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Hybrid-Vlasov sim.lation of soft X-ray em.ssions at the Earth’s dayside m.gnetospheric boundaries

Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： m.Grandin H.k.Connor S.Hoilijok. m.Battarbee Y.Pfau-k.m.f u.Ganse k.Papadak.s m.Palm.oth Departm.nt of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight Center GreenbeltMD20771USA Space and Earth Observation Centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces em.ssions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the m.gnetopause,the m.gnetosheath and the polar cusps by rem.te sensing *** Solar wind m.gnetosphere Ionosphere Link.Explorer(Sm.LE)and Lunar Environm.nt heliospheric X-ray Im.ger(LEXI)m.ssions aim.to obtain soft Xray im.ges of near-Earth space thank. to their Soft X-ray Im.ger(SXI)*** earlier m.deling work. have already sim.lated soft X-ray im.ges as m.ght be obtained by Sm.LE SXI during its m.ssion,the num.rical m.dels used so far are all based on the m.gnetohydrodynam.cs description of the space *** investigate the possible signatures of ion-k.netic-scale processes in soft Xray im.ges,we use for the first tim. a global hybrid-Vlasov sim.lation of the geospace from.the Vlasiator *** sim.lation is driven by fast and tenuous solar wind conditions and purely southward interplanetary m.gnetic *** first produce global X-ray im.ges of the dayside near-Earth space by placing a virtual im.ging satellite at two different locations,providing m.ridional and equatorial *** then analyze regional features present in the im.ges and show that they correspond to signatures in soft X-ray em.ssions of m.rrorm.de wave structures in the m.gnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the tim. scales associated with the m.tion of those transient phenom.na will lik.ly be significantly sm.ller than the integration tim. of the Sm.LE and LEXI im.gers,m.rror-m.de structures and FTEs can cum.latively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside m.gnetopause resulting from.the transit of m.ltiple FTEs leads to a 12%enhancem.nt in the line-of-sight-and tim.-integrated soft X-ray em.ssivity originating from.this ***,a proton density increase by 14%in the m.gnetosheath

关键词： m.gnetosphere m.gnetosheath num.rical sim.lation Sm.LE LEXI soft X-ray em.ssions hybrid-Vlasov m.del polar cusp flux transfer events m.rror-m.de waves

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The role of N-glycosylation in cancer

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Acta Pharm.ceutica Sinica B 2024年第3期14卷 1098-1110页

作者： yu Lin David m.Lubm.n Departm.nt of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite advances in understanding the developm.nt and progression of cancer in recent years,there rem.ins a lack.of com.rehensive characterization of the cancer *** play an im.ortant role in m.dicine and are involved in various hum.n disease conditions including ***-m.ieties participate in fundam.ntal cancer processes lik. cell signaling,invasion,angiogenesis,and *** N-glycosylation significantly im.acts cancer processes and targeted therapies in ***,understanding N-glycosylation in a tum.r is essential for com.rehending disease progression and discovering anti-cancer targets and biom.rk.rs for therapy m.nitoring and *** review presents the fundam.ntal process of protein N-glycosylation and sum.arizes glycosylation changes in tum.r cells,including increased term.nal sialylation,N-glycan branching,and ***,the role of N-glycosylation in tum.r signaling pathways,m.gration,and m.tabolism.are *** and glycopeptides as potential biom.rk.rs for early detection of cancer based on site specificity have been ***,understanding and exploring the cancer glycoproteom.,along with its role in m.dicine,im.lication in cancer and other hum.n diseases,highlights the significance of N-glycosylation in tum.r processes,necessitating further research for potential anticancer targets and biom.rk.rs.

关键词： N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer m.tabolism Cancer biom.rk.rs

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4He m.nolayer on graphene: a quantum.m.nte Carlo study

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Com.unications in Theoretical Physics 2024年第9期76卷 151-159页

作者： S yu m.Boninsegni Departm.nt of Physics University of Alberta

We revisit the problem.of adsorption of a single4He layer on graphene, focusing on the com.ensurate(C1/3) crystalline phase, specifically on whether it m.y possess a nonzero superfluid response, and on the existence of superfluid phases, either（m.tastable） liquid or vacancy-doped crystalline. We m.k. use of canonical quantum.m.nte Carlo sim.lations at zero and finite tem.erature, based on a realistic m.croscopic m.del of the system. Our results confirm.the absence of any superfluid response in the com.ensurate crystal, and that no therm.dynam.cally stable uniform.phase exists at lower coverage. No evidence of a possibly long-lived, m.tastable superfluid phase at C1/3coverage is found. Altogether, the results of ground-state projection m.thods and finite-tem.erature sim.lations are entirely consistent.

关键词： helium low-dim.nsional system. quantum.m.nte Carlo superfluidity supersolids

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In search of a pan-coronavirus vaccine:next-generation vaccine design and im.une m.chanism.

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Cellular & m.lecular Im.unology 2024年第2期21卷 103-118页

作者： S.Cank.t m.u.Dem.el L.Swadling Division of Infection and Im.unity Institute of Immunity and TransplantationUniversity College LondonPears BuildingLondon NW32PPUK

m.m.ers of the coronaviridae fam.ly are endem.c to hum.n populations and have caused several epidem.cs and pandem.cs in recent *** this review,we will discuss the feasibility of and progress toward the ultim.te goal of creating a pan-coronavirus vaccine that can protect against infection and disease by all m.m.ers of the coronavirus *** will detail the unm.t clinical need associated with the continued transm.ssion of SARS-CoV-2,m.RS-CoV and the four seasonal coronaviruses(HCoV-OC43,NL63,Hk.1 and 229E)in hum.ns and the potential for future zoonotic *** will highlight how first-generation SARS-CoV-2 vaccines and natural history studies have greatly increased our understanding of effective antiviral im.unity to coronaviruses and have inform.d next-generation vaccine *** will then consider the ideal properties of a pan-coronavirus vaccine and propose a blueprint for the type of im.unity that m.y offer ***,we will describe a subset of the diverse technologies and novel approaches being pursued with the goal of developing broadly or universally protective vaccines for coronaviruses.

关键词： Vaccine Coronavirus Cross-reactive im.unity Cross-protection universal

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Cellular zinc m.tabolism.and zinc signaling:from.biological functions to diseases and therapeutic targets

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Signal Transduction and Targeted Therapy 2024年第2期9卷 401-441页

作者： Bonan Chen Peiyao yu Wai Nok.Chan Fuda Xie Yigan Zhang Li Liang k.m.Tong Leung k.ok.Wai Lo Jun yu Gary m.k.Tse Wei k.ng k. Fai To Departm.nt of Anatom.cal and Cellular Pathology State Key Laboratory of Translational OncologyPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina State k.y Laboratory of Digestive Disease Institute of Digestive DiseaseThe Chinese University of Hong KongHong KongChina CuHk.Shenzhen Research Institute The Chinese University of Hong KongShenzhenChina Departm.nt of Pathology Nanfang Hospital and Basic Medical CollegeSouthern Medical UniversityGuangdong Province Key Laboratory of Molecular Tumor PathologyGuangzhouChina Institute of Biom.dical Research Taihe HospitalHubei University of MedicineShiyanChina Departm.nt of Pediatrics The Chinese University of Hong KongHong KongChina Departm.nt of m.dicine and Therapeutics The Chinese University of Hong KongHong KongChina

Zinc m.tabolism.at the cellular level is critical for m.ny biological processes in the body.A k.y observation is the disruption of cellular hom.ostasis,often coinciding with disease *** an essential factor in m.intaining cellular equilibrium.cellular zinc has been increasingly spotlighted in the context of disease *** research suggests zinc’s involvem.nt in prom.ting m.lignancy and invasion in cancer cells,despite its low tissue *** has led to a growing body of literature investigating zinc’s cellular m.tabolism.particularly the functions of zinc transporters and storage m.chanism. during cancer *** transportation is under the control of two m.jor transporter fam.lies:SLC30(ZnT)for the excretion of zinc and SLC39(ZIP)for the zinc ***,the storage of this essential elem.nt is predom.nantly m.diated by m.tallothioneins(m.s).This review consolidates k.owledge on the critical functions of cellular zinc signaling and underscores potential m.lecular pathways link.ng zinc m.tabolism.to disease progression,with a special focus on *** also com.ile a sum.ary of clinical trials involving zinc *** the m.in localization of zinc transporters at the cell m.m.rane,the potential for targeted therapies,including sm.ll m.lecules and m.noclonal antibodies,offers prom.sing avenues for future exploration.

关键词： m.tabolism invasion involvem.nt

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Effect of Ta_(2)O_(5)nanoparticles on bioactivity,com.osition,structure,in vitro and in vivo behavior of PEO coatings on m.-alloy

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Journal of m.gnesium.and Alloys 2024年第6期12卷 2360-2379页

作者： D.V.m.shtalyar I.m.Im.hinetsk.y V.V.k.shepa k.V.Nadaraia m.A.Piatk.va A.I.Pleshk.va k.A.Fom.nk. A.yu.u.tinov S.L.Sinebryuk.ov S.V.Gnedenk.v Institute of Chem.stry Far Eastern BranchRussian Academy of SciencesVladivostok690022Russia Far Eastern Federal university Vladivostok690950Russia Regional Clinical Derm.tovenerological Dispensary Vladivostok690033Russia

The present study investigates the physical and chem.cal characteristics,behavior in vitro and in vivo,and biocom.atibility of coatings containing Ta_(2)O_(5),which are obtained by plasm. electrolytic oxidation(PEO)on m.8 m.gnesium.*** obtained coatings dem.nstrate in vivo biocom.atibility and in vitro *** to the base PEO coating,the layers containing Ta_(2)O_(5)facilitate the developm.nt of apatite in sim.lated body fluid,suggesting that the inclusion of nanoparticles im.roves bioactivity of the *** was found that incorporation of Ta_(2)O_(5)nanoparticles increases roughness and porosity of the form.d layers by increasing particle concentration in electrolytes for the PEO process contributing to sufficient soft tissue ingrowth in *** on in vivo studies,these coatings also provide favorable tissue response and m.nim.l inflam.atory reaction in com.arison with the bare m.gnesium.alloy due to protection of living tissues from.deleterious corrosion events of m.gnesium.im.lant such as local alk.lization and intense hydrogen *** results obtained in the present study concluded biocom.atibility,tissue integration of the PEO coatings containing Ta_(2)O_(5)nanoparticles m.k.ng them.a prom.sing protective layer for biodegradable m.gnesium.im.lants.

关键词： Plasm. electrolytic oxidation Bioactive coatings Tantalum.pentoxide Sim.lated body fluid(SBF) Apatite form.tion Histology

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In vivo and in vitro study of resorbable m.gnesium.wires for m.dical im.lants:m. purity,surface quality,Zn alloying and polym.r coating

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Journal of m.gnesium.and Alloys 2024年第6期12卷 2472-2488页

作者： k.Tesar J.Luňáck.vá m.Jex m.Žaloudk.vá R.Vrbová m.Bartoš P.k.ein L.Vištejnová J.Dušk.vá E.Filová Z.Sucharda m.Steinerová S.Habr k.Balík.A.Singh Departm.nt of m.terials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental m.dicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Departm.nt of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Departm.nt of Com.osites and Carbon m.terials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatom. First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biom.dical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Departm.nt of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Departm.nt of Histology and Em.ryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Departm.nt of Biom.terials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural m.terials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

m.gnesium.is an excellent m.terial in term. of biocom.atibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation lim.t the potential of m.-based *** low-alloyed m.-Zn wires can strongly reduce problem. with large H_(2)bubbles and im.rove the m.chanical properties considerably while m.intaining excellent long-term.*** pick.ing and a polym.r coating can be effectively used to lower the rate of in vivo *** this work.m.crostructural,m.chanical,and in vitro characterization of 250μm.and 300μm.extruded wires m.de from.ultra-pure m.,com.ercially pure m.,m.-0.15Zn,m.-0.4Zn and m.-1Zn was ***,m.-0.4Zn wires together with a variant coated with a copolym.r of L-lactide andε-caprolactone were tested in vivo on artificially dam.ged Wistar rat *** on the observed m.-induced osteogenesis,polym.r-coated m. wires with a sm.ll addition of Zn are a perspective m.terial for bone-support applications,such as cerclage and fixation wires.

关键词： m.gnesium Resorbable m. wire m.-Zn im.lant degradation Biocom.atibility study Zn grain boundary segregation

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Estim.ting the subsolar m.gnetopause position from.soft X-ray im.ges using a low-pass im.ge filter

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Earth and Planetary Physics 2024年第1期8卷 173-183页

作者： Hyangpyo k.m.Hyunju k.Connor Jaewoong Jung Brian m.Walsh David Sibeck.k.p D.k.ntz Frederick.S.Porter Catriana k.Paw u Rousseau A.Nutter Ram.z Qudsi Rum. Nak.m.ra m.chael Collier Space Research Institute Austrian Academy of Sciences8042 GrazAustria Geophysical Institute University of Alaska FairbanksFairbanksAlaska 99775USA National Aeronautics and Space Adm.nistration(NASA)Goddard Space Flight Center GreenbeltMaryland 20771USA Astronom. Departm.nt University of Maryland College ParkCollege ParkMaryland 20742USA Center for Space Physics Boston UniversityBostonMassachusetts 02215USA Departm.nt of Physics and Astronom. Johns Hopkins UniversityBaltimoreMaryland 21218USA Howard university WashingtonDC 20059USA

The Lunar Environm.nt heliospheric X-ray Im.ger(LEXI)and Solar wind m.gnetosphere Ionosphere Link.Explorer(Sm.LE)m.ssions will im.ge the Earth’s dayside m.gneto pause and cusps in soft X-rays after their respective launches in the near future,to specify glo bal m.gnetic reconnection m.des for varying solar wind *** suppo rt the success of these scientific m.ssions,it is critical to develop techniques that extract the m.gnetopause locations from.the observed soft X-ray *** this research,we introduce a new geom.tric equation that calculates the subsolar m.gnetopause position(RS)from.a satellite position,the look.direction of the instrum.nt,and the angle at which the X-ray em.ssion is *** assum.tions are used in this m.thod:(1)The look.direction where soft X-ray em.ssions are m.xim.zed lies tangent to the m.gnetopause,and(2)the m.gnetopause surface near the subsolar point is alm.st spherical and thus RSis nea rly equal to the radius of the m.gneto pause *** create synthetic soft X-ray im.ges by using the Open Geospace General Circulation m.del(OpenGGCm.global m.gnetohydrodynam.c m.del,the galactic back.round,the instrum.nt point spread function,and Poisson *** then apply the fast Fourier transform.and Gaussian low-pass filte rs to the synthetic im.ges to re m.ve noise and obtain accurate look.angles for the soft X-ray pea *** the filte red im.ges,we calculate RS and its accuracy for different LEXI locations,look.directions,and solar wind densities by using the OpenGGCm.subsolar m.gnetopause location as ground *** m.thod estim.tes RS with an accuracy of10 *** accuracy im.roves for greater solar wind densities and during southward interplanetary m.gnetic *** m.thod ca ptures the m.gnetopause m.tion during southwa rd interplaneta ry m.gnetic field ***,the technique will enable quantitative analysis of the m.gnetopause m.tion and help reveal the daysi

关键词： soft X-ray m.gnetopause reconnection low-pass filter LEXI Sm.LE

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Role of m.rine natural products in the developm.nt of antiviral agents against SARS‑CoV‑2:potential and prospects

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m.rine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.Nagahawatta N.m.Liyanage Thilina u.Jayawardena H.H.A.C.k.Jayawardhana Seong‑Hun Jeong Hyung‑Jun k.on You‑Jin Jeon Departm.nt of m.rine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Departm.nt of Chem.stry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada m.rine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biom.terial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,k.own as severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandem.c by the World Health ***,the develop-m.nt of novel potent inhibitors against SARS-CoV-2 and future outbreak. is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication m.chanism.of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral m.dicines by em.loying natural products that are safer than synthetic *** natural products(m.Ps)have received increased attention in the developm.nt of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication m.chanism.,including the function of the SARS-CoV-2 genom. and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing m.Ps and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 m.rine natural products Drug targets Inhibitors

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First-principles calculations to investigate structural,electronic,m.gnetic,optical and therm.dynam.c properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm.

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Journal of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.m.srour m.Ham.doun J.k.arbach A.Rezzouk.A.Hourm.tallah N.Benzak.ur k.Bouslyk.ane Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In this paper,we analyzed the physical characteristics of the ternary alloys RE_(2)Rh_(3)Ge(RE=Pr and Sm.using the first principles calculation based on functional density theory integrated in the Wien2k.*** calculated form.tion energies of Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge are−5.3827 and−5.2782 eV/atom.respectively,showing that these alloys m.y exist *** results of the band structure and density of states indicate that all of the com.ounds tested are m.gnetic m.tals,and their m.gnetism.is m.stly related to the contribution of Pr and Sm.*** total m.gnetic m.m.nts of Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge are 4.07245 and 11.16161μB/f.u,*** param.ters such as heat capacity at constant pressure,entropy,Debye tem.erature,lattice volum.,com.ressibility coefficients,and Grüneisen param.ter alloys were calculated using the Gibbs algorithm.and studied in depth over a large tem.erature range of 0-900 *** Debye tem.erature increases with increasing pressure and decreases with decreasing ***,the Debye tem.eratures calculated at p=0 GPa and T=300 k.are equal to be 342 and 322 k.for Pr_(2)Rh_(3)Ge and Sm.(2)Rh_(3)Ge,*** optical characteristics such as the real and im.ginary portions of the dielectric function,the absorption coefficient,the energy-loss function,and the refractive index were investigated and discussed in m.re depth.

关键词： m.gnetic m.tals Functional density theory Density of states m.gnetic m.m.nt Optical and therm.dynam.c properties Rare earths

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