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Assembled Photosensitizers Applied for Enhanced Photodynamic Therapy

作     者:Jie Zhao Xia Xu Yang Yang Junbai Li Jie Zhao;Xia Xu;Yang Yang;Junbai Li

作者机构:Beijing National Laboratory for Molecular Sciences(BNLMS)CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190 University of Chinese Academy of SciencesBeijing 100049 CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190 

出 版 物:《CCS Chemistry》 (中国化学会会刊(英文))

年 卷 期:2023年第5卷第5期

页      面:1043-1060页

核心收录:

学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基  金:supported by the National Natural Science Foundation of China(grant nos.22193031 22193032 21972033) 

主  题:molecular assembly photosensitizers bioavailability improved therapeutic effect photodynamic therapy 

摘      要:Photodynamic therapy(PDT)has emerged as an efficient method for cancer ***,traditional photosensitizers(PSs)always have low *** example,hydrophobic PSs tend to aggregate in cells and lead to aggregation-induced quenching;while hydrophilic PSs that have good solubility in water systems can hardly penetrate into cells whose membranes are *** overcome these drawbacks,suitable PSs that meet the requirements of PDT are *** investigations have been introduced,especially the molecular-assembly technique that can increase the bioavailability of PSs during the tumor therapy ***,increasing the quantum yield of reactive oxygen species(ROS)by adjusting the PS triplet state lifetime as well as developing aggregation-induced emission(AIE)agents can also improve the PDT *** review summarizes the molecular-assembly technique to obtain intelligent PSs to achieve high PDT ***,increasing the quantum yield of ROS by decreasing the energy gap between S_(1)and T_(1)states or increasing the spin–orbit coupling Hamiltonian are ***,we present the bioavailability of traditional PSs by improving the amphiphilicity of the PSs or using intelligent ***,the AIE PSs that can form ROS in the aggregated state under irradiation are ***,the perspective and challenges of PDT are discussed.

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