Plant cytochrome P450 plasticity and evolution

作     者：Cecilie Cetti Hansen David R.Nelson Birger Lindberg Moller Daniele Werck-Reichhart Cecilie Cetti Hansen;David R.Nelson;Birger Lindberg M?ller;Daniele Werck-Reichhart

作者机构：Plant Biochemistry LaboratoryDepartment of Plant and Environ mental ScienceUniversity of CopenhagenCopenhage nDenmark VILLUM Research Center for Plant PlasticityUniversity of CopenhagenCopenhagenDenmark Department of MicrobiologyImmunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Institute of Plant Molecular BiologyCentre National de la Recherche Scientifique(CNRS)University of StrasbourgStrasbourgFrance 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2021年第14卷第10期

页      面：1244-1265页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by a PhD fellowship provided through a Villum Foundation Young Investigator Program fellowship granted to Elizabeth H.J.Neils on(grant number 13167) supported by the VILLUM Center for Plant Plasticity(VKR023054)(B.L.M.) a European Research Council Advanced Grant(ERC-2012-ADG_20120314) the Novo Nordisk Foundation Distinguished Investigator 2019 Grant(NNF 0054563,The Black Holes in the Plant Universe) 

主　　题：land plants green algae diversificati on promiscuity neofunctionalization convergent evolution functionalities plant metabolism 

摘      要：The superfamily of cytochrome P450(CYP)enzymes plays key roles in plant evolution and metabolic *** review provides a status on the CYP Iandscape within green algae and land *** 11 conserved CYP clans known from vascular plants are all present in green algae and several green algaespecific clans are *** 71,72,and 85 remain the largest CYP clans and include many taxaspecific CYP(sub)families reflecting emergence of linage-specific *** features and dynamics of CYP plasticity and evolution are discussed and exemplified by selected biosynthetic *** substrate promiscuity is commonly observed for CYPs from large families,favoring retention of gene duplicates and neofunctionalization,thus seeding acquisition of new *** of biosynthetic pathways producing metabolites with sporadic distribution across plant phylogeny reveals multiple exampies of convergent evolution where CYPs have been independently recruited from the same or different CYP families,to adapt to similar environmental challenges or ecological *** only a single or a few mutations are required for functional interconversion.A compilation of functionally characterized plant CYPs is provided online through the Plant P450 Database(***/public/vgrid/PlantP450/).