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Journal of Medical Colleges of PLA(China) 2014年第4期29卷 244-247页

作者： María Eugenia Castellanos Sheilee Díaz Emily Parsons Leonard F Peruski Fabiola Enríquez juan luis ramírez Norma Padilla Center for Health Studies-Universidad del Valle de Guatemala (CES-UVG).18 Av.11-95 zona 15Vista Hermosa IIIGuatemalaGuatemala National Reference Laboratory Ministry of Health and Welfare.Km.22Carretera al Pacíi coBarcenasVilla NuevaGuatemalaC.A.GuatemalaGuatemala F.Edward Hebert School of Medicine Uniformed Services University of the Health Sciences.4301 Jones Bridge RoadBethesdaMaryland 20814USA Global Disease Detection Program Centers for Disease Control and Prevention (CDC)Central America Regional Office.1600 Clifton Road NEMS-D68AtlantaGeorgia 30333USA Military Healthcare and Social Services Ministry of DefenseGuatemalaGuatemala.Finca El PalomarAcatanSta.Rosita Zona 16GuatemalaGuatemala Military Medical Center Ministry of DefenseGuatemalaGuatemala.Finca El PalomarAcatanSta.Rosita Zona 16GuatemalaGuatemala

The Mesoamerican Ministers of Health have set 2020 as the target for malaria elimination to be achieved in the region. Imported malaria cases are a potential threat to countries attempting elimination or working to prevent resurgence. We report the first imported Plasmodium ovale infection with molecular confirmation in Central America, which occurred in a Guatemalan soldier that had been deployed in Africa. The obstacles for its diagnosis using the standard microscopy technique and the need to improve its detection are discussed.

关键词： Plasmodium ovale Imported malaria Diagnosis

Pharmacokinetics of sildenafil in children with pulmonary arterial hypertension

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World Journal of Pediatrics 2017年第6期13卷 588-592页

作者： Hugo Juárez Olguín Hector Osnaya Martínez Carmen Flores Pérez Blanca ramírez Mendiola Liliana Rivera Espinosa juan luis Chávez Pacheco Janett Flores Pérez Ignacio Mora Maga(n)a Laboratory of Pharmacology National Institute of PediatricsMexico CityMexico Department of Pharmacology Faculty of MedicineNational Autonomous University of MexicoMexico CityMexico Service of Cardiology National Institute of PediatricsMexico CityMexico Laboratory of Pharmacology National Institute of PediatricsMexico CityMexico Subdirection of Teaching and Educational Programming National Institute of PediatricsMexico CityMexico

Background:Recently,sildenafil was introduced to treat pulmonary arterial hypertension (PAH);however,there are currently few studies on the pharmacokinetics of sildenalfil in ***,we aimed to carry out a pharmacokinetic study of sildenafil in children with PAH using a single ***:Twelve children diagnosed with PAH,consisting of with ten males and two females,were recruited for the study after obtaining written consent from their parents or *** samples were obtained predose and at 0.25,0.5,1,2,4,8 and 12 hours after the oral administration of 1 mg/kg of sildenafil using an extemporal pediatric formulation developed in our *** samples were analyzed using a previously validated high performance liquid chromatography ***:A pharmacokinetic analysis using the WinNonlin 3.1 program that considered the Akaike information criterion (AIC) for sdecting a more adjustable model was *** following pharmacokinetic parameters were obtained:maximal concentration (Cmax):366+179 ng/mL,time to maximal concentration:0.92±0.30 hours,elimination half-life (t1/2):2.41±1.18 hours,total clearance (CLto/F):5.85±2.81 L/hour,volume of distribution (Vd/F):20.13±14.5 L,absorption rate constants (Ka):0.343 hour-1,elimination rate (Ke):0.35 hour-1,area under curve from zero to infinity:2061±618 ng/mL/*** data of all patients adjusted to the model of one compartment were corroborated using ***:The parameters Ka,Ke and t1/2 were found to be similar to those reported in adults;however,the values of Cmax and Vd/F were significantly *** on these findings,we propose that treatment regimen of sildenafil be adjusted in children with PAH.

关键词： pharmacokinetics pulmonary arterial hypertension sildenafil

Performance assessment of two-dimensional hydraulic models for generation of flood inundation maps in mountain river basins

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Water Science and Engineering 2019年第1期12卷 11-18页

作者： juan Pinos luis Timbe Department of Water Resources and Environmental Sciences University of Cuenca

Hydraulic models for the generation of flood inundation maps are not commonly applied in mountain river basins because of the difficulty in modeling the hydraulic behavior and the complex topography. This paper presents a comparative analysis of the performance of four twodimensional hydraulic models (HEC-RAS 2D, Iber 2D, Flood Modeller 2D, and PCSWMM 2D) with respect to the generation of flood inundation maps. The study area covers a 5-km reach of the Santa B-arbara River located in the Ecuadorian Andes, at 2330 masl, in Gualaceo. The model's performance was evaluated based on the water surface elevation and flood extent, in terms of the mean absolute difference and measure of fit. The analysis revealed that, for a given case, Iber 2D has the best performance in simulating the water level and inundation for flood events with 20- and 50-year return periods, respectively, followed by Flood Modeller 2D, HEC-RAS 2D, and PCSWMM 2D in terms of their performance. Grid resolution, the way in which hydraulic structures are mimicked, the model code, and the default value of the parameters are considered the main sources of prediction uncertainty.

关键词： Two-dimensional hydraulic models Flood modeling Flood extent Water surface elevation High mountain river Ecuador

Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich juan Marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar luis Guilherme de Oliveira Silva Marcel Silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

Nickel-based cerium zirconate inorganic complex structures for CO_(2)valorisation via dry reforming of methane

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Journal of Environmental Sciences 2024年第6期140卷 12-23页

作者： juan luis Martín-Espejo Loukia-Pantzechroula Merkouri Jesús Gándara-Loe José Antonio Odriozola Tomas ramirez Reina Laura Pastor-Pérez Department of Inorganic Chemistry and Material Sciences Institute of Seville University of Seville-CSICSeville 41092Spain Department of Chemical and Process Engineering University of SurreyGuildford GU27XHUnited Kingdom

The increasing anthropogenic emissions of greenhouse gases(GHG)is encouraging extensive research in CO_(2)*** reforming of methane(DRM)depicts a viable strategy to convert both CO_(2)and CH4into syngas,a worthwhile chemical *** the different active phases for DRM,the use of nickel as catalyst is economically favourable,but typically deactivates due to sintering and carbon *** stabilisation of Ni at different loadings in cerium zirconate inorganic complex structures is investigated in this work as strategy to develop robust Ni-based DRM *** and TPR-H2analyses confirmed the existence of different phases according to the Ni loading in these ***,superficial Ni is observed as well as the existence of a CeNiO_(3)perovskite *** catalytic activity was tested,proving that 10 wt.%Ni loading is the optimum which maximises *** catalyst was also tested in long-term stability experiments at 600and 800℃in order to study the potential deactivation issues at two different *** 600℃,carbon formation is the main cause of catalytic deactivation,whereas a robust stability is shown at 800℃,observing no sintering of the active phase evidencing the success of this strategy rendering a new family of economically appealing CO_(2)and biogas mixtures upgrading catalysts.

关键词： CO_(2)conversion Dry reforming of methane Nickel catalysts Pyrochlore Cerium zirconate

Early life investment in antlers and body growth reflects adult performance in roe deer population under supplementary feeding conditions

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Integrative Zoology 2022年第3期17卷 396-407页

作者： Marta PELÁEZ Isabel SANUY juan Carlos PERAL JoséluisÁlvarez ESTEBAN Santiago LAVÍN Emmanuel SERRANO ramón PEREA Departamento de Sistemas y Recursos Naturales Universidad Politécnica de MadridMadridSpain Wildlife Ecology&Health group(WE&H)and Servei d’Ecopatologia de Fauna Salvatge(SEFaS).Facultat de Veterinària Universitat Autònoma de Barcelona(UAB)BarcelonaSpain Centro Cinegético I+D de Valsemana Junta de Castilla y LeónLa ErcinaLeónSpain

Recent research has challenged the idea that cervid antlers are such costly traits,supporting the assertion early-life antler investment is an honest signal of adult phenotypic ***,inferences were made based on antler measurements while growing(velvet)and thus,studies on fully-formed clean antlers are needed to avoid possible bias caused by the inter-individual variation in antler growth *** studied a semi-captive population of European roe deer inhabiting a sub-Mediterranean area(Valsemana research station)and living under optimal conditions(ad libitum food supply and veterinary care).Based on repeated measurements taken from 146 individuals,we assessed whether allocation to secondary sexual traits during early life affected body mass or antler development during ***,we evaluated which body measurements better predicted future male ***,using 488 individuals,we described age-class-specific variation in male body measurements and assessed the decline in antler size between adult and senescent stages(*** of senescence).Results agree with the assertion that there is no negative effect of a high investment in antler during early life on adult antler size or body mass,but we suggest the use of clean antlers as a more robust and reliable *** variables that better predicted body mass during adulthood were yearling body mass and body size at 6 *** score between 10 and 18 months resulted in the best indicator of adult antler ***,we support the idea that the magnitude of senescence in antler size is smaller in environments with higher resource availability during winter.

关键词： antler size body mass early-life investment Mediterranean environments secondary sexual traits and senescence trade-offs

Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of Geriatric Cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez juan luis Bonilla-Palomas María Anguita-Gámez María García Joséluis Bernal Náyade Del Prado Cristina Fernández-Pérez Julián Pérez-Villacastin juan JoséGómez-Doblas Francisco Javier Elola Cardiology Department Hospital Universitario Severo OchoaMadridSpain Cardiology Department Hospital Universitario Reina SofíaCórdobaSpain Cardiology Department Hospital San Juan de la CruzÚbedaSpain Cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management Control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain Cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BACKGROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International Classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(ICCU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%CI:1.07–1.07,P<0.001]and was lower in women(OR=0.96,95%CI:0.92–0.97,P<0.001).The main predictors of mortality were the presence of cardiogenic shock(OR=19.5,95%CI:16.8–22.7,P<0.001),stroke(OR=3.5,95%CI:3.0–4.0,P<0.001)and advanced cancer(OR=2.6,95%CI:2.5–2.8,P<0.001).In hospitals with ICCU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%CI:0.72–1.00,P=0.053).CONCLUSIONS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an ICCU.

关键词： patients mortality diagnosis

Hepatocyte culture in a radial-flow bioreactor with plasma polypyrrole coated scaffolds

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BIOCELL 2015年第2期39卷 9-14页

作者： Odin ramÍrez-FERNÁNDEZ Rafael GODÍNEZ Esmeralda ZUÑIGA-AGUILAR luis E.GÓMEZ-QUIROZ María C.GUTIÉRrez-RUIZ juan MORALES Roberto OLAYO Departamento de Ingeniería Eléctrica Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico. Departamento de Ciencias de la Salud Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico Departamento de Física Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico

We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated *** designed a culture chamber where a radial flow of culture medi-um was continuously delivered through *** this system was established,flow was simulated using flow dy-namics software based on numeric methods to solve Navier-Stockes flow *** within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor ***,the bioreactor was built according to the simulated design and was tested with liver carcinoma cells(HepG2)cultured over an L-polylactic acid scaffold whose surface was modified with iodine-doped *** bioreactor was tested under non-flow and in radial flow *** density under radial flow conditions was almost double than that under static conditions and both total protein and albumin output was also increased under radial flow conditions.

关键词： Cell Cultures Flow Simulation Flow Features HepG2 Cells Plasma Polymerization

Symmetrization for Fractional Elliptic and Parabolic Equations and an Isoperimetric Application(Dedicated to Haim Brezis,great master of analysis,on his 70th birthday)

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Chinese Annals of Mathematics,Series B 2017年第2期38卷 661-686页

作者： Yannick SIRE juan luis VAZQUEZ Bruno VOLZONE johns hopkins university Krieger Hall3401 N.Charles StBaltimoreM D21218USA. departamento de matemticas universidad autnoma de madrid28049 M adridSpain dipartimento di ingegneria universit degli studi di napoli"parthenope"80143 Italia.

This paper develops further the theory of symmetrization of fractional Laplacian operators contained in recent works of two of the authors. This theory leads to optimal estimates in the form of concentration comparison inequalities for both elliptic and parabolic equations. The authors extend the theory for the so-called restricted fractional Laplacian defined on a bounded domain Ω of R^N with zero Dirichlet conditions outside of Ω. As an application, an original proof of the corresponding fractional Faber-Krahn inequality is derived. A more classical variational proof of the inequality is also provided.

关键词： Symmetrization, Fractional Laplacian, Nonlocal elliptic and parabolicequations, Faber-Krahn inequality

Experimental analysis of infragravity waves in two eroded microtidal beaches

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Acta Oceanologica Sinica 2017年第5期36卷 31-43页

作者： MARIO Conde-Frias luis Otero juan Camilo Restrepo juan Carlos Ortiz Geosciences Research Group GE04 Department of PhysicsUniversidad del NorteBarranquilla 081007Colombia

This work aims to contribute to the characterization and understanding ofinfragravity waves on two beaches with erosion problems. For this reason, we have used an array of ADCP and a pressure sensor to measure wave parameters and pressure inside and outside of the surf zone during the dry and rainy period in the beaches of Galerazamba and Manzanillo del Mar （both dissipative and eroded beaches） located in the Colombian Caribbean coast. Based on these measurements, we have carried out a spectral analysis in order to identify the frequency components that characterize the wave and its energy; thus, we identified the characteristic frequencies of iufragravity waves to finally filter the infragravity signal on each beach in different seasonal periods. Among the results of the Welch spectrum applied to surface elevation time series, we found that, the frequencies＇ energy of the sea-swell band decreases due to bottom friction and wave breaking as the wave approaches the shore, while the frequencies＇ energy of the infragravity band increases significantly. In addition, for the wavelet analysis, we could observe how the energy of the infragravity band, especially the lowest frequencies gain energy as the waves approaches the coast. Furthermore, based on the infragravity wave obtained from the extreme wave event registered during the field campaign we can conclude that the contribution of this signal is important in the erosion problems presented in the beaches of Galerazamba and Manzanillo del Mar. Finally, these results show the need to realize other studies that allow us to understand deeply, the role of infragravity waves on the morphological changes that occurs in these beaches.

关键词： infragravity waves long waves experimental analysis fourier analysis wavelet transform