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人参果汁浓缩液对环磷酰胺诱导免疫抑制小鼠免疫功能的影响

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中国食品卫生杂志 2024年第4期36卷 377-382页

作者：石峻岭孙宇立郑志清王婷苏怡上海市预防医学研究院上海200336

目的研究人参果汁浓缩液对环磷酰胺致小鼠免疫损伤的作用及其可能机制。方法将72只SPF级雄性C57BL/6J小鼠随机分成空白对照组、环磷酰胺组、阳性药物组、人参果汁浓缩液低、中、高剂量组(83、166、249 mg/kg),每组12只。第1~14天,人参... 详细信息

目的研究人参果汁浓缩液对环磷酰胺致小鼠免疫损伤的作用及其可能机制。方法将72只SPF级雄性C57BL/6J小鼠随机分成空白对照组、环磷酰胺组、阳性药物组、人参果汁浓缩液低、中、高剂量组(83、166、249 mg/kg),每组12只。第1~14天,人参果汁浓缩液3个剂量组小鼠灌胃相应的人参果汁浓缩液,空白对照组和环磷酰胺组小鼠灌胃等量的水;第1~7天,阳性药物组小鼠灌胃等量的水,第8~14天,阳性药物组小鼠灌胃20 mg/kg盐酸左旋咪唑(LH);第12~14天,环磷酰胺组、阳性药物组和人参果汁浓缩液各剂量组小鼠腹腔注射80 mg/kg环磷酰胺,空白对照组腹腔注射等量的生理盐水。实验结束后,计算小鼠脾脏指数、测定小鼠外周血白细胞(WBC)、淋巴细胞(LYM)和LYM%以及检测小鼠血清和脾脏中乳酸脱氢酶(LDH)和酸性磷酸酶(ACP)活性、小鼠脾脏中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性和丙二醛(MDA)含量。结果各组小鼠体质量比较,差异无统计学意义(P>0.05)。与空白对照组比较,环磷酰胺组小鼠脾脏指数降低(P<0.01)、外周血WBC、LYM和LYM%降低(P<0.05)、血清和脾脏中ACP活性降低(P<0.05)或呈降低趋势、脾脏中SOD、CAT活性降低、MDA含量升高(P<0.05);与环磷酰胺组比较,人参果汁浓缩液各剂量组脾脏指数升高(P<0.05,P<0.01)、人参果汁浓缩液低、高剂量组LYM%升高(P<0.05)、人参果汁浓缩液各剂量组血清和脾脏组织中ACP活性呈升高趋势或升高(P<0.05)、人参果汁浓缩液低剂量组SOD和CAT活性呈升高趋势、人参果汁浓缩液各剂量组MDA含量降低(P<0.05,P<0.01)。结论人参果汁浓缩液在一定程度上可改善环磷酰胺引起的小鼠免疫损伤作用,可能与减轻小鼠免疫器官氧化损伤作用相关。

关键词：人参果环磷酰胺免疫抑制氧化损伤免疫调节

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日本新干线运营管理及对我国的启示

中国铁路 2024年第1期 132-140页

作者：史俊玲刘坦荆晓霞张佳翠中国铁道科学研究院集团有限公司科学技术信息研究所北京100081

日本新干线运营半个多世纪以来,客运量、旅客周转量、运输密度等指标不断提升,体现出安全性高、运输密度高等典型特征。在阐述日本新干线运营效果基础上,分别从列车开行方案、综合调度指挥、动车组运用、客运服务等方面总结相关做法和... 详细信息

日本新干线运营半个多世纪以来,客运量、旅客周转量、运输密度等指标不断提升,体现出安全性高、运输密度高等典型特征。在阐述日本新干线运营效果基础上,分别从列车开行方案、综合调度指挥、动车组运用、客运服务等方面总结相关做法和经验。结合我国国情、路情,并充分考虑未来铁路客运需求发展态势,参考日本新干线运营管理的有效举措和先进经验,从高速列车产品谱系化设计、客流调查、人性化服务、成本收益管理、设备设施优化等方面提出对我国高速铁路运营管理的启示和借鉴。

关键词：日本新干线铁路运营管理启示

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不同诱导物对白地霉中高级醇脱氢酶的影响

食品工业科技 2024年第6期45卷 128-141页

作者：朱静杨晓聪陈亚蓝刘海波陈龙郑雪珂师俊玲信阳农林学院河南信阳464000 西北工业大学生命学院陕西西安710072

化学或物理因子作为诱导物,能够直接或间接影响菌体基因转录表达。为探索高级醇底物对白地霉的诱导效果,以分离自土壤的白地霉S12为对象,采用五种高级醇(正丙醇、正丁醇、异丁醇、正己醇和异戊醇)作为诱导物,研究不同高级醇的诱导剂量... 详细信息

化学或物理因子作为诱导物,能够直接或间接影响菌体基因转录表达。为探索高级醇底物对白地霉的诱导效果,以分离自土壤的白地霉S12为对象,采用五种高级醇(正丙醇、正丁醇、异丁醇、正己醇和异戊醇)作为诱导物,研究不同高级醇的诱导剂量、诱导时间对菌体S12降解不同高级醇活性及脱氢酶活力的影响。结果表明,当正己醇和异丁醇分别作为诱导剂时,胞内酶活力较高。正丙醇、正丁醇、异丁醇和正己醇作为诱导剂时,最适诱导时间均为6 h;而以异戊醇为诱导剂时,最佳诱导时间为12 h。以正丙醇和正己醇为诱导剂时,最适的诱导浓度为1.5 g/L;以正丁醇、异丁醇和异戊醇为诱导剂时,最适诱导浓度分别为1.0、0.5和2.5 g/L。NativePAGE电泳结果表明,以五种高级醇为诱导剂均能使菌体合成分子量为223 kDa左右的脱氢酶。其中,以正己醇为诱导剂时所得菌体同时降解多种高级醇的能力最强,其降解产物均为其相应的酸类和酯类物质。

关键词：白地霉高级醇脱氢酶诱导物酶活性诱导条件

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中日高速铁路主要运营指标对比分析及启示

中国铁路 2024年第6期 131-140页

作者：李佳蒙齐向春史俊玲荆晓霞中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司北京100081 中国铁道科学研究院集团有限公司科学技术信息研究所北京100081

日本新干线运营超过半个世纪,发展已经较为成熟,积累了丰富的运营管理经验。从运输资源、运输规模、运输效率效益、运输质量4个维度对中国和日本高速铁路的主要运营指标进行对比分析,明确我国高速铁路的运营水平及下一步发展方向。结果... 详细信息

日本新干线运营超过半个世纪,发展已经较为成熟,积累了丰富的运营管理经验。从运输资源、运输规模、运输效率效益、运输质量4个维度对中国和日本高速铁路的主要运营指标进行对比分析,明确我国高速铁路的运营水平及下一步发展方向。结果表明,我国高速铁路运营里程、动车组保有量、运输量、市场份额、日均开行列车数量、客座利用率等指标优于日本新干线,但路网密度、每公里动车组保有量、运输密度、每百公里日均开行列车数量等平均性指标还有一定的提升空间,未来应充分发挥高铁成网运营优势,在路网建设中兼顾规模、密度和布局覆盖,以市场需求为导向优化运输供给,并加强全方位安全保障能力,以提高高铁基础设施规模质量和运输供给水平。

关键词：日本新干线高速铁路运营指标路网规模运输效率运输密度

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Kinetic and mechanism of the reaction between Cl and several mono-methyl branched alkanes

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Journal of Environmental Sciences 2024年第1期135卷 474-482页

作者： Yan Chen Weigang Wang junling Li Li Zhou Bo shi Cici Fan Ke Wang Hao Zhang Hong Li Maofa Ge State Key Laboratory for Structural Chemistry of Unstable and Stable Species Beijing National Laboratory for Molecular Sciences(BNLMS)CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China National Engineering Research Center for Flue Gas Desulfurization Department of Environmental Science and EngineeringSichuan UniversityChengdu 610065China College of Chemistry and Materials Science Hebei Normal UniversityShijiazhuang 050024China

Branched alkanes are ubiquitous in the troposphere and play an important role in the chemical *** this work,the rate constants and products for the reaction of Cl atoms with 3-methylhexane and 2-methylheptane were measured at room temperature(298±0.2K)and atmospheric pressure using a conventional relative rate *** rate constants of 3-methylhexane and 2-methylheptane in units of cm~3/(mol·sec)are(3.09±0.31)×10^(-10)and(3.67±0.40)×10^(-10),***,the corresponding atmospheric lifetime of the studied branched alkanes with Cl was 6.92-89.90 hours and 5.82-75.69 hours,*** estimated atmospheric lifetimes indicated that the reaction with Cl atoms could be the most important atmospheric degradation pathway for 3-methylhexane *** gas-phase products of the reactions were identified and quantified,and particle-phase products were also *** atmosphere oxidation mechanism of Cl atoms with 3-methylhexane and 2-methylheptane is *** SOA yields of 3-methylhexane and 2-methylheptane from the reaction of Cl atoms were determined to be7.96%±0.89%and 13.35%±1.50%***,the results reveal that the primary loss process of branched alkanes is the reaction with Cl atoms,which impacts its degradation on a regional scale.

关键词： 3-Methylhexane 2-Methylheptane Chlorine atoms Kinetics Mechanism

Current status and reflection on the development of high-speed maglev transportation

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Railway Sciences 2023年第3期2卷 327-335页

作者： Hongmei Li junling shi Xiangdong Li Junbo Zhang Yunlong Chen Railway Science and Technology Research and Development Center China Academy of Railway Sciences Corporation LimitedBeijingChina China Academy of Railway Sciences Corporation Limited Institute of Scientific and Technical InformationBeijingChina INMAI Railway Technology Co. Ltd.China Academy of Railway Sciences Corporation LimitedBeijingChina College of Mechanical and Electrical Engineering Qingdao UniversityQingdaoChina

Purpose–High-speed maglev technology can address the issues of adhesion,friction,vibration and highspeed current collection in traditional wheel-rail systems,making it an important direction for the future development of high-speed rail ***/methodology/approach–This paper elaborates on the demand and significance of developing high-speed maglev technology worldwide and examines the current status and technological maturity of several major high-speed maglev systems ***–This paper summarizes the challenges in the development of high-speed maglev railways in *** on this analysis,it puts forward considerations for future research on high-speed maglev ***/value–This paper describes the development status and technical maturity of several major high-speed maglev systems in the world for the first time,summarizes the existing problems in the development of China’s high-speed maglev railway and on this basis,puts forward the thinking of the next research of China’s high-speed maglev railway.

关键词： High-speed maglev Necessity Current development status Problems in development Reflections

Clinical characteristics and outcomes of psoriasis patients with COVID-19: A retrospective, multicenter cohort study in China

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中华医学杂志(英文版) 2024年第14期137卷 1736-1743页

作者： Liu Yanhua Xu Zhongrui Zhou Jian Chen Aijun Zhang junling Kang Xiaojing Jiang Xian Lyu Chengzhi shi Chunrui shi Yuling Liu Xiaoming Li Fuqiu Yang Bin Huang Yongmei Yu Chen Wang Gang Department of Dermatology Xijing Hospital Fourth Military Medical University Xi’an Shaanxi China Department of Dermatology The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital Tianjin China Department of Dermatology and Venereology People’s Hospital of Xinjiang Uygur Autonomous Region Urumqi Xinjiang China Department of Dermatology West China Hospital Sichuan University Chengdu Sichuan China Department of Psoriasis Dalian Dermatosis Hospital Dalian Liaoning China Department of Dermatology The First Hospital of Lanzhou University Lanzhou Gansu China Skin Disease Hospital of Tongji University Shanghai China Department of Dermatology The University of Hong Kong-Shenzhen Hospital Shenzhen Guangdong China Department of Dermatology The Second Hospital of Jilin University Changchun Jilin China Department of Dermatology Dermatology Hospital of Southern Medical University Guangzhou Guangdong China Department of Dermatology Xining First People’s Hospital Xining Qinghai China

Background: Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection on psoriasis patients. The objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 ***: A retrospective, multicenter study was conducted between March and May 2023. Univariable and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019 (COVID-19)-related psoriasis outcomes. The study included 2371 psoriasis patients from 12 clinical centers, with 2049 of them having been infected with ***: Among the infected groups, lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments (22.3% [236/1058]vs. 39.8% [92/231]vs. 37.5% [140/373],P <0.001). Psoriasis progression with lesions (adjusted odds ratio [OR] = 8.197, 95% confidence interval [95% CI] = 5.685–11.820, compared to no lesions), hypertension (adjusted OR = 1.582, 95% CI = 1.068–2.343), traditional systemic (adjusted OR = 1.887, 95% CI= 1.263–2.818), and nonsystemic treatment (adjusted OR= 1.602, 95% CI= 1.117–2.297) were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection, but not biologics (adjusted OR = 0.931, 95% CI = 0.680–1.274, compared to no treatment), according to multivariable logistic regression ***: A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic treatments. Significant risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.

关键词： COVID-19 SARS-CoV-2 Psoriasis Treatment Biologics

Interaction between diet composition and gut microbiota and its impact on gastrointestinal tract health

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Food Science and Human Wellness 2017年第3期6卷 121-130页

作者： Muhammad Shahid Riaz Rajoka junling shi Hafiza Mahreen Mehwish Jing Zhu Qi Li Dongyan Shao Qingsheng Huang Hui Yang Key Laboratory for Space Bioscience and Space Biotechnology School of Life SciencesNorthwestern Polytechnical UniversityXi’an 710072ShaanxiPeople’s Republic of China Department of Biotechnology University of AgricultureFaisalabadPakistan

A substantial amount of emerging research is indicating that the gut microbiota has a significant impact on human *** of gut microbiota have clear consequences on intestinal homeostasis,physiology,gut microbiome,immune system and host metabolic *** composition plays an important role in the control of gut microbial populations and,thus,in the prevention,management and treatment of certain diseases such as cancer,diabetes.A comprehensive analysis of previously reported results revealed that the gut microbiota can be modulated by diet and the composition of gut microbiota can be influenced by various diet *** symbiotic relationship between different gut microbial communities regulates the immune system and,therefore,any dysbiosis can dysregulate the immune *** research is needed to fully understand the mechanisms involved in the interactions between diet composition,gut microbiota and associated diseases.

关键词： Gut microbiota Dysbiosis Probiotics Human health

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铁路工程建造技术水平综合指数评价体系研究

铁道建筑 2022年第3期62卷 1-4页

作者：李恩良张雷史俊玲中国铁路设计集团有限公司土建结构研究所天津300308 中国铁道科学研究院集团有限公司科学技术信息研究所北京100081

针对现有评价体系不能准确反映各国铁路工程建造技术在国际上的发展定位问题,基于专业属性和公众视角选取19个指标构建了一套三级铁路工程建造技术水平综合指数评价体系,并对34个国家或地区进行了研究与评价。结果表明:在12个三级单项... 详细信息

针对现有评价体系不能准确反映各国铁路工程建造技术在国际上的发展定位问题,基于专业属性和公众视角选取19个指标构建了一套三级铁路工程建造技术水平综合指数评价体系,并对34个国家或地区进行了研究与评价。结果表明:在12个三级单项评价指标中中国占据10个第一,在6个二级分项评价指标中中国占据4个第一,在重载铁路、隧道工程方面中国与其他国家尚有一定差距;铁路工程建造技术水平综合指数排前十名的国家依次是中国、日本、西班牙、韩国、瑞典、瑞士、俄罗斯、芬兰、丹麦、印度。

关键词：铁路工程评价体系统计分析建造技术综合指数智能建造