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Thyroid peroxidase antibody positivity and triiodothyronine levels are associated with pediatric Graves'ophthalmopathy

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World Journal of Pediatrics 2014年第2期10卷 155-159页

作者： Jung Hyun Lee So Hyun Park Dae Gyun Koh Byung Kyu Suh Department of Pediatrics the Catholic University of KoreaSt.Vincent's Hospital93-6Ji-dongPaldal-guSuwon-siGyeonggi-doRepublic of Korea Department of Pediatrics the Catholic University of KoreaSeoul St.Mary's Hospital222 Banpo-daeroSeocho-guSeoulRepublic of Korea

Background:Graves'ophthalmopathy(GO)occurs commonly in children with Graves'disease(GD).However,there are limited studies on the clinical manifestations and thyroid autoantibodies in pediatric *** aim of this study was to investigate the prevalence and risk factors of GO in childhood ***:Clinical and biochemical data from children and adolescents with GD were retrospectively *** patients under 19 years of age were included in the present *** compared the clinical and biochemical differences between patients with and without ***:Thirty-nine percent of the patients had GO,and 81%of the GO patients were *** these,two patients showed unilateral ***(T3)levels were higher in GO patients than in those without ***-thyroglobulin antibody and thyroid stimulating hormone receptor antibody titers were not significantly different between the two ***-thyroid peroxidase antibody(TPO Ab)positivity was 68%in the patients with GO and only 47%in the patients without *** multivariate regression analysis,high T3 levels and TPO Ab positivity were related to the presence of ***:In children and adolescents with GD,TPO Ab positivity and high T3 levels could act as predictive factors for the presence of GO.

关键词： Graves'disease Graves'ophthalmopathy pediatrics thyroid peroxidase antibody triiodothyronine

Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke

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World Journal of Clinical Cases 2020年第1期8卷 76-87页

作者： Lei Mao Xiao-Han Chen Jian-Hua Zhuang Peng Li Yi-Xin Xu Yu-Chen Zhao Yue-Jin Ma Bin He You Yin Department of Neurology Changzheng Hospitalthe PLA Naval Medical UniversityShanghai 200003China Department of Neurology Shanghai First People’s Hospital Baoshan BranchShanghai 200003China

BACKGROUND Post-stroke cognitive impairment(PSCI)is not only a common consequence of stroke but also an important factor for adverse prognosis of *** indicators such as blood lipids and blood pressure are affected by many factors,and the ability of evaluating the progress of patients with PSCI is ***,it is necessary to find sensitive markers for predicting the progress of patients and avoiding *** studies have shown thatβ-amyloid protein 1-42(Aβ1-42)and thyroid hormone levels are closely related to PSCI,which may be the influencing factors of PSCI,but there are few related *** To investigate the relationship between serum levels of Aβand thyroid hormones in acute stage and PSCI and its predicted *** A total of 195 patients with acute cerebral infarction confirmed from June 2016 to January 2018 were enrolled in this *** data and serological indicators were recorded to assess cognitive function of *** patients were followed up for 1 *** cognitive functions were evaluated within 1 wk,3 mo,6 mo and 1 yr after *** the end of follow-up,the patients were divided into PSCI and non-PSCI according to Montreal cognitive assessment score,and the relationship between biochemical indexes and the progression of PSCI was *** Compared with patients with non-PSCI,the levels of Aβ1-42,triiodothyronine(T3)and free thyroxin were lower in the patients with *** measures analysis of variance showed that the overall content of Aβ1-42 and T3 in PSCI was also lower than that of the non-PSCI *** analysis revealed that Aβ1-42(r=0.348),T3(r=0.273)and free thyroxin(r=0.214)were positively correlated with disease progression(P<0.05),suggesting that these indicators have the potential to predict disease progression and *** regression analysis showed that Aβ1-42 and T3 were important factors of *** stratified analysis showed that the lower the Aβ1-42 and T3

关键词： Post-stroke cognitive impairment triiodothyronine β-amyloid protein Prognosis Montreal cognitive assessment Free thyroxin

Cardiovascular mechanisms of thyroid hormones and heart failure:Current knowledge and perspectives

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World Journal of Cardiology 2024年第5期16卷 226-230页

作者： Viktor Culic Department of Cardiology and Angiology University Hospital Centre SplitUniversity of Split School of MedicineSplit 21000Croatia

A multiple hormonal imbalance that accompanies heart failure(HF)may have a significant impact on the clinical course in such *** non-thyroidal illness syndrome(NTIS),also referred to as euthyroid sick syndrome or low triiodothyronine syndrome,can be found in about 30%of patients with *** represents a systemic adaptation to chronic illness that is associated with increased cardiac and overall mortality in patients with *** conclusions on thyroid-stimulating hormone,free triiodothyronine,total and free thyroxine are currently unresolved,serum total triiodothyronine levels and the ratio of free triiodothyronine to free thyroxine seem to provide the best correlates to the echocardiographic,laboratory and clinical parameters of disease *** patients with either hyper-or hypothyroidism should be treated according to the appropriate guidelines,but the therapeutic approach to NTIS,with or without HF,is still a matter of *** treatment options include better individual titration of levothyroxine therapy,combined triiodothyronine plus thyroxine therapy and natural measures to increase *** research should further examine the cellular and tissue mechanisms of NTIS as well as new therapeutic avenues in patients with HF.

关键词： Heart failure Non-thyroidal illness syndrome Low triiodothyronine syndrome Therapy Thyroxine triiodothyronine

EFFECTS OF ACUPUNCTURE ON THE PITUITARYTHYROID AXIS IN RABBITS WITH FRACTURE

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Journal of Traditional Chinese Medicine 1999年第4期19卷 300-303页

作者：沈梅红祁晓华黄晔吕越蔡文辉王友京 The Second Clinical College of Nanjing University of Traditional Chinese Medicine and Pharmacy Nanjing 210029 The First Hospital Affiliated to Nanjing University of Traditional Chinese Medicine and Pharmacy

PURPOSE: To observe the effects of acupuncture on the pituitary-thyroid axis in rabbits with fracture. METHOD: 36 male rabbits with a 3-mm width experimental defect in the middle segment of the left radius were randomly divided into the treatment group and control group, and the changes in serum T3, T4 and TSH contents in different weeks were investigated. RESULTS: Serum T3, T4 and TSH contents in the treatment group all were higher than those in the control group, with statistically significant differences in the contents of T4 and TSH in the second week and T3 content in the fourth week (P

关键词： Electroacupuncture Animals Hypothalamo-Hypophyseal System Male Rabbits Radius Fractures Random Allocation Thyroid Gland Thyrotropin Thyroxine triiodothyronine

The Reproductive and Thyroid Hormonal Profile of Khat (Catha Edulis) Chewers

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Pharmacology & Pharmacy 2012年第4期3卷 447-452页

作者： Saeed S. Al-Ghamdi Department of Pharmacology and Toxicology Faculty of Medicine Umm Al-Qura University Makkah Kingdom of Saudi Arabia.

The effects of khat on the hormonal levels have been established;however, the effects on human beings are controversial. The aim of our study was to investigate the possible effects of khat on the levels of serum thyroid hormones, testosterone, estradiol (E2), prolactin and cortisol in men. A total of 50 blood samples were collected from healthy males who referred to chew khat for more than 10 years and analyzed for the above hormones. The results were compared to the hormonal levels of 35 non khat chewers. Chewing khat causes significant increases in the testosterone (P < 0.03), prolactin (P < 0.05), E2 (P < 0.00005), FT3 (P < 0.04), and TSH (P < 0.05) levels. No significant differences were found in the serum level of FT4 between the two groups. The level of cortisol were significantly lower (P < 0.001) in the khat chewers group compared to the control group. This study suggests that khat chewing can cause reduction in the cortisol level, which may cause increases of testosterone, prolactin and E2. In addition, chewing khat increases the level of TSH and FT3 serum levels. Therefore, khat may contribute to the relevant disorders caused by abnormal levels of the studied hormones in the people who are chewing

关键词： Estradiol (E2) Free Thyroxine (FT4) Free triiodothyronine (FT3) Thyrotropin Stimulating Hormone (TSH) Prolactin Testosterone Cortisol Khat

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聊城市妊娠妇女甲状腺激素参考区间的建立

医学检验与临床 2014年第5期25卷 19-21页

作者：白书堂李姗姗王素红聊城市复退军人医院山东聊城252000

目的：建立本实验室妊娠妇女促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）的参考区间。方法：将826例妊娠妇女分为妊娠早中晚期3组，用Beckman access2化学发光分析仪及其配套试剂检测TSH、FT4、FT3，初步... 详细信息

目的：建立本实验室妊娠妇女促甲状腺激素（TSH）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）的参考区间。方法：将826例妊娠妇女分为妊娠早中晚期3组，用Beckman access2化学发光分析仪及其配套试剂检测TSH、FT4、FT3，初步建立参考区间。结果：TSH参考区间：妊娠早期0.11～2.88 uIU/ml，妊娠中期0.24～3.31 uIU/ml，妊娠晚期0.55～3.78 uIU/ml。FT4参考区间：妊娠早期0.69～1.13 ng/dl，妊娠中期0.56～0.99 ng/dl，妊娠晚期0.49～0.89 ng/dl。FT3参考区间：妊娠早期2.67～4.03 pg/ml，妊娠中期2.35～3.56 pg/ml，妊娠晚期2.08～3.25 pg/ml。结论：建立了本院妊娠妇女血清TSH、FT4、FT3的参考区间，该区间与Beckman access2化学发光分析仪说明书提供的参考区间有差异。各实验室应根据不同仪器和人群等建立TSH、FT4、FT3的参考区间。

关键词：妊娠促甲状腺激素游离甲状腺素游离三碘甲状腺原氨酸参考区间 Thyroid stimulating hormone (TSH) Free tetraiodothyronine (FT4) Free triiodothyronine (FT3)