Acute kidney injury in severely injured patients admitted to the Intensive Care Unit

作     者：Alberto F.García Ramiro Manzano-Nunez Juan G.Bayona Maria P.Naranjo Dary Neicce Villa Manuel Moreno Sebastian Ossa Juan M.Martinez Nathalia Martinez Juan C.Puyana Alberto F.García;Ramiro Manzano-Nunez;Juan G.Bayona;Maria P.Naranjo;Dary Neicce Villa;Manuel Moreno;Sebastian Ossa;Juan M.Martinez;Nathalia Martinez;Juan C.Puyana

作者机构：Division of Trauma and Acute Care SurgeryDepartment of SurgeryFundación Valle del LiliCaliColombia Clinical Research CenterFundación Valle del LiliCaliColombia Escuela de MedicinaCiencias de la SaludUniversidad del RosarioCarrera 98#18-49760001BogotaColombia Méderi Hospital Universitario MayorColombia School of MedicineUniversidad ICESI(ICESI University)CaliColombia Department of SurgeryUniversity of PittsburghPittsburghPAUSA 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2021年第8卷第2期

页      面：141-147页

核心收录：

学科分类：100218[医学-急诊医学] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

基　　金：supported in part by the National Institutes of Health John E.Fogarty International Center grant#D43 TW007560 

主　　题：Rhabdomyolysis Wounds and injuries Acute kidney injury Critical care Trauma 

摘      要：Background:Our objective was to identify possible associations between clinical and laboratory variables and the risk of developing acute kidney injury(AKI)in severely injured patients admitted to the Intensive Care Unit(ICU)for whom creatine kinase(CK)levels were ***:For this retrospective observational study,we analyzed adult trauma patients admitted to the ICU from 2011 to 2015 at Fundación Valle del Lili(FVL)University *** primary outcome was the incidence of *** regression analysis was used to assess risk factors for this ***:A total of 315 patients were *** trauma mechanisms were blunt(n=130),penetrating(n=66)and blast(n=44)*** median[interquartile range,(IQR)of injury severity score(ISS)was 21(16–29).AKI developed in 75 patients(23.8%).Multivariate regression analysis revealed that the thoracic abbreviated injury scale(AIS)value(median(IQR)in the AKI group:3(0–4)],Acute Physiology and Chronic Health Evaluation(APACHE Ⅱ)score[median(IQR)in the AKI group:18(10–27)],CK greater than 5000 U/L,lactic acid concentration at admission,and dobutamine administration were independently associated with ***:We found that age,APACHE Ⅱ score,thoracic trauma,lactic acidosis,and dobutamine administration were independently associated with *** surgeons need to be aware of the increased odds of AKI if one of these factors is identified during the evaluation and treatment of injured patients.