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Gut microbiome and pancreatic cancer cachexia:An evolving relationship

World Journal of Gastrointestinal Oncology 2022年第7期14卷 1218-1226页

作者： Andrew Hendifar Rasaq Akinsola Hayato Muranaka Arsen Osipov Shant Thomassian Natalie Moshayedi julianne yang Jonathan Jacobs Suzanne Devkota Neil Bhowmick Jun Gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States The Vatche and Tamar Manoukian Division of Digestive Diseases Department of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine David Geffen School of Medicine at UCLAUniversity of CaliforniaLos AngelesLos AngelesCA 90095United States Cedars-Sinai Medical Center Department of MedicineInflammatory Bowel and Immunobiology Research InstituteUniversity of CaliforniaLos AngelesCA 90048United States

Nearly 80% of patients with pancreatic ductal adenocarcinoma(PDAC)develop cachexia along their disease *** is characterized by progressive weight loss,muscle wasting,and systemic inflammation and has been linked to poorer outcomes and impairments in quality of *** of PDAC cachexia has historically involved a multidisciplinary effort comprised of nutritional support,pancreatic enzyme replacement therapy,and/or pharmacologic *** current interventions to mitigate PDAC cachexia,a significant proportion of patients continue to die from complications associated with cachexia underscoring the need for novel insights and treatments for this *** highlight the feasibility and effectiveness of a recent enteral feeding prospective trial at our institution to improve cachexia outcomes in patients with advanced ***,we were among the first to characterize the stool microbiome composition in patients with advanced PDAC receiving enteral feeding for the treatment of *** insights into the relationship between enteral nutritional support,cachexia,and the gut microbiome are *** promising results are discussed in the context of a potential ability to modulate the stool microbiome as a new interventional strategy to mitigate PDAC cachexia.

关键词： Gut microbiome Pancreatic cancer Stool Cachexia Inflammation Weight

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Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

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Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith Liwen Zhou Cameron L.Ghergherehchi Michelle Mikesh Cathy Z.yang Haley O.Tucker julianne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

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Challenges and improvements in testosterone and estradiol testing

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Asian Journal of Andrology 2014年第2期16卷 178-184,I0006,I0007页

作者： Hubert W Vesper julianne C Botelho Yuesong Wang Clinical Chemistry Branch Division of Laboratory Sciences Centers for Disease Control and Prevention Atlanta Georgia USA.

Assays that measure steroid hormones in patient care, public health, and research need to be both accurate and precise, as these criteria help to ensure comparability across all clinical and research applications. This review addresses major issues relevant to assay variability and describes recent activities by the US Centers for Disease Control and Prevention （CDC） to improve assay performance. Currently, high degrees of accuracy and precision are not always met for testosterone and estradiol measurements; although technologies for steroid hormone measurement have advanced significantly, measurement variability within and across laboratories has not improved accordingly. Differences in calibration and specificity are discussed as sources of variability in measurement accuracy. Ultimately, a combination of factors appears to cause inaccuracy of steroid hormone measurements, with nonuniform assay calibration and lack of specificity being two major contributors to assay variability. Within-assay variability for current assays is generally high, especially at low analyte concentrations. The CDC Hormone Standardization （HoSt） Program is improving clinical assays, as evidenced by a 50% decline in mean absolute bias between mass spectrometry assays and the CDC reference method from 2007 to 2011. This program provides the measurement traceability to CDC reference methods and helps to minimize factors affecting measurement variability.

关键词： CDC hormone standardization CDC HoSt estradiol steroid hormone testing testosterone

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Temporal gradients limit the accumulation of neutrophils toward sources of chemoattractant

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Microsystems & Nanoengineering 2017年第1期3卷 455-462页

作者： Arvind Chandrasekaran Felix Ellett julianne Jorgensen Daniel Irimia Department of Surgery BioMEMS Resource CenterMassachusetts General HospitalHarvard Medical SchoolShriners Burns HospitalBostonMA 02129USA

Neutrophil trafficking during inflammation is a highly orchestrated process,coordinating neutrophil recruitment,sterilization of the wound,and inflammation *** the chemotactic signals guiding neutrophil recruitment to sites of inflammation are relatively well understood,our knowledge of mechanisms controlling cessation of neutrophil recruitment and return to normal tissue physiology remains *** gain insights into these processes,we designed a microfluidic device with an array of chemoattractant reservoirs,which mimics the microenvironment in infected tissues,when multiple clusters of microbes are *** monitored the temporal dynamics of neutrophil recruitment toward the chemoattractant reservoirs at single cell resolution,for 3 *** observed robust neutrophil recruitment that reached a plateau after 1.5 h,despite the continuous presence of strong chemoattractant gradients around the *** timing of the plateau was dependent on the geometry of the devices and was independent from the number of *** the basis of these observations,we ruled out sub-population sensitivity,chemoattractant scavenging,and production of a self-limiting stop signal as potential mechanisms underpinning the plateau in neutrophil *** found a strong correlation between the temporal stabilization of concentration changes and the plateau in neutrophils *** results suggest that dynamic aspects of chemoattractant gradients are key for maximizing recruitment during the acute phase of infections and limiting the accumulation of neutrophils as soon as the infection is contained.

关键词： chemotaxis leukocyte microfluidic relay signaling scavenging

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跟踪动物健康的可注射传感器

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科技纵览 2024年第6期 9-9页

作者： julianne Pepitone 不详

2024年早些时候发表在《IEEE传感器杂志》上的一项研究表明,可注射传感器可以为兽医、农民、动物研究人员以及役用动物和宠物的主人提供新的监测数据和安全措施。在这项研究中,一种小到能穿过4毫米直径针头的可注射芯片可以提供动物健... 详细信息

2024年早些时候发表在《IEEE传感器杂志》上的一项研究表明,可注射传感器可以为兽医、农民、动物研究人员以及役用动物和宠物的主人提供新的监测数据和安全措施。在这项研究中,一种小到能穿过4毫米直径针头的可注射芯片可以提供动物健康的实时参数,包括心率、呼吸频率、运动情况和体温。

关键词：动物健康呼吸频率宠物实时参数传感器注射兽医安全措施

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Convenient synthesis of nucleoside 5'-(α-P-thio)triphosphates and phosphorothioate nucleic acids(DNA and RNA)

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Science China Chemistry 2012年第1期55卷 80-89页

作者： CATON-WILLIAMS julianne FIAZ Bilal HOXHAJ Rudiona SMITH Matthew Department of Chemistry Georgia State University

Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and deprotection of the nucleoside *** conveniently synthesize the S-modified triphosphates for enzymatically preparing phosphorothioate DNAs and RNAs(PS-DNA and PS-RNA) as potential therapeutics,herein we report a one-pot strategy to synthesize the deoxy-and ribo-nucleoside 5'-(α-P-thio)triphosphates(dNTPαS and NTPαS) without protecting any nucleoside *** facile synthesis is achieved by treating the nucleosides with a mild phosphitylating reagent,reacting selectively with the 5'-hydroxyl group of each unprotected nucleoside,followed by sulfurization and hydrolysis to afford the crude dNTPαS and NTPαS analogs(mixtures of Sp and Rp diastereomers).We also demonstrated that after just simple precipitation(without HPLC and ion-exchange purification),the quality of the synthesized dNTPαS and NTPαS analogs is excellent for direct DNA polymerization and RNA transcription,*** Klenow DNA polymerase and T7 RNA polymerase accept the Sp diastereomers of dNTPαS and NTPαS analogs,respectively,while the Rp diastereomers are neither substrates nor inhibitors,the diastereomerically-pure PS-DNAs and PS-RNAs can be conveniently synthesized enzymatically.

关键词： sulfur modification S-derivatized nucleic acid nucleoside triphosphates nucleoside phosphorothioates phosphorothioate DNA and RNA diastereomers DNA and RNA polymerases

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Synthesis and Properties of a Novel 3D Europium Coordination Polymer with Helical Chain and （3,6）-Connected rtl Net

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Chinese Journal of Chemistry 2016年第12期34卷 1304-1308页

作者： Zhifeng Liu Bowen Lai Huiliang Wen julianne Robbins Nei Huang State Key Laboratory of Food Science and Technology Nanchang University Nanchang Jiangxi 330047 China Chemicals' Analysis Department Nanchang Institute for Food and Drug Control Nanchang Jiangxi 330038 China School of Chemistry and Biochemistry Georgia Institute of Technology Atlanta Georgia 30332 United States Jiangxi Sinograin Quality Supervision Center Nanchang Jiangxi 330000 China

The first coordination polymer of 2,2＇-（（4-carboxymethyl-1,3-phenylene）bis（oxy）） diacetic acid （H3L） with eu- ropium（[II） ion, [Eu（L）（H2O）]＇3H2O （1）, has been hydrothermally synthesized and structurally characterized. Complex 1 exhibits a 3D coordination polymer with helical chain and rtl topology of the point symbol （4·6^2）2（4^2·6^10·8^3） based on [Eu2（COO）4] as secondary building unit （SBU）. Furthermore, the luminescent and magnetic properties of complex 1 are studied.

关键词： europium coordination polymer helix topological structure luminescence magnetism

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Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

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World Journal of Cardiology 2023年第5期15卷 262-272页

作者： julianne Theresa Nelson Longjian Liu Department of Epidemiology and Biostatistics Dornsife School of Public HealthDrexel UniversityPhiladelphiaPA 19104United States

BACKGROUND A limited number of studies have been conducted to test the magnitudes of the association between apparent treatment resistant hypertension(aTRH)and risk of cardiovascular disease(CVD).AIM To investigate the association between aTRH and risk of CVD and examine whether sex and age modify this *** We applied an observational analysis study design using data from the United States Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial(ALLHAT).ALLHAT recruited participants(n=25516)from 625 primary care settings throughout the United States,Canada,Puerto Rico,and United States Virgin Islands,aged 55 and older with hypertension and at least one additional risk factor for heart *** was assessed from the year 2 *** event was defined as one of the following from the year 2 follow-up visit:Fatal or non-fatal myocardial infarction,coronary revascularization,angina,stroke,heart failure,or peripheral artery *** proportional hazards regression was used to examine the effect of aTRH on CVD *** modifications of sex and age on this association were examined on the multiplicative scale by interaction term and additive scale by joint effects and relative excess risk for *** Of the total study participants(n=25516),5030 experienced a CVD event during a mean of 4.7 years *** was associated with a 30%increase in risk of CVD compared to non-aTRH[hazards ratio(HR)=1.3,95%CI:1.19-1.42].Sex and age modified this relationship on both multiplicative and additive scales *** by sex,aTRH was associated with a 64%increase in risk of CVD(HR=1.64,95%CI:1.43–1.88)in women,and a 13%increase in risk of CVD(HR=1.13,95%CI:1.01–1.27)in *** by age,aTRH had a stronger impact on the risk of CVD in participants aged<65(HR=1.53,95%CI:1.32–1.77)than it did in those aged≥65(HR=1.18,95%CI:1.05–1.32).Significant two-way interactions of sex and aTRH,and age and aTRH on risk of

关键词： Apparent treatment resistant hypertension Cardiovascular disease outcomes Chronic kidney disease Sex Age

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Repair and regeneration of peripheral nerve injuries that ablate branch points

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Neural Regeneration Research 2023年第12期18卷 2564-2568页

作者： julianne E.Allgood George D.Bittner Jared S.Bushman Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA Department of Neuroscience The University of Texas at AustinAustinTXUSA

The peripheral nervous system has an extensive branching organization, and peripheral nerve injuries that ablate branch points present a complex challenge for clinical repair. Ablations of linear segments of the PNS have been extensively studied and routinely treated with autografts, acellular nerve allografts, conduits, wraps, and nerve transfers. In contrast, segmental-loss peripheral nerve injuries, in which one or more branch points are ablated so that there are three or more nerve endings, present additional complications that have not been rigorously studied or documented. This review discusses:(1) the branched anatomy of the peripheral nervous system,(2) case reports describing how peripheral nerve injuries with branched ablations have been surgically managed,(3) factors known to influence regeneration through branched nerve structures,(4) techniques and models of branched peripheral nerve injuries in animal models, and(5) conclusions regarding outcome measures and studies needed to improve understanding of regeneration through ablated branched structures of the peripheral nervous system.

关键词： allograft animal model branched injuries femoral nerve peripheral nerve injury peripheral nervous system regeneration repair sciatic nerve surgical repair

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Predicting the performance of steam assisted gravity drainage (SAGD) method utilizing artificial neural network (ANN)

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Petroleum 2020年第4期6卷 368-374页

作者： Areeba Ansari Marco Heras julianne Nones Mehdi Mohammadpoor Farshid Torabi Faculty of Engineering and Applied Science University of ReginaReginaSaskatchewanS4S 0A2Canada

As the price of oil decreases,it is becoming increasingly important for oil companies to operate in the most costeffective *** problem is especially apparent in Western Canada,where most oil production is dependent on costly enhanced oil recovery(EOR)techniques such as steam-assisted gravity drainage(SAGD).Therefore,the goal of this study is to create an artificial neural network(ANN)that is capable of accurately predicting the ultimate recovery factor of oil reservoirs by steam-assisted gravity drainage(SAGD).The developed ANN model featured over 250 unique entries for oil viscosity,steam injection rate,horizontal permeability,permeability ratio,porosity,reservoir thickness,and steam injection pressure collected from *** collected data set was entered through a feed-forward back-propagation neural network to train,validate,and test the model to predict the recovery factor of SAGD method as accurate as *** from this study revealed that the neural network was able to accurately predict recovery factors of selected projects with less than 10%*** the neural network was exposed to a new simulation data set of 64 points,the predictions were found to have an accuracy of 82%as measured by linear ***,the feasibility of ANN to predict the recovery performance of one of the most complicated enhanced heavy oil recovery techniques with reasonable accuracy was confirmed.

关键词： Enhanced oil recovery Steam assisted gravity drainage Artificial neural network

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