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Effect of aging on expression of nitric oxide synthase I and activity of nitric oxide synthase in rat penis

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Asian Journal of Andrology 2003年第2期5卷 117-120页

作者： jun-ping shi Yong-Mei ZHAO Yu-Tong SONG Department of Andrology Shenyang Andrology Hospital Shenyang 110032 China

Aim: To investigate the effect of aging on the expression of nitric oxide synthase I (NOS I) and the activity of NOS in rat penis. Methods: Sixty male rats from 3 age groups (adult, old and senescent) were investigated. The expression of NOS I protein and mRNA in rat penis were detected by Western blot and RT-PCR respectively and the NOS activity, with ultraviolet spectrophotometry. Results: In the old and senescent group, NOS I protein expression was significantly decreased as compared with the adult. NOS I mRNA expression was well correlated with the protein expression. NOS activity was not statistically different between the adult and old groups, but it was significantly reduced in the senescent compared with the adult group (P<0.01). Conclusion: The aging-induced decreases in NOS I expression and NOS activity may be one of the main mechanisms leading to erectile dysfunction in the senescent rats.

关键词： aging nitric-oxide synthase erectile dysfunction

Hepatopulmonary metastases from papillary thyroid microcarcinoma:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4661-4668页

作者： Chuan-Yu Yang Xuan-Wu Chen Dong Tang Wen-jun Yang Xiao-Xiao Mi jun-ping shi Wei-Dong Du Department of Hepatobiliary Surgery The First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 310003Zhejiang ProvinceChina Department of Medical Imaging The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina Department of Pathology The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina Institute of Translational Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Papillary thyroid carcinoma(PTC)is the most common endocrine *** thyroid microcarcinoma(PTMC)accounts for the majority of PTC ***,concurrent pulmonary and hepatic metastases of PTMC are rarely ***,we present a patient with coexisting liver and lung metastases from *** SUMMARY We describe a 26-year-old woman with PTMC with multiple concurrent *** 3 d of unexplained fever,she was admitted to our *** thyroid functional tests were *** positron emission tomography(PET)/magnetic resonance imaging(MRI)examination showed increased fluorodeoxyglucose(FDG)metabolism and space-occupying lesions in the left lobe of the ***,PET/MRI images revealed multiple nodules in the lung and liver with increased FDG *** computer tomography(CT)showed multiple pulmonary *** ultrasound and liver MRI showed multiple space-occupying lesions in the *** patient underwent total thyroidectomy and central lymph node *** pathological analysis showed a papillary microcarcinoma multiplex in the left lobe of the thyroid.A diagnosis of hepatopulmonary metastases from papillary thyroid microcarcinoma was *** patient was given iodine-131 treatment one year after the *** recovered well after the operation,and the incision healed *** discharge,she was treated with oral levothyroxine sodium tablets,and symptomatic and supportive treatments were also given to promote radioactive excretion and prevent bone marrow suppression by iodine-131 *** Since patients with thyroid cancer concurrent with hepatopulmonary metastases have rarely been reported,our case will highlight the clinical and pathological profiles of these patients.

关键词： Papillary thyroid microcarcinoma Distant metastasis Liver Lung Case report

Trastuzumab,not lapatinib,has therapeutic effects on Chinese patients with HER2-positive cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 477-479页

作者： Hai-Bo Mou Wen-Dong Li Yan-jun Shen jun-ping shi Xiao-Di Guo Ming Yao Kai Wang Ting Zhang Department of Medical Oncology Shulan(Hangzhou)HospitalHangzhou 310022China Department of Medical Oncology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China OrigiMed ShanghaiChina Center of Precision Medicine Shulan(Hangzhou)HospitalHangzhou 310022China Department of Bone Marrow First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

As a relatively uncommon orphan tumor with high mortality,biliary tract cancer(BTC)presents an aggressive course and heterogeneous clinical features[1].BTC patients present with advanced manifestations[2].Unfortunately,there has been little progress in the management of *** patients have inoperable lesions and must receive palliative ***-based chemotherapy has been the only widely accepted first-line treatment for advanced BTC[3].Nevertheless,BTCs are often refractory to chemotherapeutic regimens,leading to a poor clinical outcome in these ***,with the rapid development of next generation sequencing(NGS)technologies,some actionable mutations such as those in IDH1,FGFR2,BRAF,HER2 genes,and unique molecular subsets in BTCs have been identified[4],and related targeted therapy against actionable mutations has been introduced into clinical practice as a promising therapeutic strategy[5].

关键词： biliary tract cancer(BTC) next generation sequencing(NGS)

From NAFLD to MAFLD:a“redefining”moment for fatty liver disease

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Chinese Medical Journal 2020年第19期133卷 2271-2273页

作者： Kenneth IZheng Jian-Gao Fan jun-ping shi Vincent Wai-Sun Wong Mohammed Eslam Jacob George Ming-Hua Zheng Department of Hepatology MAFLD Research CenterThe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 25000China Department of Gastroenterology Center for Fatty LiverXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Laboratory of Pediatric Gastroenterology and NutritionShanghai 200065China Department of Liver Diseases Hangzhou Normal University Affiliated HospitalHangzhouZhejiang 311121China Department of Medicine and Therapeutics The Chinese University of Hong KongHong Kong 999077China Storr Liver Centre Westmead Institute for Medical ResearchWestmead Hospital and University of SydneySydney 2145Australia Institute of Hepatology Wenzhou Medical UniversityWenzhouZhejiang 325000China Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province WenzhouZhejiang 325000China.

The term non-alcoholic fatty liver disease(NAFLD)was coined in 1980 to characterize a disease similar to alcoholic fatty liver disease that developed in patients without a history of excessive alcohol intake.[1]Morphologically,NAFLD is characterized by excess fatty infiltration of the liver in the absence of known causes of liver disease(eg,alcohol,autoimmune liver disease,viral hepatitis,etc).The clinical manifestations of NAFLD(both hepatic and extrahepatic)depend on the outcome of complex interactions between its primary drivers including poor lifestyle habits and diet,a dysfunctional microbiota,genetic predisposition,and environmental cues that result in metabolic dysfunction and liver ***,bringing all patients with their markedly different clinical courses under the NAFLD umbrella belies its complexity and implies a homogeneous disease state that then negatively impacts clinical management and a deeper understanding of *** advances in current knowledge on the spectrum of fatty liver diseases,it is apparent that the fourdecade-old outdated term NAFLD can no longer serve to usefully describe a highly heterogeneous *** disease as we understand it today not only impacts patients who consume alcohol and those who do not,but also potentially impacts all patients with any form of liver disease,by acting as a disease modifier.[2]

关键词： NAFLD Morphological markedly

FPGA-based position reconstruction method for neutron beam flux spatial distribution measurement in BNCT

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Nuclear Science and Techniques 2024年第3期35卷 96-108页

作者： Wei Jiang ping Cao Yi-Ming Wu Xian-Ke Liu Zhu-jun Fang Zhi-Yong Zhang Bin shi jun Chen State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China National Key Laboratory for Metrology and Calibration Techniques China Institute of Atomic EnergyBeijing 102413China

A new measurement method for the spatial distribution of neutron beam flux in boron neutron capture therapy(BNCT)is being developed based on the two-dimensional Micromegas *** address the issue of long processing times in traditional offline position reconstruction methods,this paper proposes a field programmable gate array based online position reconstruction method utilizing the micro-time projection chamber *** method encapsulates key technical aspects:a self-adaptive serial link technique built upon the dynamical adjustment of the delay chain length,fast sorting,a coordinate-matching technique based on the mapping between signal timestamps and random access memory(RAM)addresses,and a precise start point-merging technique utilizing a circular combined *** performance test of the selfadaptive serial link shows that the bit error rate of the link is better than 10-12 at a confidence level of 99%,ensuring reliable data *** experiment utilizing the readout electronics and Micromegas detector shows a spatial resolution of approximately 1.4 mm,surpassing the current method’s resolution level of 5 *** beam experiment confirms that the readout electronics system can obtain the flux spatial distribution of neutron beams online,thus validating the feasibility of the position reconstruction *** online position reconstruction method avoids traditional methods,such as bubble sorting and traversal searching,simplifies the design of the logic firmware,and reduces the time complexity from O(n2)to O(n).This study contributes to the advancement in measuring neutron beam flux for BNCT.

关键词： Position reconstruction FPGA Readout electronics Neutron flux spatial distribution

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook

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Chinese Journal of Integrative Medicine 2024年第1期30卷 62-74页

作者： JIANG Xiao-ying shi Li-ping ZHU jun-long BAI Ren-ren XIE Tian School of Pharmacy Hangzhou Normal UniversityHangzhou(311121)China Key Laboratory of Elemene Class Anti-cancer Chinese Medicines Engineering Laboratory of Development and Application of Traditional Chinese MedicinesCollaborative Innovation Center of Traditional Chinese Medicines of Zhejiang ProvinceHangzhou Normal UniversityHangzhou(311121)China Good Clinical Practice Center Affliliated Hospital of Nanjing University of Chinese MedicineNanjing(210000)China

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

关键词： molecular compatibility theory Chinese integrative medicine elemene antitumor activity drug delivery structural modification

Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian XU Ding-qiao YUE shi-jun FU Rui-jia TANG Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

Metabolic Disorders Combined with Noninvasive Tests to Screen Advanced Fibrosis in Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 607-614页

作者： Yi-Wen shi Fang-ping He Jin-jun Chen Hong Deng jun-ping shi Cai-Yan Zhao Yu-Qiang Mi Zheng-Sheng Zou Yong-Jian Zhou Fu-Sheng Di Rui-Dan Zheng Qin Du Jia Shang Rui-Xu Yang Branko Popovic Bi-Hui Zhong Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghaiChina Department of Gastroenterology II The First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Uygur Autonomous RegionsÜrümqiChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Infectious Diseases the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina The Affiliated Hospital of Hangzhou Normal University HangzhouChina Department of Infectious Disease The Third Hospital of Hebei Medical UniversityShijiazhuangChina Department of Infectious Diseases Tianjin Second People’s HospitalTianjinChina Department of Liver Disease Chinese PLA General Hospitalthe Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Gastroenterology and Hepatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina Department of Endocrinology and Metabolism The Third Central Hospital of TianjinTianjinChina Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhouChina Department of Gastroenterology the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infectious Diseases Henan Provincial Peoples’Hospital Zhengzhou ZhengzhouChina Sanofi-Aventis Deutschland GmbH FrankfurtGermany Department of Gastroenterology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)is associated with metabolic *** study aimed to explore the role of metabolic disorders in screening advanced fibrosis in NAFLD ***:A total of 246 histologically-proven NAFLD patients were enrolled across 14 *** compared the severity of fibrosis in patients with different components of metabolic *** on standard noninvasive tests and metabolic disorders,we developed new algorithms to identify advanced ***:Metabolic syndrome(MetS)was frequent in NAFLD patients(133/246,54%).Patients with MetS had a higher proportion of significant fibrosis(p=0.014)and higher LSM values(9.2 kPa,vs.7.4 kPa,p=0.002)than those without *** with more metabolic disorders had higher fibrosis stages(p=0.017).Reduced highdensity lipoprotein cholesterol(odds ratio[OR]:2.241,95%confidence interval[CI]:1.004–5.002,p=0.049)and raised fasting glucose(OR:4.500,95%CI:2.083–9.725,p<0.001)were significantly associated with advanced *** these two metabolic disorders as a screening tool,a sensitivity,specificity and accuracy of 92%,81%and 83%was achieved,*** the new algorithms combining metabolic disorders with noninvasive measurements,the number of patients requiring liver biopsy was reduced,especially in combination with the Fibrosis-4 score and metabolic disorders(36%to 17%,p<0.001).In addition,this stepwise algorithm could achieve a high accuracy(85%)and high negative predictive value(93%).Conclusions:Metabolic disorders should be taken into consideration in the diagnosis of advanced *** further validation and investigation,new algorithms could be recommended in primary care units to spare patients from unnecessary referral and liver biopsies.

关键词： Nonalcoholic fatty liver disease Liver fibrosis Metabolic syndrome Noninvasive measurement

Volume of fluid simulation of single argon bubble dynamics in liquid steel under RH vacuum conditions

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Journal of Iron and Steel Research International 2024年第4期31卷 828-837页

作者： Gu-jun Chen Sheng-ping He College of Materials Science and Engineering Yangtze Normal UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

Single argon bubble dynamics in liquid steel under Ruhrstahl-Heraeus(RH)vacuum conditions were simulated using the volume of fluid method,and the ideal gas law was used to consider bubble growth due to heat transfer and pressure *** simulation with a constant bubble density was also performed to validate the numerical method,and the predicted terminal bubble shape and velocity were found to agree with those presented in the Grace diagram and calculated by drag correlation,*** simulation results under RH conditions indicate that the terminal bubble shape and velocity cannot be *** primary bubble growth occurs within a rising distance of 0.3 m owing to heating by the high-temperature liquid steel;subsequently,the bubble continues to grow under equilibrium with the hydrostatic *** the initial diameter is 8-32 mm,the bubble diameter and rising velocity near the liquid surface are 80-200 mm and 0.5-0.8 m/s,*** bubble rises rectilinearly with an axisymmetric shape,and the shape evolution history includes an initial sphere,(dimpled)ellipsoid,and spherical cap with satellite bubbles.

关键词： Bubble dynamics Liquid steel Volume of fluid Bubble growth Bubble shape Rising velocity