Expansion of GARP-Expressing CD4^(+)CD25^(-)FoxP3^(+)T Cells and SATB1Association with Activation and Coagulation in Immune Compromised HIV-1-Infected Individuals in South Africa

作     者：Eman Teer Danzil E.Joseph Leanne Dominick Richard H.Glashoff M.Faadiel Essop Eman Teer;Danzil E.Joseph;Leanne Dominick;Richard H.Glashoff;M.Faadiel Essop

作者机构：Centre for Cardio-Metabolic Research in Africa(CARMA)Department of Physiological SciencesStellenbosch UniversityStellenbosch 7600South Africa Division of Medical Microbiology and ImmunologyDepartment of PathologyStellenbosch University and NHLSCape Town 7505South Africa 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2021年第36卷第5期

页      面：1133-1143页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by South African Medical Research Council and Stellenbosch University(to M.F.Essop) 

主　　题：Human immunodeficiency virus(HIV) Regulatory T cells(Treg) Immune activation Progression markers Glycoprotein A repetitions predominant(GARP) Forkhead box protein P3(FOXP3) 

摘      要：Although antiretroviral treatment lowers the burden of human immunodeficiency virus(HIV)-related disease,it does not always result in immunological *** manifests as persistent chronic inflammation,immune activation or exhaustion that can promote the onset of *** the exact function of regulatory T(Treg)cells in HIV remains unclear,this cross-sectional study investigated three expression markers(Forkhead box protein P3[FOXP3],glycoprotein A repetitions predominant[GARP],special AT-rich sequence binding protein 1[SATB1])and compared their expansion between CD4^(+)CD25^(-)and CD4^(+)CD25^(++)T ***-matched study subjects were recruited(Western Cape,South Africa)and sub-divided:HIV-negative subjects(n=12),HIV-positive na(i|)ve treated(n=22),HIV-positive treated based on CD4 count cells/μL(CD4500 and CD41000)(n=34).Markers of immune activation(CD38)and coagulation(CD142)on T cells(CD8)were assessed by flow cytometry together with FOXP3,GARP and SATB1 expression on CD4^(+)CD25^(-)and CD4^(+)CD25^(++)T *** levels of interleukin-10(IL-10;anti-inflammatory marker),IL-6(inflammatory marker)and D-dimer(coagulation marker)were *** study revealed three major findings in immuno-compromised patients with virological failure(CD41000):(1)the expansion of the unconventional Treg cell subset(CD4^(+)CD25^(-)FOXP3^(+))is linked with disease progression markers;(2)increased GARP expression in the CD4^(+)CD25^(-)and CD4^(+)CD25^(++)subsets;and(3)the identification of a strong link between CD4^(+)CD25^(-)SATB1+cells and markers of immune activation(CD8^(+)CD38^(+))and coagulation(CD8^(+)CD142^(+)and D-dimer).