检索结果-南通市图书馆

Friction 2024年第10期12卷 2325-2343页

作者： Cristina GARCÍA-CABEZÓN juan alfonso naranjo Celia GARCÍA-HERNÁNDEZ Cristina BERGES Gemma HERRANZ Fernando MARTÍN-PEDROSA Materials Engineering E.I.I.Universidad de ValladolidValladolid 47011Spain INEI-Escuela Técnica Superior de Ingeniería Industrial(ETSII) Universidad de Castilla La ManchaCastilla-La Mancha 13071Spain

Fused filament fabrication(FFF)is one of the additive manufacturing processes which has gained more interest because of its simplicity and *** technology is similar to the conventional metal injection moulding(MIM)process,consisting of the feedstock preparation of metal powder and polymer binders,followed by layer-by-layer 3D printing(FFF)or injection(MIM)to create green parts and,finally,debinding and ***,both technologies provide near-dense *** work presents an in-depth study of the processing method’s *** porosity,microstructure,hardness,corrosion,and tribocorrosion behaviour are compared for 17-4 PH SS samples processed from powder by additive manufacturing using FFF and MIM,as well as conventional powder metallurgy(PM)*** samples exhibited the highest macro and microhardness,while corrosion behaviour was similar for both MIM and FFF samples,but superior in comparison to conventional PM ***,the FFF-as fabricated samples displayed a significant improvement in tribocorrosion resistance that could be explained by the higher proportion of delta ferrite and retained austenite in their microstructure.

关键词： 17-4 PH SS fused filament fabrication(FFF) metal injection moulding(MIM) corrosion behaviour powder metallurgy(PM) tribocorrosion behaviour

Biomedical overview of *** molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2022年第6期46卷 1391-1415页

作者： juan CARLOS STOCKERT alfonso BLÁZQUEZ-CASTRO Facultad de Medicina Instituto de Oncología“Angel H.Roffo”Universidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Biología Facultad de CienciasUniversidad Autónoma de MadridMadrid28049Spain

Melanins represent one of the most ancient and important group of natural macromolecular *** have multiple biological roles in almost all organisms across the Phyla,examples being photoprotection,anti-oxidative action,radical scavenger activity,and heavy metal *** the biomedical point of view,melanocytes are involved in the origin of melanoma tumors,and the main therapeutic advances for their treatment have been revised in Part 1 of this *** chemical structure of eumelanin is a biological concern of great importance,and therefore,exploring theoretical molecular models and synthesis mechanisms will be here described,as well as molecular orbital features and supramolecular organization,which are responsible for the key properties that make these biological pigments so important,and so ***,this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin,in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

关键词： Eumelanin Melanin models Melanin synthesis Molecular orbitals Supramolecular structure

Biomedical overview of *** melanin biology and chemistry,physico-chemical properties,melanoma tumors,and photothermal therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2021年第4期45卷 849-862页

作者： alfonso BLÁZQUEZ-CASTRO juan CARLOS STOCKERT Department of Biology Faculty of SciencesAutonomous University of MadridCantoblancoMadrid28049Spain 2 Centro Integrativo de Biología y Química AplicadaUniversidad Bernardo O’HigginsSantiago8370854Chile 3 Universidad de Buenos AiresFacultad de Ciencias VeterinariasCátedra de Histología y Embriologíae Instituto de Investigación y Tecnología en Reproducción AnimalBuenos AiresC1427CWOArgentina

Melanins(eumelanin,pheomelanin,and allomelanin)represent a very,if not themost,important group of biological *** biological roles are multiple,from photoprotection to antioxidant activity,heavy metal disposal or the myriad uses of color in organisms across all *** the first part of this review,eumelanin biology and some chemical aspects will be presented,as well as key physico-chemical features that make this biological pigment so *** principal characteristics of the melanocyte,the melanin-synthesizing cell in mammals,will also be *** melanocytes are the cause of one of the most devastating known cancers:the malignant *** and molecular signaling aspects will be presented next,as well as the principal advances in promising oncotherapies designed and applied for the treatment of *** particular,on account of the photo-physical properties of melanin,special details will be provided regarding the use of photothermal therapy for melanoma treatment.

关键词： Antitumor therapies Biological pigments Melanin Melanoma Photothermal therapy Skin tumors

Effect of genistein supplementation of thawing medium on characteristics of frozen human spermatozoa

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2010年第3期12卷 431-441,I0012页

作者： juan Carlos Martinez-Soto juan de DiosHourcade alfonso Gutierrez-Adan Jose Lorenzo Landeras Joaquin Gadea Department of Physiology School of Veterinary Murcia University Murcia 30100 Spain IVI- MURCIA Murcia 30007 Spain Department of Animal Reproduction INIA Madrid 28040 Spain

In this study, we evaluated the effects of genistein supplementation of the thawing extender on frozen-thawed human semen parameters. We analyzed the effect of supplementation on sperm motility, capacitation （membrane lipid disorder）, reactive oxygen species （ROS） generation, chromatin condensation and DNA damage. Using this preliminary information, it maybe possible to improve the cryopreservation process and reduce the cellular damage. We have confirmed that the isoflavone genistein （10 μmol L-1） has antioxidant properties on the frozen-thawed spermatozoa. This results in a decreased ROS production that shows a slight improvement in the sperm motility, and decreases the membrane lipid disorder and DNA damage caused by cryopreservation. These results suggest an effect of genistein on sperm functionality that could be of interest for assisted reproduction treatments using frozen- thawed human spermatozoa, but further studies will be necessary to confirm our findings and to evaluate the possible clinical applications.

关键词： antioxidants cryopreservation DNA damage genistein isoflavones sperm motility

Avian malaria,haematocrit,and body condition in invasive wetland passerines settled in southwestern Spain

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Avian Research 2023年第1期14卷 99-107页

作者： Jaime Muriel Luz Garcia-Longoria Sergio Magallanes juan Antonio Ortiz alfonso Marzal Instituto de Investigación en Recursos Cinegéticos(IREC) CSIC-UCLM-JCCMRonda de Toledo 1213005Ciudad RealSpain Universidad de Extremadura Facultad de BiologíaDepartamento de AnatomíaBiología Celular y Zoología Avenida de Elvas s/n06006BadajozSpain Estación Biológica de Donana(EBD-CSIC) Departamento de Ecología de los HumedalesAvda.Américo Vespucio 2641092SevillaSpain Hirundo Bird Ringing Group BadajozSpain Grupo de Investigaciones en Fauna Silvestre Universidad Nacional de San MartínJr.Maynas177722021TarapotoPeru

Avian malaria and related haemosporidian parasites can negatively impact fitness in many *** on the malaria infection and its physiological costs on their avian hosts is heavily skewed toward native passerines,with exotic species ***,introduced species may carry on and spread new pathogens to native species,and play a role on parasite transmission cycle in invaded bird communities as pathogen ***,we molecularly assess the prevalence and diversity of haemosporidian parasites in three introduced wetland passerines(the Red Avadavat Amandava amandava,the Yellow-crowned Bishop Euplectes afer,and the Common Waxbill Estrilda astrild)captured during the same season in southwestern *** also explored the relation between parasite infection,body condition,haematocrit,and uropygial gland *** detected an overall parasite prevalence of 3.55%,where Common Waxbills showed higher prevalence(6.94%)than Red Avadavats(1.51%).None Yellow-crowned Bishops were infected with *** 60%of infections were caused by Leucocytozoon,and about 40%by *** identified four unique lineages of Plasmodium and three of ***,91%of the identified host-parasite interactions represented new host records for these haemosporidian *** infection was not related to body condition,haematocrit,and uropygial gland volume of the wetland *** values varied seasonally among bird ***,haematocrit was positively related to body condition in the Yellow-crowned Bishops,but not in the other *** Avadavats had higher haematocrit levels than Yellow-crowned Bishops,whereas Common Waxbills showed the lower haematocrit *** uropygial gland volume was positively correlated with body condition in all bird *** Waxbills showed higher uropygial gland volumes related to their body size than birds from other two *** outcomes highlight the importance of e

关键词： Avian malaria Exotic species Introduced birds Leucocytozoon Plasmodium Uropygial gland

Blood Flow Simulation in the Femoral Artery

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2018年第3期16卷 269-279页

作者： Camilo A.naranjo Andrés F.Villa juan C.Vélez Ricardo A.Prato Alberto J.Cadena juan P.Tello IPATEC Institute CONICETBariloche R8400 Integra IT Bogotá 602 the Electronic and Electric Engineering Department Universidad del NorteBarranquilla 1569 the Institute of Mathematics Universidad de AntioquiaMedellin 050010 the Cardiology Department Clínica de la CostaBarranquilla 080020

This paper presents the development of the blood flow simulation in two dimensions over the real geometry of the femoral artery. The Navier-Stokes equations are solved using the finite element method, to obtain the distributions of the blood pressure and flow velocity in multiple instants of time and different places of the femoral artery and thus determine the current condition of the blood vessels. The velocity field shows a laminar behavior,where, the velocity is higher in the center of the artery and decreases as the blood flow approaches artery walls. In spite of all artery and blood flow properties not being considered, the values of pressure and velocity obtained are within the normal ranges. Finally the model is used to verify if there exist irregularities in the blood flow in both healthy subjects and sick patients.

关键词： Blood flow femoral artery finite elements Navier-Stokes pressure velocity

一种新型Inside-Out核磁共振传感器——三圆柱磁体阵列

在线全文

学校读者我要写书评

暂无评论

电工技术学报 2016年第8期31卷 96-101页

作者：郭盼何为 juan C.García-naranjo Bruce *** 输配电装备及系统安全与新技术国家重点实验室(重庆大学) 重庆400044 新布伦瑞克大学磁共振成像中心东方大学医学生物物理学中心古巴圣地亚哥90500

介绍了一种新型的inside-out核磁共振传感器。该传感器磁体结构由三个沿轴向磁化的圆柱形永磁体同轴排列而成,结构紧凑。通过调节三个磁体之间的距离,可以在磁体结构外侧建立起径向对称的均匀静态磁场或有恒定梯度的静态磁场B_0,其方向... 详细信息

介绍了一种新型的inside-out核磁共振传感器。该传感器磁体结构由三个沿轴向磁化的圆柱形永磁体同轴排列而成,结构紧凑。通过调节三个磁体之间的距离,可以在磁体结构外侧建立起径向对称的均匀静态磁场或有恒定梯度的静态磁场B_0,其方向平行于传感器轴向。为了满足射频磁场B_1垂直于静态磁场B_0的要求,射频线圈采用马鞍形结构。传感器直径为2.8cm,长度为6cm,重为200g。该传感器磁体结构简单,且灵敏区域相对其本身尺寸较大。

关键词： Inside-out核磁共振传感器三圆柱磁体阵列均匀磁场恒定梯度磁场马鞍形线圈

Acute kidney injury in severely injured patients admitted to the Intensive Care Unit

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2021年第2期8卷 141-147页

作者： Alberto F.García Ramiro Manzano-Nunez juan G.Bayona Maria P.naranjo Dary Neicce Villa Manuel Moreno Sebastian Ossa juan M.Martinez Nathalia Martinez juan C.Puyana Division of Trauma and Acute Care Surgery Department of SurgeryFundación Valle del LiliCaliColombia Clinical Research Center Fundación Valle del LiliCaliColombia Escuela de Medicina Ciencias de la SaludUniversidad del RosarioCarrera 98#18-49760001BogotaColombia Méderi Hospital Universitario Mayor Colombia School of Medicine Universidad ICESI(ICESI University)CaliColombia Department of Surgery University of PittsburghPittsburghPAUSA

Background:Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury(AKI)in severely injured patients admitted to the Intensive Care Unit(ICU)for whom creatine kinase(CK)levels were ***:For this retrospective observational study,we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili(FVL)University *** primary outcome was the incidence of *** regression analysis was used to assess risk factors for this ***:A total of 315 patients were *** trauma mechanisms were blunt(n=130),penetrating(n=66)and blast(n=44)*** median[interquartile range,(IQR)of injury severity score(ISS)was 21(16–29).AKI developed in 75 patients(23.8%).Multivariate regression analysis revealed that the thoracic abbreviated injury scale(AIS)value(median(IQR)in the AKI group:3(0–4)],Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ)score[median(IQR)in the AKI group:18(10–27)],CK greater than 5000 U/L,lactic acid concentration at admission,and dobutamine administration were independently associated with ***:We found that age,APACHE Ⅱ score,thoracic trauma,lactic acidosis,and dobutamine administration were independently associated with *** surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.

关键词： Rhabdomyolysis Wounds and injuries Acute kidney injury Critical care Trauma

Planetary Gear Profile Modification Design Based on Load Sharing Modelling

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2015年第4期28卷 810-820页

作者： IGLESIAS Miguel FERNáNDEZ DEL RINCóN alfonso DE-juan Ana Magdalena GARCIA Pablo DIEZ Alberto VIADERO Fernando Mechanical Engineering Research Group University of Cantabria

In order to satisfy the increasing demand on high performance planetary transmissions, an important line of research is focused on the understanding of some of the underlying phenomena involved in this mechanical system. Through the development of models capable of reproduce the system behavior, research in this area contributes to improve gear transmission insight, helping developing better maintenance practices and more efficient design processes. A planetary gear model used for the design of profile modifications ratio based on the levelling of the load sharing ratio is presented. The gear profile geometry definition, following a vectorial approach that mimics the real cutting process of gears, is thoroughly described. Teeth undercutting and hypotrochoid definition are implicitly considered, and a procedure for the incorporation of a rounding arc at the tooth tip in order to deal with corner contacts is described. A procedure for the modeling of profile deviations is presented, which can be used for the introduction of both manufacturing errors and designed profile modifications. An easy and flexible implementation of the profile deviation within the planetary model is accomplished based on the geometric overlapping. The contact force calculation and dynamic implementation used in the model are also introduced, and parameters from a real transmission for agricultural applications are presented for the application example. A set of reliefs is designed based on the levelling of the load sharing ratio for the example transmission, and finally some other important dynamic factors of the transmission are analyzed to assess the changes in the dynamic behavior with respect to the non-modified case. Thus, the main innovative aspect of the proposed planetary transmission model is the capacity of providing a simulated load sharing ratio which serves as design variable for the calculation of the tooth profile modifications.

关键词： transmission planetary gear load sharing relief profile modification

Late hepatic artery pseudoaneurysm:A rare complication after resection of hilar cholangiocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第38期14卷 5920-5923页

作者： Javier Briceńo lvaro naranjo Rubén Ciria juan Manuel Sánchez-Hidalgo Luis Zurera Pedro López-Cillero Hepatobiliary Surgery and Liver Transplantation Unit Department of Surgery Hospital Universitario Reina SofíaCórdoba 14004 Spain Interventional Radiology Unit Department of Surgery Hospital Universitario Reina SofíaCórdoba 14004 Spain

We report an unusual pathological entity of a pseudoaneurysm of the right hepatic artery, which developed two years after the resection of a type 11 hilar cholangiocarcinoma and secondary to an excessive skeletonization for regional lymphadenectomy and neoadjuvant external-beam radiotherapy. After a sudden and massive hematemesis, a multidetector computed tomographic angiography （MDCTA） showed a hepatic artery pseudoaneurysm. Angiography with embolization of the pseudoaneurysm was attempted using microcoils with adequate patency of the hepatic artery and the occlusion of the pseudoaneurysm. A new episode of hematemesis 3 wk later revealed a partial revascularization of the pseudoaneurysm. A definitive interventional radiological treatment consisting of transarterial embolization （TAE） of the right hepatic artery with stainless steel coils and polyvinyl alcohol particles was effective and welltolerated with normal liver function tests and without signs of liver infarction.

关键词： Hepatic artery pseudoaneurysm Hilar cholangiocarcinoma Pseudoaneurysm embolization Transarterial embolization Chemoradiotherapy