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Phosphorylated p70S6K in urothelial carcinoma of the tumor recurrence noninvasive low-grade bladder： correlation with

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Asian Journal of Andrology 2014年第4期16卷 611-617页

作者： Soon-Ja Kim jung Hoon Kim Hui Seok jung Tae-jin Lee Kyung Mee Lee In Ho Chang Department of Convergence Medicine and Pharmaceutical Biosciences Chung-Ang University Graduate School Seoul Department of Urology Department of Pathology Chung-Ang University College of Medicine Seoul Korea.

We investigated whether inhibiting phosphorylated p70S6K （p-p70S6K） suppresses the proliferation and growth of noninvasive low-grade urothelial carcinoma （LG-URCa） in vitro and whether p-p70S6K can serve as a predictive biomarker for the recurrence of noninvasive LG-URCa of the bladder in patients. We constructed a tissue microarray （TMA） for 95 LG-URCa and 35 benign urothelium samples and performed immunohistochemical staining for p-p70S6K and p-4E-BP1. A Cox regression model was used to investigate the predictive factors for recurrence of LG-URCa. We investigated the dose-dependent antiproliferative effect of rapamycin, its antiproliferative effect and the growth-inhibition effect of p70S6K siRNA transfection in RT4 and 253J cell lines. The pT1 staged group （P 〈 0.05; hazard ratio （HR）, 2.415） and the high p-p70S6K staining group （P 〈 0.05; HR, 2.249） were independent factors for predicting recurrence. Rapamycin inhibited RT4 and 253J cell proliferation in a dose-dependent manner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 and 253J cell proliferation and growth were inhibited by the transfection of p70S6K siRNA and rapamycin, respectively （P 〈 0.05）. Transfection of p70S6K siRNA resulted in inhibitory effects on cell proliferation and growth that were similar to those of rapamycin. Our results suggest that inhibiting p70S6K phosphorylation is important to prevent recurrence and that p70S6K phosphorylation can be used as a molecular biomarker to predict recurrence of certain LG-URCa of the bladder.

关键词： bladder cancer p7OS6K

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Gold nanoparticle-assisted delivery of brain-derived neurotrophic factor to cerebral organoids

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Nano Research 2022年第4期15卷 3099-3105页

作者： Sung Bum Park Hye-jin Cho Sang Rin Moon Kyoung jin Choi Won Hoon jung Ki Young Kim Byumseok Koh Therapeutics and Biotechnology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea Chemical Platform Technology Division Korea Research Institute of Chemical Technology141 Gajeong-roYuseong-guDaejeon 34114Republic of Korea

Gold nanoparticle(AuNP)-assisted delivery of proteins/drugs to cells or in vivo systems has long been ***,their interaction with in vivo mimicking organoids is still largely ***,we conjugated brain-derived neurotropic factor(BDNF)to the AuNP surface and monitored how AuNP-BDNF interacts with cerebral *** suggest that AuNP-BDNF can successfully enter cerebral organoids and can be found up to 15.21μm inside cerebral ***-BDNF does not induce significant cytotoxicity to cerebral organoids at concentrations up to 2 nM and increases the expression of 75 genes compared to control cerebral *** data suggest the successful delivery of BDNF through AuNP-BDNF conjugation in cerebral organoids,and the conjugation can affect its differentiation.

关键词： gold nanoparticles cerebral organoids delivery penetration differentiation viability

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Inhibition of advanced glycation endproducts formation by Korean thistle,Cirsium maackii

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Asian Pacific Journal of Tropical Medicine 2015年第1期8卷 1-5页

作者： Hyun Ah jung jin Ju Park Byung Sun Min Hee jin jung Md.Nurul Islam Jae Sue Choi Department of Food Science and Human Nutrition Chonbuk National University Department of Food and Life Science Pukyong National University College of Pharmacy Catholic University of Daegu

Objective:To evaluate inhibitoy potential of seven Korean thistles against the advanced glyeatinn endproducts(AGE) formation as well as to identify responsible compounds from the most active ***:We used an in vitro AGE inhibition assay to evaluate the antidiabetic complication potential of the methanol extracts of the selected Korean ***:Among the seven Korean thistles,the leaves of Cirsium maackii(***) exhibited the most significant inhibitory activity against AGE *** means of bioassay-directed fractionation,a *** acid and 14 flavonoids were isolated from the active ethyl acetate soluble fraction of a methanol extract from *** *** and its 5-O-glueoside have been previously isolated:however,a lignan and 13 known compounds were isolated for the first lime from C maackii leaves in this *** of the isolated compounds exhibited inhibitory activities against potential AGE *** them,cernuoside was shown to be the most potent AGE inhibitor with an IC_(50) value of 21.21 μ mol/*** importantly,two major flavonoids,luteolin and ils 5-O-glucoside,also significantly inhibited AGE formation,with IC_(50) values of36.33 and 37.47 μmol/L,*** activity relationship revealed that the presence of free 3'and 4' dihydroxyl group in flavonoids skeleton played an important role in AGE ***:These results indicate that *** and C maackii-derived flavonoids might be explored further to develop therapeutic agents for the prevention of diabetic eoniplicalions due to their significant inhibitory activity against AGE formation.

关键词： Flavonoids Thistle Advanced glycation endproducts Diabetic complications Cirsium maackii

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Acute esophageal obstruction after ingestion of psyllium seed husk powder:A case report

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World Journal of Clinical Cases 2022年第7期10卷 2336-2340页

作者： Sujeong shin jung Ho Kim You Ho Mun Han Sol Chung Department of Emergency Medicine Yeungnam University School of Medicine and College of MedicineDaegu 42415South Korea

BACKGROUND Bezoar is a mass of hardened external material found in the gastrointestinal(GI)*** may form anywhere in the GI tract,but esophageal bezoar is rare because of the short esophageal transit *** seed husk is an indigestible natural derivative that is widely used as an herbal ***,we report a case of acute esophageal obstruction caused by a bezoar after ingestion of psyllium seed husk *** SUMMARY A 76-year-old male with Parkinson’s disease visited the emergency department with swallowing difficulty approximately 10 h after ingesting psyllium seed husk *** began a few hours after ingestion and progressed to severe *** were no abnormal findings on simple ***,a computed tomography scan revealed an approximately 2.0 cm×2.5 cm mass located near the gastro-esophageal *** grinding,the mass was removed using an endoscopic capture *** bezoars may cause life-threatening *** with Parkinson’s disease may have esophageal motility dysfunction,which may increase esophageal transit *** our patient had Parkinson’s disease,this effect may have contributed to the formation of the *** Attention should be paid to using bulk-laxatives,and an appropriate specified regimen will be needed when marketed as a dietary supplement.

关键词： Bezoar Esophagus Obstruction Parkinson’s disease Psyllium Case report

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Anti-scarring effects of butaprost on human subconjunctival Tenon's fibroblasts

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1028-1033页

作者： Jong Hoon shin Je Hyun Seo Jae Ho jung Tae Woo Kim Department of Ophthalmology Pusan National University Hospital Department of Ophthalmology Pusan National University Yangsan Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Ophthalmology Seoul National University College of MedicineSeoul National University Bundang Hospital

AIM： To investigate the toxicity of the E-prostanoid 2（EP2） receptor agonist, butaprost against human subconjunctival（Tenon＇s capsule） fibroblasts, and to determine the underlying mechanism. METHODS： We isolated Tenon＇s fibroblasts from the subconjunctival area of healthy subjects and evaluated the types of EP receptors expressed using quantitative realtime reverse transcription polymerase chain reaction（RTPCR）. The toxicity of butaprost against the fibroblasts was evaluated using methyl thiazolyl tetrazolium and lactic dehydrogenase assays. The inhibition of conjunctival fibroblast proliferation by butaprost was assessed by measuring α-actin levels. The underlying mechanism was assessed by measuring intracellular cyclic adenosine monophosphate（c AMP） levels. Intergroup differences were statistically analyzed using an independent t-test. Densitometry of the Western blot bands was performed using the Image J software. RESULTS： Quantitative real-time RT-PCR revealed that the fibroblast EP2 receptor levels were higher than those of the other EP receptors. Butaprost did not show toxicity against Tenon＇s tissue, but inhibited conjunctival fibroblast proliferation by reducing collagen synthesis. EP2 receptor activation enhanced the c AMP cascade, which might be an important mechanism underlying this ***： Butaprost effectively reduces the subconjunctival scarring response. Given the significanceof wound healing modulation in blebs, butaprost＇s inhibitory effect on subconjunctival Tenon＇s fibroblasts may be beneficial in managing postoperative scarring in glaucoma surgery.

关键词： butaprost Tenon's capsule trabeculectomy fibroblasts

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High-Throughput Pb Recycling for Perovskite Solar Cells Using Biomimetic Whitlockite

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Energy & Environmental Materials 2023年第3期6卷 170-176页

作者： jung Sug Hong Hee jung Kim Chang Hwun Sohn Oh Yeong Gong jin Hyuk Choi Kang Hee Cho Gill Sang Han Ki Tae Nam Hyun Suk jung Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon 16419Korea

Pb contamination in aquatic environments causes severe pollution;therefore,harmless absorbents are *** this study,we report a novel synthesis of whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12)),which is the second most abundant biomineral in human bone,and its application as a high-performing Pb^(2+)***(HAP)and WH are prepared via a simple precipitation *** Pb2+absorption performance and mechanism of the synthesized biominerals are investigated in aqueous solutions at neutral *** results demonstrate that WH exhibits an excellent Pb2+absorption capacity of 2339 mg g^(−1),which is 1.68 times higher than the recorded value for ***,the absorbed Pb^(2+) ions are recycled into high-purity PbI_(2).This is employed as a precursor for the fabrication of perovskite solar cells(PSCs),resulting in a conversion efficiency of 19.00%comparable to that of commercial PbI2 powder(99.99%purity).Our approach provides an efficient way to remove Pb^(2+)ions from water and reuse them in the recycling of PSCs.

关键词： Pb absorption Pb recycling perovskite solar cells water purification whitlockite

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Variation in Summer Surface Air Temperature over Northeast Asia and Its Associated Circulation Anomalies

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Advances in Atmospheric Sciences 2016年第1期33卷 1-9页

作者： Wei CHEN Xiaowei HONG Riyu LU Aifen jin Shizhu jin Jae-Cheol NAM jin-Ho shin Tae-Young GOO Baek-Jo KIM State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 University of Chinese Academy of Sciences Beijing 100049 Department of Geography Yanbian University Yanji 133002 National Institute of Meteorological Research Korea Meteorological Administration deju Korea

This study investigates the interannual variation of summer surface air temperature over Northeast Asia（NEA） and its associated circulation *** leading modes for the temperature variability over NEA are obtained by EOF *** first EOF mode is characterized by a homogeneous temperature anomaly over NEA and therefore is called the NEA *** anomaly extends from southeast of Lake Baikal to Japan,with a central area in Northeast *** second EOF mode is characterized by a seesaw pattern,showing a contrasting distribution between East Asia（specifically including the Changbai Mountains in Northeast China,Korea,and Japan） and north of this *** mode is named the East Asia（EA） *** modes contribute equivalently to the temperature variability in *** two leading modes are associated with different circulation anomalies.A warm NEA mode is associated with a positive geopotential height anomaly over NEA and thus a weakened upper-tropospheric westerly *** the other hand,a warm EA mode is related to a positive height anomaly over EA and a northward displaced *** addition,the NEA mode tends to be related to the Eurasian teleconnection pattern,while the EA mode is associated with the East Asia-Pacific/PacificJapan pattern.

关键词： surface air temperature Northeast Asia East Asia circulation anomaly interannual variability

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Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo Choi Jang-Hoon Kim Jun-Won Kim Da-Un jung Ji-Ho shin jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

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Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： jinwon Lim Hyo-jung Lee Bonglee Kim Jeong-Un Choi Yoeok shin Eun jung Sohn Sung-Hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

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Bowel function and quality of life after minimally invasive colectomy with D3 lymphadenectomy for right-sided colon adenocarcinoma

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World Journal of Gastroenterology 2020年第33期26卷 4972-4982页

作者： Ki-Myung Lee Se-jin Baek jung-Myun Kwak jin Kim Seon-Hahn Kim Department of Surgery Korea University College of MedicineSeoul 02841South Korea

BACKGROUND Changes in bowel function after right-sided colectomy are not well understood compared to those associated with left-sided colectomy or rectal *** particular,there are concerns about bowel function after right-sided colectomy with complete mesocolic excision,which has become popular in the *** To evaluate the functional outcomes of patients who underwent right-sided colectomy with D3 lymphadenectomy for colon *** Functional data from patients who underwent minimally invasive right-sided colectomy for colon cancer from October 2017 to September 2018 were prospectively *** outcomes were evaluated preoperatively and at 3,6,12,and 18 mo *** Prior to surgery,57 patients answered the questionnaire,and 47 responded at three months,52 at 6 mo,52 at 12 mo,and 25 at 18 mo *** scales of quality of life and bowel function improved significantly over *** persisted to a high degree throughout the period without a significant change over *** use of medications for defecation was about 10%over the entire ***(P=0.023)and fecal frequency(P<0.001)increased,and bowel dysfunction group(P=0.028)was more common among patients taking *** six months,resected bowel and colon lengths were significantly different as a risk factor between the dysfunction group and the no dysfunction group[odd ratio(OR):1.095,P=0.026;OR:1.147,P=0.031,respectively]in univariate analysis,but not in multivariate *** Despite D3 lymphadenectomy,most bowel symptoms improved over time after right-sided colectomy using a minimally invasive approach,and continuous medication was needed in only approximately 10%of patients.

关键词： Colonic neoplasm Right colectomy Bowel function D3 lymphadenectomy Complete mesocolic excision Quality of life

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