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Laboratory studies on the infectivity of human respiratory viruses:Experimental conditions,detections,and resistance to the atmospheric environment

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Fundamental Research 2024年第3期4卷 471-483页

作者： Yaohao Hu Shuyi Peng Bojiang Su Tao Wang juying Lin wei Sun Xiaodong Hu Guohua Zhang Xinming Wang Ping'an Peng Xinhui Bi State Key Laboratory of Organic Geochemistry and Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100049China Guangdong-Hong Kong-Macao Joint Laboratory for Environmental Pollution and Control Guangzhou 510640China

The environmental stability of infectious viruses in the laboratory setting is crucial to the transmission potential of human respiratory *** experimental techniques or conditions used in studies over the past decades have led to diverse understandings and predictions for the stability of viral infectivity in the atmospheric *** this paper,we review the current knowledge on the effect of simulated atmospheric conditions on the infectivity of respiratory viruses,mainly focusing on influenza viruses and coronaviruses,including severe acute respiratory syndrome coronavirus 2 and Middle East respiratory syndrome ***,we summarize the impact of the experimental conditions on viral stability;these involve the methods of viral aerosol generation,storage during aging and collection,the virus types and strains,the suspension matrixes,the initial inoculum volumes and concentrations,and the drying ***,we summarize and discuss the detection methods of viral infectivity and their ***,we integrate the results from the reviewed studies to obtain an overall understanding of the effects of atmospheric environmental conditions on the decay of infectious viruses,especially aerosolized ***,this review highlights the knowledge gaps in predicting the ability of viruses to maintain infectivity during airborne transmission.

关键词： Respiratory viruses Viral infectivity Laboratory simulation Atmospheric environmental condition Airborne transmission

Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease： a report of three cases

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Frontiers of Medicine 2017年第2期11卷 287-292页

作者： Xinping Zhou juying wei Yinjun Lou Gaixiang Xu Min Yang Hui Liu Liping Mao Hongyan Tong Jie Jin Department of Hematology the First AffiliatedHospital College of Medicine Zhejiang University Hangzhou 310003 China

Castleman disease （CD） is an uncommon non-clonal lymphoproliferative disorder with unknown etiology. No standard therapy is recommended for relapsed/refractory CD patients, thus requiring development of novel experimental approaches. Our cohort of three adult patients with multicentric CD （MCD） were treated with refractory to traditional chemotherapy lenalidomide-containing regimens （10-25 mg lenalidomide perorally administered on days 1-21 in 28-day cycle） as second- to fourth-line treatment. Partial remission was achieved in first plasma-cell CD patient, who relapsed seven months after autologous hematopoietic stem cell transplantation and then failed to respond to four cycles of chemotherapy. Partial remission was obtained in second patient with CD and polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome. Third case showed complete remission with complete disappearance of pleural effusion and ascites and normalization of platelet count. To conclude, encouraging clinical responses were achieved in cohort of three patients with lenalidomide-based regimen, though long-term efficacy remains to be observed. We propose further investigation of therapeutic potential of this drug in treating MCD.

关键词： Castleman disease lenalidomide

Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li Juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu Jiajia Liu Shikun Xu Lihua Guan Dong Huang Qibing Wang juying Qian Zexin Zhao Yabin wei Junbo Ge Xiao Huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

Diagnosis and management of acquired thrombotic thrombocy- topenic purpura in southeast China： a single center experience of 60 cases

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Frontiers of Medicine 2016年第4期10卷 430-436页

作者： Xinping Zhou XingnongYe Yanling Ren Chen Mei Liya Ma Jiansong Huang weilai Xu juying wei Li Ye Wenyuan Mai Wenbin Qian Haitao Meng Jie Jin Hongyan Tong Department of Hematology the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 China Department of Hematology the Forth Affiliated Hospital College of Medicine Zhejiang University Yiwu 322000 China

Acquired thrombotic thrombocytopenic purpura （TTP） is a rare life-threatening thrombotic microangiopathy. This study aimed to provide a profile of the diagnosis and management of patients with acquired TTP collected in 10 years in a single center in southeast China. A total of 60 patients diagnosed with acute acquired TTP from March 2005 to August 2015 were enrolled. Among the 60 patients, 52 patients presented with their first episodes, and eight patients had two or more episodes. The median age at presentation was 49 （range, 17 to 78） years with a female predominance （male：female ratio, 1：1.60）. ADAMTS 13 activity were analyzed in 43 patients, among whom 33 （76.7%） patients had a baseline level of 〈 5%. Mortality was 30%. Plasma exchange （PEX） was performed in 62 of 69 （89.9%） episodes. Corticosteroids were administered in 54 of 69 （78.3%） episodes. Other immunosuppressants （e.g., vincristine, cyclosporine, and cyclosporin） were used in 7 of 69 （10.1%） episodes. Rituximab was documented in 4 patients with refractory/relapsed TTP for 5 episodes, showing encouraging results. In conclusion, the diagnosis of TTP depended on a comprehensive analysis of clinical data. Plasma ADAMTS13 activity assay helped confirm a diagnosis. PEX was the mainstay of the therapy, and rituximab can be used in relapsed/refractory disease.

关键词： thrombotic thrombocytopenic purpura ADAMTS 13 plasma exchange

陕北黄土区退耕前(1976—1997)坡面切沟发育特征

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农业工程学报 2017年第17期33卷 120-127页

作者：陈一先焦菊英魏艳红赵珩钪中国科学院水利部水土保持研究所杨凌712100 西北农林科技大学水土保持研究所杨凌712100

以陕北黄土区坊塌流域内7条大切沟及其谷缘上的小切沟为研究对象,通过Arc GIS和MATLAB从基于1976、1997年1:10 000比例尺地形图生成的数字高程模型(DEM)上提取沟沿线,进而获得1976、1997年大切沟的面积、周长和大切沟上小切沟沟头前进距... 详细信息

以陕北黄土区坊塌流域内7条大切沟及其谷缘上的小切沟为研究对象,通过Arc GIS和MATLAB从基于1976、1997年1:10 000比例尺地形图生成的数字高程模型(DEM)上提取沟沿线,进而获得1976、1997年大切沟的面积、周长和大切沟上小切沟沟头前进距离,并结合当时的土地利用图和植被覆盖图,定量研究了退耕前陕北黄土区切沟发育的速率,以及土地利用类型和植被覆盖度对切沟发育的影响。结果显示:在1976-1997年间,7条大切沟的面积、周长增长率分别为11.01%~180.46%和8.07%~86.75%,大切沟上小切沟沟头年均前进速率为0.26~0.84 m;由溯源侵蚀导致的小切沟沟头前进是研究区内大切沟上的主要侵蚀方式,大切沟沟谷拓宽和形成新的小切沟分别是对大切沟的面积和周长增长具有较高贡献率的侵蚀方式;林草覆盖能控制切沟发育,集水区内覆盖度大于65%的植被能更加有效地控制大切沟内以沟谷拓宽为主的、多过程、多部位的综合切沟侵蚀,覆盖度大于45%的植被能更加有效地控制大切沟上小切沟沟头的溯源侵蚀。研究表明基于GIS技术和不同年份的地形图,可以确定切沟侵蚀的方式及速率,实现对切沟发育的动态监测。

关键词：土地利用侵蚀植被切沟沟沿线退耕还林(草)

Outcomes in refractory diffuse large B-cell lymphoma:results fromamulticenter real-world study in China

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Cancer Communications 2021年第3期41卷 229-239页

作者： Shuo Wang Li Wang Jianda Hu Wenbin Qian Xi Zhang Yu Hu Qi Zhu Bobin Chen Depei Wu Chung-Chou H.Chang Pengpeng Xu Xiaoyun Zheng juying wei Yao Liu Guohui Cui Yong Tang Yan Ma Haiwen Huang Hongmei Yi weili Zhao Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRui Jin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China Chinese-French Research Center in Living Science and Genomics Laboratory of Molecular PathologyShanghai 200025P.R.China Fujian Institute of Hematology Fujian Medical University Union HospitalFuzhouFujian 350001P.R.China The First Affiliated Hospital of Medical School of Zhejiang University HangzhouZhejiang 310003P.R.China Department of Hematology Xinqiao HospitalArmy Medical UniversityChongqing 400037P.R.China Union Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022P.R.China Shanghai Ninth People’s Hospital Shanghai 200011P.R.China Huashan Hospital Affiliated with Fudan University Shanghai 200040P.R.China Jiangsu Institute of Hematology Institute of Blood and Marrow Transplantationthe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215006P.R.China Department of Biostatistics Graduate School of Public HealthUniversity of PittsburghPittsburghPennsylvania 15213United States of America Department of Pathology Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025P.R.China

Background:Diffuse large B-cell lymphoma(DLBCL)patients refractory to rituximab-based immunochemotherapy have a dismal ***,the definition of refractory DLBCL remains inconsistent and no large cohort study data is available from Asian *** validate the definition and outcomes of refractory DLBCL in China,we conducted a multicenter,retrospective cohort ***:The REtrospective AnaLysis of Treatment REspoNse of refractory DLBCL(REAL-TREND)study was performed using real-world data from 8 centers in *** patients with curative intent were included in the REAL-TREND *** survival(OS)was estimated using the Kaplan-Meier method and compared by the log-rank *** to heterogeneity in response rates among different centers,the response rates of refractory patients were pooled using random-effect *** survival analysis was performed using the Cox regression ***:A total of 2778 DLBCL patients diagnosed between January,2010 and December,2015 were enrolled to this *** validating previous definitions,the SCHOLAR-1 study was most suitable to define refractory *** estimated 5-year cumulative incidence of refractory patients was 20%(95% confidence Interval[CI]=18%-22%).After the determination of refractory disease,overall response rate and complete remission rate were 30%(95%CI=22%-38%)and 9%(95%CI=4%-15%),*** with either no response to immunochemotherapy or relapse within 12 months after stem-cell transplantation had inferior survival with a median OS of 5.9 months(95%CI=5.5-7.1 months)and 2-year OS rate of 16%(95%CI=12%-20%).International prognostic index score 4-5(hazard ratio[HR]=2.22;95%CI=1.47-3.35),central nervous systemrelapse(HR=1.43;95%CI=1.04-1.97),and best response status(HR=2.68;95%CI=1.42-5.03 for partial ***=5.97,95%CI=3.21-11.11 for stable disease/progressive disease)were independent unfavorable prognostic ***:This is the first large-scale

关键词： diffuse large B-cell lymphoma multicenter cohort study refractory relapse rituximab immunochemotherapy treatment response prognosis

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原发性中枢神经系统淋巴瘤的治疗进展

中国肿瘤临床 2014年第19期41卷 1217-1220页

作者：金洁曹利红韦菊英刘萍浙江大学附属第一医院血液科浙江大学血液病研究所和浙江省血液肿瘤(诊治)重点实验室杭州市310009 西澳大利亚大学公共卫生学院

原发性中枢神经系统淋巴瘤(PCNSL)是一种少见疾病,至今尚无标准治疗方案。单纯放疗复发率高,生存期短。放疗宜在化疗结束后进行。化疗联合标准放疗明显降低了复发率,并延长了生存期,但神经毒性发生率高。老年患者易出现神经毒性,不建议... 详细信息

原发性中枢神经系统淋巴瘤(PCNSL)是一种少见疾病,至今尚无标准治疗方案。单纯放疗复发率高,生存期短。放疗宜在化疗结束后进行。化疗联合标准放疗明显降低了复发率,并延长了生存期,但神经毒性发生率高。老年患者易出现神经毒性,不建议放疗,应首选单纯化疗;年轻患者可将放疗作为难治复发时的二线治疗。目前,以大剂量甲氨蝶呤为主的化疗已成为PCNSL的一线治疗,大剂量阿糖胞苷为最常联合的药物。年轻患者可选用包含一些新药如甲基苄肼、替莫唑胺的化疗方案。替莫唑胺为老年患者一种有前途的新药。预防性鞘内化疗的必要性尚未达成共识。自体造血干细胞支持下的大剂量化疗对年轻的初发及复发PCNSL患者均有效。手术通常用于PCNSL诊断。糖皮质激素不宜在取得病理组织前使用。

关键词：原发性中枢神经系统淋巴瘤治疗研究进展

亚快速凝固Mg-Zn-Sn-Al-Ca合金的组织、拉伸性能和蠕变性能(英文)

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稀有金属材料与工程 2014年第11期43卷 2602-2608页

作者：魏菊英陈吉华严红革苏斌张光浩何玺湖南大学湖南长沙410082 江铃汽车股份有限公司江西南昌330001 湖南省喷射沉积技术及应用重点实验室湖南长沙410082

研究了7种亚快速凝固Mg-Zn-Sn-Al-Ca合金的组织、拉伸性能和抗蠕变性能。对于Mg-xZn-ySn-2Al-0.2Ca(x+y=9,x/y为2,1和0.5)合金,锌锡比为1时室温抗拉强度和屈服强度最高:150℃屈服强度随着锌锡比的增加而提高,而200℃相反。这可能与低锌... 详细信息

研究了7种亚快速凝固Mg-Zn-Sn-Al-Ca合金的组织、拉伸性能和抗蠕变性能。对于Mg-xZn-ySn-2Al-0.2Ca(x+y=9,x/y为2,1和0.5)合金,锌锡比为1时室温抗拉强度和屈服强度最高:150℃屈服强度随着锌锡比的增加而提高,而200℃相反。这可能与低锌锡比合金中Mg_2Sn较多、含Zn化合物较少且Mg_2Sn具有高温强化作用有关。对于Mg-4.5Zn-4.5Sn-2Al-zCa(z=0,0.2,0.4,0.6)合金,室温和200℃抗拉强度和屈服强度随着Ca含量的增加先提高后下降,峰值分别出现在0.2%Ca和0.4%Ca。200℃/50MPa压缩蠕变时,合金初始应变量和稳态蠕变速率随着Ca含量的增加而降低。少量Ca可以提高Mg-4.5Zn-4.5Sn-2Al合金的室温和高温强度并改善抗蠕变性能,但降低高温塑性。此外,也影响拉伸断裂模式。随着Ca含量的增加,合金室温断裂由解理断裂转变为准解理断裂,200℃断裂由韧性断裂转变为准解理断裂。

关键词： Mg-Zn-Sn合金 Ca 显微组织拉伸性能蠕变

延河流域极端暴雨下侵蚀产沙特征野外观测分析

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农业工程学报 2017年第13期33卷 159-167页

作者：焦菊英王志杰魏艳红苏嫄曹斌挺李玉进西北农林科技大学水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室杨凌712100 中国科学院水利部水土保持研究所黄土高原土壤侵蚀与旱地农业国家重点实验室杨凌712100 贵州大学生命科学学院贵阳550025

针对黄土高原目前侵蚀环境明显改善条件下能否经受得住极端暴雨事件的考验及可能出现的问题,该文依据在延河6个典型小流域的植被调查及土壤侵蚀监测结果,分析了2013年极端暴雨条件下延河流域不同尺度的侵蚀产沙特征。结果表明,天然乔木... 详细信息

针对黄土高原目前侵蚀环境明显改善条件下能否经受得住极端暴雨事件的考验及可能出现的问题,该文依据在延河6个典型小流域的植被调查及土壤侵蚀监测结果,分析了2013年极端暴雨条件下延河流域不同尺度的侵蚀产沙特征。结果表明,天然乔木(辽东栎和三角槭)植被的平均侵蚀强度<1 000 t/km^2,自然灌木植被在1 118.1~1 161.2 t/km^2之间,演替中后期的草本植被在1 245.2~1 827.8 t/km^2之间,而演替中前期的草本植被在3 087.6~4 408.4 t/km^2之间;人工灌木林(2 119.7~2 183.9 t/km^2)比人工乔木林(2 625.7~5 149.6 t/km^2)具有较强的减蚀能力。坡面良好的植被覆盖能有效抵御暴雨侵蚀,小流域坡面平均侵蚀强度基本<2 500 t/km^2;但滑坡侵蚀占主导地位,占各小流域侵蚀总量的49.0%~88.5%,特别是距暴雨中心较近流域的南部2个小流域的滑坡侵蚀可达7 290.3和7 424.9 t/km^2左右。不同小流域内有6.4%~18.3%的侵蚀量淤积在沟道里;延河甘谷驿以上不同河段的淤积量为13.2~145.2万t,平均占总侵蚀产沙量的15%。延河甘谷驿控制区的侵蚀产沙强度变化在2 326.7~7 774.4 t/km^2之间,其中强度为5 000~8 000 t/km^2的面积占59.3%。因此,加强沟间地径流蓄排措施,减轻坡面径流下沟对沟坡重力侵蚀的影响,是土壤侵蚀研究与防治中值得重视的问题。

关键词：土壤侵蚀滑坡极端降雨事件植被恢复侵蚀产沙