Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semiinter penetrating polymer network(Semi-IPN)for solar dermatitis
作者机构：Shaanxi Key Laboratory of Degradable Biomedical MaterialsShaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Nanjing IPE Institute of Green Manufacturing IndustryNanjing 211100China Biotech.&Biomed.Research InstituteNorthwest UniversityXi’an 710069China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2022年第15卷第7期
页 面：6266-6277页
核心收录：
学科分类：1002[医学-临床医学] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Nos.22078265,22108225,and 21838009) the Shaanxi Provincial Science Foundation(Nos.2017SF-201 and 2021JQ-434) China Postdoctoral Science Foundation(No.2018M643720)
主 题：enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN) sprayable hydrogel nanodrug-loaded solar dermatitis
摘 要：Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet(UV)radiation based on strong sunlight,which seriously endangers people s *** this study,we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN)sprayable nanodrug-loaded hydrogels based on gelatin,3-(4-hydroxyphenyl)propionic acid(HPA),polyvinyl alcohol(PVA),glycerol,and dexamethasone sodium phosphate(DEXP)for solar *** hydrogels had high water content,excellent biocompatibility,effective encapsulation and sustained release of nanodrugs,antiinflammatory,and strong anti-ultraviolet B(anti-UVB)radiation properties based on glycerol and phenol functional groups,but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar *** sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis,and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.
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