Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

作     者：Shin-ichi Kawano Hong-Yuan Hao Yuki Hashi Jin-Ming Lin 

作者机构：Department of ChemistryBeijing Key Laboratory of Microanalytical Methods and InstrumentationTsinghua University Shimadzu Global COE for Application & Technical DevelopmentShimadzu(China)Co.Ltd. 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2015年第26卷第1期

页      面：36-38页

核心收录：

学科分类：07[理学] 09[农学] 070302[理学-分析化学] 0903[农学-农业资源与环境] 0703[理学-化学] 

基　　金：supported by the National Natural Science Foundation of China(No.21227006) the Research Fund for the Doctoral Program of Higher Education(No.20110002110052) 

主　　题：On-line pretreatment Liquid chromatography-mass spectrometry Chloramphenicol Honey 

摘      要：hloramphenicol is an antibiotic and one of the potential contaminants in honey.Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey.In this work,an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive,reliable and higher throughput analysis was developed.With the methylcellulose-immobilized reversed-phase column,sugars in a honey sample were efficiently removed in 1 min.As a result,the limit of quantitation of chloramphenicol was 20 pg/mL（0.2 μg/kg honey）.