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Plant cytochrome P450 plasticity and evolution

Molecular Plant 2021年第10期14卷 1244-1265页

作者： Cecilie Cetti hansen David R.Nelson Birger Lindberg Moller Daniele werck-Reichhart Plant Biochemistry Laboratory Department of Plant and Environ mental ScienceUniversity of CopenhagenCopenhage nDenmark VILLUM Research Center for Plant Plasticity University of CopenhagenCopenhagenDenmark Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Institute of Plant Molecular Biology Centre National de la Recherche Scientifique(CNRS)University of StrasbourgStrasbourgFrance

The superfamily of cytochrome P450(CYP)enzymes plays key roles in plant evolution and metabolic *** review provides a status on the CYP Iandscape within green algae and land *** 11 conserved CYP clans known from vascular plants are all present in green algae and several green algaespecific clans are *** 71,72,and 85 remain the largest CYP clans and include many taxaspecific CYP(sub)families reflecting emergence of linage-specific *** features and dynamics of CYP plasticity and evolution are discussed and exemplified by selected biosynthetic *** substrate promiscuity is commonly observed for CYPs from large families,favoring retention of gene duplicates and neofunctionalization,thus seeding acquisition of new *** of biosynthetic pathways producing metabolites with sporadic distribution across plant phylogeny reveals multiple exampies of convergent evolution where CYPs have been independently recruited from the same or different CYP families,to adapt to similar environmental challenges or ecological *** only a single or a few mutations are required for functional interconversion.A compilation of functionally characterized plant CYPs is provided online through the Plant P450 Database(***/public/vgrid/PlantP450/).

关键词： land plants green algae diversificati on promiscuity neofunctionalization convergent evolution functionalities plant metabolism

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Real-time impact of power balancing on power system operation with large scale integration of wind power

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Journal of Modern Power Systems and Clean Energy 2017年第2期5卷 202-210页

作者： Abdul BASIT Anca D.hansen Poul E.SØRENSEN Georgios GIANNOPOULOS Department of wind Energy Technical University of DenmarkFrederiksborgvej 3994000 RoskildeDenmark Sino-Danish Center for Education and Research Niels Jensens Vej 28000 AarhusDenmark ELIA SYSTEM OPERATOR Keizerslaan 201000 BrusselsBelgium

Highly wind power integrated power system requires continuous active power regulation to tackle the power imbalances resulting from the wind power forecast errors. The active power balance is maintained in real-time with the automatic generation control and also from the control room, where regulating power bids are activated manually. In this article, an algorithm is developed to simulate the activation of regulating power bids, as performed in the control room, during power imbalance between generation and load demand. In addition, the active power balance is also controlled through automatic generation control, where coordinated control strategy between combined heat and power plants and wind power plant enhances the secure power system operation. The developed algorithm emulating the control room response,to deal with real-time power imbalance, is applied and investigated on the future Danish power system model. The power system model takes the hour-ahead regulating power plan from power balancing model and the generation and power exchange capacities for the year 2020 into *** real-time impact of power balancing in a highly wind power integrated power system is assessed and discussed by means of simulations for different possible scenarios.

关键词： wind power plant(wPP) Simulation power Balancing model(SimBa) Centralised or de-centralised combined heat and power plant(CHP or DCHP) Automatic generation control(AGC) Rolling balance

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海岛近岸水下生物数量预测模型

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福建电脑 2024年第5期40卷 48-52页

作者：蔡立鹏蒋海阳张汉森杨淼江苏海洋大学海洋工程学院江苏连云港222005 江苏海洋大学电子工程学院江苏连云港222005

海洋监测技术是海洋科学的重要组成部分。为了加强海岛近岸水下生物动态监测,本文提出一种海岛近岸水下生物数量预测模型。首先收集秦山岛近岸海域样本数据,并进行数据处理;然后比较随机森林、决策树等机器学习模型的性能表现;通过贝叶... 详细信息

海洋监测技术是海洋科学的重要组成部分。为了加强海岛近岸水下生物动态监测,本文提出一种海岛近岸水下生物数量预测模型。首先收集秦山岛近岸海域样本数据,并进行数据处理;然后比较随机森林、决策树等机器学习模型的性能表现;通过贝叶斯调参方法优化预测模型,确定最佳参数值。实验结果表明,本文建立的预测模型具有良好的预测性能和实际应用可行性。

关键词：水下生物随机森林预测模型

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Diagnostic procedures for submucosal tumors in the gastrointestinal tract

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world Journal of Gastroenterology 2007年第24期13卷 3301-3310页

作者： Laura Graves Ponsaing katalin kiss Annika Loft Lise Ingemann Jensen Mark Berner hansen Department of Surgical Gastroenterology k Bispebjerg University Hospital of Copenhagen Denmark Department of Pathology Herlev University Hospital Gentofte Denmark Department of Nuclear Medicine CopenhagenUniversity Hospital Rigshospitalet Denmark Department of Radiology Bispebjerg University Hospital of Copenhagen Denmark

This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.

关键词： Submucosal tumor Diagnosis Endoscopy Endoscopic ultrasonography Computed tomography Magnetic resonance imaging Positron emission tomography Capsule endoscopy Push-and-pull enteroscopy Ponsaing LG, kiss k, Loft A, Jensen LI, hansen MB.

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Influence of Thermal Radiation on Hot Cluster Decay Rates and Abundances

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Chinese Journal of Chemical Physics 2019年第2期32卷 167-174,I0002页

作者： klavs hansen P. Ferrari Center for Joint Quantum Studies and Department of Physics Tianjin University Tianjin 300072 China Department of Physics Gothenburg University Gothenburg 41296 Sweden Laboratory of Solid State Physics and Magnetism KU Leuven Leuven 3001 Belgium

The influence of radiative cooling on the unimolecular decay rates of free, hot clusters and molecules with unspecified excitation energies is quantified. Two different regimes, dedined by the magnitude of the energy of the photons emitted, are identified and the boundary between them is given. The boundary is determined in terms of the photon emission rate constants and thermal properties of the particles. Also the abundance spectra are calculated for the continuous cooling case, corresponding to small photon energies. The two regimes correspond to continuous cooling and single photon quenching of the unimolecular decay. The radiative effect can be parametrized by a redefinition of the time each individual cluster has available to undergo evaporation, expressed by an effective radiative time constant.

关键词： Clusters Thermal radiation Abundances Decay rates

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Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd(ts)] is mediated through crosstalk between Ahr–Nrf2 pathway and MAPk signaling

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分子细胞生物学报:英文版 2015年第1期7卷 73-87页

作者： Prabagaran Esakky Deborah A.hansen Andrea M.Drury kelle H.Moley Research Department of Veterans Affairs Medical CenterSt.LouisMO 63106USA Department of Obstetrics and Gynecology Washington University School of MedicineSt.LouisMO 63110USA

Our earlier studies have demonstrated that the cigarette smoke in the form of cigarette smoke condensate(CSC)causes growth arrest of a mouse spermatocyte cell line[GC-2spd(ts)]through activation of the AHR–NRF2 *** present study demonstrates the CSC-activated p38 and ERk MAPk signaling in GC-2spd(ts)via arylhydrocarbon receptor(AHR).Pharmacological inhibition by using AHR-antagonist,or p38 MAPk and ERk(MEk1)inhibitors significantly abrogates CSC-induced growth arrest by AHR and MAPk ***-PCR,western blot,and immunofluorescence of Ahr-target of Nrf2,and stress-inducible growth suppressive Atf3 and E2f4 following treatments indicate a crosstalk among these *** of Atf3 by Nrf2 and Ahr through RNA interference suggests the existence of a cross-regulatory loop between the *** induction of E2f4 via Atf3 and its regulation by pharmacological inhibitors reveal a possible regulatory mechanism of growth inhibitory *** silencing of Ahr,Nrf2,Atf3,and E2f4 genes and downregulation of cyclins by CSC corroborate the growth inhibitory effect of cigarette ***,the data obtained suggest that the CSC-mediated MAPks and AHR–NRF2 crosstalks lay the molecular basis for the growth arrest and cell death of spermatocytes.

关键词： spermatocytes Ahr Nrf2 CSC ATF3 E2F4 p38 MAPk and ERk

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Cutting force model and damage formation mechanism in milling of 70wt%Si/Al composite

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Chinese Journal of Aeronautics 2023年第7期36卷 114-128页

作者： Guolong ZHAO Lianjia XIN Liang LI Yang ZHANG Ning HE Hans Nørgaard hansen College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Civil and Mechanical Engineering Technical University of DenmarkKgs.Lyngby 2800Denmark

High-mass fraction silicon aluminium composite(Si/Al composite) has unique properties of high specific strength, low thermal expansion coefficient, excellent wear resistance and weldability. It has attracted many applications in terms of radar communication, aerospace and automobile industry. However, rapid tool wear resulted from high cutting force and hard abrasion, and damaged machined surfaces are the main problem in machining Si/Al composite. This work aims to reveal the mechanisms of milling-induced damages of 70wt% Si/Al composites. A cutting force analytical model considering the characteristics of both the primary silicon particles and the cutting-edge radius was established. Milling experiments were conducted to verify the validity of the model. The results show that the analytical model exhibits a good consistency with the experimental results, and the error is about 10%. The cutting-edge radius has significant effects on the cutting force, surface roughness and damage formation. with the increase in the cutting-edge radius, both the cutting force and the surface roughness decrease firstly and then increase. when the cutting-edge radius is 27 μm, the surface roughness(Sa) reaches the minimum of 2.3 μ***-induced surface damages mainly contain cracks, pits, scratches, matrix coating and *** damage formation is dominated by the failure mode of primary silicon particles, which includes compressive breakage, intragranular fracture, particle pull-out, and interface debonding. In addition, the high ductility of aluminium matrix leads to matrix coating. This work provides guidance for tool selection and damage inhibition in high-efficiency and high-precision machining of high mass fraction Si/Al composites.

关键词： posite Cutting force analytical model Cutting-edge radius Surface quality Damage formation mechanism

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Highly Increased Levels of Inter-α-inhibitor Heavy Chain 4(ITIH4)in Autoimmune Cholestatic Liver Diseases

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 796-802页

作者： Tea Lund Laursen Lars Bossen Rasmus Pihl Anne Troldborg Thomas Damgaard Sandahl Annette Gudmann hansen Trine Folserass Mette Vesterhus Henning Grønbæk Steffen Thiel Department of Hepatology and Gastroenterology Aarhus University HospitalAarhusDenmark Department of Biomedi-cine Aarhus UniversityAarhusDenmark Department of Rheumatology Aarhus University HospitalAarhusDenmark Department of Clinical Medicine Aarhus UniversityAarhusDenmark Norwegian PSC Research Center Department of Transplantation MedicineDivision of SurgeryInflammatory Diseases and TransplantationOslo University Hospital Rik-shospitaletOsloNorway Haraldsplass Deaconess Hospital BergenNorway Department of Clinical Science University of BergenBergenNorway

Background and Aims:There is an unmet need for new bi-omarkers to improve diagnostics and prognostics in primary biliary cholangitis(PBC)and primary sclerosing cholangitis(PSC).Inter-α-inhibitor heavy chain 4(ITIH4)is an abun-dant,liver-produced protein,and its synthesis may be al-tered in liver *** investigated whether ITIH4 plas-ma concentrations were affected in PBC and PSC ***:we developed an immunoassay specific for ITIH4 and determined ITIH4 plasma concentrations in 66 PBC,126 PSC,92 autoimmune hepatitis(AIH),67 chronic hepatitis C(CHC),33 alcoholic hepatitis(AH)patients and 138 healthy controls(HCs).Hepatic ITIH4 expression was investigated by immunohistochemistry in ***:The mean plas-ma concentration of ITIH4 was almost doubled in PBC[409μg/mL(95%CI:388-431)]and 35%higher in PSC[308μg/mL,(95%CI:296-319)]compared with HCs[226μg/mL(95%CI:221-231);pwith IgM(rho=0.49,pwer levels of ITIH4 than incomplete responders[395μg/mL(95%CI:364-425)]vs.460μg/mL(95%CI:421-498);p=0.02].Four weeks of UDCA treatment had no effect(p=0.19).In-creased ITIH4 immunohistochemical staining was seen in a liver biopsy from a PBC ***4 levels in AIH[224μg/mL(95%CI:208-241)]and HCs were similar(p=0.8).ITIH4 levels were lower in AH[199μg/mL(95%CI:175-223)]and CHC[202μg/mL(192-212)]patients than in HCs(pwas highly elevated in patients with PBC and PSC,suggesting that ITIH4 should be further investigated as a biomarker in cholestatic liver disease.

关键词： Primary biliary cholangitis Primary sclerosing cholangitis Autoim-mune hepatitis Ursodeoxycholic acid treatment Alcoholic hepatitis Chronic viral hepatitis

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黄芪多糖对绵羊精液冷冻保存的影响

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中国畜牧兽医 2024年第5期51卷 2007-2014页

作者：王振国李瀚森张丽周千时娟娟石磊任有蛇山西农业大学动物科学学院太谷030801

【目的】试验旨在研究稀释液中添加黄芪多糖对杜泊种公羊精液冷冻保存效果的影响。【方法】使用假阴道法采集6只成年杜泊种公羊的精液,将活率>80%的精液混合,使用Tris-果糖-海藻糖-柠檬酸基础稀释液和降温稀释液对绵羊新鲜精液进行逐步... 详细信息

【目的】试验旨在研究稀释液中添加黄芪多糖对杜泊种公羊精液冷冻保存效果的影响。【方法】使用假阴道法采集6只成年杜泊种公羊的精液,将活率>80%的精液混合,使用Tris-果糖-海藻糖-柠檬酸基础稀释液和降温稀释液对绵羊新鲜精液进行逐步稀释,低温缓慢降温到4℃后,分别于含黄芪多糖(0、0.01、0.05和0.1 mg/mL)的冷冻稀释液中进行平衡处理,将平衡后的精液分装于0.25 mL冻精细管中,置于液氮上方熏蒸后于液氮中冷冻保存。通过精子辅助分析系统检测冷冻-解冻后精子质量指标(活力和活率)和精子运动参数(平均路径速度、曲线运动速度、直线运动速度、摆动指数、线性度和直线运动指数),采用精子低渗肿胀试验检测质膜完整性,使用双荧光染色检测精子DNA完整性和线粒体活性。【结果】精液冷冻前后,绵羊精子活力、活率和运动能力均明显降低。0.01 mg/mL黄芪多糖添加组精液冷冻解冻后精子活力、活率、平均路径速度、线性度、摆动指数以及线粒体活性均显著高于其余各组(P0.05)。【结论】冷冻稀释液中添加0.01 mg/mL黄芪多糖能够保护绵羊精子结构,有效提高冷冻-解冻后绵羊精子活力、活率和运动能力,改善绵羊精液冷冻保存效果。

关键词：杜泊羊精液冷冻保存黄芪多糖

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s age at puberty associated with semen quality ant ＇eproductive hormones in young adult life？

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Asian Journal of Andrology 2017年第6期19卷 625-632页

作者： Lea LB Lauridsen Linn H Arendt Henrik Stovring Jorn Olsen Cecilia H Ramlau-hansen 1Department of Public Health Section for Epidemiology Aarhus University 8000 Aarhus C Denmark Department of Public Health Section for 8iostatistics Aarhus University 8000 Aarhus C Denmark Department of Clinical Epidemiology Aarhus University Hospital 8200 Aarhus N Denmark

The evidence is scarce on the association between age at puberty and semen quality. A cohort of 320 Danish men aged 18-21 years enrolled in the ＂Healthy Habits for Two＂ birth cohort provided self-reported data on pubertal indicators and delivered semen and blood samples. The results indicated an association between older age at pubertal development and lower semen quality and altered reproductive hormones concentrations as measured in young adult life. Men who had their first nocturnal emission, start of pubic hair growth and first voice break episode when older than 15 years had 37.0%, 45.0% and 32.7% lower sperm concentration; 37.8%, 44.2% and 29.1% lower total sperm count; 7.4%, 13.4% and 15.3% lower testosterone concentration; and 21.3%, 1.5% and 3.7% lower inhibin B concentration, respectively, compared with the men who were younger than 13 years at their first pubertal indicators. Only few of the results were statistically significant, but similar tendencies were seen in several of the reproductive parameters suggesting an association between the timing of pubertal development and reproductive health later in life.

关键词： pubertal development puberty reproductive health reproductive hormones semen quality

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