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Reconstitution of Motor Proteins through Molecular Assembly

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Chinese Journal of Chemistry 2020年第2期38卷 123-129页

作者： Yi Jia Mingjun Xuan Xiyun Feng li Duan Jieling li junbai li Beijing National Laboratory for Molecular Sciences CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Yunnan Normal University KunmingYunnan 650500China Northwest Institute of Nuclear Technology Xi'anShaanxi 710024China University of Chinese Academy of Sciences Beijing 100049China

What is the most favorite and original chemistry developed in your research group?The most favorite and original chemistry developed in my research group is about the reconstitution of motor proteins in artificially designed and assembled *** is based on the molecular assembly technique,but the method is different from the conventional approach.

关键词： chemistry Molecular favorite

AIEgen-lipid structures:Assembly and biological applications

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Aggregate 2020年第1期1卷 69-79页

作者： Hongqian Cao Yang Yang junbai li CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijingChina School of Public Health Shandong UniversityJinanShandong ProvinceChina CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijingChina

Aggregation-induced emission(AIE)molecules possess notable advantages outperforming traditional aggregation caused quenching(ACQ)materials on various *** are rapidly developed these *** and more AIE luminogens(AIEgens)are designed to possess multifunctions such as the abilities of near-infrared two-photon absorption and reactive oxygen species(ROS)generation,which could be used for deep tissue imaging and photodynamic *** AIEgens exhibit great potential in biological application ***,despite the photophysics stability and ROS generation ability in aggregated states are favorable conditions,their applications in biological field are retarded by uncontrolled size,single imaging mode,low targeting efficiency,and also poor biocompatibility and dispersibility in physiological *** combination of AIEgen and lipid is a straightforward,promising,and intensively used way to solve the above *** to the special amphipathic property of lipid,which results from a hydrophilic head and hydrophobic tail structure,there are various possibilities of combination modes between lipid and *** a little procedure or condition change during the synthesis process will impact the structure of obtained product,which can further influence its ***,we summarize the synthesis methods of different AIEgen-lipid compounds with diverse structures and properties,as well as their biological applications in this contribution,which has not been presented before,being aimed at serving as a synthesis and application reference for these promising AIEgen-lipid compounds applied in biological region.

关键词： aggregation-induced emission bioimaging lipid photodynamic therapy self-assembly

Perspective of energy transfer from light energy into biological energy

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Green Energy & Environment 2017年第1期2卷 18-22页

作者： Mingjun Xuan Jie Zhao Jingxin Shao Qi li junbai li Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Lab of Colloid Interface and Chemical Thermodynamics Institute of ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

Energy has always been the most concerned topic in the world due to the large consumption. Various types of energy have been exploited and developed to enhance the output amount so that high requirements can be met. like the hydro-energy, wind energy, and tidal energy, light energy as a renewable, clean, and widespread energy can be easily harvested. In microcosmic scale, some specific proteins and enzymes in green plants and bacteria play an important role in light harvest and energy conversion via photosynthesis. Inspired by the biomimetic sparks,these bioactive macromolecules and some artificially synthetic unites have been integrated together to improve the light-harvesting, and enhance their utilization efficiency. In this feature article, we primarily discuss that how to create the bio-inorganic hybrid energy converted system via biomimetic assembly strategy and artificially achieve the transformation from light into bioenergy, meanwhile highlight some promising works.

关键词： Biomimetic Molecular assembly Energy conversion light Bioenergy

Assembly of CdTe Quantum Dots and Photosystem II Multi- layer Films with Enhanced Photocurrent

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Chinese Journal of Chemistry 2017年第6期35卷 881-885页

作者： Peng Cai Yi Jia Xiyun Feng Jiao li junbai li Beijing National Laboratory for Molecule Sciences CAS Key Lab of Colloid lnterface and Chemical Thermody- namics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Tobacco Research Institute of Chinese Academy of Agricultural Sciences Qingdao Shandong 266101 China

Photosystem II （PSII） is a photoactive protein that can drive water oxidation under light irradiation. Recently, PSII has been broadly investigated with the high demand on the bioenergy. Here, we demonstrate a facile approach for the fabrication of a photoactive electrode by the integration of PSII with quantum dots （QDs）/polyelectrolyte multilayers. The assembled QDs and PSII film with a polyelectrolyte based substrate via layer-by-layer assembly can remain the photoactivity of the PSII and broaden the absorption spectrum of PSII to produce a high photocur- rent yield. The co-assembly exhibits an obviously enhanced photocurrent under UV light irradiation. The proposed strategy can be considered for the reference and usage of PSII toward the solar energy conversion.

关键词： photosystem II quantum dots solar energy conversion layer-by-layer assembly energy transfer

Assembled Photosensitizers Applied for Enhanced Photodynamic Therapy

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CCS Chemistry 2023年第5期5卷 1043-1060页

作者： Jie Zhao Xia Xu Yang Yang junbai li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing 100190

Photodynamic therapy(PDT)has emerged as an efficient method for cancer ***,traditional photosensitizers(PSs)always have low *** example,hydrophobic PSs tend to aggregate in cells and lead to aggregation-induced quenching;while hydrophilic PSs that have good solubility in water systems can hardly penetrate into cells whose membranes are *** overcome these drawbacks,suitable PSs that meet the requirements of PDT are *** investigations have been introduced,especially the molecular-assembly technique that can increase the bioavailability of PSs during the tumor therapy ***,increasing the quantum yield of reactive oxygen species(ROS)by adjusting the PS triplet state lifetime as well as developing aggregation-induced emission(AIE)agents can also improve the PDT *** review summarizes the molecular-assembly technique to obtain intelligent PSs to achieve high PDT ***,increasing the quantum yield of ROS by decreasing the energy gap between S_(1)and T_(1)states or increasing the spin–orbit coupling Hamiltonian are ***,we present the bioavailability of traditional PSs by improving the amphiphilicity of the PSs or using intelligent ***,the AIE PSs that can form ROS in the aggregated state under irradiation are ***,the perspective and challenges of PDT are discussed.

关键词： molecular assembly photosensitizers bioavailability improved therapeutic effect photodynamic therapy

Photosystem Ⅱ-based biomimetic assembly for enhanced photosynthesis

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National Science Review 2021年第8期8卷 93-107页

作者： Mingjun Xuan junbai li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of Sciences University of Chinese Academy of Sciences

Photosystem Ⅱ(PSⅡ) is a fascinating photosynthesis-involved enzyme, participating in sunlight-harvest,water splitting, oxygen release, and proton/electron generation and transfer. Scientists have been inspired to couple PSⅡ with synthetic hierarchical structures via biomimetic assembly, facilitating attainment of natural photosynthesis processes, such as photocatalytic water splitting, electron transfer and ATP synthesis, in vivo. In the past decade, there has been significant progress in PSⅡ-based biomimetic systems,such as artificial chloroplasts and photoelectrochemical cells. The biomimetic assembly approach helps PSⅡ gather functions and properties from synthetic materials, resulting in a complex with partly natural and partly synthetic components. PSⅡ-based biomimetic assembly offers opportunities to forward semi-biohybrid research and synchronously inspire optimization of artificial light-harvest micro/nanodevices. This review summarizes recent studies on how PSⅡ combines with artificial structures via molecular assembly and highlights PSⅡ-based semi-natural biosystems which arise from synthetic parts and natural components. Moreover, we discuss the challenges and remaining problems for PSⅡ-based systems and the outlook for their development and applications. We believe this topic provides inspiration for rational designs to develop biomimetic PSⅡ-based semi-natural devices and further reveal the secrets of energy conversion within natural photosynthesis from the molecular level.

关键词：

Black Phosphorus Nanosheets Enhance Photophosphorylation by Positive Feedback

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Chinese Journal of Chemistry 2022年第8期40卷 939-945页

作者： Zhenzhen Dong Jinbo Fei Tonghui Wang Xia Xu Weiguang Dong junbai li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

We construct a natural-artificial hybrid architecture containing black phosphorus nanosheets(BPNS)to enhance photosynthesis of chloroplast in a positive-feedback *** this architecture,oxygen yielded by photosynthesis during water splitting by photosystemⅡpromotes the photoreaction of BPNS to produce proton and inorganic phosphate(Pi).Further,transmembrane proton gradient is increased to drive ATP synthase to synthesize ***,additional photogenerated electrons produced by BPNS are transferred to the photosynthesis *** a consequence,photosynthesis performed by chloroplast is ***,photophosphorylation efficacy of the hybrid system is increased by 1.89 times in the case of Pi *** work offers a new path to enhance solar-to-chemical energy conversion,holding promise in boosting natural photosynthesis.

关键词： Black phosphorus nanosheets Electron transport Energy conversion Photosynthesis Positive feedback

Catalase-Conjugated Rose Bengal Biological Nanoparticles with Mitochondrial Selectivity Toward Photodynamic Therapy

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CCS Chemistry 2023年第12期5卷 2877-2887页

作者： Xia Xu Zibo li Jie Zhao Yilin liu Yang Xu Yi Jia junbai li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical EngineeringShandong UniversityJinan 250100

Photodynamic therapy(PDT)has emerged as an efficient treatment for cancers in recent ***,PDT is limited by low utilization of photosensitizers and tumor *** short lifetime and diffusion radius of singlet oxygen(^(1)O_(2))further decrease the anticancer effect of ***,we design and synthesize diameter-controllable photosensitizer nanoparticles(NPs)which can specifically accumulate on the mitochondria of cancer cells and increase the O_(2) concentrations nearby to enhance PDT ***(CAT)molecules are initially conjugated with rose bengal(RB)via amide bonds and then self-assembled into CAT-RB *** NPs show excellent enzyme activity in catalyzing the decomposition of hydrogen peroxide into O_(2),which makes the yield of 1O21.65-fold higher than that of free *** intracellular uptake efficiency of NPs is increased by up to 150 times compared with pure *** endocytosis,the NPs mainly located at mitochondria and ^(1)O_(2) can directly destroy mitochondria under irradiation,thereby greatly decreasing the production of adenosine triphosphate and further leading to the apoptosis of cancer ***,CAT-RB NPs can accumulate in tumors and show excellent PDT effects in *** work opens a unique path to break through the current limitations of PDT in cancer treatment.

关键词： molecular assembly catalase nanoparticles mitochondrial selectivity adenosine triphosphate reduction photodynamic therapy

Enhanced Bioenergy Transformation by Metal-Free Electrozyme-Based Mitochondrion Nanoarchitectonics

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CCS Chemistry 2023年第7期5卷 1644-1652页

作者： Tonghui Wang Jinbo Fei Zhenzhen Dong Xia Xu Weiguang Dong junbai li Beijing National Laboratory for Molecular Sciences(BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

Herein,we couple a synthetic electrozyme in a supramolecule-assembled nanoarchitecture to achieve enhanced bioenergy transformation by mimicking mitochondrial oxidative *** from the natural counterpart,the metal-free electrozyme is a semiconducting polymer deposited on an *** wellmatched electrocatalytic property of the electrozyme permits oxidization of reduced nicotinamide adenine dinucleotide(NADH)to release protons under a much lower electric *** a consequence,the generated proton gradient drives rotary catalysis of adenosine 5′-triphosphate(ATP)synthase reconstituted in a lipid membrane to produce ***,electrochemical bioenergy conversion of NADH to ATP is accomplished with much higher efficiency in such a bio-like system compared with the natural *** work integrates synthetic and natural catalytic chemistry to facilitate enhanced bioenergy transformation,thereby greatly improving prospects in ATP-fueled bioapplications.

关键词： molecular assembly bioenergy nanozyme biocatalysis nanoarchitectonics