Clinical characteristics and outcomes of psoriasis patients with COVID-19:A retrospective,multicenter cohort study in China

作     者：Yanhua Liu Zhongrui Xu Jian Zhou Aijun Chen Junling Zhang Xiaojing Kang Xian Jiang Chengzhi Lyu Chunrui Shi Yuling Shi Xiaoming Liu Fuqiu Li Bin Yang Yongmei Huang Chen Yu Gang Wang Yanhua Liu;Zhongrui Xu;Jian Zhou;Aijun Chen;Junling Zhang;Xiaojing Kang;Xian Jiang;Chengzhi Lyu;Chunrui Shi;Yuling Shi;Xiaoming Liu;Fuqiu Li;Bin Yang;Yongmei Huang;Chen Yu;Gang Wang

作者机构：Department of DermatologyXijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of DermatologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of DermatologyTianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300072China Department of Dermatology and VenereologyPeople’s Hospital of Xinjiang Uygur Autonomous RegionUrumqiXinjiang 830001China Department of DermatologyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of PsoriasisDalian Dermatosis HospitalDalianLiaoning 116011China Department of DermatologyThe First Hospital of Lanzhou UniversityLanzhouGansu 730000China Skin Disease Hospital of Tongji UniversityShanghai 200050China Department of DermatologyThe University of Hong Kong-Shenzhen HospitalShenzhenGuangdong 518053China Department of DermatologyThe Second Hospital of Jilin UniversityChangchunJilin 130000China Department of DermatologyDermatology Hospital of Southern Medical UniversityGuangzhouGuangdong 510091China Department of DermatologyXining First People’s HospitalXiningQinghai 810000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2024年第137卷第14期

页      面：1736-1743页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100206[医学-皮肤病与性病学] 10[医学] 

基　　金：supported by a grant from the Clinical Research Project on COVID-19 infection at the Xijing Hospital(No.XJZT23XG29) 

主　　题：COVID-19 SARS-CoV-2 Psoriasis Treatment Biologics 

摘      要：Background:Limited information exists regarding the impact of severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)infection on psoriasis *** objective of this study was to identify clinical factors associated with the prognosis of psoriasis following SARS-CoV-2 ***:A retrospective,multicenter study was conducted between March and May *** and multivariable logistic regression analyses were employed to identify factors associated with coronavirus disease 2019(COVID-19)-related psoriasis *** study included 2371 psoriasis patients from 12 clinical centers,with 2049 of them having been infected with ***:Among the infected groups,lower exacerbation rates were observed in individuals treated with biologics compared to those receiving traditional systemic or nonsystemic treatments(22.3%[236/1058]vs.39.8%[92/231]vs.37.5%[140/373],P0.001).Psoriasis progression with lesions(adjusted odds ratio[OR]=8.197,95%confidence interval[95%CI]=5.685-11.820,compared to no lesions),hypertension(adjusted OR=1.582,95%CI=1.068-2.343),traditional systemic(adjusted OR=1.887,95%CI=1.263-2.818),and nonsystemic treatment(adjusted OR=1.602,95%CI=1.117-2.297)were found to be associated with exacerbation of psoriasis after SARS-CoV-2 infection,but not biologics(adjusted OR=0.931,95%CI=0.680-1.274,compared to no treatment),according to multivariable logistic regression ***:A reduced risk of psoriasis exacerbation after SARS-CoV-2 infection was observed with biologics compared to traditional systemic and nonsystemic *** risk factors for exacerbation after infection were identified as existing psoriatic lesions and hypertension.