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Performance of braced excavation in residual soil with groundwater drawdown

Underground Space 2018年第2期3卷 150-165页

作者： W.G.Zhang A.T.C.goh k.h.goh O.Y.S.Chew D.Zhou Runhong Zhang key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityChongqingChina School of Civil Engineering Chongqing UniversityChongqingChina School of Civil and Envirormental Engineering Nanyang Technological UniversitySingapore Civil Design Division Land Transport AuthoritySingapore Geotechmical cand Tunnels Division Land Transport AuthoritySingapore

In densely built-up Singapore,relatively stiffsecant-bored piles and diaphragm walls are commonly used in cut-and-cover works to minimize the impact of ground movement on the adjacent structures and *** excavations in stiffresidual soil deposits,the asso-ciated wall deﬂections and ground settlements are generally smaller than for excavations in soft soil ***,if the residual soil permeability is high and the underlying rock is highlyﬁssured or fractured,substantial groundwater drawdown and associated seepage-induced settlement may *** this study,the excavation performance of four sites in residual soil deposits with maximum excavation depths between 20 and 24 m is *** maximum wall deﬂections were found to be relatively small compared to the signiﬁcantly larger maximum ground settlements,owing to the extensive lowering of the groundwater *** this paper,details of the subsurface conditions,excavation support system,ﬁeld instrumentation,and observed excavation responses are presented,with particular focus on the large groundwater drawdown and associated ground ***ﬁc issues encountered during the excavation,as well as the effectiveness of various groundwater control measures,are *** case studies will provide useful references and insights for future projects involving braced excavations in residual soil.

关键词： Residual soil Braced excavation Wall deﬂection Ground settlements Groundwater drawdown Strut force

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Intrumer:A Multi Module Distributed Explainable IDS/IPS for Securing Cloud Environment

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Computers, Materials & Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A S.k.B.Sangeetha Department of Computer Science and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increasing use of cloud-based devices has reached the critical point of cybersecurity and unwanted network *** environments pose significant challenges in maintaining privacy and *** approaches,such as IDS,have been developed to tackle these ***,most conventional Intrusion Detection System(IDS)models struggle with unseen cyberattacks and complex high-dimensional *** fact,this paper introduces the idea of a novel distributed explainable and heterogeneous transformer-based intrusion detection system,named INTRUMER,which offers balanced accuracy,reliability,and security in cloud settings bymultiplemodulesworking together within *** traffic captured from cloud devices is first passed to the TC&TM module in which the Falcon Optimization Algorithm optimizes the feature selection process,and Naie Bayes algorithm performs the classification of *** selected features are classified further and are forwarded to the heterogeneous Attention Transformer(hAT)*** this module,the contextual interactions of the network traffic are taken into account to classify them as normal or malicious *** classified results are further analyzed by the Explainable Prevention Module(XPM)to ensure trustworthiness by providing interpretable *** the explanations fromthe classifier,emergency alarms are transmitted to nearby IDSmodules,servers,and underlying cloud devices for the enhancement of preventive *** experiments on benchmark IDS datasets CICIDS 2017,honeypots,and NSL-kDD were conducted to demonstrate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms state-of-the-art approaches,obtaining better performance metrics:98.7%accuracy,97.5%precision,96.3%recall,and 97.8%*** results validate the robustness and effectiveness of INTRUMER in securing diverse cloud environments against sophisticated cyber threats.

关键词： Cloud computing intrusion detection system transformers and explainable artificial intelligence(XAI)

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler hans Zempel Institute of human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert hoepner Patrick küry Department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(hERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.

关键词： endogenous inflammation human

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Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

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Entropy squeezing and atomic inversion in the k-photon Jaynes–Cummings model in the presence of the Stark shift and a kerr medium:A full nonlinear approach

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Chinese Physics B 2014年第7期23卷 417-428页

作者： h R Baghshahi M k Tavassoly A Behjat Atomic and Molecular Group Faculty of PhysicsYazd University The Laboratory of Quantum Information Processing Yazd University Department of Physics Faculty of ScienceVali-e-Asr University of Rafsanjan Photonics Research Group Engineering Research CenterYazd University

The interaction between a two-level atom and a single-mode field in the k-photon Jaynes-Cummings model （JCM） in the presence of the Stark shift and a kerr medium is studied. All terms in the hamiltonian, such as the single-mode field, its interaction with the atom, the contribution of the Stark shift and the kerr medium effects are considered to be f-deformed. In particular, the effect of the initial state of the radiation field on the dynamical evolution of some physical properties such as atomic inversion and entropy squeezing are investigated by considering different initial field states （coherent, squeezed and thermal states）.

关键词： Jaynes-Cummings model entropy squeezing atomic inversion intensity-dependent coupling

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUhAMMAD M.SARFRAZ Department of humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MhD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MAThEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

关键词： Nanofluidics

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Editorial comment on: surgical outcomes of two-stage hepatectomy for colorectal liver metastasis: comparison to a benchmark procedure

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hepatobiliary Surgery and Nutrition 2021年第4期10卷 570-572页

作者： Zhongkai Wang Brian k.P.goh Department of hepatopancreatobiliary and Transplant Surgery Singapore General HospitalSingaporeSingapore Duke-National University of Singapore Medical School SingaporeSingapore

With advancements in surgical techniques,locoregional therapy and systemic therapy,patients suffering from colorectal cancer with liver metastasis now have numerous therapeutic options for local and systemic disease *** resection of the primary cancer and all metastases remains the primary objective,offering patients the best chance for long-term survival.

关键词： metastasis colorectal surgical

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Modulating neuronal plasticity with choline

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Neural Regeneration Research 2019年第10期14卷 1697-1698页

作者： Eunice W. M. Chin Eyleen L.k. goh Neuroscience Academic Clinical Programme Duke-NUS Medical SchoolSingaporeSingapore Department of Research National Neuroscience InstituteSingaporeSingapore

The American psychologist William James once wrote that nervous tissue seems to be endowed with a “very extraordinary” degree of plasticity. To be plastic means to be capable of being molded, receiving shape, or being made to assume a desired form. This can be achieved consequential to changes in the internal and/or external environment. Being plastic, neurons are highly able to amend their structural and functional output, through alteration of their morphology, activation of intracellular signaling cascades, regulation of synaptic density and neurotransmitter release, or a combination of these events.

关键词： The American psychologist tissue seems to be endowed combination of these events

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Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

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Neural Regeneration Research 2020年第4期15卷 573-585页

作者： Deepak Jain Sabrina Mattiassi Eyleen L.goh Evelyn k.F.Yim Department of Chemical Engineering University of WaterlooWaterlooOntarioCanada Neuroscience Academic Clinical Programme Duke-NUS Medical SchoolSingapore

Extracellular matrix(ECM)influences cell differentiation through its structural and biochemical *** nervous system,neuronal behavior is influenced by these ECMs structures which are present in a meshwork,fibrous,or tubular forms encompassing specific molecular *** addition to contact guidance,ECM composition and structures also exert its effect on neuronal *** short report reviewed the native ECM structure and composition in central nervous system and peripheral nervous system,and their impact on neural regeneration and neuronal *** topographies,stem cells have been differentiated to ***,focussing on engineered biomimicking topographies,we highlighted the role of anisotropic topographies in stem cell differentiation to neurons and its recent temporal application for efficient neuronal differentiation.

关键词： biomimetic platforms biophysical cues contact guidance extracellular matrix neuronal development neural regeneration neural stem cell niche neuronal differentiation neuronal maturation stem cell topography

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