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Intelligent reflecting surface-assisted federated learning in multi-platoon collaborative networks

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Digital Communications and Networks 2023年第3期9卷 628-637页

作者： Xiaoting ma junhui Zhao Jieyu Liao Ziyang Zhang School of Electronic and Information Engineering Beijing Jiaotong UniversityBeijing100044China China Telecom Corporation Limited Research Institute Beijing102209China School of Information Engineering East China Jiaotong UniversityNanchang330013China

Inspired by mobile edge computing(MEC),edge learning has gained a momentum by directly performing model training at network edge without sending massive data to a centralized data center.However,the quality of model training will be affected by the limited communication and computing resources of network edge.In this paper,how to improve the training performance of a federated learning system aided by intelligent reflecting surface(IRS)over vehicle platooning networks is studied,where multiple platoons train a shared federated learning model.Multi-platoon cooperation can alleviate the pressure of data processing caused by the limited computing resources of single platoon.Meanwhile,IRS can enhance the inter-platoon communication in a cost-effective and energy-efficient manner.Firstly,the federated learning optimization problem of maximizing the learning accuracy is formulated by jointing platoon scheduling,bandwidth allocation and phase shifts at the IRS to maximize the number of scheduled platoon.Specif-ically,in the proposed learning architecture each platoon updates the learning model with its own data and uploads it to the global model through IRS-based wireless networks.Then,a method based on sequential optimization algorithm(SOA)and a group-based optimization method are analyzed for single IRS aided and large-scale IRS aided commu-nication,respectively.Finally,a platoon scheduling scheme is designed based on the communication reliability and computing reliability of platoons.Simulation results demonstrate that large-scale IRS assisted communication can effectively improve the reliability of multi-user communication networks.The scheduling scheme based on learning reliability balances the communication performance and computing performance of platoons.

关键词： Vehicle platooning networks Federated learning Intelligent reflecting surface Platoon scheduling Resource allocation

REDUCED-RANK MODELING FOR HIGH-DIMENSIONAL MODEL-BASED CLUSTERING

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Journal of Computational mathematics 2018年第3期36卷 426-440页

作者： Lei Yang junhui Wang Shiqian ma Department of Environmental Medicine New York University New York NY USA Department of mathematics City University of Hong Kong Kowloon Tong Hong Kong Department of mathematics University of California Davis CA 95616 USA

Model-based clustering is popularly used in statistical literature, which often models the data with a Gaussian mixture model. As a consequence, it requires estimation of a large amount of parameters, especially when the data dimension is relatively large, in this paper, reduced-rank model and group-sparsity regularization are proposed to equip with the model-based clustering, which substantially reduce the number of parameters and thus facilitate the high-dimensional clustering and variable selection simultaneously. We propose an EM algorithm for this task, in which the M-step is solved using alternating minimization. One of the alternating steps involves both nonsmooth function and nonconvex constraint, and thus we propose a linearized alternating direction method of multipliers （ADMM） for solving it. This leads to an efficient algorithm whose subproblems are all easy to solve. In addition, a model selection criterion based on the concept of clustering stability is developed for tuning the clustering model. The effectiveness of the proposed method is supported in a variety of simulated and real examples, as well as its asymptotic estimation and selection consistencies.

关键词： Clustering Gaussian mixture model Group Lasso ADMM Reduced-rankmodel

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1617-1628页

作者： Shipeng He Junhui Ma Yuxin Fang Ying Liu Shanchao Wu Guoqiang Dong Wei Wang Chunquan Sheng Institute of Translational Medicine Shanghai UniversityShanghai 200444China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Pharmacology and Toxicology and BIO5 Institute University of ArizonaTucsonAZ 85721USA School of Medicine Tongji UniversityShanghai 200072China

The dose-related adverse effects of MDM2-P5 3 inhibitors have caused significant concern in the development of clinical safe anticancer agents.Herein we report an unprecedented homo-PROTAC strategy for more effective disruption of MDM2-P53 interaction.The design concept is inspired by the capacity of sub-stoichiometric catalytic PROTACs enabling to degrade an unwanted protein and the dual functions of MDM2 as an E3 ubiquitin ligase and a binding protein with tumor suppressor P53.The new homo-PROTACs are designed to induce self-degradation of MDM2.The results of the investigation have shown that PROTAC 11 a efficiently dimerizes MDM2 with highly competitive binding activity and induces proteasome-dependent self-degradation of MDM2 in A549 non-small cell lung cancer cells.Furthermore,markedly,enantiomer 11 a-1 exhibits potent in vivo antitumor activity in A549 xenograft nude mouse model,which is the first example of homo-PROTAC with in vivo therapeutic potency.This study demonstrates the potential of the homo-PROTAC as an alternative chemical tool for tumorigenic MDM2 knockdown,which could be developed into a safe therapy for cancer treatment.

关键词： Homo-PROTAC MDM2 Self-degradation In vivo antitumor activity

Effect of supports on the redox performance of pyrite cinder in chemical looping combustion

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Chinese Journal of Chemical Engineering 2021年第9期34卷 168-174页

作者： Zhong ma Chuan Yuan Shuai Zhang Yonggang Lu junhui Xiong School of Energy&Power Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory of High-Efficiency Utilization of Coal and Green Chemical Engineering Ningxia UniversityYinchuan 750021China Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China

Chemical looping combustion(CLC)is a clean and efficient flame-free combustion technology,which combust the fuels by lattice oxygen from a solid oxygen carrier with inherent CO_(2)capture.The development of oxygen carriers with low cost and high redox performance is crucial to the whole efficiency of CLC process.As the solid by-product from the sulfuric acid production,pyrite cinder presented excellent redox performance as an oxygen carrier in CLC process.The main components in pyrite cinder are Fe_(2)O_(3),CaSO_(4),Al_(2)O_(3)and SiO_(2)in which Fe_(2)O_(3)is the active component to provide lattice oxygen.In order to systematic investigate the functions of supports(CaSO_4,Al_(2)O_(3)and SiO_(2))in pyrite cinder,three oxygen carriers(Fe_(2)O_(3)-CaSO_(4),Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2))were prepared and evaluated in this study.The results showed that Fe_(2)O_(3)-CaSO_(4) displayed high redox activity and cycling stability in the multiple redox cycles.However,both Fe_(2)O_(3)-Al_(2)O_(3)and Fe_(2)O_(3)-SiO_(2)experienced serious deactivation during redox reactions.It indicated that the inert Fe-Si solid solution(Fe_(2)SiO_(4))was formed in the spent Fe_(2)O_(3)-SiO_(2)sample,which decreased the oxygen carrying capacity of this sample.The XPS results showed that the oxygen species on the surface of Fe_(2)O_(3)-CaSO_(4) could be fully recovered after the 20 redox cycles.It can be concluded that CaSO_(4) is the key to the high redox activity and cycling stability of pyrite cinder.

关键词： Chemical looping Pyrite cinder Supports Fixed-bed Redox performance Waste treatment

What is an effective cardiopulmonary resuscitation training mode?

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Chinese Medical Journal 2022年第9期135卷 1131-1132页

作者： Xiaojun He Yuefeng ma Zilong Li junhui Zhang Jinjun Zhang Jun Liang Chinese Journal of Emergency Medicine Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310009China China County Hospital Emergency Alliance HangzhouZhejiang 310009China Department of Emergency Yuyao People's HospitalNingboZhejiang 315400China SunLife Medical Technology Co. Ltd.Shanghai 200233China Beijing Emergency Medical Center Beijing 100031China

To the Editor:Out-of-hospital cardiac arrest(OHCA)is a serious threat to people's lives and safety.The annual incidence of OHCA in North America is approximately 55/100,000,and it is approximately 59/100,000 in Asia.[1,2]How can the success rate of resuscitation be improved in patients with cardiac arrest?The American Heart Association(AHA)and the European Resuscitation Council have put forward their own cardiopulmonary resuscitation(CPR)guidelines,which are constantly updated with the latest research evidence.CPR training is also an important part of the guidelines.[3,4]Chinese colleagues also try to improve the success rate of rescuing patients with cardiac arrest based on the experience of their international counterparts and combine it with Chinese characteristics.CPR training is in full swing,which includes the training of first responders and medical staff.

关键词： resuscitation cardiac combine

Genetic variation of wood tracheid traits and their relationships with growth and wood density in clones of Pinus tabuliformis

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Journal of Forestry Research 2018年第4期29卷 1014-1023页

作者： Fangqun Ouyang Jianwei ma Sanping An junhui Wang Yuhui Weng State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry Administration Research Institute of Forestry Chinese Academy of Forestry Beijing 100083 People's Republic of China Research Institute of Forestry of Xiaolong Mountain Tianshui 741020 Gansu People's Republic of China Arthur Temple College of Forestry and Agriculture Stephen F. Austin State University Nacogdoches TX 75962 USA

To improve wood quality for pulpwood industries, it is important to examine not only wood density but also its components, especially tracheid characteristics. We studied genetic variations in the following tracheid traits by earlywood （EW） and latewood （LW）： tracheid length （TL）, double wall thickness （WT）, radial lumen diameter （R_D1）, tangential lumen diameter （T_D1）, radial central diameter （R_D2）, and tangential central diameter （T_D2）. We also studied the relationship with the following growth traits： diameter at breast height （DBH）, height （H）, crown breadth south-north axis （NSC）, crown breadth east-west axis （EWC）, ring width （RW）, latewood percentage （LWP）, and wood density （WD）. All sample materials were collected from a 33-year old clonal seed orchard of Pinus tabuliformis Carr. Genetic variation among clones was moderate for all tracheid traits, 9.49-26.03%. Clones significantly affected WT, R_D1, R_D2, T_D1, T_D2, and the two ratios WT/R_D1 and TL/T_D2 in EW but had no effects in LW. Clones significantly affected TL in LW but had no effects in EW. H2/C was higher in LW （0.50） than in EW （0.20） for TL, while H 2/C was higher in EW （0.27-0.46） for other tracheid traits and the two ratios （TL/T_D2 and WT/R_D1） than in EW （0.06-0.22）. WD and TL were significantly positively correlated, but WT and TL were negatively correlated both at individual and clone levels; all tracheid diameters and the four ratio values （EW_WT/ R_D1, LW WT/R_D1, EW_TL/T_D2 and LW_TL/ T_D2）, were strongly positively correlated with DBH, H, NSC, WEC and RW, and strongly negatively correlated with WD both at individual and clone levels. The most important variables for predicting WD were LW_TL, EW_WT and R_D1 in both EW and LW （r2= 0.22）. Selecting the top 10% of the clones by DBH would improve DBH growth by 12.19% （wood density was reduced by 0.14%） and produced similar responses between EW and LW for all tracheid traits： a reduction of 0.94 and 3.69% in tracheid length and increases in tracheid diameters （from 0.36 to 5.24%） and d

关键词： Pinus tabuliformis Clone Tracheid traits Wood density Genetic variation Correlation coefficient

Overexpression of CfPIP1-1,CfPIP1-2,and CfPIP1-4 genes of Catalpa fargesii in transgenic Arabidopsis thaliana under drought stress

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Journal of Forestry Research 2021年第1期32卷 285-296页

作者： Wenjun ma Yao Xiao Yuan Li Pan Hu Zhi Wang Guijuan Yang junhui Wang State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and CultivationNational Forestry and Grassland AdministrationNational Forest Genetic Resource PlatformResearch Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101People’s Republic of China Central South University of Forestry and Technology Changsha 410004People’s Republic of China

Catalpa fargesii is an important economic tree species used for furniture and timber production because of its high density and hardness.Its survival and growth are severely aff ected and primarily limited by drought stress.Thus,to better understand the mechanism of drought resistance in C.fargesii,we used qRT-PCR to reveal signifi cantly diff erent expression of three plasma membrane intrinsic protein genes:CfPIP1-1,CfPIP1-2 and CfPIP1-4.We then cloned their full-length cDNA sequences and characterized the encoded proteins.We analyzed the genes phylogenetically and predicted conserved motifs,domains,and secondary and tertiary structures.To verify the function ofthe CfPIP1 genes further,we ectopically expressed CfPIP1 transgenes in Arabidopsis thaliana.The results showed that CfPIP1-1,CfPIP1-2 and CfPIP1-4 had several characteristics of aquaporins.The transgenic plants grew better than the WT plants did under drought stress,and overexpression of the CfPIP1 genes increased the plant water content and resistance to drought.Thus,CfPIP1-1,CfPIP1-2 and CfPIP1-4 of C.fargesii play key roles in regulating the intracellular and extracellular water balance and in mediating the plant response to drought.

关键词： Catalpa fargesii Drought tolerance PIP1 Aquaporin Heterologous transformation

Global Lysine Acetylome Analysis of Flower Bud Development in Catalpa bungei

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Phyton-International Journal of Experimental Botany 2022年第3期91卷 507-524页

作者： Danlong Jing Nan Wang Nan Lu Guanzheng Qu Guolu Liang Wenjun ma Shougong Zhang junhui Wang State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry and Grassland AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing100091China Key Laboratory of Horticulture Science for Southern Mountains Regions of Ministry of Education College of Horticulture and Landscape ArchitectureAcademy of Agricultural SciencesSouthwest UniversityChongqing400715China State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbin150040China

Lysine acetylation,a reversible and dynamic post-translational modification,plays pivotal roles in regulating many biological processes in plants.However,the information of lysine acetylation during flower development of woody angiosperm remains unclear.Herein,we identified a total of 667 lysine acetylation sites in 467 proteins in flower buds of Catalpa Bungei.The acetylated proteins were mainly involved in the pathways of carbon metabolism,glycometabolism and oxidative phosphorylation.Using functional enrichment analysis,61 and 13 acetylated proteins were involved in the glycometabolism and oxidative phosphorylation pathways,respectively.This suggests that lysine acetylated proteins play critical roles in the energy metabolism pathways.Accordingly,the protein–protein interactions were also highly enriched in the carbon metabolic pathway.Integrative analysis of lysine acetylome and transcriptome showed that transcript level changes of seven key lysine-acetylated proteins/genes involved in energy metabolism were significant different during floral transition.Importantly,compared with the normal flowering variety,the expression levels of phosphoribulokinase,phosphoenolpyruvate carboxykinase,ATP synthase and pyruvate dehydrogenase complex genes were significantly up-regulated at the stages of vegetative and transition buds during early flowering of C.bungei.These data represent the first lysine acetylome in the C.bungei flowers,and can serve as an essential basis for exploring the function of lysine acetylated proteins in the flower bud development of plants.

关键词： Lysine acetylome Catalpa bungei flower development energy metabolism

Genetic architecture of leaf morphology revealed by integrated trait module in Catalpa bungei

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Horticulture Research 2023年第4期10卷 161-173页

作者： Miaomiao Zhang Bingyang Liu Yue Fei Xiaowei Yang Linjiao Zhao Chaozhong Shi Yueying Zhang Nan Lu Chuangye Wu Wenjun ma junhui Wang State Key Laboratory of Tree Genetics and Breeding Key Laboratory of Tree Breeding and Cultivation of State Forestry AdministrationResearch Institute of ForestryChinese Academy of ForestryBeijing 100091China Academy of Forest and Grassland Inventory and Planning National Forestry and Grassland AdministrationBeijing 100714China Wenxian Forestry Science Research Institute Jiaozuo 454850China

Leaves are crucial for maintaining plant growth and development via photosynthesis,and their function is simultaneously regulated by a suite of phenotypic traits.Although much is known about the genetic architecture of individual leaf traits,unraveling the genetic basis of complex leafmorphology remains a challenge.Based on the functional correlation and coordination ofmulti-traits,we divided 15 leaf morphological traits into three modules,comprising size(area,length,width,and perimeter),shape(leaf lobes,aspect ratio,circularity,rectangularity,and the relevant ratios),and color(red,green,and blue)for an ornamental tree species,Catalpa bungei.A total of 189 significant single-nucleotide polymorphisms were identified in the leaves of C.bungei:35,82,and 76 in the size,shape,and color modules,respectively.Four quantitative trait loci were common between the size and shape modules,which were closely related according to phenotype correlation,genetic mapping,and mRNA analysis.The color module was independent of them.Synergistic changes in the aspect ratio,leaf lobe,and circularity suggest that these traits could be the core indicators of the leaf shape module.The LAS and SRK genes,associated with leaf lobe and circularity,were found to function in plant defense mechanisms and the growth of leaves.The associations between the SRK and CRK2 genes and the leaf lobe and circularity traits were further verified by RT-qPCR.Our findings demonstrate the importance of integrating multi-trait modules to characterize leaf morphology and facilitate a holistic understanding of the genetic architecture of intraspecific leaf morphology diversity.

关键词： circular integrating finding