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Differential transcriptional regulation of the NANOG gene in chicken primordial germ cells and embryonic stem cells

Journal of Animal Science and Biotechnology 2021年第3期12卷 877-890页

作者： Hee jung Choi So Dam jin Deivendran Rengaraj jin Hwa Kim Bertrand Pain Jae Yong Han Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826South Korea Univ Lyon UniversitéLyon 1INSERMINRAEStem Cell and Brain Research InstituteU1208USC136169500 BronFrance Institute for Biomedical Sciences Shinshu UniversityMinamiminowaNagano 399-4598Japan

Background:NANOG is a core transcription factor(TF)in embryonic stem cells(ESCs)and primordial germ cells(PGCs).Regulation of the NANOG gene by TFs,epigenetic factors,and autoregulatory factors is well characterized in ESCs,and transcriptional regulation of NANOG is well established in these *** NANOG plays a key role in germ cells,the molecular mechanism underlying its transcriptional regulation in PGCs has not been ***,we investigated the mechanism that regulates transcription of the chicken NANOG(cNANOG)gene in PGCs and ***:We first identified the transcription start site of cNANOG by 5′-rapid amplification of cDNA ends PCR ***,we measured the promoter activity of various 5′flanking regions of cNANOG in chicken PGCs and ESCs using the luciferase reporter *** expression required transcriptional regulatory elements,which were positively regulated by POU5F3(OCT4)and SOX2 and negatively regulated by TP53 in *** proximal region of the cNANOG promoter contains a positive transcriptional regulatory element(CCAAT/enhancer-binding protein(CEBP)-binding site)in ***,small interfering RNA-mediated knockdown demonstrated that POU5F3,SOX2,and CEBP played a role in cell type-specific transcription of ***:We show for the first time that different trans-regulatory elements control transcription of cNANOG in a cell type-specific *** finding might help to elucidate the mechanism that regulates cNANOG expression in PGCs and ESCs.

关键词： Chicken Embryonic stem cells NANOG gene Primordial germ cells Regulatory elements

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Recent research progress on magnesium alloys in Korea:A review

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Journal of Magnesium and Alloys 2023年第10期11卷 3545-3584页

作者： Sung Hyuk Park Ye jin Kim Hyun Ji Kim Sang-Cheol jin Jong Un Lee Alexander Komissarov Kwang Seon shin School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Laboratory of Hybrid Nanostructured Materials National University of Science and TechnologyMoscow 119049Russia Laboratory of Medical Bioresorption and Bioresistance Moscow State University of Medicine and DentistryMoscow 127473Russia Magnesium Technology Innovation Center School of Materials Science and EngineeringSeoul National UniversitySeoul 08826Republic of Korea

This review highlights the recent advancements in Mg research in South Korea with a prime focus on high-speed-extrudable Mg–Bi-based alloys for high productivity and strength,innovative techniques utilizing{10–12}twinning for improved mechanical properties,and alloying and processing methods for enhanced corrosion ***-alloyed Mg–Bi-based alloys possess thermally stableα-Mg matrix and secondary phase,which ensures high-speed extrusion of these alloys at elevated temperatures without hot ***,they exhibit outstanding extrudability with a maximum extrusion speed of up to 70 m/***,their high alloying contents offer excellent strength even after high-speed extrusion through strong solid solution hardening and particle hardening effects,making them suitable for high-performance extruded Mg *** pre-twinning process utilizing{10–12}twinning and the combined process of pre-twinning and subsequent annealing have shown promise in controlling microstructure and texture of wrought Mg alloys and thus enhancing their mechanical *** pre-twinning process enhances tensile strength,fatigue properties,and age-hardening rate of Mg ***,the combined processes of pre-twinning and subsequent annealing considerably improve their ductility,stretch formability,bending formability,and damping *** have been made to improve the corrosion resistance of Mg alloys through alloying additions,process treatments,and surface *** elements like Ca,Sc,and Sm alter the microstructural features(such as secondary phases and grain size)that affect the corrosion *** treatments such as multidirectional forging,screw rolling,and pulse electron beam can also improve the corrosion resistance by refining the ***,advanced surface coating technologies can create durable and corrosion-resistant layers for effectively protecting the Mg *** these research activities conducted

关键词： South Korea Mg–Bi alloys {10–12}twinning Corrosion Mechanical properties

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Evaluation of recurrence in gastric carcinoma: Comparison of contrast-enhanced computed tomography and positron emission tomography/computed tomography

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World Journal of Gastroenterology 2017年第35期23卷 6448-6456页

作者： Jong Hyeon Kim Suk Hee Heo jin Woong Kim Sang Soo shin jung Jun Min Seong Young Kwon Yong Yeon Jeong Heoung Keun Kang Department of Radiology Chonnam National University Medical SchoolChonnam National University Hwasun Hospital Department of Radiology Chonnam National University Medical SchoolChonnam National University Hospital Department of Nuclear Medicine Chonnam National University Medical SchoolChonnam National University Hwasun Hostpital

AIM To compare the value of contrast-enhanced abdominal computed tomography(CT) and fluorodeoxyglucose(FDG) positron emission tomography/computed tomography(PET/CT) for detecting gastric carcinoma *** We retrospectively examined data from 2475 patients who underwent both contrast-enhanced abdominal CT and FDG PET/CT for the surveillance of gastric carcinoma curative resection. Patients had an interval of less than 1 mo between their CT and PET/CT scans. Sixty patients who had recurrence were enrolled. Among 1896 patients who did not have recurrence, 60 were selected by simple random sampling. All CT and PET/CT images were reviewed retrospectively by two reviewers blinded to all clinical and pathologic information except curative resection due to gastric carcinoma. RESULTS The pathological stage of the recurrence group was statistically significantly higher than that of the control group(P < 0.001). In the 60 patients who had recurrence, there were 79 recurrent lesions. Fortyfour patients had only one location of recurrence, 13 patients had two locations, and 3 patients had three. In the detection of patient-based overall recurrence, no statistically significant differences existed between the two modalities(P = 0.096). However, for peritoneal carcinomatosis, CT had a statistically significantly higher sensitivity compared to PET/CT(96% vs 50%, P = 0.001). Adenocarcinoma was the most common type of gastric carcinoma. On the pathology-based analysis, CT also had a statistically significantly higher sensitivity compared to PET/CT(98% vs 80%, P = 0.035).CONCLUSION Contrast-enhanced CT was superior to PET/CT in the detection of peritoneal carcinomatosis and pathologic type of adenocarcinoma.

关键词： Gastric carcinoma Surgery Contrastenhanced abdominal computed tomography Fluorodeoxyglucose positron emission tomograph/computed tomography Surveillance Recurrence

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Effect of Zhubin(KI9) Acupuncture in Reducing Alcohol Craving in Patients with Alcohol Dependence:A Randomized Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2015年第4期21卷 307-311页

作者： jin-Seong Lee Sung-Gon Kim Taek-Geun jung Woo Young jung Seong-Yeon Kim Department of Psychiatry Pusan National University Yangsan Hospital Biomedical Research Institute Pusan National University Hospital Jang-Cheon Korean Medicine Clinic Division of Management Information Science(S-YK) Dong-A University

Objective： To examine the effect of acupuncture on Zhubin （KI9） in reducing alcohol craving in alcohol-dependent patients. Methods： Twenty male alcohol-dependent patients were randomly assigned to two groups, a treatment group （10 cases, age 43.0 ± 6.8 years） and a placebo group （10 cases, age 44.5 ± 7.9 years）. The treatment group was treated with real needle acupuncture on Zhubin （KI9） twice a week for 4 weeks, and the control group was treated with placebo needle acupuncture. Both groups were given acupuncture treatment using Park Sham Device （PSD）. Alcohol craving was measured by the Visual Analogue Scale （VAS） before treatment to establish a baseline, and after 1, 2, and 4 weeks of treatment. Repeated measures ANOVA was used to determine the main and interaction effects of time and on the outcome measure （VAS）. Results： There was a significant effect of time on VAS score （dr=3, F=13.3, P〈0.01）. Main effect of group on VAS score was significant （df=1, F=10.9, P〈0.01） and the time × group interaction was also significant （df=3, F=4.7, P〈0.01）. Conclusions： Real-needle acupuncture therapy on Zhubin （KI9） showed effectiveness in reducing alcohol craving. These results strongly suggest the usefulness of acupuncture therapy on Zhubin （KI9） in preventing a relapse in alcohol dependent patients.

关键词： alcohol craving alcohol dependence acupuncture Zhubin (KI9)

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A new technique for Nd:YAG laser posterior capsulotomy

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 345-349页

作者： jung Kee Min Jae Hwan An jin Ho Yim Department of Ophthalmology Ulsan University HospitalUlsan University College of Medicine 290-3 Jeonha-dongDong-gu Ulsan 682-714 Republic of Korea Samsung Eye Clinic Cheongju 361-270 Republic of Korea

AIM:To investigate the effects of a new opening pattern in neodymium:yttrium-aluminum-garnet(Nd:YAG)laser posterior capsulotomy on visual ***:This technique was conducted along a circular *** energy ranged between 0.8 and1.2 mJ/pulse was consumed and mean total energy levels were 74±21 mJ(mean±standard deviation:SD,from 40 to167)and laser shots aimed at 150μm away behind a datum point and went along an imaginary line which extends 0.5 mm inside from optic margin and into the circular en bloc *** stands were attached with fragment and then they were cut off by the laser after circular *** circular fragment was completely separated from vitreous,and then this fragment was quickly sunk in intravitreal ***:The follow-up period ranges from at least a week to 40mo,making 15.8mo on *** procedural outcome showed 96%(74 eyes out of the 77eyes)enhancement in patients’visual *** macular edema or retinal detachment was not observed in any of the patients during follow-up ***:This new technique is expected to improve the weaknesses that the conventional procedures have by adding the process to cut off vitreous stands attached with the fragment by the laser to the circular application.

关键词： cataract intraocular lens damage posterior capsular opacification vitreous strand YAG laser capsulotomy

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Fabrication of Polythiophene Patterns through Blending of a Thermally Curable Polythiophene with Poly(methyl methacrylate) and Selective Thermal Curation

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Chinese Journal of Polymer Science 2017年第3期35卷 422-433页

作者： Mushtaque A.Memon jin-hua Sun Hee-Tae jung 闫寿科耿建新 State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology Beijing 100029 China Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China National Research Laboratory Department of Chemical and Biomolecular Engineering (BK-21) Korea Advanced Institute of Science and Technology 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 Korea

In this study, we demonstrate a novel method for fabricating polythiophene patterns, i.e., cylindrical holes and cylinders, through blending of a thermally curable polythiophene carrying with tertiary ester groups(PT-tert-ESTER) and poly(methyl methacrylate)(PMMA), followed by thermal conversion of the PT-tert-ESTER to an insoluble polythiophene via low-temperature cleavage of the tertiary ester groups and removal of the PMMA component via ultraviolet degradation. We show that the surface polarity of substrates, the mass ratio of PT-tert-ESTER to PMMA in the blend solutions as well as the concentration of the blend solutions strongly influence the formation of the polythiophene patterns. Cylindrical holes are more readily formed on less polar substrates when a PT-tert-ESTER dominated blend solution is used, while cylinders are more readily formed on more polar substrates when a PMMA dominated blend solution is used. Moreover, the diameters of both the cylindrical holes and the cylinders decrease as the PT-tert-ESTER concentration is increased in the respective ranges of the PT-tert-ESTER/PMMA ratios where the patterns are formed. Grazing incident X-ray diffraction data have indicated that the patterning of the PT-tert-ESTER component in the blend films improves the crystallinity of PT-tert-ESTER as well as the molecular packing of the insoluble polythiophene in the resultant patterned polythiophene films.

关键词： Polythiophene Patterns Cylindrical holes Cylinders Blending

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An Asynchronous Clustering and Mobile Data Gathering Schema Based on Timer Mechanism in Wireless Sensor Networks

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Computers, Materials & Continua 2019年第3期58卷 711-725页

作者： jin Wang Yu Gao Wei Liu Wenbing Wu Se-jung Lim Hunan Provincial Key Laboratory of Intelligent Processing of Big Data on Transportation School of Computer&Communication EngineeringChangsha University of Science&TechnologyChangsha410114China School of Information Science and Engineering Fujian University of TechnologyFuzhou350000China College of Information Engineering Yangzhou UniversityYangzhou225000China Department of Computer Engineering Chonnam National UniversityYeosu596597Korea.

Recently,Wireless sensor networks(WSNs)have become very popular research topics which are applied to many *** provide pervasive computing services and techniques in various potential applications for the Internet of Things(IoT).An Asynchronous Clustering and Mobile Data Gathering based on Timer Mechanism(ACMDGTM)algorithm is proposed which would mitigate the problem of“hot spots”among sensors to enhance the lifetime of *** clustering process takes sensors’location and residual energy into consideration to elect suitable cluster ***,one mobile sink node is employed to access cluster heads in accordance with the data overflow time and moving time from cluster heads to *** experimental results display that the presented method can avoid long distance communicate between sensor ***,this algorithm reduces energy consumption effectively and improves package delivery rate.

关键词： Internet of things wireless sensor networks clustering mobile data collection timer.

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Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke

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Neural Regeneration Research 2022年第7期17卷 1556-1565页

作者： Hong Ju Lee Da Hee jung Nam Kwen Kim Hwa Kyoung shin Byung Tae Choi Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanRepublic of Korea Graduate Training Program of Korean Medicine for Healthy Aging Pusan National UniversityYangsanRepublic of Korea Department of Korean Ophthalmology Otolaryngology and DermatologySchool of Korean MedicinePusan National UniversityYangsanRepublic of Korea

Neural/glial antigen 2(NG2)-expressing cells has multipotent stem cell activity under cerebral *** study examined the effects of electroacupuncture(EA)therapy(2 Hz,1 or 3 mA,20 minutes)at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic *** stimulation alleviated motor deficits caused by ischemic stroke,and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control treatment with edaravone,a free radical *** properties of NG2-expressing cells were altered with 1 mA EA stimulation,enhancing their survival in perilesional brain tissue via reduction of tumor necrosis factor alpha *** stimulation robustly activated signaling pathways related to proliferation and survival of NG2-expressing cells and increased the expression of neurotrophic factors such as brain-derived neurotrophic factor,tumor growth factor beta,and neurotrophin *** the perilesional striatum,EA stimulation greatly increased the number of NG2-expressing cells double-positive for oligodendrocyte,endothelial cell,and microglia/macrophage markers(CC1,CD31,and CD68).EA therapy also greatly activated brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase kinase 3 beta *** results indicate that EA therapy may prevent functional loss at the perilesional site by enhancing survival and differentiation of NG2-expressing cells via the activation of brain-derived neurotrophic factor-induced signaling,subsequently ameliorating motor *** animal experiments were approved by the Animal Ethics Committee of Pusan National University(approval ***2019-2199 and PNU2019-2884)on April 8,2019 and June 19,2019.

关键词： brain-derived neurotrophic factor differentiation electroacupuncture motor function neural/glial antigen 2 perilesional striatum stroke survival

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Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

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Chinese Chemical Letters 2015年第1期26卷 36-38页

作者： shin-ichi Kawano Hong-Yuan Hao Yuki Hashi jin-Ming Lin Department of Chemistry Beijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University Shimadzu Global COE for Application & Technical Development Shimadzu(China)Co.Ltd.

hloramphenicol is an antibiotic and one of the potential contaminants in ***-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in *** this work,an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive,reliable and higher throughput analysis was *** the methylcellulose-immobilized reversed-phase column,sugars in a honey sample were efficiently removed in 1 *** a result,the limit of quantitation of chloramphenicol was 20 pg/mL（0.2 μg/kg honey）.

关键词： On-line pretreatment Liquid chromatography-mass spectrometry Chloramphenicol Honey

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Subcarrier BD with Cooperative Communication for MIMO-NOMA System

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Computers, Materials & Continua 2022年第9期72卷 5807-5821页

作者： jung-In Baik Ji-Hwan Kim Beom-Sik shin Ji-Hye Oh Hyoung-Kyu Song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea

With the rapid evolution of Internet of things(IoT),many edge devices require simultaneous connection in 5G communication *** afford massive data of IoT devices,multiple input multiple output non-orthogonal multiple access(MIMO-NOMA)method has been considered as a promising ***,there are numerous drawbacks due to error propagation and inter-user ***,proposed scheme aims to improve the reliability of the MIMO-NOMA system with digital beamforming and intracluster cooperative multi point(CoMP)to efficiently support IoT *** the conventional MIMO-NOMA system,user entities are grouped into *** diagonalization(BD)is applied to efficiently eliminate the inter-cluster interference of the MIMO-NOMA ***,since the channel path of the data stream from a single antenna to a single cluster doesn’t hold other cluster’s data,the system can’t fully utilize the selective subcarrier channel *** indicates that there can be better channel paths for a data stream at a certain subcarrier ***,proposed scheme allocates data streams to antennas adaptively considering selective channel ***,intra-cluster CoMP method is adjusted to enhance the reliability of the system in the *** simulation results show that the proposed scheme improves BER and throughput performance compared to the conventional MIMO-NOMA system.

关键词： 5G MIMO-NOMA CoMP BD interference

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