In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,Zn alloying and polymer coating

作     者：K.Tesar J.Luňácková M.Jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová Z.Sucharda M.Steinerová S.Habr K.Balík A.Singh K.Tesař;J.Luňáčková;M.Jex;M.Žaloudková;R.Vrbová;M.Bartoš;P.Klein;L.Vištejnová;J.Dušková;E.Filová;Z.Sucharda;M.Steinerová;S.Habr;K.Balík;A.Singh

作者机构：Department of MaterialsFaculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of PhysicsCzech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental MedicineFirst Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of PhysicsFaculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon MaterialsInstitute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of AnatomyFirst Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical CenterFaculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological PhysiologyFaculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and EmbryologyFaculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of PathologyFirst Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue EngineeringInstitute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural MaterialsNational Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan 

出 版 物：《Journal of Magnesium and Alloys》 (镁合金学报（英文）)

年 卷 期：2024年第12卷第6期

页      面：2472-2488页

核心收录：

学科分类：080503[工学-材料加工工程] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 

基　　金：the project Ferr Mion of the Ministry of Education,Youth and Sports,Czech Republic,co-funded by the European Union(CZ.02.01.01/00/22_008/0004591) the support of The Charles University Grant Agency in the frame of the project No.121724 and the project Cooperatio No.207030 Dental Medicine/LF1 of the Charles University financial support from the Ministry of Education,Youth and Sport of the Czech Republic under the grant No.RVO 14000 supported by the Ministry of Health of the Czech Republic-RVO project VFN64165 the support of the project GAMA 2 of the Technology Agency of the Czech Republic No.TP01010055 the project of the Czech Academy of Sciences,Czech Republic(Praemium Academiae grant No.AP2202) the support of the Ministry of Health of the Czech Republic,grant project No.NU20-08-00150 

主　　题：Magnesium Resorbable Mg wire Mg-Zn implant degradation Biocompatibility study Zn grain boundary segregation 

摘      要：Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-Zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15Zn,Mg-0.4Zn and Mg-1Zn was ***,Mg-0.4Zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of Zn are a perspective material for bone-support applications,such as cerclage and fixation wires.