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World Journal of Pediatrics 2018年第6期14卷 548-554页

作者： Alexander K.C.Leung Kin Fon Leong joseph m.Lam Department of Pediatrics The Alberta Children's HospitalThe University of Calgary#200233-16th Avenue NWCalgaryAB T2M 0H5Canada Pediatric Institute Kuala Lumpur General HospitalKuala LumpurMalaysia Department of Pediatrics and Department of Dermatology and Skin Sciences University of British ColumbiaVancouverBCCanada

Background Erythema nodosum can be associated with a number of systemic diseases. There is, however, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum. Data sources A Pubmed search was completed in Clinical Queries using the key terms 'erythema nodosum'. Results Clinically, erythema nodosum presents with a sudden onset of painful, erythematous, subcutaneous nodules mainly localized to the pretibial areas. Lesions are usually bilateral and symmetrical, ranging from 1 to 5 cm in diameter. Erythema nodosum may be associated with a variety of conditions such as infection, medications, sarcoidosis, pregnancy, inflamma-tory bowel disease, vaccination, autoimmune disease, malignancy, and miscellaneous causes. The condition is idiopathic in approximately 50% of cases. The diagnosis is mainly clinical with biopsy reserved for atypical cases. To evaluate for the underlying cause, some basic laboratory screening studies are worthwhile in most cases and include a complete blood cell count, erythrocyte sedimentation rate and/or C-reactive protein, throat swab culture, antistreptococcal O titers, and a chest radiograph. Other tests should be individualized, guided by the history and physical examination results. most cases of ery-thema nodosum are self-limited and require no treatment. Bed rest and leg elevation are generally recommended to reduce the discomfort. Nonsteroidal anti-inflammatory drugs are the first-line treatment for pain management. Conclusions As erythema nodosum is often a cutaneous manifestation of a systemic disease, a thorough search should be performed to reveal the underlying cause.

关键词： Drug-induced Group A β-hemolytic streptococcal infection Sarcoidosis Subcutaneous pretibial nodules Tuberculosis Yersinia infection

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mechanical Characterization of Rubber Latex-Based Carpets (Hevea bresiliensis): Influence of Rubber Latex Content and Fiber Fabrics (Cotton and mosquito Nets) on Wear Resistance of Rubber Latex-Based Carpets

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Open Journal of Composite materials 2023年第3期13卷 47-55页

作者： Assoumou joseph Yomanfo Obre Sery Paul Jolissaint Edjikémé Emeruwa maméry Adama Serifou Soil Water and Geomaterials Laboratory (UFR-STRM) Felix Houphouet-Boigny University Abidjan Ivory Coast

This work focuses on the development of carpets from sand, fabrics of cotton fiber and mosquito nets and rubber latex. Following a study on the choice of the best formulations, the quantity of rubber latex used for shaping varies between 14% and 18% (latex/sand + latex ratio) for the carpet with the fabric of mosquito nets and between 16% and 18% for the one made with the fabric of cotton fiber. Thus, with a mixture of sand, fiber fabrics (cotton and mosquito nets) and rubber latex, carpets were developed. In addition, the wear test carried out on these samples indicates that it is possible to produce carpets with the new material made of rubber sand and latex: SABLATEX At room temperature. Following the characterization test, it resorts to only 16% latex with cotton fiber fabric, allowing to have carpets with good mechanical characteristics.

关键词： Carpet Rubber Latex Wear Test Latex Content Fiber Fabrics

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Obesity is associated with decreased risk of microscopic colitis in women

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World Journal of Gastroenterology 2022年第2期28卷 230-241页

作者： Robert S Sandler Temitope O Keku John T Woosley Dale P Sandler joseph A Galanko Anne F Peery Department of medicine University of North CarolinaChapel HillNC 27514-7555United States Department of medicine University of North CarolinaChapel HillNC 27514-7555United States Department of PathologyUniversity of North CarolinaChapel HillNC 27514United States Department of Health and Human Services National Institute of Environmental Health SciencesDurhamNC 27709United States

BACKGROUND microscopic colitis is a leading cause of diarrhea in the older *** is limited information about risk *** hypothesized that obesity would be associated with microscopic *** To examine the association between obesity and microscopic colitis in men and women undergoing *** We conducted a case-control study at the University of North Carolina *** identified and enrolled men and women referred for elective,outpatient colonoscopy for chronic *** excluded patients with a past diagnosis of Crohn’s disease or ulcerative colitis.A research pathologist reviewed biopsies on every patient and classified them as microscopic colitis cases or non-microscopic colitis *** provided information on body weight,height and exposure to medications via structured interviews or Internet based *** analysis included 110 patients with microscopic colitis(cases)and 252 nonmicroscopic colitis *** analyses were performed using logistic regression to estimate odds ratios and 95%confidence *** Cases were older and more likely than controls to be white *** subjects were well educated,but cases were better educated than *** with microscopic colitis had lower body mass index than controls and reported more weight loss after the onset of *** to patients who were normal or under-weight,obese(BmI>30 kg/m2)patients were substantially less likely to have microscopic colitis after adjusting for age and education,adjusted OR(aOR)0.35,95%confidence interval(CI)0.18-0.66).When stratified by sex,the association was limited to obese women,aOR 0.21,95%CI:*** with microscopic colitis were more likely to report weight loss after the onset of *** stratifying by weight loss,there remained a strong inverse association between obesity and microscopic colitis,aOR 0.33,95%CI:0.10-1.11 among the patients who did not lose *** use of birth

关键词： Colitis microscopic/epidemiology Humans Diarrhea/epidemiology Obesity

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The Belt and Road Initiative and Technical and Vocational Education and Training(TVET)in Kenya:The Kenya-China TVET Project

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Frontiers of Education in China 2018年第3期13卷 346-374页

作者： Caroline m.mUSYImI joseph mALECHWANZI LUO Heng Department of Engineering Coast Institute of TechnologyVoi 80300Kenya School of Educational Information Technology Central China Normal UniversityWuhan 430079China

This study explores the impact of China’s Belt and Road Initiative on improving vocational education quality and employment rates in Kenya through a collaborative educational program known as the Kenya-China Technical and Vocational Education and Training(TVET)*** opinions and narratives of teachers and students with vibrant knowledge of the project were analyzed through the theoretical lenses of globalization and *** results show that the Kenya-China TVET Project has improved Kenyan TVET classrooms with modern equipment to meet industrial standards and allowed essential skills to be developed through various collaborative opportunities with Chinese *** minor challenges and obstacles,early evidence suggests benefits brought by the project including increased self-employment,a growth in Kenya’s manufacturing,and more mutual understanding between the two countries.

关键词： Technical and Vocational Education and Training(TVET) the Belt and Road Initiative(BRI) educational collaboration employment Kenya

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Colorectal cancer risk following appendectomy:a pooled analysis of three large prospective cohort studies

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Cancer Communications 2022年第5期42卷 486-489页

作者： joseph A.Rothwell Nagisa mori Fanny Artaud Agnès Fournier marco Conte marie-Christine Boutron-Ruault Simon S.m.Chan marc J.Gunter Neil murphy Gianluca Severi UniversitéParis-Saclay UVSQInsermGustave RoussyExposome and Heredity teamCentre for Epidemiology and Population Health(CESP U1018)Villejuif 94800France Nutrition and metabolism Branch International Agency for Research on Cancer(IARC)150 Cours Albert ThomasLyon 69008France Department of Gastroenterology Norfolk and Norwich University Hospital NHS TrustNorwich NR47UYUnited Kingdom Department of medicine Bob Champion Research and Education BuildingNorwich Medical SchoolUniversity of East AngliaNorwich NR47UQUnited Kingdom Department of Statistics Computer ScienceApplications“G.Parenti”University of FlorenceFlorence 50134Italy

Dear Editor,Appendectomy is usually performed to treat acute appendicitis although it may also be conducted in the absence of appendicitis when patients suffer from chronic abdominal *** is also known to mitigate the risk of ulcerative colitis[1],a risk factor for colorectal *** impact of appendectomy on colorectal cancer risk,particularly in the long term,is *** procedurewas initially hypothesized to increase colorectal cancer risk due to decreased immunocompetency.

关键词： cancer colorectal acute

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Gianotti-Crosti syndrome(papular acrodermatitis of childhood)in the era of a viral recrudescence and vaccine opposition

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World Journal of Pediatrics 2019年第6期15卷 521-527页

作者： Alexander K.C.Leung Consolato maria Sergi joseph m.Lam Kin Fon Leong Department of Pediatrics The University of CalgaryCalgaryCanada The Alberta Children's Hospital #200233-16th Avenue NWCalgaryAB T2M OH5Canada The University of Alberta EdmontonABCanada Departments of Pediatrics Dermatology and Skin SciencesUniversity of British ColumbiaVancouverBCCanada Pediatric Institute Kuala Lumpur General HospitalKuala LumpurMalaysia

Background Gianotti-Crosti syndrome is characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical *** sources A Pubmed search was conducted using Clinical Queries with the key terms"Gianotti-Crosti syndrome"OR"papular acrodermatitis".The search strategy included meta-analyses,randomized controlled trials,clinical trials,observa-tional studies,and *** paper is based on,but not limited to,the search *** The eruption of Gianotti-Crosti syndrome is found predominantly on the cheeks,extensor surfaces of the extremities,and *** is a sparing of antecubital and popliteal fossae as well as palms,soles,and mucosal *** often asymptomatic,the lesions may be mildly to moderately ***-Crosti syndrome is most common in children between 1 and 6 years of *** Epstein-Barr virus and the hepatitis B virus are the most common pathogens associated with Gianotti-Crosti *** treatment for Gianotti-Crosti syndrome is necessary because it is *** an era of vaccine hesitancy and refusal,Gianotti-Crosti syndrome may be important to mention to parents,because it can occur and trigger *** Gianotti-Crosti syndrome is mainly a disease of early childhood,characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical *** the advent of more universal vaccination against hepatitis B virus,Epstein-Barr virus has become the most common etiologic agent of Gianotti-Crosti *** cases of post-vaccination Gianotti-Crosti syndrome have been ***,the emphasis should be placed on its self-limiting attribution.

关键词： Epstein-Barr virus Hepatitis B virus Papular acrodermatitis Papular symmetrical eruption

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Electro-acupuncture to prevent prolonged postoperative ileus:A randomized clinical trial

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World Journal of Gastroenterology 2010年第1期16卷 104-111页

作者： m Kay Garcia joseph S Chiang Bob Thornton J Lynn Palmer Jennifer mcQuade Lorenzo Cohen Department of Anesthesiology and Pain medicine/Integrative medicine M.D.Anderson Cancer CenterThe University of Texas Department of Anesthesiology and Pain medicine M.D.Anderson Cancer CenterThe University of Texas Department of Palliative Care and Rehabilitation medicine M.D.Anderson Cancer CenterThe University of Texas Department of Behavioral Science M.D.Anderson Cancer CenterThe University of Texas Department of GI medical Oncology M.D. Anderson Cancer CenterThe University of Texas

AIm:To examine whether acupuncture can prevent prolonged postoperative ileus(PPOI)after intraperitoneal surgery for colon cancer. mETHODS:Ninety patients were recruited from the Fudan University Cancer Hospital,Shanghai,China. After surgery,patients were randomized to receive acupuncture(once daily,starting on postoperative day 1, for up to six consecutive days)or usual *** was defined as an inability to pass flatus or have a bowel movement by 96 h after *** main outcomes were time to first flatus,time to first bowel movement, and *** outcomes were quality of life(QOL)measures,including pain, nausea,insomnia,abdominal distension/fullness,and sense of well-being. RESULTS:No significant differences in PPOI on day 4 (P=0.71)or QOL measures were found between the *** were also no group differences when the data were analyzed by examining those whose PPOI had resolved by day 5(P=0.69)or day 6(P= 0.88).No adverse events related to acupuncture were reported. CONCLUSION:Acupuncture did not prevent PPOI andwas not useful for treating PPOI once it had developed in this population.

关键词： Acupuncture Gastrointestinal motility Gastrointestinal disorders Gastrointestinal neoplasms

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INITIAL BOUNDARY VALUE PROBLEm FOR A NONCONSERVATIVE SYSTEm IN ELASTODYNAmICS

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Acta mathematica Scientia 2018年第3期38卷 1043-1056页

作者： K.Divya joseph P.A.DINESH Department of mathematics M.S.Ramaiah Institute of Technology MSRIT P.O

This article is concerned with the initial boundary value problem for a nonconservative system of hyperbolic equation appearing in elastodynamics in the space time domain x 〉 0, t 〉 0. The number of boundary conditions, to be prescribed at the boundary x = 0,depends on the number of characteristics entering the domain. Because our system is nonlinear, the characteristic speeds depends on the unknown and the direction of the characteristics curves are known apriori. As it is well known, the boundary condition has to be understood in a generalised way. One of the standard way is using vanishing viscosity method. We use this method to construct solution for a particular class of initial and boundary data, namely the initial and boundary datas that lie on the level sets of one of the Riemann invariants.

关键词： Elastodynamics viscous shocks

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Expansion of GARP-Expressing CD4^(+)CD25^(-)FoxP3^(+)T Cells and SATB1Association with Activation and Coagulation in Immune Compromised HIV-1-Infected Individuals in South Africa

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Virologica Sinica 2021年第5期36卷 1133-1143页

作者： Eman Teer Danzil E.joseph Leanne Dominick Richard H.Glashoff m.Faadiel Essop Centre for Cardio-metabolic Research in Africa(CARmA) Department of Physiological SciencesStellenbosch UniversityStellenbosch 7600South Africa Division of medical microbiology and Immunology Department of PathologyStellenbosch University and NHLSCape Town 7505South Africa

Although antiretroviral treatment lowers the burden of human immunodeficiency virus(HIV)-related disease,it does not always result in immunological *** manifests as persistent chronic inflammation,immune activation or exhaustion that can promote the onset of *** the exact function of regulatory T(Treg)cells in HIV remains unclear,this cross-sectional study investigated three expression markers(Forkhead box protein P3[FOXP3],glycoprotein A repetitions predominant[GARP],special AT-rich sequence binding protein 1[SATB1])and compared their expansion between CD4^(+)CD25^(-)and CD4^(+)CD25^(++)T ***-matched study subjects were recruited(Western Cape,South Africa)and sub-divided:HIV-negative subjects(n=12),HIV-positive na(i|")ve treated(n=22),HIV-positive treated based on CD4 count cells/μL(CD4>500 and CD4mL(VL1000)(n=34).markers of immune activation(CD38)and coagulation(CD142)on T cells(CD8)were assessed by flow cytometry together with FOXP3,GARP and SATB1 expression on CD4^(+)CD25^(-)and CD4^(+)CD25^(++)T *** levels of interleukin-10(IL-10;anti-inflammatory marker),IL-6(inflammatory marker)and D-dimer(coagulation marker)were *** study revealed three major findings in immuno-compromised patients with virological failure(CD41000):(1)the expansion of the unconventional Treg cell subset(CD4^(+)CD25^(-)FOXP3^(+))is linked with disease progression markers;(2)increased GARP expression in the CD4^(+)CD25^(-)and CD4^(+)CD25^(++)subsets;and(3)the identification of a strong link between CD4^(+)CD25^(-)SATB1+cells and markers of immune activation(CD8^(+)CD38^(+))and coagulation(CD8^(+)CD142^(+)and D-dimer).

关键词： Human immunodeficiency virus(HIV) Regulatory T cells(Treg) Immune activation Progression markers Glycoprotein A repetitions predominant(GARP) Forkhead box protein P3(FOXP3)

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Twenty years of drought-mediated change in snag populations in mixed-conifer and ponderosa pine forests in Northern Arizona

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Forest Ecosystems 2021年第2期8卷 265-277页

作者： joseph L.Ganey Jose m.Iniguez Scott C.Vojta Amy R.Iniguez US Forest Service Rocky Mountain Research Station2500 S.Pine KnollAZ 86001 FlagstaffUSA

Background:Snags(standing dead trees)are important biological legacies in forest systems,providing numerous resources as well as a record of recent tree *** 1997 to 2017,we monitored snag populations in drought-influenced mixed-conifer and ponderosa pine(Pinus ponderosa)forests in northern ***:Snag density increased significantly in both forest *** increase was driven largely by a pulse in snag recruitment that occurred between 2002 and 2007,fol owing an extreme drought year in 2002,with snag recruitment returning to pre-pulse levels in subsequent time *** later years during the study also were warmer and/or drier than average,but these years were not as extreme as 2002 and did not trigger the same level of snag *** recruitment was not equal across tree species and size classes,resulting in significant changes in species composition and size-class distributions of snag populations in both forest *** trees were far more abundant than snags in these forests,the effect of this mortality pulse on tree populations was far smal er than its effect on snag *** loss rates increased over time during the study,even though many snags were newly *** may reflect the increasing prevalence of white fir snags and/or snags in the smal er size classes,which general y decay faster than snags of other species or larger ***,although total numbers of snags increased,many of the newly recruited snags may not persist long enough to be valuable as nesting substrates for native ***:Increases in snag abundance appeared to be due to a short-term tree mortality"event"rather than a longerterm pattern of elevated tree *** mortality event fol owed a dry and extremely warm year(2002)embedded within a longer-term *** models suggest that years like 2002 may occur with increasing frequency in the southwestern *** years may result in additional mortality pulses,wh

关键词： Climate change Drought monitoring Snag abundance Snag creation Snag dynamics Species composition Tree mortality

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