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Factors associated with complicated erosive esophagitis: A Japanese multicenter, prospective, cross-sectional study

World Journal of Gastroenterology 2017年第2期23卷 318-327页

作者： Masahiro Sakaguchi Noriaki Manabe Nobuo Ueki jun miwa Tomoki Inaba Norimasa Yoshida Kouichi Sakurai Masahiro Nakagawa Hajime Yamada Michiya Saito Koji Nakada Katsuhiko Iwakiri Takashi Joh Ken Haruma Department of Gastroenterology Moriguchi Keijinkai Hospital Division of Endoscopy and Ultrasonography Department of Clinical Pathology and Laboratory MedicineKawasaki Medical School Department of Internal Gastroenterology and Hepatology Tokyo Rosai Hospital Department of Gastroenterology Toshiba General Hospital Department of Gastroenterology Kagawa Prefectural Central Hospital Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital Hattori Clinic Department of Endoscopy Hiroshima City Hospital Department of Gastroenterology and Hepatology Shinko Hospital1 Michiya Clinic1 Department of Laboratory Medicine Daisan Hospital Jikei University School of Medicine1 Department of Gastroenterology Nippon Medical School Graduate School of Medicine1 Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences1 Department of General Internal Medicine 2 Kawasaki Medical School General Medical Center

AIMTo assess the clinical characteristics of patients with complicated erosive esophagitis (EE) and their associated *** prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database. Logistic regression analysis was used to calculate adjusted odds ratios (aOR) and 95%CI for the association with complicated *** the study period, 1749 patients diagnosed with EE, 38.3% of whom were prescribed proton pump inhibitors (PPIs) were included. Of them, 143 (8.2%) had EE complications. Esophageal bleeding occurred in 84 (4.8%) patients, esophageal strictures in 45 (2.6%) patients, and 14 (0.8%) patients experienced both. Multivariate analysis showed that increased age (aOR: 1.05; 95%CI: 1.03-1.08), concomitant use of psychotropic agents (aOR: 6.51; 95%CI: 3.01-13.61), and Los Angeles grades B (aOR: 2.69; 95%CI: 1.48-4.96), C (aOR: 15.38; 95%CI: 8.62-28.37), and D (aOR: 71.49; 95%CI: 37.47-142.01) were significantly associated with complications, whereas alcohol consumption 2-4 d/wk was negatively associated (aOR: 0.23; 95%CI: 0.06-0.61). Analyzing associated factors with each EE complication separately showed esophageal ulcer bleeding were associated with increased age (aOR: 1.05; 95%CI: 1.02-1.07) and Los Angeles grades B (aOR: 3.60; 95%CI: 1.52-8.50), C (aOR: 27.61; 95%CI: 12.34-61.80), and D (aOR: 119.09; 95%CI: 51.15-277.29), while esophageal strictures were associated with increased age (aOR: 1.07; 95%CI: 1.04-1.10), gastroesophageal reflux symptom (aOR: 2.51; 95%CI: 1.39-4.51), concomitant use of psychotropic agents (aOR: 11.79; 95%CI: 5.06-27.48), Los Angeles grades C (aOR: 7.35; 95%CI: 3.32-16.25), and D (aOR: 20.34; 95%CI: 8.36-49.53) and l

关键词： Complication Erosive esophagitis Proton pump inhibitor Esophageal ulcer bleeding Esophageal stricture

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Effects of repeated antigen exposure to sensitized rats on agonist-induced NO production and its downstream signaling in nasal mucosal veins

Effects of repeated antigen exposure to sensitized rats on a...

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第十五届国际药理学大会

作者： jun Enzaka Hiroyasu Sakai Yoshihiko Chiba miwa Misawa Dept.of Pharmacol. Sch.of Pharm.Hoshi Univ.2-4-41 EbaraShinagawa-kuTokyo 142-8501Japan Dept.of Pharmacol. Sch.of Pharm.Hoshi Univ.2-4-41 EbaraShinagawa-kuTokyo 142-8501Japan Dept.of Pharmacol. Sch.of Pharm.Hoshi Univ.2-4-41 EbaraShinagawa-kuTokyo 142-8501Japan Dept.of Pharmacol. Sch.of Pharm.Hoshi Univ.2-4-41 EbaraShinagawa-kuTokyo 142-8501Japan

＜正＞ In allergic rhinitis, nasal obstruction is considered to be induced by both a dilatation of plexus caverosum and an increase in vascular permeability in nasal mucosa. Nitric oxide （NO）,a powerful vasodilator, is suggested to be involved in allergic inflammation. In the present study, the effect of repeated antigen exposure on leukotriene D4（LTD4）-induced NO production in nasal mucosa was investigated. The changes in mRNA expression of NO synthase （NOS） isoforms in nasal mucosae of the antigen-induced nasal hyperresponsive rats were also determined by immunoblottings. The mRNA level of iNOS. but not eNOS and nNOS. was significantly increased in nasal mucosae of repeatedly antigen challenged rats. In addition, the LTD4-induced NO production in nasal mucosae of nasal hyperresponsive rats was markedly augmented as compared with that of control animals . Interestingly, the venodilatation induced by sodium nitroprusside. an NO donor, was also augmented in nasal hyperresponsive rats. Therefore, not only increased NO production but also enhanced NO responsiveness might be involved in the development of nasal hyperresponsiveness in allergic rhinitis.

关键词： nitric oxide NOS allergic rhinitis nasal hyperresponsiveness

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Clinical outcomes and risk factors for perforation in gastric endoscopic submucosal dissection: A prospective pilot study

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World Journal of Gastrointestinal Endoscopy 2013年第6期5卷 281-287页

作者： Jiro Watari Toshihiko Tomita Fumihiko Toyoshima jun Sakurai Takashi Kondo Haruki Asano Takahisa Yamasaki Takuya Okugawa Hisatomo Ikehara Tadayuki Oshima Hirokazu Fukui Hiroto miwa Division of Upper Gastroenterology Department of Internal Medicine Hyogo College of Medicine

AIM: To evaluate clinical outcomes and risk factors for endoscopic perforation during endoscopic submucosal dissection (ESD) in a prospective study. METHODS: We investigated the clinical outcomes and risk factors for the development of perforation in 98 consecutive gastric neoplasms undergoing ESD regarding. Demographic and clinical parameters including patient-, tumor-, and treatment-related factors, clinical parameters, and duration of hospital stay were analyzed for risk factors for perforation. In subgroup analysis, we also compared the clinical outcomes between perforation and "silent" free air without endoscopically visible perforation detected only by computed ***: Perforation was identified in 8.2% of patients. All patients were managed conservatively by the administration of antibiotics. The mean procedure time was significantly longer in patients with endoscopic perforation than in those without. According to the receiver-operating characteristic analysis, the resulting cutoff value of the procedure time for perforation was 115 min (87.5% sensitivity, 56.7% specificity). Prolonged procedure time (≥ 115 min) was associated with an increased risk of perforation (odds ratio 9.15; 95%CI: 1.08-77.54; P = 0.04). Following ESD, body temperature and C-reactive protein level were significantly higher in patients with perforation than in those without (P = 0.02), whereas there was no difference between these patient groups on the starting day of oral intake or of hospitalization. In subgroup analysis, the post-ESD clinical course was not different between endoscopic perforation and silent free air. CONCLUSION: Only prolonged procedure time (≥ 115 min) was significantly associated with perforation. The clinical outcomes of perforation are favorable and are comparable to those of patients with or without silent free air.

关键词： Gastric cancer Endoscopic submucosal dissection Perforation Risk factors Treatment outcome

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Gelatin methacryloyl granular scaffolds for localized mRNA delivery

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Aggregate 2024年第2期5卷 386-400页

作者： Bruna Gregatti Carvalho Aya Nakayama Hiromi miwa SangWon Han Lucimara Gaziola de la Torre Dino Di Carlo junmin Lee Han-jun Kim Ali Khademhosseini Natan Roberto de Barros Terasaki Institute for Biomedical Innovation(TIBI) Los AngelesCaliforniaUSA Department of Materials and Bioprocess Engineering School of Chemical EngineeringUniversity of Campinas(UNICAMP)CampinasBrazil Department of Bioengineering University of California at Los Angeles(UCLA)Los AngelesCaliforniaUSA Department of Biophysics Paulista School of MedicineFederal University of São Paulo(UNIFESP)CampinasBrazil Department of Materials Science and Engineering Pohang University of Science and Technology(POSTECH)PohangRepublic of Korea Institute for Convergence Research and Education in Advanced Technology Yonsei UniversityIncheonRepublic of Korea College of Pharmacy Korea UniversityPohangRepublic of Korea Centre for Biomaterials Cellular and Molecular Theranostics(CBCMT)Vellore Institute of Technology(VIT)VelloreIndia

Messenger RNA(mRNA)therapy is the intracellular delivery of mRNA to produce desired therapeutic *** strategies for local mRNA delivery is still required where direct intra-articular injections are inappropriate for targeting a specific *** mRNA delivery efficiency depends on protecting nucleic acids against nuclease-mediated degradation and safe site-specific intracellular ***,novel mRNA-releasing matrices based on RGD-moiety-rich gelatin methacryloyl(GelMA)microporous annealed particle(MAP)scaffolds are *** concentration in aerogel-based microgels(μgels)produced through a microfluidic process,MAP stiffnesses,and microporosity are crucial parameters for cell adhesion,spreading,and *** being loaded with mRNA complexes,MAP scaffolds composed of 10%GelMAμgels display excellent cell viability with increasing cell infiltration,adhesion,proliferation,and gene *** intracellular delivery is achieved by the sustained release of mRNA complexes from MAP scaffolds and cell adhesion on mRNA-releasing *** findings highlight that hybrid systems can achieve efficient protein expression by delivering mRNA complexes,making them promising mRNA-releasing biomaterials for tissue engineering.

关键词： GelMA lipid-based nanocarriers MAP scaffolds microfluidics mRNA

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Diagnosis of small intramucosal signet ring cell carcinoma of the stomach by non-magnifying narrow-band imaging: A pilot study

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1070-1077页

作者： Jiro Watari Toshihiko Tomita Hisatomo Ikehara Masato Taki Tomohiro Ogawa Takahisa Yamasaki Takashi Kondo Fumihiko Toyoshima jun Sakurai Tomoaki Kono Katsuyuki Tozawa Yoshio Ohda Tadayuki Oshima Hirokazu Fukui Seiichi Hirota Hiroto miwa Division of Gastroenterology Department of Internal Medicine Hyogo College of Medicine NishinomiyaHyogo 663-8501 Japan Department of Surgical Pathology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Division of Gastroenterology Department of Internal Medicine Hyogo College of MedicineNishinomiyaHyogo 663-8501 Japan

AIM: To examine the efficacy of non-magnifying narrow-band imaging(NM-NBI) imaging for small signet ring cell carcinoma(SRC).METHODS: We retrospectively analyzed 14 consecutive small intramucosal SRCs that had been treated with endoscopic submucosal dissection(ESD) and 14 randomly selected whitish gastric ulcer scars(control). The strength and shape of the SRCs and whitish scars by NM-NBI and white-light imaging(WLI) were assessed with Image J(NIH, Bethesda).RESULTS: NM-NBI findings of SRC showed a clearly isolated whitish area amid the brown color of the surrounding normal mucosa. The NBI index, which indicates the potency of NBI for visualizing SRC, was significantly higher than the WLI index(P = 0.001), indicating SRC was more clearly identified by NM-NBI. Although the NBI index was not significantly different between SRCs and controls, the circle(C)-index, as an index of circularity of tumor shape, was significantly higher in SRCs(P = 0.001). According to the receiveroperating characteristic analysis, the resulting cut-off value of the circularity index(C-index) for SRC was 0.60(85.7% sensitivity, 85.7% specificity). Thus a lesion with a C-index ≥ 0.6 was significantly more likely to be an SRC than a gastric ulcer scar(OR = 36.0; 95%CI: 4.33-299.09; P = 0.0009).CONCLUSION: Small isolated whitish round area by NM-NBI endoscopy is a useful finding of SRCs which is the indication for ESD.

关键词： Gastric cancer Signet ring cell carcinoma Narrow-b

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细胸金针虫田间分布型及抽样技术

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华北农学报 1989年第3期4卷 110-115页

作者：苏骏崔景岳李仲秀河北省沧州地区农业科学研究所

细胸金针虫幼虫在田间的空间分布,既符合负二项式分布,又符合当n大于某一值的奈曼分布.土壤10cm以上浅层分布基本与幼虫在整个活动深度上层内的空间分布相一致,春、秋期间,大部分幼虫在10cm以上浅层土壤内取食危害.幼虫的抽样调查可选... 详细信息

细胸金针虫幼虫在田间的空间分布,既符合负二项式分布,又符合当n大于某一值的奈曼分布.土壤10cm以上浅层分布基本与幼虫在整个活动深度上层内的空间分布相一致,春、秋期间,大部分幼虫在10cm以上浅层土壤内取食危害.幼虫的抽样调查可选在春、秋危害期于10cm以上土层内进行.本研究采取的几种简单随机抽样方法与实地虫量调查无显著差异,其中以平行线方法效果较佳.

关键词：细胸金针虫田间分布抽样技术

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应用改进的简单方程法求非线性数学物理方程的精确解

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数学的实践与认识 2017年第10期47卷 222-226页

作者：杨娟黄朝军冯庆江凯里学院数学科学学院贵州凯里556000

应用改进的简单方程法求得Cahn-Allen方程和Jimbo-miwa方程的精确解,这些解包括双曲函数解、三角函数解.当对双曲函数解中的参数取特殊值时,可以得到了孤立波解.当对三角函数解中的参数取特殊值时,可以得到对应的周期波函数解.实践证明... 详细信息

应用改进的简单方程法求得Cahn-Allen方程和Jimbo-miwa方程的精确解,这些解包括双曲函数解、三角函数解.当对双曲函数解中的参数取特殊值时,可以得到了孤立波解.当对三角函数解中的参数取特殊值时,可以得到对应的周期波函数解.实践证明,简单方程法对于研究非线性数学物理方程具有非常广泛的应用意义.

关键词：简单方程法 Cahn-Allen方程 Jimbo-miwa方程精确解

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临床Ⅰ期非小细胞肺癌胸腔镜下三种手术方式的结果比较

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循证医学 2013年第2期13卷 91-93页

作者：赵峰王建军谢亮华中科技大学同济医学院附属协和医院胸外科武汉430022 广东省人民医院肿瘤中心广东省医学科学院广东省肺癌研究所广州510080

1文献来源 Nakamura H, Taniguchi Y, miwa K, et al. Comparison of the surgical outcomes of thoracoscopic lobectomy, segmentectomy, and wedge resection for clinical stage Ⅰnon-small cell lung cancer [J]. Thorac Cardiova... 详细信息

关键词：非小细胞肺癌电视胸腔镜手术肺叶切除术肺段切除术楔形切除术

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