Repair and regeneration of peripheral nerve injuries that ablate branch points

作     者：JuliAnne E.Allgood George D.Bittner Jared S.Bushman JuliAnne E.Allgood;George D.Bittner;Jared S.Bushman

作者机构：Division of Pharmaceutical SciencesUniversity of WyomingLaramieWYUSA Department of NeuroscienceThe University of Texas at AustinAustinTXUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第12期

页      面：2564-2568页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：University of Wyoming Startup funds,United States Department of Defense,No. W81XWH-17-1-0402 (to JSB) the University of Wyoming Sensory Biology COBRE under National Institutes of Health (NIH),No. 5P20GM121310-02 (to JSB) the National Institute of General Medical Sciences of the NIH,No. P20GM103432 (to JSB) DOD AFIRM III,No. W81XWH-20-2-0029 (to GDB) a Lone Star Paralysis Foundation gi?t (to GDB) 

主　　题：allograft animal model branched injuries femoral nerve peripheral nerve injury peripheral nervous system regeneration repair sciatic nerve surgical repair 

摘      要：The peripheral nervous system has an extensive branching organization, and peripheral nerve injuries that ablate branch points present a complex challenge for clinical repair. Ablations of linear segments of the PNS have been extensively studied and routinely treated with autografts, acellular nerve allografts, conduits, wraps, and nerve transfers. In contrast, segmental-loss peripheral nerve injuries, in which one or more branch points are ablated so that there are three or more nerve endings, present additional complications that have not been rigorously studied or documented. This review discusses:(1) the branched anatomy of the peripheral nervous system,(2) case reports describing how peripheral nerve injuries with branched ablations have been surgically managed,(3) factors known to influence regeneration through branched nerve structures,(4) techniques and models of branched peripheral nerve injuries in animal models, and(5) conclusions regarding outcome measures and studies needed to improve understanding of regeneration through ablated branched structures of the peripheral nervous system.