Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

作     者：Deepak Jain Sabrina Mattiassi Eyleen L.Goh Evelyn K.F.Yim Deepak Jain;Sabrina Mattiassi;Eyleen L. Goh;Evelyn K.F. Yim

作者机构：Department of Chemical EngineeringUniversity of WaterlooWaterlooOntarioCanada Neuroscience Academic Clinical ProgrammeDuke-NUS Medical SchoolSingapore 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第4期

页      面：573-585页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the Natural Sciences and Engineering Research Council of Canada(NSERC) Discovery(NSERC 2016040 to DJ,SM and EKFY) University of Waterloo start up fund(to DJ,SM and EKFY) for their generous funding NSERC Undergraduate Student Research Awards(USRA to SM and EKFY) Collaborative Research and Training Experience(CREATE,401207296 to SM and EKFY) for their generous partial funding 

主　　题：biomimetic platforms biophysical cues contact guidance extracellular matrix neuronal development neural regeneration neural stem cell niche neuronal differentiation neuronal maturation stem cell topography 

摘      要：Extracellular matrix(ECM)influences cell differentiation through its structural and biochemical *** nervous system,neuronal behavior is influenced by these ECMs structures which are present in a meshwork,fibrous,or tubular forms encompassing specific molecular *** addition to contact guidance,ECM composition and structures also exert its effect on neuronal *** short report reviewed the native ECM structure and composition in central nervous system and peripheral nervous system,and their impact on neural regeneration and neuronal *** topographies,stem cells have been differentiated to ***,focussing on engineered biomimicking topographies,we highlighted the role of anisotropic topographies in stem cell differentiation to neurons and its recent temporal application for efficient neuronal differentiation.