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Management of end-stage erectile dysfunction and stress urinary incontinence after radical prostatectomy by simultaneous dual implantation using a single trans-scrotal incision： surgical technique and outcomes

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Asian Journal of Andrology 2015年第5期17卷 792-796,I0008页

作者： juan I Martinez-Salamanca Estefania Linares Espinos Ignacio Moncada luis Del Portillo Joaquin Carballido Department of Urology Hospital Universitario Puerta de Hierro Majadahonda Autonomous University of Madrid Madrid 28222 Spain Hospital Universitario Infanta Sofia Madrid 28702 Spain Hospital La Zarzuela Madrid 28023 Spain

Stress urinary incontinence （SUI） and end-stage erectile dysfunction （ED） after radical prostatectomy （RP） can decrease a patient＇s quality of life （QoL）. We describe a surgical technique involving scrotal incision for simultaneous dual implantation of an artificial urinary sphincter （AUS） and an inflatable penile prosthesis （IPP）. Patients with moderate to severe SUI （〉3 pads per day） and end-stage ED following RP were selected for dual implantation. An upper transverse scrotal incision was made, followed by bulbar urethra dissection and AUS cuff placement. Through the same incision, the corpora cavernosa was exposed, and an IPP positioned. Followed by extraperitoneal reservoirs placement and pumps introduced in the scrotum. Short-term, intra- and post-operative complications; continence status and erectile function; and patient satisfaction and QoL were recorded. A total of 32 patients underwent dual implantation. Early AUS-related complications were： AUS reservoir migration and urethral erosion. One case of distal corporal extrusion occurred. No prosthetic infection was reported. Over 96% of patients were socially the continent （≤1 pad per day） and 〉95% had sufficient erections for intercourse. Limitations of the study were the small number of patients, the lack of the control group using a perineal approach for AUS placement and only a 12 months follow-up. IPP and AUS dual implantation using a single scrotal incision technique is a safe and effective option in patients with SUI and ED after RP. Further studies on larger numbers of patients are warranted.

关键词： artificial urinary sphincter erectile dysfunction penile prosthesis radical prostatectomy single scrotal incision urinary incontinence

Hepatocellular carcinoma in non-alcoholic fatty liver disease from a clinical and public health perspective

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 755-758页

作者： luis Antonio Díaz Marco Arrese juan Pablo Arab Departamento de Gastroenterología Escuela de MedicinaPontificia Universidad Católica de ChileSantiagoChile Division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonONCanada Alimentiv LondonONCanada

Non-alcoholic fatty liver disease(NAFLD)is the leading cause of chronic liver disease in the western world(1).Currently,the global prevalence of NAFLD is estimated at 30%and is notably higher in South America and the Middle East(1).NAFLD prevalence has been rising during the last decades,and cases of decompensated NAFLD cirrhosis could increase by 168%in 2030(Figure 1A)(2).These trends are probably explained by several factors including the decrease in viral hepatitis incidence and the increasing prevalence of obesity and type 2 diabetes mellitus(T2DM)among the general population(2).

关键词： prevalence NAFLD liver

the 20GD Superfamily： Emerging Functions in Plant Epigenetics and Hormone Metabolism

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Molecular Plant 2018年第10期11卷 1222-1224页

作者： Riad Nadi Eduardo Mateo-Bonmati Lucia juan-Vicente Jose luis Micol Instituto de Bioingenieria Universidad Miguel Hern&ndez Campus de Elche 03202 Elche Spain

The 2-oxoglutarate and Fe （ll）-dependent dioxygenase （2OGD） superfamily includes oxidative enzymes with an active site con- taining two histidines and （in most cases） one aspartic or glutamic acid residue. This conserved motif is termed the 2-His-1-carboxylate facial triad, chelates iron, and is housed within a double-stranded β-helix fold, also known as the DSBH, jelly-roll, cupin, or Jumonji C fold （Martinez and Hausinger, 2015）. The reactions catalyzed by 2OGDs （also called 2ODDs, 2ODQs, and 2OGXs） include but are not limited to demethylation, demethylenation, hydroxytation, halogenation, desaturation, ring cleavage, ring closure, and epimerization （Farrow and Facchini, 2014）.

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Involvement of ethylene receptors in the salt tolerance response of Cucurbita pepo

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Horticulture Research 2021年第1期8卷 1058-1071页

作者： Gustavo Cebrian Jessica Iglesias-Moya Alicia garcia Javier MartInez Jonathan Romero Jose Javier Regalado Cecilia Martinez juan luis Valenzuela Manuel Jamilena Department of Biology and Geology Agri-food Campus of International Excellence(CeiA3)and Research Center CIAMBITALUniversity of Almeria04120 AlmeriaSpain

Abiotic stresses have a negative effect on crop production,affecting both vegetative and reproductive *** plays a relevant role in plant response to environmental stresses,but the specific contribution of ethylene biosynthesis and signalling components in the salt stress response differs between Arabidopsis and rice,the two most studied model *** this paper,we study the effect of three gain-of-function mutations affecting the ethylene receptors CpETR1B,CpETR1A,and CpETR2B of Cucurbita pepo on salt stress response during germination,seedling establishment,and subsequent vegetative growth of *** mutations all reduced ethylene sensitivity,but enhanced salt tolerance,during both germination and vegetative growth,demonstrating that the three ethylene receptors play a positive role in salt *** salt stress,etr1b,etr1a,and etr2b germinate earlier than WT,and the root and shoot growth rates of both seedlings and plants were less affected in mutant than in *** enhanced salt tolerance response of the etr2b plants was associated with a reduced accumulation of Na^(+)in shoots and leaves,as well as with a higher accumulation of compatible solutes,including proline and total carbohydrates,and antioxidant compounds,such as *** membrane monovalent cation transporters,including Na^(+)/H^(+)and K^(+)/H^(+)exchangers(NHXs),K^(+)efflux antiporters(KEAs),high-affinity K^(+)transporters(HKTs),and K^(+)uptake transporters(KUPs)were also highly upregulated by salt in etr2b in comparison with *** aggregate,these data indicate that the enhanced salt tolerance of the mutant is led by the induction of genes that exclude Na+in photosynthetic organs,while maintaining K^(+)/Na^(+)homoeostasis and osmotic *** the salt response of etr mutants occurs via the ethylene signalling pathway,our data show that ethylene is a negative regulator of salt tolerance during germination and vegetative ***,the higher upregulation

关键词： subsequent aggregate likely

Comparison of biological fitness in crosses between subspecies of Meccus phyllosomus （Hemiptera： Reduviidae： Triatominae） in southern Mexico

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Insect Science 2017年第1期24卷 114-121页

作者： Jose Alejandro Martinez-Ibarra Benjamin Nogueda-Torres luis Fernando Salazar-Montano juan Carlos garcia-Lino Demver Arroyo-Reyes juan Angel Hernandez-Navarro Area de Entomologia Medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de Medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Understanding the biological parameters of some triatomine subspecies of Meccus phyllosomus （Burmeister） is a crucial first step in estimating the epidemiologie importance of this group. Biological parameters related to hatching, lifetime, number of blood meals to molt, percentage of females at the end of the cycle, number of laid eggs, and mortality for each instar of 3 M. phyllosomus subspecies [M. p. mazzottii （Usinger）, M. p. pallidipennis （Stal）, and M. p. phyllosomus] and their laboratory hybrids were evaluated and compared. No significant differences （P 〉 0.05） were found among the experimental hybrids （MaPa, MaPhy, PaPhy） and reciprocal cohorts. In 5 （hatching, number of blood meals to molt, accumulative mortality, percentage of females, and mean number of laid eggs） of the 6 studied parameters （with the exception of development time）, the hybrid cohorts had better fitness results than the parental cohorts involved in each set of crosses. The increase in hybrid fitness found in our study could lead to an increase in the epidemiologic risks caused by transmission of Trypanosoma cruzi to humans.

关键词： biological parameters Chagas disease Meccus subspecies Mexico tri- atomines Trypanosoma cruzi transmission

An updated overview on the development of new photosensitizers for anticancer photodynamic therapy

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Acta Pharmaceutica Sinica B 2018年第2期8卷 137-146页

作者： juan Zhang Chengshi Jiang Joao Paulo Figueiró Longo Ricardo Bentes Azevedo Hua Zhang luis Alexandre Muehlmann School of Biological Science and Technology University of Jinan Institute of Biological Sciences University of Brasilia Faculty of Ceilandia University of Brasilia

Photodynamic therapy(PDT), based on the photoactivation of photosensitizers(PSs), has become a well-studied therapy for cancer. Photofrin~?, belonging to the first generation of PS, is still widely used for the treatment of different kinds of cancers; however, it has several drawbacks that significantly limit its general clinical use. Consequently, there has been extensive research on the design of PS molecules with optimized pharmaceutical properties, with aiming of overcoming the disadvantages of traditional PS, such as poor chemical purity, long half-life, excessive accumulation into the skin, and low attenuation coefficients. The rational design of novel PS with desirable properties has attracted considerable research in the pharmaceutical field. This review presents an overview on the classical photosensitizers and the most significant recent advances in the development of PS with regard to their potential application in oncology.

关键词： Anti-cancer Photosensitizers Photodynamic therapy Photochemical reactions Oncology BODIPY

The impact of the design of learning spaces on attention and memory from a neuroarchitectural approach:A systematic review

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Frontiers of Architectural Research 2022年第3期11卷 542-560页

作者： Mar Llorens-Gamez juan luis Higuera-Trujillo Carla Sentieri Omarrementeria Carmen Llinares Department of Architectural Projects Universitat Politecnica de ValenciaValencia 46022Spain Institute for Research and Innovation in Bioengineering(i3B) Universitat Politecnica de ValenciaValencia 46022Spain

Enriched environments in animal models have demonstrated that exposure to an optimal stimulus improves behavior,cognition,and ***,the evidence base for the neurophysiological influence of human environment enrichment has not been extensively *** systematic review compiles indicators about the effect of built,indoor environments on the cognitive processes of memory and attention in *** work pursues two main objectives:(1)to define current knowledge and the methods that are useful and identify whether previously published studies indicate consistencies and(2)to report the approaches and strategies that can be used in evaluating cognitive processes affected by environment *** of this systematic review show that(1)form and geometry,(2)space distribution and context,(3)color and texture,(4)height,width,and enclosure,(5)transition and circulation,and(6)light,sound,and temperature have an impact on memory and/or attention,and they can be assessed *** all the advances in this field,methodological limitations and a lack of cross-validated standard protocols are ***,future research is necessary to provide a deep insight into how human cognition can be heightened by the environment to which it is exposed.

关键词： Built environment Neuroarchitecture Cognition Attention Memory Learning spaces

Eucalyptus grandis plantations:effects of management on soil carbon,nutrient contents and yields

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Journal of Forestry Research 2020年第2期31卷 601-611页

作者： Diego Martin Sandoval Lopez Marcelo Fabian Arturi juan Francisco Goya Carolina Alejandra Perez Jorge luis Frangi Laboratorio de Investigacion de Sistemas Ecologicos y Ambientales(LISEA) Universidad Nacional de La PlataDiagonal 113 N°4691900 La PlataBuenos AiresArgentina

The expansion of fast-growing tree plantations is a worldwide process,with consequences on soil fertility and soil carbon *** results were found on the effects of afforestation with Eucalyptus on soil carbon and other nutrient *** discrepancies are usually caused by differences in climate,land use history,soil texture as well as by management related factors such as plantation age,number of rotations,method of establishment(plantation or coppice),harvest residue management and soil *** studied the effect of plantation age,number of rotations,and method of establishment on soils and plant nutrient concentrations in Eucalyptus grandis plantations in NE Argentina on different textured *** also determined if yields changed with nutrient variations in soils,and compared soils under plantations to soils under grasslands they ***-one *** stands of different ages,number of rotations and method of establishment were evaluated as well as eight grassland *** of carbon,nitrogen,phosphorus,potassium,calcium and magnesium were determined for soils and *** carbon and nitrogen decreased over the number of rotations and were more pronounced in soils with 50-60%sand than soils with>75%*** stands showed higher soil carbon and nitrogen levels than plantations,suggesting a negative effect of site preparation before planting on soil nutrient conservation,especially in fine-textured *** nutrient concentrations did not follow the trends observed for soil nutrients nor did they reflect nutrient *** was no evidence of decreased yields over successive *** carbon and nitrogen contents decrease when grasslands are replaced by *** plantations,and therefore a yield limitation may occur in a medium to long-term frame,especially in stands re-established for short-rotation *** residue management and site preparation must be specifically designed for improving so

关键词： Soil texture Grasslands Foliar nutrient concentrations Successive harvest Coppice Eucalyptus grandis

Partial Derivatives, Singular Integrals and Sobolev Spaces in Dyadic Settings

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Analysis in Theory and Applications 2023年第3期39卷 287-298页

作者： Hugo Aimar juan Comesatti Ivana Gómez luis Nowak Instituto de Matemática Aplicada del Litoral“Dra.Eleonor Harboure” UNLCONICETCCT CONICET Santa FePredio“Dr.Alberto Cassano”Colectora Ruta Nac.168 km 0Paraje El PozoS3007ABA Santa FeArgentina Instituto de Investigación en Tecnologías y Ciencias de la Ingeniería Universidad Nacional del ComahueCONICET/Departamento de Matemática-FaEA-UNComaNeuquénArgentina

In this note we show that the general theory of vector valued singular integral operators of Calderón-Zygmund defined on general metric measure spaces,can be applied to obtain Sobolev type regularity properties for solutions of the dyadic fractional *** doing so,we define partial derivatives in terms of Haar multipliers and dyadic homogeneous singular integral operators.

关键词： Sobolev regularity Haar basis space of homogeneous type Calder´on-Zygmund operator dyadic analysis