabolic markers have become a method for T2D ***,region,race,and diet all affect the metabolism of the *** purpose of current study is to explore the differences of metabolites in T2D patients from ***:We recruited 103 T2D patients in two clinical centers,including 52 T2D patients from Beijing(T2D_(B))and 51 T2D patients from kaifeng(T2D_(K)).The serum samples from T2D patients were analyzed using high-resolution mass *** screened using univariate and multivariate analysis,the differential metabolites were ***,to reveal biological information,we performed pathway analysis with the differential ***:Thirty-six differential metabolites were identified,including 16 metabolites were higher concentrations while 20 metabolites were lower concentrations in the serum of T2D_(B) patients than T2D_(K) *** were higher serum concentrations of L-phenylalanine,4-methyl-2-oxovaleric acid,L-carnitine,decanoylcarnitine,9-decenoylcarnitine and sphinganine in T2D_(B) patients,in which decanoylcarnitine in T2D_(B) patients was up to 35-fold higher than T2D_(K) *** there were lower concentrations of L-valine,L-isoleucine,arachidonic acid,oleic acid,16-hydroxyhexadecanoic acid,lysophosphatidylcholine(18:0)and 1-Phenylethylamine in T2D_(B) patients,in which 1-phenylethylamine in T2D_(B) patients was decreased to 0.45-fold lower than T2D_(K) *** reason for the differences might be that phosphatidylethanolamine biosynthesis,phosphatidylcholine biosynthesis,valine,leucine and isoleucine degradation,and beta-oxidation of very long chain fatty acids were different in T2D_(B) patients and in T2D_(K) ***:Metabolites from different pathways are independently related to regions,providing valuable insight and potential for the diagnosis and treatment

关键词： type 2 diabetes metabolomics region high-resolution mass spectrometer

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian Wu hui Hong Wei Quan Xinyu Qiao Chun cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Epidemiological Characteristics of Human Parainfluenza Viruses Infections-China,2019-2023

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China CDC weekly 2024年第12期6卷 235-241,I0003,I0004页

作者： Yixuan Gao Yingwei Ma Daxing Feng Feng Zhang Biao Wang Xiaoqing Liu Bing Zhu hui Xie Linqing Zhao Xiaoru Long Ying Chen Bing Wang Jie Jiang Zhen Zhu Yan Zhang Aili cui Baicheng Xia Naiying Mao National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Precision Medicine Research Center Children’s Hospital of ChangchunChangchun CityJilin ProvinceChina Henan Provincial Center for Disease Control and Prevention Zhengzhou CityHenan ProvinceChina Laboratory of Viral Diseases Qingdao Municipal Centre for Disease Control and PreventionQingdao CityShandong ProvinceChina Virus Laboratory Gansu Provincial Center for Disease Control and PreventionLanzhou CityGansu ProvinceChina Jiangxi Provincial Center for Disease Control and Prevention Nanchang CityGansu ProvinceChina Virus Laboratory Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou CityGuangdong ProvinceChina Institute for Immunization and Prevention Beijing Center for Disease Prevention and ControlAcademy for Preventive MedicineInstitute of Tuberculosis Control Research and PreventionBeijingChina Laboratory of Virology Beijing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBeijingChina Department of Infection Children’s Hospital of Chongqing Medical UniversityChongqingChina Inner Mongolia Autonomous Region Comprehensive Center for Disease Control and Prevention Hohhot CityInner Mongolia Autonomous RegionChina Shenyang Prefecture Center for Disease Control and Prevention Shenyang CityLiaoning ProvinceChina

Introduction:A retrospective study based on sentinel surveillance was conducted in 10 provinciallevel administrative divisions(PLADs)in China to enhance the understanding of the epidemiological characteristics of human parainfluenza viruses(HPIVs).Methods:From January 2019 to June 2023,respiratory specimens were collected from individuals with acute respiratory infections(ARIs)and screened for four HPIVs serotypes and other common respiratory viruses using multiplex real-time polymerase chain reaction(PCR).This study analyzed the association of HPIVs infections with seasonal patterns,geographical distribution,demographic profiles,clinical features,and co-infection ***:During the study period,a total of 12,866 ARIs were *** overall detection rate of HPIVs was 6.15%,varying from 5.04%in 2022 to 9.70%in *** median age of HPIVs-infected patients was 3 ***2 was more prevalent among individuals aged 5–17 years(42.57%),while HPIV4 was more common in those over 65 years(12.24%).HPIV3(54.16%)and HPIV1(27.18%)were the predominant serotypes,and their prevalence exhibited significant seasonal fluctuations postcoronavirus disease 2019(COVID-19)*** peak of HPIV3 shifted three months later in 2020 compared to 2019 and returned to a summer peak *** peaks of HPIV1 were observed in 2021 following the peak of ***,coinfections were frequent in HPIVs cases(overall rate:22.12%),with human rhinovirus being the most common co-infecting ***:The prevalence of HPIVs in China was predominantly due to HPIV3 and HPIV1,and their seasonal patterns were altered by pandemic ***,continuous surveillance of HPIVs is essential.

关键词： prevalence seasonal Human

基于大数据驱动的农村电商产品自动化识别系统

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现代电子技术 2024年第4期47卷 59-64页

作者：崔巍李慧太原科技大学山西太原030024 山西工程职业学院山西太原030009

农村电子商务的发展和建设,为多样化的电商产品流向农村、服务农村提供了良好契机。促进农村电商产品推广和分销的同时,如何正确甄别面向农村的电商产品是否合适,通过电商产品的参数识别、统计进行分析,从而提高电商产品质量,降低管理... 详细信息

农村电子商务的发展和建设,为多样化的电商产品流向农村、服务农村提供了良好契机。促进农村电商产品推广和分销的同时,如何正确甄别面向农村的电商产品是否合适,通过电商产品的参数识别、统计进行分析,从而提高电商产品质量,降低管理电商产品成本,成为亟需解决的问题。电商产品在电商平台中的介绍往往以图像形式呈现,想要对电商产品进行参数识别,提取参数并进行统计分析,就需要一种时效性好、精确度高的自动化识别系统,针对此种问题,提出以大数据驱动为基础,依靠神经网络学习算法结合OCR技术的方式进行商品图像识别,保证在提高时效性的同时,提高图像识别的精确度。改进的识别系统以YOLO模型为基础依据,并针对其存在的不足进行了进一步优化。系统设计的部分包括检测模型的搭建、文字识别以及图片处理等。

关键词：电商产品识别自动化识别大数据驱动农村电子商务 OCR技术 YOLO模型

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电流密度对单晶铜棒材电化学冷拉拔的影响

塑性工程学报 2024年第3期31卷 76-82页

作者：崔智慧陈体军兰州理工大学省部共建有色金属先进加工与再利用国家重点实验室甘肃兰州730050

通过显微维氏硬度计、电子背散射衍射和透射电子显微镜等分析手段研究了不同电流密度对单晶铜棒材电化学冷拉拔过程中拉拔力、硬度、晶体取向及位错的影响。结果表明,当电流密度为6.7 m A·cm^(-2)时,激活的滑移系数量最多,拉拔力最小,... 详细信息

通过显微维氏硬度计、电子背散射衍射和透射电子显微镜等分析手段研究了不同电流密度对单晶铜棒材电化学冷拉拔过程中拉拔力、硬度、晶体取向及位错的影响。结果表明,当电流密度为6.7 m A·cm^(-2)时,激活的滑移系数量最多,拉拔力最小,且拉拔后棒材的表面硬度也最小。不同的电流密度使单晶铜棒材的塑化程度不同,其主要原因是由于晶体内滑移系激活数量不同引起,导致位错易于运动,使得位错缠结减少。而在更高的电流密度下,由于表面腐蚀层厚度的增加,激活的滑移系数量减少,继而摩擦力增大,位错密度增大,使得拉拔力再次增大。

关键词：电化学冷拉拔电化学腐蚀滑移系位错软化

Jianpi Gushen Huayu decoction ameliorated diabetic nephropathy through modulating metabolites in kidney,and inhibiting TLR4/NF-κB/NLRP3 and JNK/P38 pathways

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World Journal of Diabetes 2024年第3期15卷 502-518页

作者： Zi-Ang Ma Li-Xin Wang hui Zhang Han-Zhou Li Li Dong Qing-Hai Wang Yuan-Song Wang Bao-ChaoPan Shu-Fang Zhang Huan-Tian cui Shu-Quan Lv Graduate School Hebei University of Chinese MedicineShijiazhuang 050000Hebei ProvinceChina Department of Endocrinology Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei Province Affiliated to Hebei University of Chinese MedicineCangzhou 061000Hebei ProvinceChina School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 300000China The First School of Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 065000Yunnan ProvinceChina Department of Endocrinology Hebei Cangzhou Hospital of Integrative MedicineCangzhou 061000Hebei ProvinceChina

BACKGROUND Jianpi Gushen Huayu Decoction(JPGS)has been used to clinically treat diabetic nephropathy(DN)for many ***,the protective mechanism of JPGS in treating DN remains *** To evaluate the therapeutic effects and the possible mechanism of JPGS on *** We first evaluated the therapeutic potential of JPGS on a DN mouse *** then investigated the effect of JPGS on the renal metabolite levels of DN mice using non-targeted ***,we examined the effects of JPGS on c-Jun N-terminal kinase(JNK)/P38-mediated apoptosis and the inflammatory responses mediated by toll-like receptor 4(TLR4)/nuclear factor-kappa B(NF-κB)/NOD-like receptor family pyrin domain containing 3(NLRP3).RESULTS The ameliorative effects of JPGS on DN mice included the alleviation of renal injury and the control of inflammation and oxidative *** metabolomic analysis revealed that JPGS altered the metabolites of the kidneys in DN mice.A total of 51 differential metabolites were *** analysis results indicated that nine pathways significantly changed between the control and model groups,while six pathways significantly altered between the model and JPGS *** related to cysteine and methionine metabolism;alanine,tryptophan metabolism;aspartate and glutamate metabolism;and riboflavin metabolism were identified as the key pathways through which JPGS affects *** experimental validation showed that JPGS treatment reduced the expression of TLR4/NF-κB/NLRP3 pathways and JNK/P38 pathway-mediated apoptosis related *** JPGS could markedly treat mice with streptozotocin(STZ)-induced DN,which is possibly related to the regulation of several metabolic pathways found in ***,JPGS could improve kidney inflammatory responses and ameliorate kidney injuries in DN mice via the TLR4/NF-κB/NLRP3 pathway and inhibit JNK/P38 pathwaymediated apoptosis in DN mice.

关键词： Diabetic nephropathy Jianpi Gushen Huayu Decoction Oxidative stress Inflammation Untargeted metabolomics Toll-like receptor 4/nuclear factor-kappa B/NOD-like receptor family pyrin domain containing 3 pathway c-Jun N-terminal kinase/P38-mediated apoptosis

Partial oxidation of methane by photocatalysis

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Chinese Chemical Letters 2024年第1期35卷 153-168页

作者： Zhongshan Yang Qiqi Zhang hui Song Xin Chen Jiwei cui Yanhui Sun Lequan Liu Jinhua Ye TJU-NIMS International Collaboration Laboratory School of Materials Science and EngineeringTianjin UniversityTianjin 300072China International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)1-1 NamikiIbaraki 3050047Japan Zhejiang LAMP Co. Ltd.Wenzhou 325206China

Methane chemistry is one of the“Holy Grails of catalysis”.It is highly desirable but challenge to transform methane into value-added chemicals,because of its high C-H bonding energy(435 kJ/mol),lack ofπbonding or unpaired ***,commercial methane conversion is usually carried out in harsh conditions with enormous energy *** partial oxidation of methane to liquid oxygenates(PPOMO)is a future-oriented technology towards realizing high efficiency and high selectivity under mild *** selection of oxidant is crucial to the PPOMO ***,attentions are paid to the research progress of PPOMO with various oxidants(O_(2),H_(2)O,H_(2)O_(2)and other oxidants).Moreover,the activation of the selected oxidants is also highly ***,we summarized the methane activation mechanisms focusing on the C-H bond that was broken mainly by·OH radical,O-specie or photogenerated hole(h+).Finally,the challenges and prospects in this subject are briefly discussed.

关键词： Partial oxidation of methane Photocatalysis Liquid oxygenates Oxidants C-H activation