Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves'ophthalmopathy

作     者：Jung Hyun Lee So Hyun Park Dae Gyun Koh Byung Kyu Suh 

作者机构：Department of Pediatricsthe Catholic University of KoreaSt.Vincent's Hospital93-6Ji-dongPaldal-guSuwon-siGyeonggi-doRepublic of Korea Department of Pediatricsthe Catholic University of KoreaSeoul St.Mary's Hospital222 Banpo-daeroSeocho-guSeoulRepublic of Korea 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2014年第10卷第2期

页      面：155-159页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Graves'disease Graves'ophthalmopathy pediatrics thyroid peroxidase antibody triiodothyronine 

摘      要：Background:Graves ophthalmopathy(GO)occurs commonly in children with Graves disease(GD).However,there are limited studies on the clinical manifestations and thyroid autoantibodies in pediatric *** aim of this study was to investigate the prevalence and risk factors of GO in childhood ***:Clinical and biochemical data from children and adolescents with GD were retrospectively *** patients under 19 years of age were included in the present *** compared the clinical and biochemical differences between patients with and without ***:Thirty-nine percent of the patients had GO,and 81%of the GO patients were *** these,two patients showed unilateral ***(T3)levels were higher in GO patients than in those without ***-thyroglobulin antibody and thyroid stimulating hormone receptor antibody titers were not significantly different between the two ***-thyroid peroxidase antibody(TPO Ab)positivity was 68%in the patients with GO and only 47%in the patients without *** multivariate regression analysis,high T3 levels and TPO Ab positivity were related to the presence of ***:In children and adolescents with GD,TPO Ab positivity and high T3 levels could act as predictive factors for the presence of GO.