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Rapid synthesis of oxygen-defected molybdenum oxides quantum dots as efficient nanozymes for healing diabetic ulcers

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Nano Research 2024年第7期17卷 6376-6385页

作者： Fangjun Cao hui Feng Jiaxin Yao Xiang Hou Tiezhi Jin junfeng hui Shaanxi Key Laboratory of Qinling Ecological Security Shaanxi Institute of ZoologyXi’an 710072China Engineering Research Center of Western Resource Innovation Medicine Green Manufacturing Ministry of EducationSchool of Chemical EngineeringNorthwest UniversityXi'an 710069China Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXi'an 710069China

The continuous inflammatory response in diabetic skin wounds leads to excessive production of reactive oxygen species,which cause a vicious circle of long-term *** the therapeutic research of metal nanoenzymes for healing diabetic ulcers,it still faces the challenges in poor nanoenzymes activity and low-efficient therapeutic ***,ultrasmall oxygen-deficient MoO_(3−X)quantum dots were fabricated and employed as nanoenzymes for healing fiabetic *** PEGylation,PEGylated MoO_(3−X)quantum dots(MoO_(3−X)/PEG)with oxygen vacancies exhibits excellent photothermal,peroxidase/catalase-like *** addition,these MoO_(3−X)/PEG showed superior properties in scavenging H_(2)O_(2)and effectively inhibiting the scavenging of reactive oxygen *** importantly,such an oxygen-defected MoO_(3−X)/PEG had obvious antibacterial and skin repairing effects on alleviating hypoxia and excessive oxidative stress even in a mouse model of diabetic ulcers,inhibiting proinflammatory cytokines and significantly accelerating the healing of infected wounds,which shows great application potential for promoting wound *** work highlights that the developed oxygen defected molybdenum oxide compounds capable of peroxidaselike and catalase-like activities show great application potential for healing diabetes wound.

关键词： oxygen-defected molybdenum-based nanoenzymes antioxidant anti-inflammatory diabetes ulcer wounds

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Eu^(3+)/Tb^(3+)-doped whitlockite nanocrystals:Controllable synthesis,cell imaging,and the degradation process in the bone reconstruction

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Nano Research 2022年第2期15卷 1303-1309页

作者： Zichen Yang Tianyu Yao Xiaoyan Zheng junfeng hui Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials and Shaanxi R&D Center of Biomaterials and Fermentation Engineering School of Chemical EngineeringNorthwest UniversityXian 710069China College of Life Sciences Northwest UniversityXian 710069China

Whitlockite(WH,Ca_(18)Mg_(2)(HPO_(4))_(2)(PO_(4))_(12))is an important inorganic phase in human bones and has positive significance for participating in the bone reconstruction *** this paper,we report different doping strategies to prepare WH and WH-Ln(Eu/Tb)nanocrystals,and have successfully synthesized WH-Ln(Eu/Tb)nanoparticles(NPs)with bright red or green fluorescence based on ions exchange doping by two-step hydrothermal ***-5%Ln(Eu/Tb)NPs with the best fluorescence properties were successfully applied to live cell imaging,and WH-5%Eu NPs were implanted into the bone defect site in rabbit femoral condyles to visually observe its degradation *** related results would help us understand WH nanocrystals and further expand their potential applications in tissue engineering and related fields.

关键词： whitlockite ions doping controllable synthesis cell imaging degradation process

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Sprayable nanodrug-loaded hydrogels with enzyme-catalyzed semiinter penetrating polymer network(Semi-IPN)for solar dermatitis

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Nano Research 2022年第7期15卷 6266-6277页

作者： Jialing Yao junfeng hui Jing Yang Jiaxin Yao Chaoquan Hu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China

Solar dermatitis is an acute or chronic high incidence of skin injury caused by ultraviolet(UV)radiation based on strong sunlight,which seriously endangers people's *** this study,we designed and demonstrated enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN)sprayable nanodrug-loaded hydrogels based on gelatin,3-(4-hydroxyphenyl)propionic acid(HPA),polyvinyl alcohol(PVA),glycerol,and dexamethasone sodium phosphate(DEXP)for solar *** hydrogels had high water content,excellent biocompatibility,effective encapsulation and sustained release of nanodrugs,antiinflammatory,and strong anti-ultraviolet B(anti-UVB)radiation properties based on glycerol and phenol functional groups,but also controllable spray gelation mode to make them adhere well on the dynamic skin surfaces and achieve continuous transdermal drugs delivery for solar *** sprayable nanodrug-loaded hydrogel systems could be used as a highly effective therapeutic method for solar dermatitis,and also provide a good strategy for designing novel nanodrug-loaded hydrogel delivery systems.

关键词： enzyme-catalyzed semi-inter penetrating polymer network(Semi-IPN) sprayable hydrogel nanodrug-loaded solar dermatitis

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Chiral inorganic nanomaterials:Harnessing chirality-dependent interactions with living entities for biomedical applications

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Nano Research 2023年第8期16卷 11107-11124页

作者： Qi Gao Lili Tan Zhihao Wen Daidi Fan junfeng hui Peng-peng Wang Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China State Key Laboratory for Mechanical Behavior of Materials Shaanxi International Research Center for Soft MatterSchool of Materials Science and EngineeringXi’an Jiaotong UniversityXi’an 710049China

Chirality is an intriguing and fundamental property of natural matter,which is especially crucial in supporting the processes of living *** selective interactions between natural chiral compounds are widespread at all levels in living entities and play a vital role in biochemical *** cutting-edge advancements in synthetic chiral inorganic nanostructures have led to significant progress in their applications within biological *** developments have unraveled chirality-dependent interactions at the nanoscale and molecular scale,providing a better understanding of intricate process of chiral selection in biological systems and demonstrating the potential of chiral inorganic nanostructures for life science ***,we summarize recent progress in understanding the chirality origin of inorganic chiral nanoparticles and the development of wet-chemical *** also discuss the captivating interaction between chiral inorganic nanostructures and biological entities at various ***,we discuss the challenges and potential of functional chiral nanomaterials for future biomedical and bioengineering applications,offering design ideas and a forecast for their future impact.

关键词： chiral inorganic nanomaterials living system chirality-dependent interaction bioengineering application

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Antimicrobial hydrogel with multiple pH-responsiveness for infected burn wound healing

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Nano Research 2023年第8期16卷 11139-11148页

作者： Na Li Wan Liu Xiaoyan Zheng Qing Wang Lixin Shen junfeng hui Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China The college of life sciences Northwest UniversityXi’an 710069China

Burns are a common medical problem globally,and wound infection is one of the major causes of inducing related *** antibiotics effectively prevent wound infections,the misuse of antibiotics has created a new problem of ***,we propose a new strategy to obtain pH-responsive antimicrobial P-ZIF(ZIF:zeolitic imidazolate framework)by loading polyhexamethylenebiguanide(PHMB)into the framework of ZIF-8 *** will enable PHMB to be released in the weak acid environment of an infected *** address burn infections,P-ZIF nanoparticles were loaded into a hydrogel system made of sodium alginate(SA)and 3-aminophenylboronic acid modified human-like collagen(H-A)through borate ester *** resulting H-A/SA/P-ZIF(HASPZ)hydrogel dressing not only possesses antibacterial and wound healing properties but also has dual pH responsiveness to prevent the overuse of medication while effectively treat deep second-degree ***,P-ZIF nanoparticles and the corresponding HASPZ hydrogel dressing are considered of significant importance in antimicrobial,drug delivery,and wound repair.

关键词： P-ZIF nanoparticles hydrogel dressing antibacterial pH-responsive burn wound healing

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Ce and Se co-doped MBG/SA/HLC microgel bone powder for repairing tumor bone defects

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Nano Research 2023年第1期16卷 746-756页

作者： Miaolin Fan Wan Liu Cuiying Fan Xiaoyan Zheng junfeng hui Chaoquan Hu Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical EngineeringNorthwest UniversityXi’an 710069China Biotech.&Biomed.Research Institute Northwest UniversityXi’an 710069China Xi’an Giant Biogene Technology Co. Ltd.Xi’an 710069China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100China

The repair and treatment of tumor bone defects is a difficult problem to solve urgently in clinical *** tumor resection,patients are not only faced with a large area of bone defect,but also may have the risk of tumor recurrence,which can easily cause huge physical and mental harm to *** this study,we successfully designed and constructed an organic/inorganic composite microgel bone powder(S-H-M3%Ce/3%Se)based on cerium(Ce)and selenium(Se)elements co-doped mesoporous bioactive glass(M3%Ce/3%Se),sodium alginate(SA),and recombinant human-like collagen(HLC).The obtained S-H-M3%Ce/3%Se could inhibit the growth of osteoma cells and promote the growth of normal cells,and effectively promote the repair of defect *** integration of the“treatment and repair”organic/inorganic composite microgel bone powder provided a new strategy for the treatment of cancerous bone defects.

关键词： mesoporous bioactive glass functional elements osteoma inhibition bone repair

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Mild stir-assisted membrane dispersion for enhancing propionic acid extraction

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2666-2674页

作者： Xiaoyan Zheng Dong Feng Liangrong Yang junfeng hui Jiemiao Yu Qiyu Meng huizhou Liu Daidi Fan Shaanxi Key Laboratory of Degradable BiomedicalMaterials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical and EngineeringNorthwest UniversityXi'an710069China College of Life Sciences Northwest UniversityXi'an710069China Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesChinese Academy of Sciences UniversityBeijing 100190China

Mild stir-assisted membrane dispersion extraction(MDE) method was employed to enhance propionic acid(HA)extraction and compared to the mechanical stirred extraction(MSE) method. Triocylamine(TOA) and tributyl phosphate(TBP) were chosen as model extractant to extract HA. Firstly, droplet size and the size distribution of organic phase were analyzed, and then the effects of phase ratio, extractant and HA concentration on extraction performance were investigated. Comparing the two extraction methods, the results show mild stir-assisted MDE method reduced the mass transfer equilibrium time compared to MSE method. The mass transfer mechanism was explored by analyzing mass transfer resistance. Mild stir-assisted MDE had less total mass transfer resistance than MSE. When the extractant concentration was 40%, the extraction process was controlled by organic phase mass transfer process with HA volume fraction was 1% and controlled by both of reaction process and organic phase mass transfer process when HA concentration increased to 5%. This work may provide a new type of extraction method for the recovery of organic carboxylic acid.

关键词： Membrane dispersion extraction Propionic acid Triocylamine Tributyl phosphate

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A temperature responsive adhesive hydrogel for fabrication of flexible electronic sensors

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npj Flexible Electronics 2022年第1期6卷 603-612页

作者： Wan Liu Ruijie Xie Jingyu Zhu Jiansheng Wu junfeng hui Xiaoyan Zheng Fengwei Huo Daidi Fan Shaanxi Key Laboratory of Degradable Biomedical Materials Shaanxi R&D Center of Biomaterials and Fermentation EngineeringSchool of Chemical and EngineeringNorthwest UniversityTaibai North Road 229Xi’anShaanxi 710069China Biotech.&Biomed.Research Institute Northwest UniversityTaibai North Road 229Xi’anShaanxi 710069China Key Laboratory of Flexible Electronics(KLOFE) Institute of Advanced Materials(IAM)Nanjing Tech University30 South Puzhu RoadNanjing 211816China

Flexible electronics are playing an increasingly important role in human health monitoring and healthcare *** adhesion on human tissue would be ideal for reducing interface resistance and motion artifacts,but arising problems such as skin irritation,rubefaction,and pain upon device removal have hampered their ***,inspired by the temperature reversibility of hydrogen bonding,a skin-friendly conductive hydrogel with multiple-hydrogen bonds was designed by using biocompatible poly(vinyl alcohol)(PVA),phytic acid(PA),and gelatin(Gel).The obtained PVA/PA/Gel(PPG)hydrogel with temperature-triggered tunable mechanic could reliably adhere to skin and detect electrophysiological signals under a hot compress while be readily removed under a cool ***,the additional advantages of transparency,breathability,and antimicrobial activity of the PPG hydrogel ensure its long-time wearable value on the *** is both environmentally friendly and cost saving for the waste PPG hydrogel during production can be recycled based on their reversible physical *** PPG hydrogel sensor is expected to have good application prospects to record electrophysiological signals in human health monitoring.

关键词： hydrogel removed bonds

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深俯冲陆壳部分熔融初始熔体的厘定:来自苏鲁超高压地体混合岩中浅色体证据

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岩石学报 2018年第3期34卷 547-566页

作者：高名迪续海金章军锋陈辉中国地质大学地球科学学院全球构造中心

深俯冲陆壳物质部分熔融产生的熔体,实验岩石学方面已有广泛报道,而天然初始熔体的组分却难以厘定。对此,本文从苏鲁超高压地体荣成混合岩中识别出了深俯冲花岗质陆壳部分熔融产生的天然初始熔体组成。野外露头显示,混合岩中主要矿物组... 详细信息

深俯冲陆壳物质部分熔融产生的熔体,实验岩石学方面已有广泛报道,而天然初始熔体的组分却难以厘定。对此,本文从苏鲁超高压地体荣成混合岩中识别出了深俯冲花岗质陆壳部分熔融产生的天然初始熔体组成。野外露头显示,混合岩中主要矿物组成为钾长石+斜长石+石英的浅色熔体呈不连续的条带状与残余体互层产出,指示了原位或近源区的部分熔融特征。混合岩浅色体锆石CL图像呈明显的核-边结构,继承核部为扬子板块来源的岩浆锆石,形成时代为721±24Ma;新生边部CL图像具震荡环带结构,微量元素上REE呈明显左倾,具有Eu的负异常及Ce的正异常,低的Hf/Y和Th/U比值,具深熔锆石特征,指示形成于花岗质陆壳物质的部分熔融。边部U-Pb谐和年龄为225.9±2Ma,略晚于苏鲁超高压地体超高压峰期变质年龄,表明初始熔融发生在超高压地体折返早期。浅色熔体的全岩地球化学特征表明,主量元素上具有高SiO_2、K_2O及Na_2O含量,低的Fe_2O_3~T、MgO及CaO含量,A/CNK=1.02~1.04,呈弱过铝质亚碱性花岗岩的特征,这与实验岩石学中富硅陆壳物质部分熔融产生的熔体组分极为相近;微量元素上富集大离子亲石元素(如Rb、Ba、Pb等),亏损Nb、Ta、Ti等高场强元素,REE呈较为平坦的配分模式,具弱的Eu负异常并亏损Sr。本文通过上述对天然样品研究,厘定了深俯冲花岗质陆壳部分熔融及其初始熔体的组成,为理解大陆俯冲带壳幔相互作用提供了关键依据。

关键词：大陆俯冲带部分熔融初始熔体苏鲁超高压地体混合岩

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Analytical Solutions for an Isotropic Elastic Half-Plane with Complete Surface Effects Subjected to a Concentrated/Uniform Surface Load

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Acta Mechanica Solida Sinica 2024年第3期37卷 371-384页

作者： Xia-hui Pan School of Civil Engineering Henan Polytechnic UniversityJiaozuo454003China

Within the context of Gurtin-Murdoch surface elasticity theory,closed-form analytical solutions are derived for an isotropic elastic half-plane subjected to a concentrated/uniform surface *** the effects of residual surface stress and surface elasticity are *** stress function method and Fourier integral transform technique are *** solutions are provided in a compact manner that can easily reduce to special situations that take into account either one surface effect or none at *** results indicate that surface effects generally lower the stress levels and smooth the deformation profiles in the *** elasticity plays a dominant role in the in-plane elastic fields for a tangentially loaded half-plane,while the effect of residual surface stress is fundamentally crucial for the out-of-plane stress and displacement when the half-plane is normally *** the remaining situations,combined effects of surface elasticity and residual surface stress should be *** results for a concentrated surface force serve essentially as fundamental solutions of the Flamant and the half-plane Cerruti problems with surface *** solutions presented in this work may be helpful for understanding the contact behaviors between solids at the nanoscale.

关键词： Surface effects Residual surface stress Surface elasticity Half-plane Analytical solutions

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