Biomedical overview of *** molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy
作者机构:Facultad de MedicinaInstituto de Oncología“Angel H.Roffo”Universidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada(CIBQA)Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadrid28049Spain
出 版 物:《BIOCELL》 (生物细胞(英文))
年 卷 期:2022年第46卷第6期
页 面:1391-1415页
核心收录:
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Eumelanin Melanin models Melanin synthesis Molecular orbitals Supramolecular structure
摘 要:Melanins represent one of the most ancient and important group of natural macromolecular *** have multiple biological roles in almost all organisms across the Phyla,examples being photoprotection,anti-oxidative action,radical scavenger activity,and heavy metal *** the biomedical point of view,melanocytes are involved in the origin of melanoma tumors,and the main therapeutic advances for their treatment have been revised in Part 1 of this *** chemical structure of eumelanin is a biological concern of great importance,and therefore,exploring theoretical molecular models and synthesis mechanisms will be here described,as well as molecular orbital features and supramolecular organization,which are responsible for the key properties that make these biological pigments so important,and so ***,this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin,in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.