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Update of transmission modelling and projections of gambiense human African trypanosomiasis in the Mandoul focus, Chad

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Infectious Diseases of Poverty 2022年第1期11卷 34-46页

作者： Kat s.Rock Ching-I Huang Ronald E.Crump Paul R.Bessell Paul E.Brown Inaki Tirados Philippe solano Marina Antillon Albert Picado severin Mbainda justin Darnas Emily H.Crowley steve J.Torr Mallaye Peka Mathematics Institute University of WarwickAcademic Loop RoadCoventryCV47ALUK Zeeman Institute for systems Biology&Infectious Disease Epidemiology Research(sBIDER) University of WarwickAcademic Loop RoadCoventryCV47ALUK Independent Consultant EdinburghUK Department of Vector Biology Liverpool School of Tropical MedicineLiverpoolUK Institut de Recherche pour le Développement UMR INTERTRYP IRD-CIRADUniversitéde Montpellier34398MontpellierFrance swiss Tropical and Public Health Institute BaselSwitzerland University of Basel BaselSwitzerland Foundation for Innovative New Diagnostics(FIND) GenevaSwitzerland Programme National de Lutte contre la Trypanosomiase Humaine Africaine(PNLTHA) MoundouChad

Background:In recent years,a programme of vector control,screening and treatment of gambiense human African trypanosomiasis(gHAT)infections led to a rapid decline in cases in the Mandoul focus of *** represent the biology of transmission between humans and tsetse,we previously developed a mechanistic transmission model,fitted to data between 2000 and 2013 which suggested that transmission was interrupted by *** present study outlines refinements to the model to:(1)Assess whether elimination of transmission has already been achieved despite low-level case reporting;(2)quantify the role of intensified interventions in transmission reduction;and(3)predict the trajectory of gHAT in Mandoul for the next decade under different ***:Our previous gHAT transmission model for Mandoul was updated using human case data(2000-2019)and a series of model *** include how diagnostic specificity is incorporated into the model and improvements to the fitting method(increased variance in observed case reporting and how underreporting and improvements to passive screening are captured).A side-by-side comparison of fitting to case data was performed between the ***:we estimated that passive detection rates have increased due to improvements in diagnostic availability in fixed health facilities since 2015,by 2.1-fold for stage 1 detection,and 1.5-fold for stage *** find that whilst the diagnostic algorithm for active screening is estimated to be highly specific(95%credible interval(CI):99.9-100%,specificity=99.9%),the high screening and low infection levels mean that some recently reported cases with no parasitological confirmation might be false *** also find that the focus-wide tsetse reduction estimated through model fitting(95%CI:96.1-99.6%,Reduction=99.1%)is comparable to the reduction previously measured by the decline in tsetse catches from monitoring *** line with previous results,the model suggests that transmission was

关键词： Gambiense human African trypanosomiasis (gHAT) Modelling Elimination of transmission Validation Tsetse Vector control Glossina Diagnostics

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Dual Circulation and China's Development

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Frontiers of Economics in China-selected Publications from Chinese Universities 2021年第1期16卷 30-34页

作者： justin Yifu Lin Institute of New structural Economics Peking UniversityBeijing 100871China Institute of south-south Cooperation and Development Peking UniversityBeijing 100871China National school of Development Peking UniversityBeijing 100871China

In 2020,China proposed a new development paradigm centered on domestic circulation with a"dual circulation"model in which domestic circulation and international circulation promote each *** new paradigm reflects a clear understanding of China's development trend that saw its share of exports in the GDP declining steadily since ***,the new paradigm does not necessarily mean that China should change its past policy of fully utilizing domestic and international markets and resources in economic *** of large economies of scale in modern manufacturing sector,China should continue to make full use of international markets.

关键词： China dual circulation domestic circulation international circulation economic development

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Engineered neuronal microtissue provides exogenous axons for delayed nerve fusion and rapid neuromuscular recovery in rats

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Bioactive Materials 2022年第12期7卷 339-353页

作者： justin C.Burrell suradip Das Franco A.Laimo Kritika s.Katiyar Kevin D.Browne Robert B.shultz Vishal J.Tien Phuong T.Vu Dmitriy Petrov Zarina sAli Joseph M.Rosen D.Kacy Cullen Center for Brain Injury&Repair Department of NeurosurgeryPerelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA Department of Bioengineering School of Engineering&Applied ScienceUniversity of PennsylvaniaPhiladelphiaPAUSA Center for Neurotrauma Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPA19104USA Axonova Medical LLCPhiladelphiaPAUSA Dartmouth-Hitchcock Medical Center Division of Plastic SurgeryDartmouth CollegeLebanonNHUSA

Nerve injury requiring surgical repair often results in poor functional recovery due to the inability of host axons to re-grow long distances and reform meaningful connections with the target muscle. while surgeons can re-route local axon fascicles to the target muscle, there are no technologies to provide an exogenous source of axons without sacrificing healthy nerves. Accordingly, we have developed tissue engineered neuromuscular interfaces (TE-NMIs) as the first injectable microtissue containing motor and sensory neurons in an anatomically-inspired architecture. TE-NMIs provide axon tracts that are intended to integrate with denervated distal structures and preserve regenerative capacity during prolonged periods without host innervation. Following implant, we found that TE-NMI axons promoted schwann cell maintenance, integrated with distal muscle, and preserved an evoked muscle response out to 20-weeks post nerve transection in absence of innervation from host axons. By repopulating the distal sheath with exogenous axons, TE-NMIs also enabled putative delayed fusion with proximal host axons, a phenomenon previously not achievable in delayed repair scenarios due to distal axon degeneration. Here, we found immediate electrophysiological recovery after fusion with proximal host axons and improved axon maturation and muscle reinnervation at 24-weeks post-transection (4-weeks following delayed nerve fusion). These findings show that TE-NMIs provide the potential to improve functional recovery following delayed nerve repair.

关键词： Nerve regeneration Neuromuscular injury Muscle preservation Tissue engineering Microtissue Axon fusion

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Multiplex PCR for Identification and Detection of Cassava Mosaic Begomoviruses in Togo

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Advances in Microbiology 2023年第11期13卷 517-525页

作者： senya sakina Allado Djodji Kossikouma Adjata justin simon Pita Assion sétu Mivedor Kodjovi Atassé Dansou-Kodjo Koffi Tozo Laboratoire de Virologie et de Biotechnologies Vé g&eacutetales Ecole Sup&eacuterieure d’Agronomie (ESA) Universit&eacute de Lom&eacute Lom&eacute Togo Laboratory of Plant Virology Universit&eacute F&eacutelix Houphou&eumlt-Boigny P&ocircle Scientifique et d’Innovation Bingerville C&ocircte d’Ivoire Laboratoire de Physiologie et Biotechnologies Vé g&eacutetales Facult&eacute des Sciences Universit&eacute de Lom&eacute Lom&eacute Togo

Cassava mosaic disease (CMD) caused by Cassava Mosaic Begomoviruses (CMBs) is one of the most devastating crop diseases and a major constraint for cassava production. In order to ensure surveillance for epidemic prevention, low-cost diagnostic tools are appropriate for large-scale testing of cassava viruses. Multiplex PCR diagnosis is one approach that can reduce diagnostic costs and delays. A multiplex PCR approach was developed for simultaneous detection of African cassava mosaic virus (ACMV), East African Cassava Mosaic Virus and East African cassava mosaic Cameroon virus (EACMV/CM) in Togo CMD-infected cassava leaves. Three primers pairs were used to target their respective viruses in a single tube PCR. Multiplex PCR detected ACMV, EACMV and EACMV/CM in plant DNA extracts prepared from cassava leaves infected with CMB. The primers amplified 783 bp specific to ACMV, 650 bp specific to EACMV and 560 bp specific to EACMCV/CM in both uniplex and multiplex formats. Multiplex PCR is an excellent tool for the effective control of cassava diseases. .

关键词： Cassava Begomovirus CMD CMB EACMV/CM PCR Multiplex

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Levels and correlates of 24-hour movement behaviors among south Koreans:Results from the Korea National Health and Nutrition Examination surveys,2014 and 2015

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Journal of sport and Health science 2019年第4期8卷 376-385页

作者： Eun-Young,Lee Valerie Carson justin Y.Jeon John C.spence Mark s.Tremblay school of Kinesiology and Health studies Queen's UniversityKingston ON K7L 2N9Canada Faculty of Kinesiology Sportand RecreationUniversity of AlbertaEdmonton AB T6G 2H9Canada Department of sport Industry Faculty of Education SciencesYonsei UniversitySeoul 03722Republic of Korea Healthy Active Living and Obesity(HALO)Research Group CHEO Research InstituteOttawa ON KIH 8L1Canada

*** study aimed to examine the levels and correlates of 24-h movement behaviors(i.e.,physical activity,sedentary time,and sleep),and different patterns of these behaviors in a nationally representative sample of south Koreans aged 12 years and *** study also aimed to examine the sociodemographic correlates of 24?h movement behaviors stratified by age ***-reported,repeated cross-sectional data from 10,708 participants in the 2014 and 2015 Korea National Health and Nutrition Examination surveys were *** variables included moderate-to-vigorous intensity physical activity,muscular strengthening exercises,walking,active transportation,sedentary time,and *** variables included age,sex,household income,area of residence,and education *** statistics by sex and age as well as general linear models by age group were *** proportions of individuals meeting the moderate-to-vigorous intensity physical activity,muscular strengthening exercises,and sleep guidelines were,respectively,21.6%,22.1%,and 32.5%in male youth;6.9%,4.5%,and 22.8%in female youth;55.5%,30.8%,and 54.0%in male adults;48.8%,14.4%,and 57.6%in female adults;44.0%,30.6%,and 45.5%in male older adults;and 29.5%,8.9%,and 37.3%in female older *** proportions of individuals showing the most ideal combinations of 24-h movement behaviors were only 3.2%in youth,0.4%in adults,and 0 in older ***,older age,female sex,or living in metro seoul were associated with unfavorable patterns of 24-h movement behaviors across different age ***,the associations of income and education with movement behaviors were mixed across age ***,the proportion of south Koreans with a healthy 24-h movement behavior pattern is *** sociodemographic correlates of different types of 24-h movement behaviors should be considered when designing targeted interventions for the promotion of healthy active living for

关键词： 24-h movement behavior Behavioral epidemiology Guideline adherence Health behavior surveillance

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Taxonomic revision of genus Rohanixalus(Anura:Rhacophoridae)in China with description of one new species

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Zoological Research 2023年第6期44卷 1146-1151页

作者： Xiao-Long Liu Jun-Kai Huang Bryan L.stuart Ren-Da Ai justin M.Bernstein Chatmongkon suwannapoom siriwadee Chomdej Jing Che Zhi-Yong Yuan Integrative science Center of Germplasm Creation in western China(Chongqing)science City Biological Science Research CenterSouthwest UniversityChongqing 400715China Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) School of Life SciencesSouthwest UniversityChongqing 400715China Guangxi Key Laboratory of Rare and Endangered Animal Ecology Guangxi Normal UniversityGuilinGuangxi 541004China North Carolina Museum of Natural sciences Raleigh NC 27601USA Key Laboratory for Conserving wildlife with small Populations in Yunnan Southwest Forestry UniversityKunmingYunnan 650224China Center for Genomics University of KansasLawrenceKansas 66044USA Division of Fishery School of Agriculture and Natural ResourcesUniversity of PhayaoPhayao 56000Thailand Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand state Key Laboratory of Genetic Resources and Evolution Yunnan Key Laboratory of Biodiversity and Ecological Conservation of Gaoligong MountainKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

DEAR EDITOR,Based upon morphological and molecular evidence,the authors revised the genus Rohanixalus Biju,Garg,Gokulakrishnan,Chandrakasan,Thammachoti,Ren,Gopika,Bisht,Hamidy and shouche,2020(Anura:Rhacophoridae)in China through describing one new species,adding one species to the fauna(***)and supplementing data on one species(Rohanixalus hansenae;supplementary Materials).

关键词： Anura species Taxonomic

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Growth,structural and Microhardness studies on New semiorganic single Crystals of Calcium Para Nitrophenolate Dihydrate

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Journal of Materials science & Technology 2007年第6期23卷 855-859页

作者： C.Vesta R.Uthrakumar C.justin Raj A.Jonie Varjula J.Mary Linet s.Jerome Das Department of Physics Loyola CollegeChennai-34India

Good quality crystals of calcium p-nitrophenolate （NPCa） were grown from saturated solution by slow evaporation method. The crystal structure analysis and the molecular arrangement of these crystals were determined using X-ray diffraction （XRD）. From single crystal XRD studies, NPCa is found to be crystallized in the mon- oclinic system with a space group P21/n. The functional groups of the material were confirmed qualitatively by F-FIR （Fourier transform infrared spectroscopy） spectral analysis. Optical absorption studies reveal the absorption region and microhardness studies were carried out to confirm the mechanical behaviour of the crystals.

关键词： Characterization Crystal growth structural analysis FTIR spectral analysis Microhardness UV-Vis analysis

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Epidemiological, Diagnostic and Therapeutic Aspects of Locally Advanced and/or Metastatic Breast Cancers at the Chu-Mel of Cotonou

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Advances in Breast Cancer Research 2022年第4期11卷 195-205页

作者： sèdjro Raoul Atade Patrice Dangbemey Roger Klipezo Donald Adjagba David Lionel Togbenon Kabibou salifou Benjamin Hounkpatin justin Lewis Denakpo Mother and Child Department Institute of Nursing and Obstetrical Care (IFSIO) University of Parakou Parakou Benin Mother and Child Department Faculty of Health Sciences (FSS) University of Abomey Calavi Godomey Benin Mother and Child Department Faculty of Medicine (FM) University of Parakou Parakou Benin

Introduction: Breast cancer mortality remains high in most developing countries. Benin Republic does not yet have a technical platform required for the diagnosis and effective management of breast cancer “according to the recommendations”. Objective: To study the epidemiological, diagnostic and therapeutic aspects of locally advanced and/or metastatic breast cancers at the Centre Hospitalier Universitaire-de la Mère et de l’Enfant Lagune (CHU-MEL) of Cotonou from 2018 to 2021. study Methods: This was a retrospective cross-sectional study with a descriptive purpose, carried out from January 1, 2018 to september 30, 2021 in the Gynaecology-Obstetrics section of the CHU-MEL of Cotonou. The study population was patients diagnosed with locally advanced and/or metastatic breast cancers. Results: At the end of the study, 63 cases of locally advanced and/or metastatic breast cancer were recorded in 80 cases of breast cancer;a 74.11% prevalence of locally advanced and metastatic breast cancer. The mean age of the patients was 42.6 years. The main reason for consultation was the discovery of a mass in the breast (65.1%). Clinically, an orange peel was noted in 39.6%. Mammography (47.6%) and breast ultrasonography (42.9%) were the reference imaging workups for breast cancer diagnosis. Histopathologically, infiltrating ductal carcinoma (94.1%) was the predominant type with scarff-Bloom and Richardson (sBR) grade II found in 35.3%. Progesterone and estrogen receptors were present in 42.9%. Mastectomy with axillary node dissection was the surgical treatment performed (80%) after neoadjuvant chemotherapy (39.6%). Only one patient had received radiotherapy. No patient received hormone therapy. Conclusion: Locally advanced and metastatic cancers remain a real public health problem. It is essential that major investments be made in order to improve both their diagnosis and management.

关键词： Cancer Breast Metastasis Ultrasonography Mammography

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seventy Years of Economic Development: A Review from the Angle of New structural Economics

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China & world Economy 2020年第4期28卷 26-50页

作者： justin Yifu Lin Yan wang south-south Cooperation and Development Peking UniversityChina Institute of New structural Economics Peking UniversityChina

This review paper provides a new narrative by combing through the experiences of structural transformation among developing countries and discussing the roles of government and market in different *** performance has been influenced by the prevailing development thinking:the structuralism in the 1950s-1970s,which stresses an active government's role to overcome market failures for industrialization,and the neoliberalism in the 1980s-present,which advocates for eliminating government failures to build up a well-functioning *** find that almost all countries failing by following structuralism in their industrialization and neoliberalism in their transition to a market economy,and the few countries successful in catching up have a few characteristics that go against the prevailing structuralism and *** new structural economics,generated from the experiences of successful East Asian economies and proposing active facilitating roles of government in a market economy to remove market failures,will gain traction and take root.

关键词： deindustrialization development industrial policy new structural economics structural transformation

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Progressive familial intrahepatic cholestasis

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 570-578页

作者： Tomohide Hori justin H.Nguyen shinji Uemoto Department of Neuroscience Mayo Clinic in Florida Division of Transplant surgery Department of Transplantation Mayo Clinic in Florida Divisions of Hepato-Biliary-Pancreatic Pediatric and Transplant SurgeryDepartment of SurgeryKyoto University Hospital

BACKGROUND:Three types of progressive familial intrahepatic cholestasis(PFIC)have been identified,but their etiologies include unknown mechanisms. DATA sOURCEs:A PubMed search on'progressive familial intrahepatic cholestasis'and'PFIC'was performed on the topic,and the relevant articles were reviewed. REsULTs:The etiologies of the three PFIC types still include unknown *** in PFIC type 1,enterohepatic circulation of bile acid should be *** acid,partial external biliary diversion and liver transplantation have been used for the treatment of PFIC patients according to disease course. CONCLUsIONs:since the etiologies and disease mechanisms of PFIC are still unclear,detailed studies are urgently required. strategies for more advanced therapies are also *** developments in the future are indispensable,especially for PFIC type 1 patients.

关键词： progressive familial intrahepatic cholestasis Byler's disease liver transplantation steatosis

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