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Nano Research 2022年第2期15卷 1303-1309页

作者： Zichen Yang Tianyu Yao Xiaoyan Zheng junfeng hui Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXian 710069China College of Life Sciences Northwest UniversityXian 710069China

Whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12))is an important inorganic phase in human bones and has positive significance for participating in the bone reconstruction process.In this paper,we report different doping strategies to prepare WH and WH-Ln(Eu/Tb)nanocrystals,and have successfully synthesized WH-Ln(Eu/Tb)nanoparticles(NPs)with bright red or green fluorescence based on ions exchange doping by two-step hydrothermal reaction.WH-5%Ln(Eu/Tb)NPs with the best fluorescence properties were successfully applied to live cell imaging,and WH-5%Eu NPs were implanted into the bone defect site in rabbit femoral condyles to visually observe its degradation process.The related results would help us understand WH nanocrystals and further expand their potential applications in tissue engineering and related fields.

关键词： whitlockite ions doping controllable synthesis cell imaging degradation process

Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semiinter penetrating polymer network(Semi-IPN)for solar dermatitis

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Nano Research 2022年第7期15卷 6266-6277页

作者： Jialing Yao junfeng hui Jing Yang Jiaxin Yao Chaoquan Hu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China

Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet(UV)radiation based on strong sunlight,which seriously endangers people's health.In this study,we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN)sprayable nanodrug-loaded hydrogels based on gelatin,3-(4-hydroxyphenyl)propionic acid(HPA),polyvinyl alcohol(PVA),glycerol,and dexamethasone sodium phosphate(DEXP)for solar dermatitis.The hydrogels had high water content,excellent biocompatibility,effective encapsulation and sustained release of nanodrugs,antiinflammatory,and strong anti-ultraviolet B(anti-UVB)radiation properties based on glycerol and phenol functional groups,but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar dermatitis.The sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis,and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.

关键词： enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN) sprayable hydrogel nanodrug-loaded solar dermatitis

Chiral inorganic nanomaterials:Harnessing chirality-dependent interactions with living entities for biomedical applications

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Nano Research 2023年第8期16卷 11107-11124页

作者： Qi Gao Lili Tan Zhihao Wen Daidi Fan junfeng hui Peng-peng Wang Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Chirality is an intriguing and fundamental property of natural matter,which is especially crucial in supporting the processes of living systems.The selective interactions between natural chiral compounds are widespread at all levels in living entities and play a vital role in biochemical reactions.The cutting-edge advancements in synthetic chiral inorganic nanostructures have led to significant progress in their applications within biological systems.These developments have unraveled chirality-dependent interactions at the nanoscale and molecular scale,providing a better understanding of intricate process of chiral selection in biological systems and demonstrating the potential of chiral inorganic nanostructures for life science applications.Herein,we summarize recent progress in understanding the chirality origin of inorganic chiral nanoparticles and the development of wet-chemical synthesis.We also discuss the captivating interaction between chiral inorganic nanostructures and biological entities at various scales.Finally,we discuss the challenges and potential of functional chiral nanomaterials for future biomedical and bioengineering applications,offering design ideas and a forecast for their future impact.

关键词： chiral inorganic nanomaterials living system chirality-dependent interaction bioengineering application

Antimicrobial hydrogel with multiple pH-responsiveness for infected burn wound healing

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Nano Research 2023年第8期16卷 11139-11148页

作者： Na Li Wan Liu Xiaoyan Zheng Qing Wang Lixin Shen junfeng hui Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China The college of life sciences Northwest UniversityXi’an 710069China

Burns are a common medical problem globally,and wound infection is one of the major causes of inducing related complications.Although antibiotics effectively prevent wound infections,the misuse of antibiotics has created a new problem of superbugs.Herein,we propose a new strategy to obtain pH-responsive antimicrobial P-ZIF(ZIF:zeolitic imidazolate framework)by loading polyhexamethylenebiguanide(PHMB)into the framework of ZIF-8 nanoparticles.This will enable PHMB to be released in the weak acid environment of an infected wound.To address burn infections,P-ZIF nanoparticles were loaded into a hydrogel system made of sodium alginate(SA)and 3-aminophenylboronic acid modified human-like collagen(H-A)through borate ester bonds.The resulting H-A/SA/P-ZIF(HASPZ)hydrogel dressing not only possesses antibacterial and wound healing properties but also has dual pH responsiveness to prevent the overuse of medication while effectively treat deep second-degree burns.Therefore,P-ZIF nanoparticles and the corresponding HASPZ hydrogel dressing are considered of significant importance in antimicrobial,drug delivery,and wound repair.

关键词： P-ZIF nanoparticles hydrogel dressing antibacterial pH-responsive burn wound healing

Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects

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Nano Research 2023年第1期16卷 746-756页

作者： Miaolin Fan Wan Liu Cuiying Fan Xiaoyan Zheng junfeng hui Chaoquan Hu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co. Ltd.Xi’an 710069China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100China

The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical medicine.After tumor resection,patients are not only faced with a large area of bone defect,but also may have the risk of tumor recurrence,which can easily cause huge physical and mental harm to patients.In this study,we successfully designed and constructed an organic/inorganic composite microgel bone powder(S-H-M3%Ce/3%Se)based on cerium(Ce)and selenium(Se)elements co-doped mesoporous bioactive glass(M3%Ce/3%Se),sodium alginate(SA),and recombinant human-like collagen(HLC).The obtained S-H-M3%Ce/3%Se could inhibit the growth of osteoma cells and promote the growth of normal cells,and effectively promote the repair of defect bone.The integration of the“treatment and repair”organic/inorganic composite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.

关键词： mesoporous bioactive glass functional elements osteoma inhibition bone repair

Mild stir-assisted membrane dispersion for enhancing propionic acid extraction

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2666-2674页

作者： Xiaoyan Zheng Dong Feng Liangrong Yang junfeng hui Jiemiao Yu Qiyu Meng huizhou Liu Daidi Fan Shaanxi Key Laboratory of Degradable BiomedicalMaterials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical and EngineeringNorthwest UniversityXi'an710069China College of Life Sciences Northwest UniversityXi'an710069China Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesChinese Academy of Sciences UniversityBeijing 100190China

Mild stir-assisted membrane dispersion extraction(MDE) method was employed to enhance propionic acid(HA)extraction and compared to the mechanical stirred extraction(MSE) method. Triocylamine(TOA) and tributyl phosphate(TBP) were chosen as model extractant to extract HA. Firstly, droplet size and the size distribution of organic phase were analyzed, and then the effects of phase ratio, extractant and HA concentration on extraction performance were investigated. Comparing the two extraction methods, the results show mild stir-assisted MDE method reduced the mass transfer equilibrium time compared to MSE method. The mass transfer mechanism was explored by analyzing mass transfer resistance. Mild stir-assisted MDE had less total mass transfer resistance than MSE. When the extractant concentration was 40%, the extraction process was controlled by organic phase mass transfer process with HA volume fraction was 1% and controlled by both of reaction process and organic phase mass transfer process when HA concentration increased to 5%. This work may provide a new type of extraction method for the recovery of organic carboxylic acid.

关键词： Membrane dispersion extraction Propionic acid Triocylamine Tributyl phosphate

A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors

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npj Flexible Electronics 2022年第1期6卷 603-612页

作者： Wan Liu Ruijie Xie Jingyu Zhu Jiansheng Wu junfeng hui Xiaoyan Zheng Fengwei Huo Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical and EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi 710069China Biotech.&Biomed.Research Institute Northwest UniversityTaibai North Road 229Xi’anShaanxi 710069China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)Nanjing Tech University30 South Puzhu RoadNanjing 211816China

Flexible electronics are playing an increasingly important role in human health monitoring and healthcare diagnosis.Strong adhesion on human tissue would be ideal for reducing interface resistance and motion artifacts,but arising problems such as skin irritation,rubefaction,and pain upon device removal have hampered their utility.Here,inspired by the temperature reversibility of hydrogen bonding,a skin-friendly conductive hydrogel with multiple-hydrogen bonds was designed by using biocompatible poly(vinyl alcohol)(PVA),phytic acid(PA),and gelatin(Gel).The obtained PVA/PA/Gel(PPG)hydrogel with temperature-triggered tunable mechanic could reliably adhere to skin and detect electrophysiological signals under a hot compress while be readily removed under a cool compress.Furthermore,the additional advantages of transparency,breathability,and antimicrobial activity of the PPG hydrogel ensure its long-time wearable value on the skin.It is both environmentally friendly and cost saving for the waste PPG hydrogel during production can be recycled based on their reversible physical bonding.The PPG hydrogel sensor is expected to have good application prospects to record electrophysiological signals in human health monitoring.

关键词： hydrogel removed bonds

Light People:Professor Laura Na Liu

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Light(Science & Applications) 2024年第2期13卷 184-189页

作者： hui Wang Cun Yu Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences130033ChangchunChina

Editorial The DNA nanotechnology outlines a new chapter in biological sciences,opening a new era of scientific and technological advancements.A pioneer of DNA nanotechnology,Professor Liu from the University of Stuttgart in Germany,our latest Light People,has been working at the interface,where nanophotonics meets biology and chemistry.On the path of scientific explorations.

关键词： chemistry. advancement pioneer

Vibration attenuation performance of wind turbine tower using a prestressed tuned mass damper under seismic excitation

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Earthquake Engineering and Engineering Vibration 2024年第2期23卷 511-524页

作者： Lei Zhenbo Liu Gang Wang hui hui Yi School of Civil Engineering Chongqing UniversityChongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area Chongqing UniversityMinistry of EducationChongqing 400045China

With the rapid development of large megawatt wind turbines,the operation environment of wind turbine towers(WTTs)has become increasingly complex.In particular,seismic excitation can create a resonance response and cause excessive vibration of the WTT.To investigate the vibration attenuation performance of the WTT under seismic excitations,a novel passive vibration control device,called a prestressed tuned mass damper(PS-TMD),is presented in this study.First,a mathematical model is established based on structural dynamics under seismic excitation.Then,the mathematical analytical expression of the dynamic coefficient is deduced,and the parameter design method is obtained by system tuning optimization.Next,based on a theoretical analysis and parameter design,the numerical results showed that the PS-TMD was able to effectively mitigate the resonance under the harmonic basal acceleration.Finally,the time-history analysis method is used to verify the effectiveness of the traditional pendulum tuned mass damper(PTMD)and the novel PS-TMD device,and the results indicate that the vibration attenuation performance of the PS-TMD is better than the PTMD.In addition,the PS-TMD avoids the nonlinear effect due to the large oscillation angle,and has the potential to dissipate hysteretic energy under seismic excitation.

关键词： wind turbine tower prestressed tuned mass damper vibration control seismic excitation numerical simulation

Clinical study on the relationship between liver cirrhosis,ascites,and hyponatremia

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 751-758页

作者： Xuan-Ji Li hui-hui Meng Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina Department of Hepatology Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430065Hubei ProvinceChina

BACKGROUND Cirrhosis is a common liver disease,and ascites is one of the common clinical conditions.However,the clinical manifestations of ascites combined with hyponatremia as a high-risk condition and its relationship to patient prognosis have not been fully studied.AIM To explore the clinical manifestations,prognostic factors,and relationships of ascites with hyponatremia in patients with cirrhosis to provide better diagnostic and treatment strategies.METHODS In this study,we retrospectively analyzed the clinical data of 150 patients diagnosed with cirrhosis and ascites between 2017 and 2022.Patients were divided into two groups:ascites combined with hyponatremia group and ascites group.We compared the general characteristics,degree of hyponatremia,complications,treatment,and prognosis between the two groups.RESULTS In the study results,patients in the ascites combined with hyponatremia group showed an older average age(58.2±8.9 years),64.4%were male,and had a significantly longer hospitalization time(12.7±5.3 d).Hyponatremia was more severe in this group,with a mean serum sodium concentration of 128.5±4.3 mmol/L,which was significantly different from the ascites group of 137.6±2.1 mmol/L.Patients with ascites and hyponatremia were more likely to develop hepatic encephalopathy(56.2%vs 39.0%),renal impairment(45.2%vs 28.6%)and infection(37.0%vs 23.4%).Regarding treatment,this group more frequently used diuretics(80.8%vs 62.3%)and salt supplements(60.3%vs 38.9%).Multiple logistic regression analysis identified older age[Odds ratio(OR)=1.06,P=0.025]and male gender(OR=1.72,P=0.020)as risk factors for hyponatremia combined with ascites.Overall,patients with ascites and hyponatremia present a clear high-risk status,accompanied by severe complications and poor prognosis.CONCLUSION In patients with cirrhosis,ascites with hyponatremia is a high-risk condition that is often associated with severe complications.

关键词： Liver cirrhosis Ascites Hyponatremia Risk Complications