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Near infrared light-induced dynamic modulation of enzymatic activity through polyphenol-functionalized liquid metal nanodroplets

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Chinese Chemical Letters 2023年第2期34卷 475-480页

作者： Chaojun Zhang Yang Tang Qin Wang Yunxiang He Xiaoling Wang Sebastian Beyer junling guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China School of Pharmacy Southwest Minzu UniversityChengdu 610225China National Engineering Research Center of Clean Technology in Leather Industry Sichuan UniversityChengdu 610065China Department of Biomedical Engineering Chinese University of Hong KongHong Kong 999077China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China Bioproducts Institute Department of Chemical and Biological EngineeringUniversity of British ColumbiaVancouverBC V6T 1Z4Canada

Dynamic manipulation of enzymatic activity is a challenging task for applications in chemical and pharmaceutical industries due to the difficult modification and variable conformation of various ***, we report a new strategy for reversible dynamic modulation of enzymatic activity by near-infrared light-induced photothermal conversion based on polyphenol-functionalized liquid metal nanodroplets(LM). The metal-phenolic nanocoating not only provides colloidal stability of LM nanodroplets but also generates nanointerfaces for the assembly of various enzymes on the LM nanodroplets. Upon near infrared(NIR) irradiation, the localized microenvironmental heating through photothermal effect of the LM nanodroplets allows tailoring the enzymatic activity without affecting the bulk temperature. A library of functional enzymes, including proteinase K, glucoamylase, glucose oxidase, and Bst DNA polymerase, is integrated to perform a reversible control and enhanced activities even after five times of cycles, demonstrating great potential in bacterial fermentation, bacteriostasis, and target gene amplification.

关键词： Enzymatic activity Photo-modulation Near infrared light Liquid metal nanodroplets Metal-phenolic nanocoating

Liquid metal compartmented by polyphenol-mediated nanointerfaces enables high-performance thermal management on electronic devices

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InfoMat 2024年第1期6卷 83-95页

作者： Chaojun Zhang Yang Tang Tianyu guo Yizhou Sang Ding Li Xiaoling Wang Orlando J.Rojas junling guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengduSichuanthe People's Republic of China Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBritish ColumbiaCanada Institute of Development Studies Southwestern University of Finance and EconomicsChengduSichuanthe People's Republic of China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengduSichuanthe People's Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengduSichuanthe People's Republic of China

The exponentially increasing heat generation in electronic devices,induced by high power density and miniaturization,has become a dominant issue that affects carbon footprint,cost,performance,reliability,and *** metals(LMs)with high thermal conductivity are promising candidates for effective thermal management yet are facing pump-out and surface-spreading *** in the form of metallic particles can address these problems,but apparent alloying processes elevate the LM melting point,leading to severely deteriorated ***,we propose a facile and sustainable approach to address these challenges by using a biogenic supramolecular network as an effective diffusion barrier at copper particle-LM(EGaIn/Cu@TA)interfaces to achieve superior thermal *** supramolecular network promotes LM stability by reducing unfavorable alloying and fluidity *** EGaIn/Cu@TA exhibits a record-high metallic-mediated thermal conductivity(66.1 W m^(-1) K^(-1))and fluidic ***,mechanistic studies suggest the enhanced heat flow path after the incorporation of copper particles,generating heat dissipation suitable for computer central processing units,exceeding that of commercial *** results highlight the prospects of renewable macromolecules isolated from biomass for the rational design of nanointerfaces based on metallic particles and LM,paving a new and sustainable avenue for high-performance thermal management.

关键词： Electronic devices High thermal conductivity Liquid metals Natural polyphenols Thermal management

Catalytic hosts with strong adsorption strength for long shelf-life lithium-sulfur batteries under lean electrolyte

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Nano Research 2023年第1期16卷 427-438页

作者： Siyuan Zhao Huayu Pei Quan Yang Kangli Liu Yuanyuan Huang Zhuo Wang guosheng Shao Jinping Liu junling guo State Center for International Cooperation on Designer Low-carbon&Environmental Materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Zhengzhou Materials Genome Institute Xingyang 450100China School of Chemistry Chemical Engineering and Life ScienceState Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070China

Low electrolyte/sulfur ratio(E/S)is an important factor in increasing the energy density of lithium-sulfur batteries(LSBs).Recently,the E/S has been widely lowered using catalytic hosts that can suppress“shuttle effect”during cycling by relying on a limited adsorption ***,the shelf-lives of these cathodes have not yet received ***,we show that the selfdischarge of sulfur cathodes based on frequently-used catalytic hosts is serious under low E/S because the“shuttle effect”during storage process caused by polysulfides(PSs)disproportionation cannot be suppressed using a limited adsorption *** further prove that the adsorption strength toward PSs,which is unfortunately weak in commonly-used catalytic hosts,is critical for effectively hindering the disproportionation of the ***,to verify this conclusion,we prepare a sulfur-doped titanium nitride(S-TiN)catalytic array *** the adsorption strength and catalytic activity of TiN can be improved by S doping simultaneously,the constructed S/S-TiN cathodes under a low E/S(6.5μL·mg−1)exhibit better shelf-life and cycle-stability than those of S/TiN *** work suggests that enhancing the adsorption strength of catalytic hosts,while maintaining their function to reduce E/S,is crucial for practical LSBs.

关键词： lithium-sulfur battery low electrolyte/sulfur ratio(E/S) self-discharge catalytic host adsorption strength

Supramolecular phenolic network-engineered C-CeO_(2) nanofibers for simultaneous determination of isoniazid and hydrazine in biological fluids

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Chinese Chemical Letters 2024年第6期35卷 496-501页

作者： Gang Lang Jing Feng Bo Feng Junlan Hu Zhiling Ran Zhiting Zhou Zhenju Jiang Yunxiang He junling guo School of Science Xihua UniversityChengdu 610039China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China Southwest Computer Co. Ltd.Chongqing 400060China Bioproducts Institute Department of Chemical and Biological EngineeringThe University of British ColumbiaVancouver V6T 1Z4Canada State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan University Chengdu 610065China

Electrochemical sensing provides a powerful technological means for the therapeutic drug monitoring of drug-resistant tuberculosis but requires a functionalized electrode to capture the analytes and catalyze their redox ***,we construct a nickel-tannic acid supramolecular network(Ni-TA)on the surface of electrospun-derived C-CeO_(2) nanofiber for the sensitive and simultaneous detection of isoniazid(INZ)and hydrazine(HYD).Mechanistic investigations demonstrate that Ni-TA is electronegative and hydrophilic,thus facilitating an efficient mass and electron ***-TA/C-CeO_(2) has higher adsorption rate constants(0.091 g mg^(-1)h^(-1)for INZ,and 0.062 g mg^(-1)h^(-1)for HYD)than native C-CeO_(2)(0.075 g mg^(-1)h^(-1)for INZ,and 0.047 g mg^(-1)h^(-1)for HYD).Moreover,Ni-TA/C-CeO_(2)(56Ω)has lower charge transfer resistances than C-CeO_(2)(417Ω).Ni-TA/C-CeO_(2) performs low detection limits and wide linearity ranges for INZ(0.012μmol/L and 0.1-400μmol/L,respectively)and HYD(0.008μmol/L and 0.015-1420μmol/L,respectively),coupled with high selectivity,cycle stability and *** research demonstrated the promising applications of Ni-TA/C-CeO_(2) by analyzing human-collected plasma and urine samples.

关键词： Electrochemical detection Therapeutic drug monitoring Isoniazid Hydrazine Tuberculosis

Collagen peptide provides Streptomyces coelicolor CGMCC 4.7172 with abundant precursors for enhancing undecylprodigiosin production

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Journal of Leather Science and Engineering 2021年第1期3卷 192-201页

作者： Xia Li Meifeng Li junling guo Xian Liu Xuepin Liao Bi Shi Department of Biomass Science and Engineering Sichuan University610065 ChengduPeople’s Republic of China National Engineering Research Center of Clean Technology in Leather Industry Sichuan University610065 ChengduPeople’s Republic of China The Key Laboratory of Leather Chemistry and Engineering of Ministry of Education Sichuan University610065 ChengduPeople’s Republic of China

Effective and ecofriendly converting biomass to chemicals is important for sustainable engineering based on the foreseeable shortage of fossil ***(UP)is a promising antibiotic,but the direct feeding of pure precursor amino acids makes it costly for large-scale ***,collagen peptide(CP),a renewable animal-derived biomass contains abundant precursor amino acids of *** can act as carbon and nitrogen source for the growth of Streptomyces coelicolor CGMCC *** plant biomasses including soybean meal,wheat bran,and malt extract were unsuitable for UP ***,365.40µg/L UP was detected after 24 h in the media containing CP,and its highest concentration reached 1198.01µg/*** was also detected in the media containing meat hydrolysates of domestic animals,but its initial production time was delayed,and final concentration was lower than that in the medium containing CP *** the fermentation performances of CP and other proteins,CP has a special superiority for UP *** results revealed that UP biosynthesis may be dependent on amino acid availability of substrates and CP is beneficial for UP production because of its specific amino acid composition.

关键词： Biomass Collagen peptide Fermentation Streptomyces coelicolor Antibiotic Undecylprodigiosin

Zinc finger-inspired peptide-metal-phenolic nanointerface enhances bone-implant integration under bacterial infection microenvironment through immune modulation and osteogenesis promotion

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Bioactive Materials 2024年第11期41卷 564-576页

作者： Lin Xu Jie Fang Jiezhou Pan Hexu Qi Yun Yin Yunxiang He Xueqi Gan Yifei Li Yu Li junling guo State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of Pediatric DentistryWest China Second University HospitalSichuan UniversityChengdu610041China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu610065China State Key Laboratory of Oral Diseases National Center for StomatologyNational Clinical Research Center for Oral DiseasesDepartment of ProsthodonticsWest China Hospital of StomatologySichuan UniversityChengdu610041China Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE Department of PediatricsWest China Second University HospitalSichuan UniversityChengdu610041China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu610065China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu610065China Bioproducts Institute Department of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada

Orthopedic and dental implantations under bacterial infection microenvironment face significant challenges in achieving high-quality bone-implant integration. Designing implant coatings that incorporate both immune defense and anti-inflammation is difficult in conventional single-functional coatings. We introduce a multifunctional nanointerface using a zinc finger-inspired peptide-metal-phenolic nanocoating, designed to enhance implant osseointegration under such conditions. Abaloparatide (ABL), a second-generation anabolic drug for treating osteoporosis, can be integrated into the design of a zinc-phenolic network constructed on the implant surface (ABL@ZnTA). Importantly, the phenolic-coordinated Zn2+ ions in ABL@ZnTA can act as zinc finger motif to co-stabilize the configuration of ABL through multiple molecular interactions, enabling high bioactivity, high loading capacity (1.36 times), and long-term release (>7 days) of ABL. Our results showed that ABL@ZnTA can modulate macrophage polarization from the pro-inflammatory M1 towards the anti-inflammatory M2 phenotype, promoting immune osteogenesis with increased OCN, ALP, and SOD 1 expression. Furthermore, the ABL@ZnTA significantly reduces inflammatory fibrous tissue encapsulation and enhances the long-term stability of the implants, indicated by enhanced binding strength (6 times) and functional connectivity (1.5−3 times) in the rat bone defect model infected by S. aureus. Overall, our research offers a nano-enabled synergistic strategy that balances infection defense and osteogenesis promotion in orthopedic and dental implantations.

关键词： Metal-phenolic network Implant Osseointegration Inflammation Abaloparatide

Collagen-based materials in reproductive medicine and engineered reproductive tissues

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Journal of Leather Science and Engineering 2022年第1期4卷 37-51页

作者： Hanxiao Chen Luqi Xue Guidong Gong Jiezhou Pan Xiaoling Wang Yaoyao Zhang junling guo Lang Qin Department of Obstetrics and Gynecology The Reproductive Medical CenterWest China Second University HospitalSichuan UniversityChengdu 610041China Key Laboratory of Birth Defects and Related of Women and Children of Ministry of Education West China Second University HospitalSichuan UniversityChengdu 610041China West China School of Medicine Sichuan UniversityChengdu 610041China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065SichuanChina State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065SichuanChina.

Collagen,the main component of mammal skin,has been traditionally used in leather manufacturing for thousands of years due to its diverse physicochemical *** is the most abundant protein in mammals and the main component of the extracellular matrix(ECM).The properties of collagen also make it an ideal building block for the engineering of materials for a range of biomedical *** medicine,especially human fertility preservation strategies and reproductive organ regeneration,has attracted significant attention in recent years as it is key in resolving the growing social concern over aging populations ***-based biomaterials such as collagen hydrogels,decellularized ECM(dECM),and bioengineering techniques including collagen-based 3D bio-printing have facilitated the engineering of reproductive *** review summarizes the recent progress in apply-ing collagen-based biomaterials in ***,we discuss the prospects of collagen-based materials for engineering artificial reproductive tissues,hormone replacement therapy,and reproductive organ reconstruction,aiming to inspire new thoughts and advancements in engineered reproductive tissues research.

关键词： Collagen-based biomaterials Leather and collagen Leather tanning process Reproductive medicine Reproductive tissues

A biologically stable, self-catalytic DNAzyme machine encapsulated by metal-phenolic nanoshells for multiple microRNA imaging

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Chinese Chemical Letters 2023年第10期34卷 197-203页

作者： Xin Jin Qin Wang Jiezhou Pan Jin Wang Yunxiang He Jiaojiao Shang Mei Chen Xianglian He Yaoyao Zhang Bo Wang Yajie Wang Guidong Gong junling guo BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniversityChengdu 610065China School of Pharmacy Southwest Minzu UniversityChengdu 610225China Department of Chemical and Biological Engineering Bioproducts InstituteUniversity of British ColumbiaVancouver BC V6T 1Z4Canada State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China National Engineering Laboratory for Clean Technology of Leather Manufacture Sichuan UniversityChengdu 610065China Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related of Women and Children of Ministry of EducationThe Reproductive Medical CenterWest China Second University HospitalSichuan UniversityChengdu 610041China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China School of Engineering Westlake UniversityHangzhou 310034China

DNAzyme machines play critical roles in the fields of cell imaging, disease diagnosis, and cancer therapy. However, the applications of DNAzyme machines are limited by the nucleases-induced degradation,non-specific binding of proteins, and insufficient provision of cofactors. Herein, protected DNAzyme machines with different cofactor designs(referred to as Pro Ds) were nanoengineered by the construction of multifunctional metal-phenolic nanoshells to deactivate the interferential proteins, including nucleases and non-specific binding proteins. Moreover, the nanoshells not only facilitate the cellular internalization of Pro Ds but provide specific metal ions acting as cofactors of the designed DNAzymes. Cellular imaging results demonstrated that Pro Ds could effectively and simultaneously monitor multiple tumor-related micro RNAs in living cells. This facile and rapid strategy that encapsulates DNAzyme machines into the protective metal-phenolic nanoshells is anticipated to extend to a wide range of functional nucleic acidsbased biomedical applications.

关键词： DNAzyme machine Metal-phenolic nanoshells Interference protection Cofactors self-supply Cell imaging

Alloyed nanostructures integrated metal-phenolic nanoplatform for synergistic wound disinfection and revascularization

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Bioactive Materials 2022年第10期7卷 95-106页

作者： Yi Xie Shengqiu Chen Xu Peng Xiaoling Wang Zhiwei Wei Joseph J.Richardson Kang Liang Hirotaka Ejima junling guo Changsheng Zhao College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengduSichuan610065China BMI Center for Biomass Materials and Nanointerfaces College of Biomass Science and EngineeringSichuan UniverisityChengduSichuan610065China Laboratory Animal Center Sichuan UniversityChengduSichuan610065China School of Chemical Engineering Graduate School of Biomedical Engineeringand Australian Centre for NanoMedicineUniversity of New South WalesSydneyNSW2052Australia Department of Materials Engineering School of EngineeringThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo113􀀀8656Japan Bioproducts Institute Departments of Chemical and Biological EngineeringThe University of British ColumbiaVancouverBCV6T 1Z4Canada School of Chemical Engineering Sichuan UniversityChengduSichuan610065China

New materials for combating bacteria-caused infection and promoting the formation of microvascular networks during wound healing are of vital *** antibiotics can be used to prevent infection,treatments that can disinfect and accelerate wound healing are ***,we engineer a coating that is both highly compatible with current wound dressing substrates and capable of simultaneously disinfecting and revascularizing wounds using a metal-phenolic nanoplatform containing an alloyed nanostructured architecture(Ag@Cu-MPNNC).The alloyed nanostructure is formed by the spontaneous co-reduction and catalytic disproportionation reaction of multiple metal ions on a foundation metal-phenolic supramolecular *** synergistic presence of metals greatly improves the antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria,while demonstrating negligible cytotoxicity to normal *** infected rat models,the Ag@Cu-MPNNC could kill bacteria efficiently,promoting revascularization and accelerate wound closure with no adverse side effects in infected in vivo *** other words,this material acts as a combination therapy by inhibiting bacterial invasion and modulating bio-nano interactions in the wound.

关键词： Metal-phenolic network Wound healing Antibacterial activity Revascularization