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Asian Herpetological Research 2011年第4期2卷 223-229页

作者： jung-hyun lee Daesik PARK Department of Biology Kangwon National UniversityChuncheonKangwon 200-701South Korea Department of Environmental Resources Research National Institute of Environmental ResearchSeo-GuIncheon 404-708South Korea Division of Science Education Kangwon National UniversityChuncheonKangwon 200-701South Korea

The translocation of snakes has been viewed as a useful tool to augment declining populations and to mitigate human-wildlife conflicts, even though released snakes often exhibit relatively high mortality. We radio-tracked 13 Amur Ratsnakes （Elaphe schrenckii） in the Woraksan National Park in South Korea from July 2008 to May 2009. Two of these snakes were residents, and 11 had been illegally captured in areas remote from the study site and were donated by the park office. During the study period, six of the translocated snakes were lost： two were killed by predators, one died of unknown causes, and the radio signals of three of the snakes were lost. In the field, the ratsnakes laid eggs in early August, moved into hibemacula in late November, and moved away from the hibemacula in mid-April. Compared to the resident snakes, five of the translocated snakes traveled approximately 1.3 times farther per week, and the home ranges of the translocated snakes were three to six times larger than those of the resident snakes. In addition, the translocated snakes were found underground more frequently than the resident snakes. The management recommendations resulting from this study will guide biologists and land use managers in making appropriate decisions regarding release sites and the use of gravid females in the translocation of this endangered ratsnake.

关键词： Amur Ratsnake conservation Elaphe schrenckii radiotelemetry translocation

Inverse relationship between bioavailable testosterone and subclinical coronary artery calcification in non-obese Korean men

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Asian Journal of Andrology 2012年第4期14卷 612-615页

作者： Byoung-Jin Park Jae-Yong Shim Yong-Jae lee jung-hyun lee Hye-Ree lee Department of Family Medicine Yonsei University College of Medicine Seou1135-720 Korea Department of Health Promotion Center Gangnam Severance Hospita Yonsei University College of Medicine Seou1135-720 Korea

Although low testosterone levels in men have been associated with high risk for cardiovascular disease, little is known about the association between male sex hormones and subclinical coronary disease in men with apparently low cardiometabolic risk. This study was performed to investigate the association between male sex hormones and subclinical coronary artery calcification measured as coronary calcium score in non-obese Korean men. We examined the relationship of total testosterone, sex hormone-binding globulin, bioavai lable testosterone and free testosterone with coronary calcium score in 291 non-obese Korean men （mean age： 52.8--- 9.3 years） not having a history of cardiovascular disease. Using multiple linear regression, we evaluated associations between log （sex hormone） levels and log （coronary calcium score） after adjusting for confounding variables in 105 men with some degree of coronary calcification defined as coronary calcium score ~〉 1. In multiple linear regression analysis, bioavailable testosterone was inversely associated with coronary calcium score （P=0.046） after adjusting for age, body mass index, smoking status, alcohol consumption, regular exercise, mean blood pressure, resting heart rate, C-reactive protein, fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein （HDL） cholesterol, hypertension medication and hyperlipidernia medication, whereas total testosterone, sex hormone-binding globulin and free testosterone were not （P=0.674, P=O. 121 and P=O. 102, respectively）. Our findings indicate that bioavailable testosterone is inversely associated with the degree of subclinical coronary artery calcification in non-obese men.

关键词： bioavailable testosterone cardiovascular disease coronary calcium score male sex hormone subclinical coronary arterydisease testosterone

Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves'ophthalmopathy

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World Journal of Pediatrics 2014年第2期10卷 155-159页

作者： jung hyun lee So hyun Park Dae Gyun Koh Byung Kyu Suh Department of Pediatrics the Catholic University of KoreaSt.Vincent's Hospital93-6Ji-dongPaldal-guSuwon-siGyeonggi-doRepublic of Korea Department of Pediatrics the Catholic University of KoreaSeoul St.Mary's Hospital222 Banpo-daeroSeocho-guSeoulRepublic of Korea

Background:Graves'ophthalmopathy(GO)occurs commonly in children with Graves'disease(GD).However,there are limited studies on the clinical manifestations and thyroid autoantibodies in pediatric *** aim of this study was to investigate the prevalence and risk factors of GO in childhood ***:Clinical and biochemical data from children and adolescents with GD were retrospectively *** patients under 19 years of age were included in the present *** compared the clinical and biochemical differences between patients with and without ***:Thirty-nine percent of the patients had GO,and 81%of the GO patients were *** these,two patients showed unilateral ***(T3)levels were higher in GO patients than in those without ***-thyroglobulin antibody and thyroid stimulating hormone receptor antibody titers were not significantly different between the two ***-thyroid peroxidase antibody(TPO Ab)positivity was 68%in the patients with GO and only 47%in the patients without *** multivariate regression analysis,high T3 levels and TPO Ab positivity were related to the presence of ***:In children and adolescents with GD,TPO Ab positivity and high T3 levels could act as predictive factors for the presence of GO.

关键词： Graves'disease Graves'ophthalmopathy pediatrics thyroid peroxidase antibody triiodothyronine

Effect of Dioscorea batatas on longitudinal bone growth rate in adolescent female rats

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中国药理学与毒理学杂志 2015年第S1期29卷 103-104页

作者： hyun Soo KIM Donghun lee Young-Sik KIM jung-bin SONG hyun jung lee Seunggyeong lee Sung hyun lee Juyeon PARK Hocheol KIM Department of Herbal Pharmacology College of Korean Medicine Kyung Hee University Seoul Kirea Korea Institute of Science and Technology for Eastern Medicine NeuMed Inc. Seoul Korea

OBJECTIVE The root of Dioscorea batatas,rich in steroidal saponins,alkaloids,tannins,phytosterols,and starch,is an herbal medicine of tonifying qi and nourishing stomach after invigorating spleen with a long history of safe use for treatment of chronic dysentery and weakness of the spleen and stomach in *** study was aimed to investigate the effect of *** on longitudinal bone growth rate in adolescent female *** *** was extracted with 30% EtOH for 3h at 90℃in a reflux *** two groups,we administered a twice daily dosage of *** extract(at 30 and 300mg·kg-1,respectively)per os for 4d,and in a control group,we administered vehicle only under the same *** human growth hormone(rhGH)was subcutaneously injected once *** rats were born at same day(33d-old).On day 3,tetracycline was injected intraperitoneally to form a fluorescent band on the growth *** The bone growth rate in groups administered *** 300mg·kg-1 and rhGH was significantly increased to 343.8±20.7,and 359.6±30.2μm·d-1 respectively from control group,320.7±23.2μm·*** difference was observed in the amount of food intake or mean body weight among all groups during the acclimation or administration *** These results suggest that *** extracts have the potential to induce height increase;however,further research,including clinical trials,is necessary.

关键词： Dioscorea batatas longitudinal bone growth rhGH te

Applications of scaffolds:Tools for enhancing the immunomodulation of mesenchymal stromal cells

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BIOCELL 2022年第6期46卷 1439-1443页

作者： OK-HYEON KIM EUN RAN KIM JUN hyunG PARK hyun jung lee Department of Anatomy and Cell Biology College of MedicineChung-Ang UniversitySeoul06974South Korea Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974South Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteCollege of MedicineYonsei UniversitySeoul03722South Korea

Exogenously delivered mesenchymal stromal cells(MSCs)are therapeutically beneficial owing to their paracrine effect;they secrete various cytokines,nucleic acids,and *** bioengineering techniques can help MSC cultures to release secretomes by providing stem cell niche-like conditions(both structurally and functionally).Various scaffolds mimic the natural extracellular matrix(ECM)using both natural and synthetic polymers,providing favorable environments for MSC proliferation and *** on material properties,either topographically or elastically structured scaffolds can be ***-dimensional scaffolds have tunable substrate rigidities and structures,aiding MSC *** ECM-derived hydrogels are similar to the natural ECM,thus improving the paracrine effects of ***,we discuss recent research on the application of scaffolds to maximize the immunomodulatory function of MSCs.

关键词： Extracellular matrix(ECM) Immunomodulation Mesenchymal stromal cells(MSCs) Scaffolds Stem cell niche

Molecular phylogenetic analyses based on the complete plastid genomes and nuclear sequences reveal Daphne(Thymelaeaceae)to be non-monophyletic as current circumscription

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Plant Diversity 2022年第3期44卷 279-289页

作者： Shiou Yih lee Ke-Wang Xu Cui-Ying Huang jung-hyun lee Wen-Bo Liao Yong-Hong Zhang Qiang Fan State Key Laboratory of Biocontrol and Guangdong Provincial Key Laboratory of Plant Resources School of Life SciencesSun Yat-sen University510275GuangzhouChina Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the EnvironmentKey Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity ConservationNanjing Forestry University219937NanjingChina Department of Biology Education Chonnam National University61186GwangjuRepublic of Korea School of Life Sciences Yunnan Normal University650001KunmingChina Faculty of Health and Life Sciences INTI International University71800NilaiMalaysia

The diverse members of the genus Daphne are prized for their fragrant *** being promising ornamental plants in many countries,genetic information of Daphne is *** this study,the plastomes of four species and one variety of Daphne were sequenced and *** plastomes were typical and contained a pair of inverted repeat(IR)regions that separated the large single-copy(LSC)region from the small single-copy(SSC)*** a length ranging from 132,869 bp(***)to 174,773 bp(***),106 to 141 genes were *** plastome analysis of the newly sequenced plastomes with four publicly available Daphne plastomes identified an expansion of the IRs,sequence variations,and mutational *** analyses indicated that the genus Daphne in its current circumscription is *** genkwa was nested within the genus Wikstroemia,while *** was well resolved as sister to *** findings concurred with results from our study that used nuclear ribosomal internal transcribed spacer sequence *** conflicts on the molecular placement of *** and *** and the present taxonomic classification in Daphne suggest that a new intergeneric classification system of Daphneae warrants consideration.

关键词： Daphneae Comparative plastome analysis Internal transcribed spacer region Polyphyletic relationship Wikstroemia

Tonsil-derived stem cells as a new source of adult stem cells

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World Journal of Stem Cells 2019年第8期11卷 506-518页

作者： Kyung-Ah Cho hyun jung lee Hansaem Jeong Miri Kim Soo Yeon jung Hae Sang Park Kyung-Ha Ryu Seung Jin lee Byeongmoon Jeong Hyukjin lee Han Su Kim Department of Microbiology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 03760 South Korea College of Pharmacy Graduate School of Pharmaceutical Sciences Ewha Womans University Seoul 03760 South Korea Department of Otorhinolaryngology College of Medicine Ewha Womans University Seoul 07985 South Korea Department of Otorhinolaryngology College of Medicine Hallym University Chuncheon 24252 South Korea Department of Pediatrics College of Medicine Ewha Womans University Seoul 07985 South Korea

Located near the oropharynx, the tonsils are the primary mucosal immune organ. Tonsil tissue is a promising alternative source for the high-yield isolation of adult stem cells, and recent studies have reported the identification and isolation of tonsil-derived stem cells (T-SCs) from waste surgical tissue following tonsillectomies in relatively young donors (i.e., under 10 years old). As such, TSCs offer several advantages, including superior proliferation and a shorter doubling time compared to bone marrow-derived mesenchymal stem cells (MSCs). T-SCs also exhibit multi-lineage differentiation, including mesodermal, endodermal (e.g., hepatocytes and parathyroid-like cells), and even ectodermal cells (e.g., Schwann cells). To this end, numbers of researchers have evaluated the practical use of T-SCs as an alternative source of autologous or allogenic MSCs. In this review, we summarize the details of T-SC isolation and identification and provide an overview of their application in cell therapy and regenerative medicine.

关键词： Stem cell Tonsil-derived stem cell Differentiation Endoderm Mesoderm Ectoderm Cell therapy

Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

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World Journal of Gastroenterology 2020年第37期26卷 5661-5672页

作者： Eun Ae Kang Jaeyoung Chun Jee hyun Kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong jung Min Moon Jooyoung lee hyun jung lee Jun-Beom Park Jong Pil Im Joo Sung Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06229South Korea Department of Internal Medicine Bundang CHA Medical CenterCHA University School of MedicineSeoul 13496South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Periodontics the Catholic University of Korea College of MedicineSeoul 06591South Korea

BACKGROUND Periodontitis is a chronic inflammation of periodontal *** effect of periodontitis on the development of inflammatory bowel disease(IBD)remains *** To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to *** A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance *** total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were *** diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until *** A total of 1092825 individuals(11.0%)had *** was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular *** mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),*** mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,*** mean follow-up duration was 7.26 *** with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical *** smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without *** Periodontitis was significantly associated with the risk of developing UC,b

关键词： Inflammatory bowel disease Periodontitis Smoking Ulcerative colitis Crohn’s disease

Trends and risk factors of elderly-onset Crohn’s disease: A nationwide cohort study

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World Journal of Gastroenterology 2020年第4期26卷 404-415页

作者： jung Min Moon Eun Ae Kang Kyungdo Han Seung Wook Hong Hosim Soh Seona Park Jooyoung lee hyun jung lee Jong Pil Im Joo Sung Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of MedicineSeoul 03080South Korea Department of Biostatistics College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND The incidence of inflammatory bowel disease(IBD)is increasing in *** risk factors associated with IBD development have been *** To investigate trends and environmental risk factors of Crohn’s disease(CD)diagnosed in persons aged≥40 years in South *** Using the National Health Insurance Service database,a total of 14060821 persons aged>40 years who underwent national health screening in 2009 were followed up until December *** with newly diagnosed CD were enrolled and compared with non-CD *** was identified according to the International Classification of Diseases 10th revision and the rare/intractable disease registration program codes from the National Health Insurance Service *** mean follow-up periods was 7.39 ***,sex,diabetes,hypertension,smoking,alcohol consumption,regular exercise,body mass index,anemia,chronic kidney disease(CKD)and dyslipidemia were adjusted for in the multivariate analysis *** During the follow-up,1337(1.33/100000)patients developed *** in the middle-aged group(40-64 years)had a higher risk than women[adjusted hazard ratio(aHR)1.46,95%confidence interval(CI):1.29-1.66];however,this difference tended to disappear as the age of onset *** the middle-aged group,patients with a history of smoking[(aHR 1.46,95%CI:1.19-1.79)and anemia(aHR 1.85,95%CI:1.55-2.20)]had a significantly higher CD *** the elderly group(age,≥65 years),ex-smoking and anemia also increased the CD risk(aHR 1.68,95%CI:1.22-2.30)and 1.84(95%CI:1.47-2.30,respectively).Especially in the middle-aged group,those with CKD had a statistically elevated CD risk(aHR 1.37,95%CI:1.05-1.79).Alcohol consumption and higher body mass index showed negative association trend with CD incidence in both of the age groups.[Middle-aged:aHR 0.77(95%CI:0.66-0.89)and aHR 0.73(95% CI:0.63-0.84),respectively][Elderly-group:aHR 0.57(95% CI:0.42-0.78)and aHR 0.84(95%CI 0.67-1.04),respectively].For regular p

关键词： Crohn’s disease Aged Environmental Risk factors Epidemiology Nationwide cohort

Change in renal function after sodium phosphate preparation for screening colonoscopy

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World Journal of Gastroenterology 2010年第16期16卷 2010-2016页

作者： Dong Choon Seol Sung Noh Hong Jeong Hwan Kim In Kyung Sung hyung Seok Park jung hyun lee Chan Sup Shim Department of Internal Medicine Konkuk University School of Medicine Department of Health Promotion Healthcare CenterKonkuk University Medical Center Healthcare Center Konkuk University Medical CenterDepartment of Internal MedicineKonkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology Department of Internal Medicine Konkuk University School of MedicineMedical Immunology CenterInstitute of Biomedical Science and Technology

AIM:To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate(NaP) preparation for screening ***:We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 *** to screening colonoscopy,224 patients underwent bowel cleansing with NaP(NaP group) and 113 patients with polyethylene glycol(PEG group).The control group comprised 672 age-matched *** compared the changes in the creatinine levels and the glomerular filtration rates(GFRs) from baseline to 12-24 mo between the NaP,PEG,and control groups using two-way repeated measured analysis of *** addition,multivariate linear regression analysis was performed to assess the risk factors for a decreased ***:The baseline mean serum creatinine level in the NaP,PEG,and control groups was 1.12 ± 0.15,1.12 ± 0.16,and 1.12 ± 0.15 mg/dL,which increased to 1.15 ± 0.15,1.15 ± 0.18,and 1.15 ± 0.15 mg/dL,respectively,after 12-24 *** baseline mean GFR in the NaP,PEG,and control groups was 69.0 ± 7.7,68.9 ± 8.0,and 69.6 ± 6.7 mL/min per 1.73 m2,which decreased to 66.5 ± 7.8,66.5 ± 8.3,and 67.4 ± 6.4 mL/min per 1.73 m2,respectively,after 12-24 *** changes in serum creatinine levels and GFRs were not significantly between the NaP,PEG,and control groups(P = 0.992 and P = 0.233,respectively).Using multivariate linear regression analysis,only the baseline GFR was associated with the change in GFR(P < 0.001).Indeed,the bowel preparations were not associated with the change in GFR(P = 0.297).CONCLUSION:NaP bowel preparation in subjects with normal renal function was not associated with renal injury,and NaP can thus be used safely for screening colonoscopy.

关键词： Sodium phosphate Polyethylene glycol Purgatives Colonoscopy Creatinine Glomerular filtration rate