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腰椎间盘突出症模型大鼠疼痛的针刺干预

中国组织工程研究 2025年第5期29卷 936-941页

作者：支芳朱满华熊伟林星镇南昌市洪都中医院江西省南昌市330038

背景:针灸是缓解腰椎间盘突出症腰痛的有效方法,但其机制目前尚未明确。JAk2/STAT3信号通路相关因子可调节机体炎症反应,参与神经病理性疼痛的过程。目的:基于JAk2/STAT3信号通路研究针刺对腰椎间盘突出症模型大鼠的作用机制。方法:采... 详细信息

背景:针灸是缓解腰椎间盘突出症腰痛的有效方法,但其机制目前尚未明确。JAk2/STAT3信号通路相关因子可调节机体炎症反应,参与神经病理性疼痛的过程。目的:基于JAk2/STAT3信号通路研究针刺对腰椎间盘突出症模型大鼠的作用机制。方法:采用随机数字表法将40只SD大鼠分为假手术组、模型组、针刺组与针刺+激动剂组,每组10只。模型组、针刺组及针刺+激动剂组采用自体髓核移植法构建l5腰椎间盘突出症模型,造模3 d后,针刺组开始进行针刺治疗(作用于阳陵泉、肾俞、环跳、大肠俞等穴位),针刺+激动剂组造模后第6,12,18天针刺治疗前向l4/l5椎间隙鞘内注射JAk2激动剂香豆霉素A1,针刺治疗1次/d,20 min/次,连续治疗15 d。造模前及造模后3,6,9,12,15,18 d,检测大鼠机械缩足阈值;造模后18 d,检测血清炎症因子水平,苏木精-伊红染色观察l5-l6组织形态,RT-PCR检测l5-l6组织JAk2、STAT3 mRNA表达,Western Blot检测l5-l6组织JAk2、STAT3、p-JAk2及p-STAT3蛋白表达。结果与结论:①模型组大鼠造模后不同时间点的机械缩足阈值均低于假手术组(Pk2与STAT3 mRNA表达、p-JAk2与p-STAT3蛋白表达均升高(Pk2与STAT3 mRNA表达、p-JAk2与p-STAT3蛋白表达均降低(Pk2与STAT3 mRNA表达、p-JAk2与p-STAT3蛋白表达均升高(Pk2/STAT3信号通路有关。

关键词： JAk2/STAT3信号通路针刺腰椎间盘突出症病理性疼痛机械缩足阈值炎症反应

Connection Between Screw-Instability in Black Hole Magnetosphere and Pairs of High-Frequency Quasi-Periodic Oscillations

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Chinese Physics letters 2004年第7期21卷 1405-1408页

作者： YAOGuo-Zheng WANGDing-xiong DepartmentofPhysics HuazhongUniversityofScienceandTechnologyWuhan430074

The correlation of screw-instability in black hole magnetosphere with pairs of high-frequency quasi-periodic oscillations (HFQPOs) is discussed in the coexistence of the Blandford–Znajek (BZ) and magnetic coupling (MC) processes. It turns out that screw-instability can result in HFQPOs. Such an HFQPO can be regarded as the transient process in an equivalent circuit with resistor and inductor in series (R-l circuit), and its period can be estimated by the relaxation time of this process. When the BZ process and the MC process coexist, the screw-instability can occur both in the BZ region and in the MC region, and the pairs of HFQPOs can be generated. Calculations show that such pairs of HFQPOs are likely to show frequencies in a 3:2 ratio. The frequencies of pairs of HFQPOs in our model scale inversely with the mass of central black hole, which is consistent with the observations.

关键词： Magnetic couplings

Synthesis and Crystal Structure of Ni(Ⅱ) Complex with N-Salicylaldehyde-N'-phenoxyacetylhydrazine ligand

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Chinese Journal of Structural Chemistry 2004年第1期23卷 33-37页

作者： CHENXiao-Hua lIUShi-xiong Centrallaboratory FuzhouUniversityFuzhou350002China Centrallaboratory FuzhouUniversityFuzhou350002ChinaStateKeyLaboratoryofStructuralChemistryFujianInstituteofResearchontheStructureofMatterTheChineseAcademyofSciencesFuzhou350002China

The title complex Nil(py)3, where H2l = N-salicylaldehyde-N-phenoxyacetyl hydrazine, was prepared and characterized by X-ray diffraction. The single crystal of the title compound, Ni(C15H12N2O3)(C5H5N)3, is of monoclinic, space group P21/c with a = 11.900(1), b = 9.6855(7), c = 23.658(2) , b = 92.357(2)? V = 2724.5(4) 3, Z = 4, F(000) = 1176, Dc = 1.376 g/cm3, ?= 0.753 mm-1, R = 0.0332 and wR = 0.0820. The coordination polyhedron around the nickel atom is an elongated octahedron. The basal plane consists of one phenol oxygen, one amine carbonyl oxygen and one hydrazine nitrogen atoms from the ligand l2- and one nitrogen atom from one coordinated pyridine ligand, while the axial sites are occupied by two nitrogen atoms of two coordinated pyridine ligands.

关键词： crystal structure nickel complex Schiff base hydrazone

Plant target of rapamycin signaling network:Complexes,conservations,and specificities

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Journal of Integrative Plant Biology 2022年第2期64卷 342-370页

作者： Yanlin liu Yan xiong College of life Sciences Fujian Agriculture and Forestry UniversityFuzhou350002 China Crop Synthetic Biology Center Haixia Institute of Science and TechnologyFujian Agriculture and Forestry UniversityFuzhou350002 China

Target of rapamycin(TOR)is an evolutionarily conserved protein kinase that functions as a central signaling hub to integrate diverse internal and external cues to precisely orchestrate cellular and organismal *** evolution,TOR both maintains the highly conserved TOR complex compositions,and cellular and molecular functions,but also evolves distinctive roles and strategies to modulate cell growth,proliferation,metabolism,survival,and stress responses in ***,we review recent discoveries on the plant TOR signaling *** present an overview of plant TOR complexes,analyze the signaling landscape of the plant TOR signaling network from the upstream signals that regulate plant TOR activation to the downstream effectors involved in various biological processes,and compare their conservation and specificities within different biological ***,we summarize the impact of dysregulation of TOR signaling on every stage of plant growth and development,from embryogenesis and seedling growth,to flowering and senescence.

关键词： abiotic and biotic stress hormone sensing metabolism regulation nutrient sensing plant growth and development target of rapamycin transcriptional reprogramming translational regulation

Synthesis and Crystal Structure of Potassium Triethylenetetraaminehexaacetatodi [Oxo-vanadium(Ⅳ)] Hexahydrate, k_2[V_2O_2(ttha)]·6(H_2O)

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Chinese Journal of Structural Chemistry 2003年第4期22卷 423-426页

作者： JIANGYa-Qi XIEZhao-xiong DepartmentofChemistry XiamenUniversityXiamen361005China StatekeylaboratoryforPhysicalChemistryofSolidSurfaces XiamenUniversityXiamen361005China

The title complex, potassium triethylenetetraaminehexaacetatodi [oxo-vanadium (Ⅳ)] hexahydrate k2[V2O2(ttha)]6(H2O), was synthesized in aqueous solution and its crystal structure has been determined by X-ray diffraction. The complex belongs to a triclinic system, space group P?with a = 6.645(1), b = 9.870(2), c = 13.263(3) ? a = 70.68(3), b = 76.27(3), g = 71.66(3), V = 770.5(3) 3, Mr = 808.58, Dc = 1.743 g/cm3, Z = 1, m = 0.968 mm-1, l(Moka) = 0.71073 and F(000) = 416. The final R = 0.0465 and wR = 0.1091 for 2974 observed diffractions with I ≥ 2s(I). In the complex, the V atom is octahedrally coordinated to the oxo ligand, two N and three O atoms of the triethylenetetraaminehexaacetic (TTHA) ligand. All of the ten chelating sites are coordinated to the two vanadium atoms, and the coordination octahedron is distorted. Each [V2O2(ttha)]2- ion is further connected by the k+ ions through carboxyl groups of TTHA6- ion, forming a two dimensional network structure.

关键词： vanadium complex TTHA crystal structure

Sorption behavior of iminodiacetic acid resin for indium

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Rare Metals 2008年第2期27卷 153-157页

作者： xiong Chunhua YAO Caiping Department of Applied Chemistry Zhejiang Gongshang University Hangzhou 310035 China

In（Ⅲ） was quantitatively adsorbed by iminodiacetic acid resin （IDAAR） in the medium of pH = 4.52. The statically saturated sorption capacity of IDAAR is 235.5 mg·g^-1. 1.0 mol·l^-1 HCl can be used as an eluant. The elution efficiency is 97.9%. The resin can be regenerated and reused without apparent decrease of sorption capacity. The sorption rate constant is k298 = 1.94 × 10-5 s^-1. The apparent sorption activation energy of IDAAR for In（Ⅲ） is 20.1 kJ·mol^-1. The sorption behavior of IDAAR for In（HI） obeys the Freundlich isotherm. The enthalpy change is AH= 17.2 kJ·mol^-1.

关键词： iminodiacetic acid resin indium(Ⅲ) sorption activation energy enthalpy change

Enhanced Adhesion of Mussel-inspired Adhesive through Manipulating Contents of Dopamine Methacrylamide and Molecular Weight of Polymer

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Journal of Bionic Engineering 2018年第3期15卷 461-470页

作者： xiong xiong Yumei liu Feng Shi Guowei Zhang Jie Weng Shuxin Qu key lab of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China School of life Science and Engineering Southwest Jiaotong University Chengdu 610031 China College of Environmental Science and Engineering China West Normal University Nanchong 637009 China Collaboration Innovation Center for Tissue Repair Material Engineering Technology China West Normal University Nanehong 637009 China

The aim of this study is to investigate the effect of the contents of modified 3, 4-dihydroxyphenyl-l-alanine （DOPA）, named as do- pamine methacrylamide （DMA）, on the adhesion of mussel-inspired adhesives in air and water. A series of adhesives, p（DMA-co-MEA）, were synthesized by copolymerized DMA and methoxy ethylacrylate （MEA） with the content of DMA from 2 mol.% to 10 mol.%. Results of IH NMR show that the contents of DMA in all adhesives are near to the theory ratios of DMA in the staring reagents. Adhesives with more than 5 mol.% of DMA appear adhesion, while adhesives with 2 mol. % and 3 mol. % of DMA show almost no adhesion in air and water. Adhesive with 7 mol.% of DMA has the highest molecular weight and adhesion either in air or in water in all adhesives. Adhesion of adhesive is synergistically influenced by the content of DMA, molecular weight and elastic modulus of adhesive. It is because that higher content of DMA would provide more DOPA, which leads to the coordination bond between DOPA and metal ions. It is feasible to develop the mussel-inspired adhesive through incorporating DMA into polymers, which will have potential application in the clinic.

关键词： mussel-inspired adhesive adhesion dopamine methacrylamide

Characterization of a Purine Permease Family Gene OsPUP7 Involved in Growth and Development Control in Rice

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Journal of Integrative Plant Biology 2013年第11期55卷 1119-1135页

作者： Zhuyun Qi lizhong xiong National key laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University

In this study, PUP-type cytokinin transporter genes were identified in rice （Oryza sativa l.）. The Oryza sativa purine permease （OsPUP） family has 12 members that show similar predicted protein sequences with AtPUPs. To reveal the functions of OsPUP genes, we searched the T-DNA mutant library of rice and found one mutant for the member OsPUP7. The T-DNA insertion caused a new transcript that encodes a protein with 26 amino acids different from the native OsPUP7 at the C-terminus. The mutant showed multiple phenotypic changes including increased plant height, big seeds, and delayed flowering. The mutant also showed increased sensitivity to drought and salt stresses and treatments with kinetin and abscisic acid. OsPUP7is expressed mainly in the vascular bundle, pistil, and stamens. The measurement of cytokinins （Cks） showed that Ck content in the mutant spikelets accumulated higher than that in the wild type. Moreover, uptake experiment in the yeast fcy2 mutant suggested that OsPUP7 has the ability to transport caffeine, a Ck derivative. Our results indicate that the PUP transport system also exists in rice, and OsPUP7has an important role in the transport of Ck, thus affecting developmental process and stress responses.

关键词： Abiotic stress cytokinin purine permease transporter rice.

A TRIANGUlAR FINITE VOlUME ElEMENT METHOD FOR A SEMIlINEAR EllIPTIC EQUATION

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Journal of Computational Mathematics 2014年第2期32卷 152-168页

作者： Zhiguang xiong Yanping Chen School of Mathematics and Computational Science Hunan University of Science and Technology Xiangtan 411201 China School of Mathematical Sciences South China Normal University Guangzhou 510631 China

In this paper we extend the idea of interpolated coefficients for a semilinear problem to the triangular finite volume element method. We first introduce triangular finite volume element method with interpolated coefficients for a boundary value problem of semilinear elliptic equation. We then derive convergence estimate in Hi-norm, l2-norm and l∞-norm, respectively. Finally an example is given to illustrate the effectiveness of the proposed method.

关键词： Semilinear elliptic equation Triangulation Finite volume element with interpolated coefficients.