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A cloud-based platform to predict wind pressure coefficients on buildings

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Building Simulation 2022年第8期15卷 1507-1525页

作者： Facundo Bre juan m.Gimenez Centro de Investigacion de metodos Computacionales(CImEC) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and improve indoor air ***,accurate modeling of the NV effects is a basic requirement to include this technique during the building design ***,there is an important lack of wind pressure coefficients(CP)data,essential input parameters for NV *** this,there are no simple but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which means a significant limitation to NV modeling in real *** this reason,the present contribution proposes a novel cloud-based platform to predict wind pressure coefficients on *** platform comprises a set of tools for performing fully unattended computational fluid dynamics(CFD)simulations of the atmospheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are implemented to automatize the generation of the computational domain,the meshing procedure the solution stage,and the post-processing of the *** evaluate the performance of the platform,an exhaustive validation against wind tunnel experimental data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreement with experimental data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform introduced shows being a reliable and practical C_(P) data source for NV modeling in real building design scenarios.

关键词： natural ventilation building simulation airflow network model EnergyPlus wind pressure coefficient computational fluid dynamics

Genome-Wide Survey and Evolutionary Analysis of Trypsin Proteases in Apicomplexan Parasites

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Genomics, Proteomics & Bioinformatics 2010年第2期8卷 103-112页

作者： Aylan Farid Arenas juan Felipe Osorio-méndez Andres Julian Gutierrez Jorge E. Gomez-marin Grupo de Parasitología molecular (GEPAmOL) Centro de Investigaciones BiomédicasUniversidad del QuindíoArmeniaColombia

Apicomplexa are an extremely diverse group of unicellular organisms that infect humans and other animals. Despite the great advances in combating infectious diseases over the past century, these parasites still have a tremendous social and economic burden on human societies, particularly in tropical and subtropical regions of the world. Proteases from apicomplexa have been characterized at the molecular and cellular levels, and central roles have been proposed for proteases in diverse processes. In this work, 16 new genes encoding for trypsin proteases are identified in 8 apicomplexan genomes by a genome-wide survey. Phylogenetic analysis suggests that these genes were gained through both intracellutar gene transfer and vertical gene transfer. Identification, characterization and understanding of the evolutionary origin of protease-mediated processes are crucial to increase the knowledge and improve the strategies for the development of novel chemotherapeutic agents and vaccines.

关键词： Apicomplexa trypsin endosymbiotic gene transfer

Intracameral 5-fluorouracil and viscous dispersive viscoelastic for diffuse epithelial downgrowth management in aphakia

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 845-847页

作者： Santiago montolío-marzo Ester fernández-López Jose Vicente Piá-Ludena juan maría Davó-Cabrera Enrique Antonio Alfonso-munoz Cristina Peris-martínez FISABIO Oftalmología médica Valencia 46015Spain

Dear Editor,I am *** montolío-marzo from FISABIO Oftalmología médica,Valencia,Spain.I write you to present a case report of epithelial downgrowth in an aphakic *** epithelial downgrowth is one of the most feared complications in cases of penetrating ocular trauma or recurrent ocular *** progress can affect all the ocular structures,giving rise to corneal decompensation,retinal detachment,difficult-to-treat glaucoma or phthisis bulbi and many cases end in enucleation[1].Fortunately,the incidence of this condition is very low,there being between 0.08%and 0.12%after cataract surgery and 0.25%after penetrating *** infrequency means that scientific evidence is reduced to case series and the opinions of experts without there being a homogeneous criterion to guide the work of the doctor in *** these reasons,epithelial downgrowth is still a diagnostic and therapeutic challenge.

关键词： viscoelastic viscous camera

Regeneration of Plants from Embryogenic Cell Suspensions of cv.“Datil”(musa AA):morphological Evaluation of Plants in the Field

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Journal of Agricultural Science and Technology(B) 2018年第1期8卷 29-41页

作者： juan Luis Ortiz Vargas Jorge Sandoval fernández maría Elena Aguilar Vega Biotechnology Laboratories Tropical Agricultural Research and Higher Education Center(CATIE)Turrialba 30501Costa Rica National Banana Corporation(CORBANA) Guápiles 390-7210PococíCosta Rica

The full cycle from embryogenic callus(EC)induction to field evaluation of regenerated plants is reported for the first time for banana cv.“Datil”(musa AA).Immature male flowers were used for EC induction on a modified m1 culture *** ideal type of EC was obtained in the presence of 4.5μm and 9.0μm 2,4-dichlorophenoxyacetic acid(2,4-D).Embryogenic cell suspensions were established in both concentrations of 2,4-D;however,only the suspensions from ideal callus(IC)formed with 4.5μm of 2,4-D were regenerated.A histological study revealed the formation of structurally different cell masses during the regeneration phase of cv.“Datil”.The embryos germination was characterized by the growth cellular aggregates,indicating the possible occurrence of secondary *** and acclimatization of the plants were carried out in a normal manner as observed for other *** evaluation of the plants’genetic stability was based on observation of morphological *** the vegetative growth phase,6.61%of the plants presented drooping leaves and deformed *** traits,however,did not affect further plant growth during flowering and harvest *** produced fruits were of good *** the present study indicates that this cultivar may be stable genetically.

关键词： musa Pisang mas somatic embryogenesis cell suspension plant regeneration field evaluation

Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish multicenter Registry

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Journal of Geriatric Cardiology 2021年第10期18卷 809-815页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi maría Cespón-fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubelos-fernández Álvaro López-masjuán Ríos maría melendo-Viu AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain Department of Cardiology University Hospital of LeónLeónSpain Department of Cardiology University Hospital Juan Ramón JiménezHuelvaSpain

BACKGROUND The association between digoxin and mortality is an unclear *** older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is *** aim is to assess the safety of digoxin in nonagenarian patients with *** We evaluated data from 795 nonagenarian patients with non-valvular AF from the Spanish multicenter *** analyzed the relationship between digoxin and all-cause mortality with the Cox proportional-hazards *** Follow-up was 27.7±18.3 *** age was 92.5±3.8 years,and 71%of nonagenarian patients were *** was not associated with increased risk of mortality[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortality in the subgroup with estimated glomerular filtration rate(eGFR)mL/min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 mL/min per 1.73 m^(2) and≥60 mL/min per 1.73 m^(2)).When exploring the risk of mortality according to sex,male subgroup was associated with an in-crease in mortality(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in females subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart failure,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 ***=1.15,95%CI:0.90−1.47,P=0.273,respectively).CONCLUSIONS In our large registry of nonagenarian patients with AF,we did not find an association between digoxin and mortality in the total ***,in the subgroup analyses,we found an increase in mortality with the use of digoxin in men and in patients with an eGFRmL/min per 1.73 m^(2).

关键词： patients digoxin fibrillation

Hepatocyte culture in a radial-flow bioreactor with plasma polypyrrole coated scaffolds

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BIOCELL 2015年第2期39卷 9-14页

作者： Odin RAmÍREZ-fernÁndez Rafael GODÍNEZ Esmeralda ZUÑIGA-AGUILAR Luis E.GÓmEZ-QUIROZ maría C.GUTIÉRREZ-RUIZ juan mORALES Roberto OLAYO Departamento de Ingeniería Eléctrica Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico. Departamento de Ciencias de la Salud Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico Departamento de Física Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico

We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated *** designed a culture chamber where a radial flow of culture medi-um was continuously delivered through *** this system was established,flow was simulated using flow dy-namics software based on numeric methods to solve Navier-Stockes flow *** within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor ***,the bioreactor was built according to the simulated design and was tested with liver carcinoma cells(HepG2)cultured over an L-polylactic acid scaffold whose surface was modified with iodine-doped *** bioreactor was tested under non-flow and in radial flow *** density under radial flow conditions was almost double than that under static conditions and both total protein and albumin output was also increased under radial flow conditions.

关键词： Cell Cultures Flow Simulation Flow Features HepG2 Cells Plasma Polymerization

Rehabilitation of degraded areas in northeastern Patagonia, Argentina: Effects of environmental conditions and plant functional traits on performance of native woody species

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Journal of Arid Land 2020年第4期12卷 653-665页

作者： juan m ZEBERIO Carolina A PÉREZ National University of Río Negro Atlantic HeadquartersCenter for Environmental Studies from Norpatagonia(CEANPa)Viedma 8500Argentina National Council of Scientific and Technical Research(CONICET) Viedma 8500Argentina Ecological and Environmental Systems Research Laboratory(LISEA) National University of La PlataLa Plata 1900Argentina

Degradation processes affect a vast area of arid and semi-arid lands around the world and damage the environment and people′s health. Degradation processes are driven by human productive activities that cause direct and indirect effects on natural resources, such as species extinction at regional scale, reduction and elimination of vegetation cover, soil erosion, etc. In this context, ecological rehabilitation is an important tool to recover key aspects of the degraded ecosystem. Rehabilitation trials rely on the use of native plant species with characteristics that allow them to obtain high survival and growth rates. The aim of this work was to assess the survival and growth of native woody species in degraded areas of northeastern Patagonia and relate them to plant functional traits and environmental variables. We observed high early and late survival rates, and growth rates in Prosopis flexuosa DC. var. depressa F.A. Roig and Schinus johnstonii F.A. Barkley, and low values in Condalia microphylla Cav. and Geoffroea decorticans(Gillies ex Hook. & Arn.) Burkart. Early survival rates were positively associated with specific leaf area(SLA) and precipitation, but negatively associated with wood density, the maximum mean temperature of the warmest month and the minimum mean temperature of the coldest month. Late survival rates were positively associated with SLA and soil organic matter, but negatively associated with plant height and precipitation. The temperature had a positive effect on late survival rates once the plants overcame the critical period of the first summer after they were transplanted to the field. Prosopis flexuosa and S. johnstonii were the most successful species in our study. This could be due to their functional traits that allow these species to acclimatize to the local environment. Further research should focus on C. microphylla and G. decorticans to determine how they relate to productive conditions, acclimation to environmental stress, auto-eco

关键词： arid lands Condalia microphylla Geoffroea decorticans Prosopis flexuosa Schinus johnstonii survival rates height growth basal diameter growth

Accuracy of tree mapping based on hand-held laser scanning comparing leaf-on and leaf-off conditions in mixed forests

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Journal of Forestry Research 2024年第5期35卷 14-25页

作者： Frederico Tupinambá-Simões Adrián Pascual juan Guerra-Hernández Cristóbal Ordóñez Tiago de Conto Felipe Bravo iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Department of Geographical Sciences University of MarylandCollege ParkMD 20742USA Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile laser scanning to survey forest ecosystems is a promising,scalable technology to describe forest 3D structures at high *** confirm the con-sistency in the retrieval of forest structural parameters using hand-held laser scanning(HLS),before operationalizing the method,confirming the data is *** analyzed the per-formance of tree-level mapping based on HLS under differ-ent phenology conditions on a mixed forest in western Spain comprising Pinus pinaster and two deciduous species,Alnus glutinosa and Quercus *** area was surveyed twice during the growing season(July 2022)and once in the deciduous season(February 2022)using several scan-ning *** reference data(418 trees,15 snags)was used to calibrate the HLS data and to assess the influence of phenology when converting 3D data into tree-level attrib-utes(DBH,height and volume).The HLS-based workflow was robust at isolating tree positions and recognizing stems despite changes in ***-six percent of all pairs matched below 65 *** DBH,phenology barely altered *** observed a strong agreement when comparing HLS-based tree height *** values exceeded 2 m when comparing height measurements,confirming height data should be carefully used as reference in remote sensing-based inventories,especially for deciduous *** volume was more precise for pines(r=0.95,and rela-tive RmSE=21.3–23.8%)compared to deciduous species(r=0.91–0.96,and relative RmSE=27.3–30.5%).HLS data and the forest structural complexity tool performed remark-ably,especially in tree positioning considering mixed forests and mixed phenology conditions.

关键词： Precision forestry Forest monitoring mobile laser scanning Forest inventory

Telomere function in colorectal cancer

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World Journal of Gastrointestinal Oncology 2009年第1期1卷 3-11页

作者： Cristina Frías Alberto morán Carmen de juan Paloma Ortega Tamara fernández-marcelo Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio m.nuel Benito Pilar Iniesta Department of Biochemistry and molecular Biology Faculty of PharmacyComplutense University Surgery Service San Carlos Hospital Oncology Service San Carlos Hospital

Colorectal cancer is the third most common form of cancer and the second leading cause of cancer-related death in the western *** cells acquire the hallmarks of cancer during the carcinogenic selection *** immortality is one of the principal features acquired during this process which involves the stabilization of telomere *** is achieved mainly,by telomerase ***,the discovery of telomeres and telomerase allowed an understanding of the mechanisms by which cells can become *** studies have shown that tumour cells have shorter telomeres than nontumour cells and have detected telomerase activity in the majority of *** studies have determined that telomere maintenance and telomerase activity are associated with poor *** into account all the results achieved by different groups,quantification and evaluation of telomerase activity and measurement of telomere length may be useful methods for additional biologic and prognostic staging of colorectal carcinoma.

关键词： Colorectal cancer Telomeres Immortality