检索结果-南通市图书馆

The changes of large conductance ,calcium activated potassium channels(Bkca) in the detrusor myocytes from a rat overactive bladder model

在线全文

学校读者我要写书评

暂无评论

The changes of large conductance ,calcium activated potassiu...

第十五届全国泌尿外科学术会议

作者： Wen QianJun, Song Bo,Lu GenSheng, Li WeiBing, Li LongKun yan junan(The Urological center of Southwest hospital ,Third military medical university 400038)

Background and Objective Detrusor overactivity (DO) is a very common urinary dysfunction which could give rise to a variety of irritating symptoms such as urgency,,frequency with or without urge incontinence .DOcould seriously affect the suffers’ life quality or even mental health and it now apparently becomes a heavy burden to the social medical system. Though a lot have been done

关键词：

The changes of voltage gated L and T type calcium channels in the detrusor myocytes from a rat overactive bladder model

在线全文

cnki会议

学校读者我要写书评

暂无评论

The changes of voltage gated L and T type calcium channels i...

第十五届全国泌尿外科学术会议

作者： Wen QianJun , Song Bo,Lu GenSheng, Li WeiBing, Li LongKun yan junan(The Urological center of Southwest hospital ,Third military medical university 400038)

Background and Objective Detrusor overactivity (DO) is a very common urinary dysfunction and few effective treatments is available now. Though a lot have been done regarding the pathophysiology of DO,unfortunately, in fact,it is still largely a puzzle. Recently, emerging evidences have pointed out that an increased cellular excitability of detrusor myocytes play a pivotal role in the pathology of DO.

关键词：

MATRIEX imaging:multiarea two-photon real-time in vivo explorer

在线全文

cnki会议

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 156-166页

作者： Mengke yang Zhenqiao Zhou Jianxiong Zhang Shanshan Jia Tong Li Jiangheng Guan Xiang Liao Bing Leng Jing Lyu Kuan Zhang Min Li yan Gong Zhiming Zhu junan yan Yi Zhou Jian K Liu Zsuzsanna Varga Arthur Konnerth Yuguo Tang Jinsong Gao Xiaowei Chen Hongbo Jia Key Laboratory of Optical System Advanced Manufacturing Technology Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China Graduate School University of the Chinese Academy of SciencesBeijing 100039China Brain Research Instrument Innovation Center Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163China Brain Research Center and State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical UniversityChongqing 400038China Center for Neurointelligence Chongqing UniversityChongqing 401331China Center for Hypertension and Metabolic Diseases Daping HospitalChongqing 400042China Advanced Institute of Brain and Intelligence Guangxi UniversityNanning 530005China Centre for Systems Neuroscience Department of NeurosciencePsychology and BehaviourUniversity of LeicesterLeicesterUK Institute of Neuroscience Technical University Munich80802 MunichGermany

Two-photon laser scanning microscopy has been extensively applied to study in vivo neuronal activity at cellular and subcellular resolutions in mammalian ***,the extent of such studies is typically confined to a single functional region of the ***,we demonstrate a novel technique,termed the multiarea two-photon real-time in vivo explorer(MATRIEX),that allows the user to target multiple functional brain regions distributed within a zone of up to 12mm in diameter,each with a field of view(FOV)of ~200μm in diameter,thus performing two-photon Ca2+imaging with single-cell resolution in all of the regions *** example,we demonstrate real-time functional imaging of single-neuron activities in the primary visual cortex,primary motor cortex and hippocampal CA1 region of mice in both anesthetized and awake states.A unique advantage of the MATRIEX technique is the configuration of multiple microscopic FOVs that are distributed in three-dimensional space over macroscopic distances(>1 mm)both laterally and axially but that are imaged by a single conventional laser scanning *** particular,the MATRIEX technique can be effectively implemented as an add-on optical module for an existing conventional single-beam-scanning two-photon microscope without requiring any modification to the microscope ***,the MATRIEX technique can be readily applied to substantially facilitate the exploration of multiarea neuronal activity in vivo for studies of brain-wide neural circuit function with single-cell resolution.

关键词： photon readily typically

超极化激活环核苷酸门控阳离子通道(HCN)研究进展

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代生物医学进展 2009年第10期9卷 1973-1975页

作者：鄢俊安宋波第三军医大学附属西南医院全军泌尿外科研究所重庆400038

HCN是超极化激活环核苷酸门控阳离子通道,其激活后产生If/Ih电流,能被ZD7288和Cs+特异性阻断。该通道有4个亚型,具有稳定细胞膜电位、参与心脏和神经节律调节、参与树突整合,以及调节神经递质释放等生理功能。近期实验中发现豚鼠膀胱IC... 详细信息

HCN是超极化激活环核苷酸门控阳离子通道,其激活后产生If/Ih电流,能被ZD7288和Cs+特异性阻断。该通道有4个亚型,具有稳定细胞膜电位、参与心脏和神经节律调节、参与树突整合,以及调节神经递质释放等生理功能。近期实验中发现豚鼠膀胱ICC上存在Ih电流,其功能特点值得进一步研究和探讨。

关键词： HCN 超极化激活:离子通道

Clinical evaluation of double-J catheter in patients with upper urinary tract diseases:2027 cases reported

在线全文

学校读者我要写书评

暂无评论

Clinical evaluation of double-J catheter in patients with up...

第十三届全国泌尿外科学术会议暨第八届全球华人泌尿外科学术会议

作者： Weibing Li, Longkun Li, Caiping Song, junan yan, Zhansong Zhou, Bo Song, Ruiqi Zhang. Urological Center, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People’s Republic of China

Objectives: So far endoscopic procedures for diagnosis and therapy, such as Cystoscopy, extracorporeal shock-wave lithotripsy (ESWL), ureteroscopy, percutaneous nephrostomy, laparoscopy, and even robot machine, are mo...

关键词：

Identification and management of emptying failure in male patients with orthotopic neobladders after radical cystectomy for bladder cancer

在线全文

cnki会议

学校读者我要写书评

暂无评论

Identification and management of emptying failure in male pa...

第十七届全国泌尿外科学术会议

作者： zhiwen Chen,Huixiang Ji,Jinhong Pan,Wenhao Shen, Xiaojun Wu,Jiahua Zhang,Qiang Fang,Xin Li,junan yan, Xuemei Li,Bo Song Section of Urological Oncology,Urology Institute of People Liberation Army,Southwest Cancer Center,Southwest Hospital,Third Military Medical University

Objective Neobladder emptying failure is one of the important factors affecting the quality of life after radical cystectomy in patients with bladder *** treatment approach is based on the identification of etiology.

关键词：

上尿路梗阻解除后患侧肾功能恢复情况的回顾性研究

在线全文

cnki会议

学校读者我要写书评

暂无评论

中华泌尿外科杂志 2017年第3期38卷 170-173页

作者：王浩宇代林勇李前伟鄢俊安李为兵第三军医大学西南医院泌尿外科重庆400038

目的探讨上尿路梗阻解除后患侧肾功能的恢复情况.方法回顾性分析2015年1-12月我们收治的78例上尿路梗阻患者的临床资料,男42例,女36例.年龄21 ～ 68岁,平均（51.3±12.8）岁.确诊为上尿路狭窄6例,上尿路结石72例.所有患者术前均行CT... 详细信息

目的探讨上尿路梗阻解除后患侧肾功能的恢复情况.方法回顾性分析2015年1-12月我们收治的78例上尿路梗阻患者的临床资料,男42例,女36例.年龄21 ～ 68岁,平均（51.3±12.8）岁.确诊为上尿路狭窄6例,上尿路结石72例.所有患者术前均行CT和发射型计算机断层扫描（emission computed tomography,ECT）检查.根据术前患肾肾小球滤过率（glomemlarfiltration rate,GFR）将患者分为中度组（GFR≥15.0 ml/min）43例,GFR均值为（23.1±5.0）ml/min,术前肾皮质厚度均值为（12.5 ±4.3）mm;重度组（7.5 ml/min≤GFR＜ 15.0 ml/min）23例,GFR均值为（11.2±2.3） ml/min,术前肾皮质厚度均值为（8.3±3.7）mm;极重度组（GFR＜7.5 ml/min） 12例,GFR均值为（4.3 ±2.9） ml/min.对78例患者分别采用输尿管镜碎石取石术、经皮肾造瘘术、经皮肾镜取石术、输尿管软镜碎石取石术等术式解除梗阻.术后1个月复查患肾ECT检查,比较各组患者的患肾功能恢复情况,对手术前后GFR及恢复差值与术前肾皮质厚度做直线相关性分析.对极重度组,术后随访时间延长至8～12个月.结果解除梗阻后,中度组患肾GFR均值为（30.6±8.5） ml/min,平均恢复（7.6±7.6）ml/min;重度组患肾GFR均值为（13.1±4.5）ml/min,平均恢复（1.9±3.4）ml/min.两组数据与术前比较差异均有统计学意义（均P＜0.05）,中度组术后GFR恢复差值大于重度组,差异有统计学意义（P＜0.05）.极重度组术后1个月GFR均值为（11.1±3.4） ml/min,平均恢复（6.8±4.8）ml/min;术后8～12个月GFR均值为（12.7±3.6） ml/min,与术前比较差异均有统计学意义（均P＜0.05）.患肾术前、术后GFR以及GFR恢复差值与术前肾皮质厚度呈非完全线性正相关（P＜0.05）,术前相关系数（0.59）低于术后相关系数（0.70）,差异有统计学意义（P＜0.05）.结论上尿路梗阻解除后大部分患肾功能能够得到不同程度的恢复;梗阻影响术前ECT检查对患肾实际功能测定的准确性;部分术前评估认为可切除的肾脏,解除梗阻后GFR能够恢复至可予保留的水平.

关键词：上尿路梗阻肾功能恢复保留

输尿管软镜治疗肾结石的安全性和有效性分析(附716例报道)

在线全文

学校读者我要写书评

暂无评论

重庆医科大学学报 2018年第4期43卷 604-606页

作者：李前伟王聪蒲春晓姚基伟李贤平鄢俊安陆军军医大学第一附属医院泌尿外科重庆400038

目的:探讨输尿管软镜联合钬激光碎石治疗肾结石的安全性和有效性。方法:回顾性分析2017年7月至2017年12月我科收治的716例肾结石患者,行输尿管软镜钬激光碎石手术,其中一期手术组377例,术前留置双J管二期手术组339例,统计软镜工作鞘置... 详细信息

目的:探讨输尿管软镜联合钬激光碎石治疗肾结石的安全性和有效性。方法:回顾性分析2017年7月至2017年12月我科收治的716例肾结石患者,行输尿管软镜钬激光碎石手术,其中一期手术组377例,术前留置双J管二期手术组339例,统计软镜工作鞘置入成功率、手术时间、住院时间、结石清除率、并发症发生率等;并发症包括输尿管损伤、狭窄、发热及尿源性脓毒症、大出血等。结果:2组术前结石大小、结石位置、结石清除率(94.1%vs.93.7%)等无统计学差异(P>0.05),但一期手术组与二期手术组在工作鞘置入成功率(90.2%vs.100%)上有明显统计学差异(P<0.05)。2组均未出现输尿管撕脱、尿源性脓毒症等严重并发症。结论:术前免留置双J管行一期输尿管软镜钬激光碎石安全有效,与二期输尿管软镜手术相比,无明显差异,一期手术成功率关键取决于软镜工作鞘置入成功与否,与患者本身输尿管是否狭窄、扭曲等,以及术者经验有关。

关键词：肾结石输尿管软镜软镜工作鞘双J管

在线全文

学校读者我要写书评

暂无评论

经尿道前列腺电切术后暂时性尿失禁临床分析

重庆医学 2013年第28期42卷 3370-3371页

作者：张悦鄢俊安石英李安国李国成李凯贵州航天医院泌尿外科贵州遵义563003 第三军医大学西南医院泌尿外科重庆400038

目的探讨与常规经尿道前列腺电切术(TURP)相比,保留前列腺前叶TURP的临床疗效。方法将贵州航天医院收治的良性前列腺增生(BPH)患者736例随机均分为两组,观察组采用保留前列腺前叶的TURP,对照组采用常规不保留前列腺前叶的TURP,观察两组... 详细信息

目的探讨与常规经尿道前列腺电切术(TURP)相比,保留前列腺前叶TURP的临床疗效。方法将贵州航天医院收治的良性前列腺增生(BPH)患者736例随机均分为两组,观察组采用保留前列腺前叶的TURP,对照组采用常规不保留前列腺前叶的TURP,观察两组临床疗效及术后常见并发症的发生情况。结果观察组手术后最大尿流率、残余尿量及国际前列腺症状评分与对照组比较,差异无统计学意义(P>0.05)。观察组术后2个月内暂时性尿失禁的发生率为1.09%,对照组为5.16%,两组差异具有统计学意义(P0.05)。结论保留前列腺前叶的TURP能够有效减少术后暂时性尿失禁的发生,值得在临床上大力推广使用。

关键词：经尿道前列腺切除术前列腺增生尿失禁