Cell membrane-covered nanoparticles as biomaterials
Cell membrane-covered nanoparticles as biomaterials作者机构：Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Lab of ColloidInterface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of Sciences (ICCAS)
出 版 物：《National Science Review》 (国家科学评论(英文版))
年 卷 期：2019年第6卷第3期
页 面：551-561页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0702[理学-物理学]
基 金：supported by the National Natural Science Foundation of China(21433010 and 21320102004)
主 题：cell membranes synthetic nanosystem bio-stealth long circulation time biomedical applications
摘 要：Surface engineering of synthetic carriers is an essential and important strategy for drug delivery in ***, exogenous properties make synthetic nanosystems invaders that easily trigger the passive immune clearance mechanism, increasing the retention effect caused by the reticuloendothelial systems and bioadhesion, finally leading to low therapeutic efficacy and toxic effects. Recently, a cell membrane cloaking technique has been reported as a novel interfacing approach from the biological/immunological perspective, and has proved useful for improving the performance of synthetic nanocarriers in vivo. After cell membrane cloaking, nanoparticles not only acquire the physiochemical properties of natural cell membranes but also inherit unique biological functions due to the presence of membrane-anchored proteins, antigens, and immunological moieties. The derived biological properties and functions, such as immunosuppressive capability, long circulation time, and targeted recognition integrated in synthetic nanosystems, have enhanced their potential in biomedicine in the future. Here, we review the cell membrane-covered nanosystems, highlight their novelty, introduce relevant biomedical applications, and describe the future prospects for the use of this novel biomimetic system constructed from a combination of cell membranes and synthetic nanomaterials.
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